Qiqiong Cui1, Wei Zhang2, Hu Wang3, Xin Sun1, Rong Wang2, Homer Yang1, Xian‐Qiang Meng1, Yun Zhang1, Hao Wang1
1Department of Echocardiography, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing;
2Department of Cardiology, Qilu Hospital, Shandong;
3Sino‐German Laboratory for Molecular Medicine, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China
Tóm tắt
AbstractBackgroundSequential analysis of atrial electromechanical coupling (P‐A) by Doppler tissue imaging (DTI) might provide important insight into the mechanisms of paroxysmal atrial fibrillation (PAF).HypothesisThe purpose of this study was to evaluate P‐A and the dispersion of P‐A, and to analyze the influential factors of P‐A.MethodsOne hundred and ten patients with PAF and 87 normal controls were enrolled. Using DTI, the time intervals from the beginning of P‐wave to the onset of atrioventricular ring motion related to atrial contraction were measured.ResultsAtrial electromechanical coupling at the interventricular septum atrioventricular annulus (P‐A1), left lateral mitral annulus (P‐A2) and right lateral tricuspid annulus (P‐A3) in PAF group were significantly longer than those in control (p < 0.001). The difference between P‐A2 and P‐A1 (T1), P‐A2 and P‐A3 (T3) in PAF group were greater than those in control before age correction (p < 0.05). The linear regression analysis showed that the duration of PAF episodes and age were the greatest influential factors of P‐A1 (r = 0.564). Left atrial anterior‐posterior dimension (LAD) and age were the greatest influential factors of P‐A2 (r = 0.459). The LAD was the greatest influential factors of T1 and T3 (r = 0.408, 0.542).ConclusionsThe atrial electromechanical coupling was significantly longer and the dispersion of P‐A at left lateral mitral annulus was greater in PAF patients. The prolongation of P‐A may be related to left atrial enlargement, long episodes of PAF and aging and the dispersion of P‐A at left lateral mitral annulus to LAD. Copyright © 2008 Wiley Periodicals, Inc.
