Assessment of intention and hesitancy to receive a booster dose of COVID-19 vaccine among community pharmacists using a vaccine hesitancy scale

Anmar Al-taie1, Zekiye Yilmaz2
1Anmar AL-TAIE Clinical Pharmacy Department, Faculty of Pharmacy, Istinye University, Istanbul, Türkiye
2Clinical Pharmacy Department, Faculty of Pharmacy, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Türkiye

Tóm tắt

To assess the patterns regarding COVID-19 infection and vaccination, along with the intention and hesitancy towards receiving a booster dose of the COVID-19 vaccine among community pharmacists in Istanbul, Türkiye. This was a cross-sectional, descriptive study conducted using a three-part structured validated questionnaire among community pharmacists. Vaccine hesitancy from a booster dose of the COVID-19 vaccine was assessed using the Vaccine Hesitancy Scale. A total of 145 community pharmacists were included, with a mean age of 43.22 ±13.3 years. Ninety-eight percent of the respondents received the COVID-19 vaccine. Most of the participants reported significant agreement to receiving a booster dose of the vaccine (91.7%, P < 0.0001). There was a statistically significant correlation between the intention to receive a booster vaccine dose and female gender (P = 0.0008), pharmacy education degree (bachelor’s degree; P < 0.0001), and work experience more than 10 years (P < 0.0001). Regardless of side effects from the previous dose, most of pharmacists who received the COVID-19 vaccine reported an intention to receive the booster dose, which generally builds trust in vaccine acceptance and undoubtedly plays a significant role in the control of the COVID-19 pandemic.

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Abdelmoneim SA, Sallam M, Hafez DM et al (2022) COVID-19 Vaccine Booster Dose Acceptance: Systematic Review and Meta-Analysis. Trop Med Infect Dis 7(10):298. https://doi.org/10.3390/tropicalmed7100298 Aburas W, Alshammari TM (2020) Pharmacists’ roles in emergency and disasters: COVID-19 as an example. Saudi Pharm J 28(12):1797–1816. https://doi.org/10.1016/j.jsps.2020.11.006 Al Janabi T, Pino M, York N (2021) Predictors for actual COVID-19 vaccine uptake and intended booster dosage among medical students of an osteopathic medical school in New York. Epidemiol 2:553–563. https://doi.org/10.3390/epidemiologia2040038 Albasry Z, Al-Taie A (2023) Assessment of acceptance, concerns and side effects towards COVID-19 vaccination among the community: A cross-sectional study from Baghdad, Iraq. CEGH 20:1–11. https://doi.org/10.1016/j.cegh.2023.101217 Alhasan K, Aljamaan F, Temsah MH et al (2021) COVID-19 delta variant: perceptions, worries, and vaccine-booster acceptability among healthcare workers. Healthc 9:1566. https://doi.org/10.3390/healthcare9111566 Al-Taie A, Yilmaz ZK, Dahman H et al (2022) Insights into disease and pharmacotherapy knowledge of Alzheimer's disease among community pharmacists: a cross-sectional study. Curr Med Res Opin 38(12):2209–2217. https://doi.org/10.1080/03007995.2022.2129802 Berec L, Šmíd M, Přibylová L et al (2022) Protection provided by vaccination, booster doses and previous infection against covid-19 infection, hospitalisation or death overtime in Czechia. PLoS One 17(7):e0270801. https://doi.org/10.1371/journal.pone.0270801 Biswas N, Mustapha T, Khubchandani J et al (2021) The Nature and Extent of COVID-19 Vaccination Hesitancy in Healthcare Workers. J Community Health 46(6):1244–1251. https://doi.org/10.1007/s10900-021-00984-3 Chen YT (2021) The Effect of Vaccination Rates on the Infection of COVID-19 under the Vaccination Rate below the Herd Immunity