Association Between Prehospital Tranexamic Acid Administration and Outcomes of Severe Traumatic Brain Injury

JAMA Neurology - Tập 78 Số 3 - Trang 338 - 2021
Sebastiaan M. Bossers1, Stephan A. Loer1, Frank W. Bloemers2, Dennis Den Hartog3, Esther M.M. Van Lieshout3, Nico Hoogerwerf4,5, Joukje van der Naalt6, Anthony Absalom7, Saskia M. Peerdeman8, Lothar A. Schwarte1,9, Christa Boer1, Patrick Schober1,9, Anne de Boer10, Johannes C. Goslings10, S.H. van Helden10, Danique Hesselink10, Gijs van Aken10, Albertus Beishuizen10, Rolf Egberink10, Nancy ter Bogt10, Mariska A. C. de Jongh10, Koen W. W. Lansink10, Gerwin Roks10, Pieter Joosse10, Kees Jan Ponsen10, Lukas L. van Spengler10, Stasja J. G. Aspers10, Annelies Toor10, Robert Jan Houmes10, Jan C. van Ditshuizen10, Tea van Voorden10, Michael J. Edwards10, Bert Dercksen10, Rob Spanjersberg10, Lieneke F. Venema10, Ellen Weelink10, Inge H. F. Reininga10, Gerard Innemee10, Matthijs de Visser10, Marcel A. de Leeuw10
1Department of Anesthesiology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
2Department of Surgery, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
3Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
4Department of Anesthesiology, Radboud University Medical Center, Nijmegen, The Netherlands
5Helicopter Emergency Medical Service Lifeliner 3, Nijmegen, The Netherlands
6Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
7Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
8Department of Neurosurgery, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
9Helicopter Emergency Medical Service Lifeliner 1, Amsterdam, the Netherlands
10for the BRAIN-PROTECT collaborators

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Tài liệu tham khảo

Rubiano, 2015, Global neurotrauma research challenges and opportunities., Nature, 527, S193, 10.1038/nature16035

Dewan, 2018, Estimating the global incidence of traumatic brain injury., J Neurosurg, 130, 1

Perel, 2009, Intracranial bleeding in patients with traumatic brain injury: a prognostic study., BMC Emerg Med, 9, 15, 10.1186/1471-227X-9-15

Shakur, 2010, Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial., Lancet, 376, 23, 10.1016/S0140-6736(10)60835-5

Roberts, 2014, Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial., Crit Care, 18, 685, 10.1186/s13054-014-0685-8

CRASH-3 trial collaborators, 2019, Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial., Lancet, 394, 1713, 10.1016/S0140-6736(19)32233-0

Rowell, 2020, Effect of out-of-hospital tranexamic acid vs placebo on 6-month functional neurologic outcomes in patients with moderate or severe traumatic brain injury., JAMA, 324, 961, 10.1001/jama.2020.8958

von Elm, 2007, The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies., Lancet, 370, 1453, 10.1016/S0140-6736(07)61602-X

Bossers, 2019, Dutch prospective observational study on prehospital treatment of severe traumatic brain injury: the BRAIN-PROTECT study protocol., Prehosp Emerg Care, 23, 820, 10.1080/10903127.2019.1587126

Franschman, 2012, Effects of physician-based emergency medical service dispatch in severe traumatic brain injury on prehospital run time., Injury, 43, 1838, 10.1016/j.injury.2012.05.020

Ringdal, 2008, The Utstein template for uniform reporting of data following major trauma: a joint revision by SCANTEM, TARN, DGU-TR and RITG., Scand J Trauma Resusc Emerg Med, 16, 7, 10.1186/1757-7241-16-7

Schober, 2019, Descriptive statistics in medical research., Anesth Analg, 129, 1445, 10.1213/ANE.0000000000004480

Vetter, 2018, Regression: the apple does not fall far from the tree., Anesth Analg, 127, 277, 10.1213/ANE.0000000000003424

