Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data

Vox Sanguinis - Tập 111 Số 1 - Trang 8-15 - 2016
Andrew Jordan1,2, Deborah Chen3,4, Qijian Yi5, Tamir Kanias6,7, Mark T. Gladwin8,6,7, Jason P. Acker1,2
1Centre for Innovation, Canadian Blood Services, Edmonton, AB, Canada
2Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
3Canadian Blood Services, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4Department of Pathology, University of British Columbia, Vancouver, BC, Canada
5Canadian Blood Services, Ottawa, ON, Canada
6Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
7Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA
8Department of Medicine, University of Pittsburgh, Pittsburgh, Pa. USA

Tóm tắt

Background and ObjectivesQuality control (QC) data collected by blood services are used to monitor production and to ensure compliance with regulatory standards. We demonstrate how analysis of quality control data can be used to highlight the sources of variability within red cell concentrates (RCCs).Materials and MethodsWe merged Canadian Blood Services QC data with manufacturing and donor records for 28 227 RCC between June 2011 and October 2014. Units were categorized based on processing method, bag manufacturer, donor age and donor sex, then assessed based on product characteristics: haemolysis and haemoglobin levels, unit volume, leucocyte count and haematocrit.ResultsBuffy‐coat method (top/bottom)‐processed units exhibited lower haemolysis than units processed using the whole‐blood filtration method (top/top). Units from female donors exhibited lower haemolysis than male donations. Processing method influenced unit volume and the ratio of additive solution to residual plasma.ConclusionsStored red blood cell characteristics are influenced by prestorage processing and donor factors. Understanding the relationship between processing, donors and RCC quality will help blood services to ensure the safety of transfused products.

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Tài liệu tham khảo

10.1111/j.1537-2995.2009.02275.x

10.1016/S1246-7820(03)00032-6

10.1016/j.tracli.2008.04.006

10.1016/j.transci.2006.11.003

10.1111/trf.12143

10.1111/j.1423-0410.1988.tb04699.x

10.1111/j.1537-2995.2012.03752.x

10.1111/trf.12489

10.1111/trf.12679

10.1111/j.1537-2995.2007.01489.x

10.1159/000441959

10.1111/j.1537-2995.2011.03298.x

10.4103/0973-6247.33446

10.1111/j.1537-2995.2011.03511.x

10.1111/j.1537-2995.2012.03748.x

10.1016/S0162-0134(00)80291-3

Ulker P, 2009, Mechanical stimulation of nitric oxide synthesizing mechanisms in erythrocytes, Biorheology, 46, 121, 10.3233/BIR-2009-0532

10.1182/blood-2005-10-3992

10.1172/JCI59770

10.1161/CIRCULATIONAHA.110.008698

10.3109/10715762.2013.860225

10.1111/j.1423-0410.1998.tb05419.x

10.1373/clinchem.2006.079582

10.1111/j.1537-2995.2005.00672.x

10.1111/j.1423-0410.2012.01660.x

10.1182/blood.V99.9.3439

10.1016/j.blre.2007.07.003

10.1016/j.jamcollsurg.2011.12.032

10.1053/tmrv.2002.31463

10.1007/s00134-007-2873-3

10.1111/j.1423-0410.2010.01439.x

10.1046/j.1537-2995.1976.16276155103.x

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Vox Sanguinis

Tập 111 Số 1

8-15

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