Đánh giá kiến thức, thái độ và các yếu tố quyết định việc chấp nhận liều tăng cường vắc-xin COVID-19 thứ ba của công chúng: tình hình hiện tại và triển vọng tương lai

Informa UK Limited - Tập 15 - Trang 1-13 - 2022
Ammar Abdulrahman Jairoun1,2, Sabaa Saleh Al-Hemyari2,3, Faris El-Dahiyat4,5, Maimona Jairoun6, Moyad Shahwan6,7, Mena Al Ani8, Mustafa Habeb9,10, Zaheer-Ud-Din Babar11
1Health and Safety Department, Dubai Municipality, Dubai, UAE
2School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, Malaysia
3Pharmacy Department, Emirates Health Services, Dubai, UAE
4College of Pharmacy, Al Ain University, Al Ain, UAE
5AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, UAE
6College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE
7Center of Medical and Bio-Allied Health Sciences Research, Ajman University Ajman, Ajman, UAE
8College of Medicine, University of Sharjah, Sharjah, UAE
9Department of Family and Community Medicine and Behavioural Science University of Sharjah, Sharjah, UAE
10Edgware Community Hospital Barnet, Enfield and Haringey Mental Health, NHS Trust, Edgware, UK
11Department of Pharmacy, University of Huddersfield, Huddersfield, UK

Tóm tắt

Người có hệ miễn dịch suy yếu có thể không phát triển được sự bảo vệ đầy đủ sau khi tiêm hai liều vắc-xin COVID-19 công nghệ mRNA. Liều bổ sung có thể cải thiện mức độ bảo vệ chống lại Covid-19. Nghiên cứu hiện tại nhằm đánh giá kiến thức, thái độ và các yếu tố quyết định về việc chấp nhận liều tăng cường vắc-xin COVID-19 thứ ba trong cộng đồng tại UAE. Đây là một nghiên cứu mô tả cắt ngang dựa trên cộng đồng được thực hiện trong số sinh viên và giảng viên của Đại học Ajman từ ngày 25 tháng 8 đến ngày 20 tháng 10 năm 2021. Câu hỏi khảo sát, được thiết kế bằng tiếng Anh, gồm hai phần chứa tổng cộng 22 câu hỏi. Phần một thu thập thông tin nhân khẩu học của người trả lời, trong khi phần hai sử dụng 13 câu hỏi để đánh giá kiến thức và thái độ của họ đối với liều tăng cường vắc-xin COVID-19 thứ ba. 614 người tham gia đã tham gia vào nghiên cứu này. Điểm kiến thức trung bình là 44,6% với khoảng tin cậy 95% (CI) là [41%, 49%]. Những điểm số kiến thức tốt hơn được ghi nhận ở các sinh viên sau đại học (OR 4,29; 95% CI 2,28–8,11), nhân viên trong lĩnh vực chăm sóc sức khỏe (OR 1,62; 95% CI 1,05–2,51), những người có họ hàng bị nhiễm Covid-19 (OR 1,46; 95% CI 1,05–2,02), những người đã bị nhiễm Covid-19 (OR 2,21; 95% CI 1,43–3,43) và những người đã nhận hai liều đầu tiên của vắc-xin COVID-19 (OR 2,08; 95% CI 1,40–3,11). Điểm thái độ trung bình là 70,2% với khoảng tin cậy 95% (CI) là [69,2%, 71,2%]. Các bước cần thiết nên được thực hiện bởi chính phủ và các cơ quan y tế cộng đồng, phù hợp với văn hóa địa phương, nhằm tăng cường sự chấp nhận vắc-xin và thúc đẩy thái độ tích cực đối với vắc-xin. Một phương pháp phù hợp cho vấn đề này là phát triển một khung giáo dục có thể trình bày những rủi ro của việc tránh hoặc trì hoãn tiêm vắc-xin đối với công chúng nói chung. Hơn nữa, các cơ quan y tế nên chú ý hơn đến thông tin sai lệch đang được phát tán trên internet, đặc biệt là mạng xã hội. Ngoài ra, các nhân viên y tế nên được đào tạo về vaccinology và virology để đảm bảo họ có thể hiểu những phát triển quan trọng trong các lĩnh vực này và truyền đạt những phát hiện đến bệnh nhân của mình.

