Assessment of the bleeding risk of anticoagulant treatment in non-severe frail octogenarians with atrial fibrillation

Go, 2001, Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study, JAMA, 285, 2370, 10.1001/jama.285.18.2370 Wolf, 1991, Atrial fibrillation as an independent risk factor for stroke: the Framingham Study, Stroke, 22, 983, 10.1161/01.STR.22.8.983 Wolf, 1987, Atrial fibrillation: a major contributor to stroke in the elderly: the Framingham Study, Arch Intern Med, 147, 1561, 10.1001/archinte.1987.00370090041008 Clegg, 2013, Frailty in elderly people, Lancet, 381, 752, 10.1016/S0140-6736(12)62167-9 Ho, 2015, New oral anticoagulants: an approach in older people, Geriatr Ther, 45, 217 Rockwood, 2005, A global clinical measure of fitness and frailty in elderly people, CMAJ, 173, 489, 10.1503/cmaj.050051 Guidelines for Diagnosis Treatment of Cardiovascular Diseases (Joint Working Groups Report), 2014, Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013), Circ J, 78, 1997, 10.1253/circj.CJ-66-0092 Rosendaal, 1993, A method to determine the optimal intensity of oral anticoagulant therapy, Thromb Haemost, 69, 236, 10.1055/s-0038-1651587 Dent, 2016, Frailty measurement in research and clinical practice: a review, Eur J Intern Med, 31, 3, 10.1016/j.ejim.2016.03.007 Gregorevic, 2016, The clinical frailty scale predicts functional decline and mortality when used by junior medical staff: a prospective cohort study, BMC Geriatr, 16, 10.1186/s12877-016-0292-4 Wallis, 2015, Association of the clinical frailty scale with hospital outcomes, QJM, 108, 943, 10.1093/qjmed/hcv066 Morley, 2013, Frailty consensus: a call to action, J Am Med Dir Assoc, 14, 392, 10.1016/j.jamda.2013.03.022 Lefebvre, 2016, The effect of bleeding risk and frailty status on anticoagulation patterns in octogenarians with atrial fibrillation: the FRAIL-AF Study, Can J Cardiol, 32, 169, 10.1016/j.cjca.2015.05.012 Pessanha, 2017, Body mass index and its relationship with disability, chronic diseases and frailty in older people: a comparison of the Lipschitz and WHO classifications, J Frailty Aging, 6, 24 Australian and New Zealand Society for Geriatric Medicine, 2009, Australian and New Zealand Society for Geriatric Medicine Position Statement No. 6 – under-nutrition and the older person, Australas J Ageing, 28, 99, 10.1111/j.1741-6612.2009.00357.x Jain, 2011, Implications of obesity for drug therapy: limitations and challenges, Clin Pharmacol Ther, 90, 77, 10.1038/clpt.2011.104 Park, 2017, Increased risk of major bleeding in underweight patients with atrial fibrillation who were prescribed non-vitamin K antagonist oral anticoagulants, Heart Rhythm, 14, 501, 10.1016/j.hrthm.2016.12.036 Ruff, 2014, Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials, Lancet, 383, 955, 10.1016/S0140-6736(13)62343-0 Bengtson, 2017, Comparative effectiveness of dabigatran and rivaroxaban versus warfarin for the treatment of non-valvular atrial fibrillation, J Cardiol, 69, 868, 10.1016/j.jjcc.2016.08.010 Sadlon, 2016, Direct oral anticoagulants in the elderly: systematic review and meta-analysis of evidence, current and future directions, Swiss Med Wkly, 146, w14356 Nakamura, 2017, Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database, J Cardiol, 70, 155, 10.1016/j.jjcc.2016.10.012 Olesen, 2012, Stroke and bleeding in atrial fibrillation with chronic kidney disease, N Engl J Med, 367, 625, 10.1056/NEJMoa1105594 Eikelboom, 2011, Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial, Circulation, 123, 2363, 10.1161/CIRCULATIONAHA.110.004747 Granger, 2011, ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation, N Engl J Med, 365, 981, 10.1056/NEJMoa1107039 Hamatani, 2015, Low body weight is associated with the incidence of stroke in atrial fibrillation patients – insight from the Fushimi AF Registry, Circ J, 79, 1009, 10.1253/circj.CJ-14-1245 Pisters, 2010, A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey, Chest, 138, 1093, 10.1378/chest.10-0134 Lip, 2011, J Am Coll Cardiol, 57, 173, 10.1016/j.jacc.2010.09.024