Association Between Serum Fetuin-A levels, Carotid Artery Stiffness, and Intima–Media Thickness in Patients With Normotensive Obstructive Sleep Apnea Syndrome

Angiology - Tập 65 Số 7 - Trang 607-613 - 2014
Aydın Akyüz1, Mustafa Oran2, Şeref Alpsoy1, Levent Cem Mutlu3, Dursun Çayan Akkoyun1, Savaş Güzel4, Recep Alp5
1Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
2Department of Internal Medicine, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
3Department of Chest Disease, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
4Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
5Department of Neurology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey

Tóm tắt

Increased carotid intima–media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 ± 6.5 vs 68.2 ± 5.8 ng/mL, P = .029), higher mean cIMT (0.73 ± 0.2 vs 0.63 ± 0.3 mm, P < .001), and greater stiffness (β) index (7.45 ± 0.9 vs 5.2 ± 0.7, P = .001) in the OSAS group. The cIMT and stiffness (β) index were inversely correlated with fetuin-A levels ( r = −.324, P = .033; r = −.466, P < .001, respectively) and positively correlated with apnea hypopnea index ( r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.

Từ khóa


Tài liệu tham khảo

10.1177/0003319710394161

10.1378/chest.106.2.466

10.1161/01.CIR.0000136587.68725.8E

10.1161/CIRCULATIONAHA.108.783290

10.1164/ajrccm.163.1.2001008

10.1056/NEJM200005113421901

10.1056/NEJMoa043104

10.1016/j.ncl.2005.05.005

10.1161/01.CIR.0000118216.84358.22

10.1161/01.HYP.0000101686.98973.A3

10.1164/ajrccm.165.5.2103001

10.1183/09031936.06.00042105

10.1161/CIRCULATIONAHA.106.628875

10.1093/eurheartj/ehl254

10.1161/CIRCRESAHA.110.234260

10.1016/j.amjcard.2010.01.342

10.2174/156652412800620039

10.1161/circ.106.25.3143

10.1016/j.cca.2010.04.020

10.1161/01.CIR.94.11.3026

10.1161/01.HYP.0000202052.25238.68

10.1002/jcu.20093

10.1159/000093531

10.1016/j.atherosclerosis.2009.07.034

10.1161/CIRCULATIONAHA.108.830380

10.1038/hr.2012.136

10.1016/j.regpep.2008.12.001

Hakeem F, 2010, J Coll Physicians Surg Pak, 20, 79

Raman PG, 2001, J Assoc Physicians India, 49, 1074

10.1164/ajrccm.162.6.2001048

10.1007/s00408-012-9427-3

10.3109/15412555.2012.727922

10.1161/CIRCULATIONAHA.108.814418

10.1111/j.1365-2265.2006.02716.x

Thông tin
Thông tin xuất bản

Angiology

Tập 65 Số 7

607-613

Thông tin tác giả