Assessment of genotoxicity and cytotoxicity of standardized aqueous extract from leaves of Erythroxylum cuneatum in human HepG2 and WRL68 cells line

Ahmad, 2007, Treatment of common ailments by plant-based remedies among the people of district Attock (Punjab) of northern Pakistan, Afr J Trad CAM, 4, 112 Cardoso, 2006, Mutagenic activity promoted by amentoflavone and methanol extract of Byrsonima crassa Niedenzu, Toxicology, 225, 55, 10.1016/j.tox.2006.05.003 De Sa Ferreira, 1999, Mutagenicity of medicinal plant extracts in Salmonella/microsome assay, Phytother Res, 13, 397, 10.1002/(SICI)1099-1573(199908/09)13:5<397::AID-PTR473>3.0.CO;2-# Mohd-Fuat, 2007, Mutagenic and cytotoxic properties of three herbal plants from Southeast Asia, Trop Biomed, 24, 49 Abdul Salam, Rosfarahhanim. Protective effect of erythroxylum cuneatum and mitragyna speciosa leaf extract on RAW 264.7 and MCF-7/Rosfarahhanim Abdul Salam. Other thesis, Universiti Teknologi Mara. Andrea, 2005, Calystegines in wild and cultivated Erythroxylum species, Phytochemistry, 66, 1231, 10.1016/j.phytochem.2005.04.017 Anderson, 1998, Comet assay responses as indicators of carcinogen exposure, Mutagenesis, 13, 539, 10.1093/mutage/13.6.539 Plazar, 2007, Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells, Mutat Res/Genet Toxicol Environ Mutagen, 632, 1, 10.1016/j.mrgentox.2007.03.013 Mitic-Culafic, 2009, Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells, Food Chem Toxicol, 47, 260, 10.1016/j.fct.2008.11.015 Abbas, 1993, Fumonisins and other inhibitors of de novo sphingolipid biosynthesis, Adv Lipid Res, 26, 215 Malich, 1997, The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 chemicals using human cell lines, Toxicology, 124, 179, 10.1016/S0300-483X(97)00151-0 Fink, 2005, Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells, Infect Immun, 73, 1907, 10.1128/IAI.73.4.1907-1916.2005 Burtis, 2001, 31 Valentin-Severin, 2003, Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays, Mutation Res, 536, 79, 10.1016/S1383-5718(03)00031-7 Duthie, 1997, The influence of cell growth, detoxifying enzymes and DNA repair on hydrogen peroxide-mediated DNA damage (measured using the comet assay) in human cells, Free Radical Biol Med, 22, 717, 10.1016/S0891-5849(96)00421-2 Fairbairn, 1995, The comet assay: a comprehensive review, Mutat Res, 339, 37, 10.1016/0165-1110(94)00013-3 Zampini, 2008, Evaluation of genotoxic and antigenotoxic effects of hydroalcoholic extracts of Zuccagnia punctata Cav, J Ethnopharmacol, 115, 330, 10.1016/j.jep.2007.10.007 Ratera, 1980, 189 Toursarkissian, 1980 Gupta, 1995, Transcription factor ATF2 regulation by the JNK signal transduction pathway, Science, 267, 389, 10.1126/science.7824938