Schober, 2018, Repeated measures designs and analysis of longitudinal data: if at first you do not succeed-try, try again., Anesth Analg, 127, 569, 10.1213/ANE.0000000000003511

Kyriacou, 2016, Confounding by indication in clinical research., JAMA, 316, 1818, 10.1001/jama.2016.16435

Schober, 2020, Confounding in observational research., Anesth Analg, 130, 635, 10.1213/ANE.0000000000004627

Bossers, 2020, Epidemiology, prehospital characteristics and outcomes of severe traumatic brain injury in the Netherlands: the BRAIN-PROTECT study., Prehosp Emerg Care, 10.1080/10903127.2020.1824049

Vetter, 2018, Diagnostic testing and decision-making: beauty is not just in the eye of the beholder., Anesth Analg, 127, 1085, 10.1213/ANE.0000000000003698

Schober, 2020, Missing data and imputation methods., Anesth Analg, 131, 1419, 10.1213/ANE.0000000000005068

Schober, 2020, Adjustments for multiple testing in medical research., Anesth Analg, 130, 99, 10.1213/ANE.0000000000004545

Schober, 2018, Survival analysis and interpretation of time-to-event data: the tortoise and the hare., Anesth Analg, 127, 792, 10.1213/ANE.0000000000003653

Lier, 2019, Tranexamic acid for acute hemorrhage: a narrative review of landmark studies and a critical reappraisal of its use over the last decade., Anesth Analg, 129, 1574, 10.1213/ANE.0000000000004389

WOMAN Trial Collaborators, 2017, Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial., Lancet, 389, 2105, 10.1016/S0140-6736(17)30638-4

Ker, 2013, Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss., Br J Surg, 100, 1271, 10.1002/bjs.2013.100.issue-10

Dekker, 2016, Relationship between tissue perfusion and coagulopathy in traumatic brain injury., J Surg Res, 205, 147, 10.1016/j.jss.2016.06.023

Talving, 2009, Coagulopathy in severe traumatic brain injury: a prospective study., J Trauma, 66, 55

Harhangi, 2008, Coagulation disorders after traumatic brain injury., Acta Neurochir (Wien), 150, 165, 10.1007/s00701-007-1475-8

Stein, 2004, Coagulopathy in traumatic brain injury., Neurocrit Care, 1, 479, 10.1385/NCC:1:4

Skrifvars, 2017, Venous thromboembolic events in critically ill traumatic brain injury patients., Intensive Care Med, 43, 419, 10.1007/s00134-016-4655-2

Schober, 2020, Tranexamic acid for traumatic brain injury., Lancet, 396, 164, 10.1016/S0140-6736(20)30542-0

Weng, 2019, Effect of tranexamic acid in patients with traumatic brain injury: a systematic review and meta-analysis., World Neurosurg, 123, 128, 10.1016/j.wneu.2018.11.214

Manley, 2001, Hypotension, hypoxia, and head injury: frequency, duration, and consequences., Arch Surg, 136, 1118, 10.1001/archsurg.136.10.1118

Wafaisade, 2016, Prehospital administration of tranexamic acid in trauma patients., Crit Care, 20, 143, 10.1186/s13054-016-1322-5

Shah Jahan, 2019, Administration of tranexamic acid for victims of severe trauma within pre-hospital care ambulance services (PHCAS) in Malaysia., Med J Malaysia, 74, 300

Huebner, 2017, Tranexamic acid use in prehospital uncontrolled hemorrhage., Wilderness Environ Med, 28, S50, 10.1016/j.wem.2016.12.006

Queensland Ambulance Service. Drug therapy protocols: tranexamic acid. Accessed May 31, 2020. https://www.ambulance.qld.gov.au/docs/clinical/dtprotocols/DTP_Tranexamic%20acid.pdf?

West Midlands Ambulance Service. Trauma management guidelines. Accessed May 31, 2020. https://www.midlandsairambulance.com/media/1292/trauma-management-guidelines-may-2017.pdf?