Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

JAMA - Journal of the American Medical Association - Tập 324 Số 13 - Trang 1330 - 2020
Jonathan A C Sterne1,2, Srinivas Murthy3, Janet Dı́az4, Arthur S. Slutsky5, Jesús Villar6,7, Derek C. Angus8, Djillali Annane9, Luciano César Pontes Azevedo10,11, Otávio Berwanger12, Alexandre Biasi Cavalcanti13, Pierre‐François Dequin14,15, Bin Du16, Jonathan Emberson17,18, David J. Fisher19, Bruno Giraudeau20, Anthony Gordon21, Anders Granholm22, Cameron Green23, Richard Haynes17,18, Nicholas Heming9, Julian P. T. Higgins24,1,2, Peter Horby25, Peter Jüni5, Martin Landray17,26,18, Amélie Le Gouge20, M Leclerc20, Wei Shen Lim27, F.S. Machado28, Colin McArthur23,29, Ferhat Meziani30,31, Morten Hylander Møller22, Anders Perner22, Marie Warrer Munch22, Jelena Savović24,2, Bruno Martins Tomazini32,11, Viviane Cordeiro Veiga33, Steve Webb23,34, John C. Marshall35
1NIHR Bristol Biomedical Research Centre, Bristol, England
2Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England
3Department of Pediatrics, University of British Columbia, Vancouver, Canada
4Clinical Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland
5Applied Health Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
6CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
7Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain
8Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
9Department of Intensive Care, Raymond Poincaré Hospital (APHP), School of Medicine Simone Veil, University Paris Saclay-UVSQ, Paris, France
10Emergency Medicine Department, University of São Paulo School of Medicine, São Paulo, Brazil
11Hospital Sírio-Libanês, São Paulo, Brazil
12Academic Research Organization, Hospital Israelita Albert Einstein, São Paulo, Brazil
13HCor Research Insitute, São Paulo, Brazil
14CRICS-TriGGERSep Network, Centre d’Etude des Pathologies Respiratoires, Université de Tours, Tours, France
15Médecine Intensive-Réanimation, INSERM CIC1415, CHRU de Tours, Tours, France
16Peking Union Medical College Hospital, Beijing, China
17MRC Population Health Research Unit, University of Oxford, Oxford, England
18Nuffield Department of Population Health, University of Oxford, Oxford, England
19MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, Faculty of Population Health Sciences, University College London, London, England
20CIC INSERM 1415-CHRU de Tours, Tours, France
21Division of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, London, England
22Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
23Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
24NIHR Applied Research Collaboration West, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England
25Nuffield Department of Medicine, University of Oxford, Oxford, England
26NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, England
27Respiratory Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham, England
28Anesthesiology, Pain and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil
29Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand
30Hôpitaux Universitaires de Strasbourg, Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Strasbourg, France
31INSERM UMR 1260, Regenerative Nanomedicine, FMTS, Strasbourg, France
32Department of Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil
33BP—A Beneficência Portuguesa de São Paulo, São Paulo, Brazil
34St John of God Healthcare, Subiaco, Australia
35Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

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JAMA - Journal of the American Medical Association

Tập 324 Số 13

1330

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