Threshold. Int J Environ Res Public Health 18(14):7491. https://doi.org/10.3390/ijerph18147491 Feleszko W, Lewulis P, Czarnecki A et al (2021) Flattening the Curve of COVID-19 Vaccine Rejection-An International Overview. Vaccines (Basel) 9(1):44. https://doi.org/10.3390/vaccines9010044 Filip R, Gheorghita Puscaselu R, Anchidin-Norocel L et al (2022) Global Challenges to Public Health Care Systems during the COVID-19 Pandemic: A Review of Pandemic Measures and Problems. J Pers Med 12(8):1295. https://doi.org/10.3390/jpm12081295 Ghazy RM, Abdou MS, Awaidy S et al (2022a) Acceptance of COVID-19 Vaccine Booster Doses Using the Health Belief Model: A Cross-Sectional Study in Low-Middle- and High-Income Countries of the East Mediterranean Region. Int J Environ Res Public Health 19(19):12136. https://doi.org/10.3390/ijerph191912136 Ghazy RM, Ashmawy R, Hamdy NA et al (2022b) Efficacy and Effectiveness of SARS-CoV-2 Vaccines: A Systematic Review and Meta-Analysis. Vaccines (Basel) 10(3):350. https://doi.org/10.3390/vaccines10030350 Guidry JPD, Laestadius LI, Vraga EK et al (2021) Willingness to get the COVID-19 vaccine with and without emergency use authorization. Am J Infect Control 49(2):137–142. https://doi.org/10.1016/j.ajic.2020.11.018 Hastings TJ, Hohmann LA, McFarland SJ et al (2017) Pharmacists’ attitudes and perceived barriers to human papillomavirus (HPV) vaccination services. Pharmacy (Basel) 5(3):45. https://doi.org/10.3390/pharmacy5030045 Jones S, Mason N, Palser T et al (2021) Trends in Risk-Adjusted 28-Day Mortality Rates for Patients Hospitalized with COVID-19 in England. J Hosp Med 16(5):290–293. https://doi.org/10.12788/jhm.3599 Kaplan RM, Milstein A (2021) Influence of a COVID-19 vaccine's effectiveness and safety profile on vaccination acceptance. Proc Natl Acad Sci U S A 118(10):e2021726118. https://doi.org/10.1073/pnas.2021726118 Larson HJ, Jarrett C, Schulz WS et al (2015) Measuring vaccine hesitancy: the development of a survey tool. Vaccine 33(34):4165–4175. https://doi.org/10.1016/j.vaccine.2015.04.037 Lin Y, Hu Z, Zhao Q et al (2020) Understanding COVID-19 vaccine demand and hesitancy: a nationwide online survey in China. PLoS Negl Trop Dis 14(12):e0008961. https://doi.org/10.1371/journal.pntd.0008961 Liu Q, Qin C, Liu M, Liu J (2021) Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis. Infect Dis Poverty 10(1):132. https://doi.org/10.1186/s40249-021-00915-3 MacDonald NE (2015) Vaccine hesitancy: definition, scope, and determinants. Vaccine 33:4161–4164. https://doi.org/10.1016/j.vaccine.2015.04.036 Mathioudakis AG, Ghrew M, Ustianowski A et al (2021) Self-Reported Real-World Safety and Reactogenicity of COVID-19 Vaccines: A Vaccine Recipient Survey. Life (Basel, Switzerland) 11(3):249. https://doi.org/10.3390/life11030249 Menni C, Klaser K, May A et al (2021) Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infect Dis 21(7):939–949. https://doi.org/10.1016/S1473-3099(21)00224-3 Munro APS, Janani L, Cornelius V et al (2021) Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial. Lancet 398(10318):2258–2276. https://doi.org/10.1016/S0140-6736(21)02717-3 Okuyan B, Bektay MY, Demirci MY et al (2022) Factors associated with Turkish pharmacists' intention to receive COVID-19 vaccine: an observational study. Int J Clin Pharm 44(1):247–255. https://doi.org/10.1007/s11096-021-01344-w Patalon T, Gazit S, Pitzer VE et al (2022) Odds of testing positive for SARS-CoV-2 following receipt of 3 vs. 2 doses of the BNT162b2 mRNA vaccine. JAMA Intern Med 182(2):179–184. https://doi.org/10.1001/jamainternmed.2021.7382 Paudyal V, Fialová D, Henman MC et al (2021) Pharmacists’ involvement in COVID-19 vaccination across Europe: a situational analysis of current practice and policy. Int J Clin 43(4):1139–1148. https://doi.org/10.1007/s11096-021-01301-7 Peretti-Watel P, Larson HJ, Ward JK et al (2015) Vaccine hesitancy: clarifying a theoretical framework for an ambiguous notion. PLoS Curr 7:ecurrents.outbreaks.6844c80ff9f5b273f34c91f71b7fc289. https://doi.org/10.1371/currents.outbreaks.6844c80ff9f5b273f34c91f71b7fc289 Peterson CJ, Lee B, Nugent K (2022) COVID-19 Vaccination Hesitancy among Healthcare Workers-A Review. Vaccines (Basel) 10(6):948. https://doi.org/10.3390/vaccines10060948 Rahman MM, Masum MHU, Wajed S et al (2022) A comprehensive review on COVID-19 vaccines: development, effectiveness, adverse effects, distribution and challenges. Virusdisease 33(1):1–22. https://doi.org/10.1007/s13337-022-00755-1 Rzymski P, Poniedziałek B, Fal A (2021) Willingness to Receive the Booster COVID-19 Vaccine Dose in Poland. Vaccines (Basel) 9(11):1286. https://doi.org/10.3390/vaccines9111286 Tolentino V, Unni E, Montuoro J et al (2018) Utah pharmacists’ knowledge, attitudes, and barriers regarding human papillomavirus vaccine recommendation. J Am Pharm Assoc 58(4S):S16–S23. https://doi.org/10.1016/j.japh.2018.04.014 Türk Eczacıları Birliği (2020) Hastaya, kamuya, eczacıya ilaçtır. https://dergi.tebeczane.net/public_html/kitaplar/bilgilendirmekitapcigi/html5/index.html?&lo. Accessed 27.03.2021 Udow-Phillips M, Lantz PM (2020) Trust in Public Health Is Essential Amid the COVID-19 Pandemic. J Hosp Med 15(7):431–433. https://doi.org/10.12788/jhm.3474 Verger P, Scronias D, Dauby N et al (2021) Attitudes of healthcare workers towards COVID-19 vaccination: a survey in France and French-speaking parts of Belgium and Canada, 2020. Euro Surveill 26(3):2002047. https://doi.org/10.2807/1560-7917.ES.2021.26.3.2002047 Wang K, Wong ELY, Ho KF et al (2020) Intention of nurses to accept coronavirus disease 2019 vaccination and change of intention to accept seasonal influenza vaccination during the coronavirus disease 2019 pandemic: a cross-sectional survey. Vaccine 38(45):7049–7056. https://doi.org/10.1016/j.vaccine.2020.09.021 Wong LP, Alias H, Siaw YL et al (2022) Intention to receive a COVID-19 vaccine booster dose and associated factors in Malaysia. Hum Vaccin Immunother 18(5):2078634. https://doi.org/10.1080/21645515.2022.2078634 World Health Organization (2022a) Interim Recommendations for Use of the Pfizer–BioNTech COVID-19 Vaccine, BNT162b2, under Emergency Use Listing. Available online: https://www.who.int/publications/i/item/WHO-2019-nCoV-vaccines-SAGE_recommendation-BNT162b2-2021.1 [accessed on 10. Novermber. 2022] World Health Organization (2022b) Interim Statement on Booster Doses for COVID-19 Vaccination. Available online: https://www.who.int/news/item/04-10-2021-interim-statement-on-booster-doses-for-covid-19-vaccination [accessed on 8.October 2022] World Health Organization (2023) Statement for healthcare professionals: How COVID-19 vaccines are regulated for safety and effectiveness (Revised March 2022). Available from: https://www.who.int/news/item/17-05-2022-statement-for-healthcare-professionals-how-covid-19-vaccines-are-regulated-for-safety-and-effectiveness. [accessed on 10.May.2023] Wu Harrison EAJW (2020) Vaccine confidence in the time of COVID-19. Eur J Epidemiol 35(4):325e30. https://doi.org/10.1007/s10654-020-00634-3 Yue L, Xie T, Yang T et al (2022) A third booster dose may be necessary to mitigate neutralizing antibody fading after inoculation with two doses of an inactivated SARS-CoV-2 vaccine. J Med Virol 94(1):35–38. https://doi.org/10.1002/jmv.27334