Assessment of oxLDL, anti-oxLDL antibodies and lipoprotein-associated phospholipase A2 as cardiovascular risk markers in obese adolescents with and without T1DM

Maahs, 2014, Cardiovascular disease risk factors in youth with diabetes mellitus: a scientific statement from the American Heart Association, Circulation, 130, 1532, 10.1161/CIR.0000000000000094 Faienza, 2012, Oxidative stress in obesity and metabolic syndrome in children and adolescents, Horm. Res. Paediatr., 78, 158, 10.1159/000342642 Daniels, 2011, Screening and treatment of dyslipidemias in children and adolescents, Horm. Res. Paediatr., 76, 47, 10.1159/000329163 Diabetes Control and Complications Trial (DCCT), 2016, Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up, Diabetes Care, 39, 686, 10.2337/dc15-1990 Kilpatrick, 2007, Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: “double diabetes” in the Diabetes Control and Complications Trial, Diabetes Care, 30, 707, 10.2337/dc06-1982 Turner, 2007, Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents, Diabetes, 56, 2085, 10.2337/db07-0093 Bakhshaeshi, 2012, Antioxidative role of quercetin derived from Allium cepa on aldehyde oxidase (OX-LDL) and hepatocytesapoptosis in streptozotocin-induced diabetic rat, Asian Pac. J. Trop. Biomed., 2, 528, 10.1016/S2221-1691(12)60090-2 Codoñer-Franch, 2010, Is obesity associated with oxidative stress in children?, Int. J. Pediatr. Obes., 5, 56, 10.3109/17477160903055945 Deigner, 2008, Oxidized phospholipids: emerging lipid mediators in pathophysiology, Curr. Opin. Lipidol., 19, 289, 10.1097/MOL.0b013e3282fe1d0e Sun, 2009, RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice, Cardiovasc. Res., 82, 371, 10.1093/cvr/cvp036 Pirillo, 2013, Soluble lectin-like oxidized low density lipoprotein receptor-1 as a biochemical marker for atherosclerosis-related diseases, Dis. Markers, 35, 413, 10.1155/2013/716325 Rizvi, 2014, The role of vitamin e in human health and some diseases, Sultan Qaboos Univ. Med. J., 14, 157 Rodenburg, 2006, Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin, J. Am. Coll. Cardiol., 47, 1803, 10.1016/j.jacc.2005.12.047 Sobenin, 2014, Low density lipoproteincontaining circulating immune complexes: role in atherosclerosis and diagnostic value, Biomed. Res. Int., 2014, 205697, 10.1155/2014/205697 Mallat, 2010, Lipoprotein-associated and secreted phospholipases A2 in cardiovascular disease: roles as biological effectors and biomarkers, Circulation, 122, 2183, 10.1161/CIRCULATIONAHA.110.936393 Fan, 2012, Apolipoprotein E-containing HDL-associated platelet-activating factor acetylhydrolase activities and malondialdehyde concentrations in patients with PCOS, Reprod. Biomed. Online, 24, 197, 10.1016/j.rbmo.2011.10.010 Ragab, 2015, Lipoprotein-associated phospholipase A2 (Lp-PLA2) and tumor necrosis factor-alpha (TNF-α) and their relation to premature atherosclerosis in β-thalassemia children, Hematology, 20, 228, 10.1179/1607845414Y.0000000180 American Diabetes Association, 2007, Diagnosis and classification of diabetes mellitus, Diabetes Care, 30, 42, 10.2337/dc07-S042 Allain, 1974, Enzymatic determination of total serum cholesterol, Clin. Chem., 20, 470, 10.1093/clinchem/20.4.470 McGowan, 1983, Peroxidase-coupled method for the colorimetric determination of serum triglycerides, Clin. Chem., 29, 538, 10.1093/clinchem/29.3.538 Finley, 1978, Cholesterol in high- density lipoprotein: use of Mg 2+/dextran sulphate in its enzymatic measurement, Clin. Chem., 24, 931, 10.1093/clinchem/24.6.931 Friedewald, 1972, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin. Chem., 18, 499, 10.1093/clinchem/18.6.499 Timóteo, 2014, Optimal cut-off value for homeostasis model assessment (HOMA) index of insulin-resistance in a population of patients admitted electively in a Portuguese cardiology ward, Acta Med. Port., 27, 473, 10.20344/amp.5180 Juutilainen, 2005, Type 2 diabetes as a “coronary heart disease equivalent”: an 18-year prospective population-based study in Finnish subjects, Diabetes Care, 28, 2901, 10.2337/diacare.28.12.2901 Marin, 2015, Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers, J. Diabetes Complications, 29, 679, 10.1016/j.jdiacomp.2015.03.015 Viola, 2013, Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells, J. Biol. Chem., 288, 29595, 10.1074/jbc.M113.508341 Ait-Oufella, 2010, Bcell depletion reduces the development of atherosclerosis in mice, J. Exp. Med., 207, 1579, 10.1084/jem.20100155 Abd El Dayem, 2014, Asymmetric dimethyl L-arginine, nitric oxide and cardiovascular disease in adolescent type 1 diabetics, J. Pediatr. Endocrinol. Metab., 27, 437 Kinney, 2011, Lipoprotein associated phospholipase A₂ activity predicts rogression of subclinical coronary atherosclerosis, Diabetes Technol. Ther., 13, 381, 10.1089/dia.2010.0175 Cavallo-Perin, 2000, Camussi G Increased blood levels of platelet-activating factor in insulin-dependent diabetic patients with microalbuminuria, Nephrol. Dial. Transplant., 15, 994, 10.1093/ndt/15.7.994 Miller, 2010, Lipoprotein-associated phospholipase A, C-reactive protein, and coronary artery disease in individuals with type 1 diabetes and macroalbuminuria, Diab. Vasc. Dis. Res., 7, 47, 10.1177/1479164109346358 Gomes, 2009, Plasma PAF acetylhydrolase activity, inflammatory markers and susceptibility of LDL to in vitro oxidation inpatients with type 1 diabetes mellitus, Diabetes Res. Clin. Pract., 85, 61, 10.1016/j.diabres.2009.04.016 de Castro, 2007, Platelet-activating factor acetylhydrolase (PAF-AH) activity in patients with type 1 diabetes mellitus, Arq. Bras. Cardiol., 88, 179 Paik, 2015, Circulating Lp-PLA₂ activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy, Age (Dordr)., 37, 32, 10.1007/s11357-015-9770-4 Goswami, 2008, Apo-B/apo-AI ratio: a better discriminator of coronary artery disease risk than other conventional lipid ratios in Indian patients with acute myocardial infarction, Acta Cardiol., 63, 749, 10.2143/AC.63.6.2033393 Hun, 2013, DCCT/EDIC research group oxidized LDL and AGE-LDL in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes, Atherosclerosis, 231, 315, 10.1016/j.atherosclerosis.2013.09.027 da Silva, 2013, Influence of obesity and cardiometabolic makers on lipoprotein-associated phospholipase A2 (Lp-PLA2) activityin adolescents: the healthy young cross-sectional study, Lipids Health Dis., 12, 19, 10.1186/1476-511X-12-19