Từ khóa

#COVID-19 #liều tăng cường #vắc-xin #kiến thức #thái độ #sự chấp nhận

Tài liệu tham khảo

Valencia DN. Brief review on COVID-19: the 2020 pandemic caused by SARS-CoV-2. Cureus. 2020;12(3):e7386. Baloch S, Baloch MA, Zheng T, Pei X. The coronavirus disease 2019 (COVID-19) pandemic. Tohoku J Exp Med. 2020;250(4):271–8. Lotfi M, Hamblin MR, Rezaei N. COVID-19: transmission, prevention, and potential therapeutic opportunities. Clinica chimica acta Int J Clin Chem. 2020;508:254–66. Rahman HS, Aziz MS, Hussein RH, Othman HH, Salih Omer SH, Khalid ES, Abdulrahman NA, Amin K, Abdullah R. The transmission modes and sources of COVID-19: a systematic review. Int J Surg Open. 2020;26:125–36. Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Transmission of SARS-CoV-2: a review of viral, host, and environmental factors. Ann Intern Med. 2021;174(1):69–79. Esakandari H, Nabi-Afjadi M, Fakkari-Afjadi J, Farahmandian N, Miresmaeili SM, Bahreini E. A comprehensive review of COVID-19 characteristics. Biol Proc Online. 2020;22:19. https://doi.org/10.1186/s12575-020-00128-2. Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, Azman AS, Reich NG, Lessler J. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann Intern Med. 2020;172(9):577–82. Alimohamadi Y, Sepandi M, Taghdir M, Hosamirudsari H. Determine the most common clinical symptoms in COVID-19 patients: a systematic review and meta-analysis. J Prev Med Hyg. 2020;61(3):E304–12. Pfeifer M, Hamer OW. COVID-19-pneumonie [COVID-19 pneumonia]. Der Internist. 2020;61(8):793–803. https://doi.org/10.1007/s00108-020-00854-5. Romero Starke K, Petereit-Haack G, Schubert M, Kämpf D, Schliebner A, Hegewald J, Seidler A. The age-related risk of severe outcomes due to COVID-19 infection: a rapid review, meta-analysis, and meta-regression. Int J Environ Res Public Health. 2020;17(16):5974. https://doi.org/10.3390/ijerph17165974. Treskova-Schwarzbach M, Haas L, Reda S, Pilic A, Borodova A, Karimi K, Koch J, Nygren T, Scholz S, Schönfeld V, Vygen-Bonnet S, Wichmann O, Harder T. Pre-existing health conditions and severe COVID-19 outcomes: an umbrella review approach and meta-analysis of global evidence. BMC Med. 2021;19(1):212. McGurnaghan SJ, Weir A, Bishop J, Kennedy S, Blackbourn L, McAllister DA, Hutchinson S, Caparrotta TM, Mellor J, Jeyam A, O’Reilly JE, Wild SH, Hatam S, Höhn A, Colombo M, Robertson C, Lone N, Murray J, Butterly E, Petrie J, Scottish Diabetes Research Network Epidemiology Group. Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland. Lancet Diabetes Endocrinol. 2021;9(2):82–93. https://doi.org/10.1016/S2213-8587(20)30405-8. Preskorn SH. The 5% of the population at high risk for severe COVID-19 infection is identifiable and needs to be taken into account when reopening the economy. J Psychiatr Pract. 2020;26(3):219–27. Pai SM, Othman AA, Rusch L, Masters JC, Greene D, Rogge M, Gries JM, Clementi W, Kumar P, Younis I, Salem AH, Gaynes BI, Pastino G, Derendorf H, Public Policy Committee of the American College of Clinical Pharmacology. Science and evidence-based review and approval of COVID-19 vaccines: a statement of support for the US FDA. J Clin Pharmacol. 2021;61(3):277–9. Kaur SP, Gupta V. COVID-19 vaccine: a comprehensive status report. Virus Res. 2020;288:198114. Burki T. Booster shots for COVID-19-the debate continues. Lancet Infect Dis. 2021;21(10):1359–60. Del Bello A, Abravanel F, Marion O, Couat C, Esposito L, Lavayssière L, Izopet J, Kamar N. Efficiency of a boost with a third dose of anti-SARS-CoV-2 messenger RNA-based vaccines in solid organ transplant recipients. Am J Transplant. 2021. https://doi.org/10.1111/ajt.16775.Advanceonlinepublication. In brief: Third dose of mRNA-based COVID-19 vaccines for immunocompromised persons. The Medical letter on drugs and therapeutics, 2021; 63(1633): 145–146. World Health Organization. Ten threats to global health in 2019. 2019 (cited 2021 Dec 20). https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019. Al-Mohaithef M, Padhi BK. Determinants of COVID-19 vaccine acceptance in Saudi Arabia: a web-based National Survey. J Multidiscip Healthc. 2020;13:1657–63. Elhadi M, Alsoufi A, Alhadi A, Hmeida A, Alshareea E, Dokali M, Abodabos S, Alsadiq O, Abdelkabir M, Ashini A, Shaban A. Knowledge, attitude, and acceptance of healthcare workers and the public regarding the COVID-19 vaccine: a cross-sectional study. BMC Public Health. 2021;21(1):1–21. Sherman SM, Smith LE, Sim J, et al. COVID-19 vaccination intention in the UK: results from the COVID-19 vaccination acceptability study (CoVAccS), a nationally representative cross-sectional survey. Hum Vaccin Immunother. 2020;25:1–10. Malik AA, McFadden SM, Elharake J, Omer SB. Determinants of COVID-19 vaccine acceptance in the US. EClinicalMedicine. 2020;26: 100495. https://doi.org/10.1016/j.eclinm.2020.100495. Cerda AA, García LY. Hesitation and refusal factors in individuals’ decision-making processes regarding a coronavirus disease 2019 vaccination. Front Public Health. 2021;9:626852. https://doi.org/10.3389/fpubh.2021.62685230. Biswas MR, Alzubaidi MS, Shah U, Abd-Alrazaq AA, Shah Z. A scoping review to find out worldwide COVID-19 vaccine hesitancy and its underlying determinants. Vaccines. 2021;9(11):1243. https://doi.org/10.3390/vaccines9111243. Wiysonge CS, Ndwandwe D, Ryan J, et al. Vaccine hesitancy in the era of COVID-19: could lessons from the past help in divining the future? Hum Vaccin Immunother. 2021. https://doi.org/10.1080/21645515.2021.189306249. Harapan H, Wagner AL, Yufika A, et al. Acceptance of a COVID-19 Vaccine in Southeast Asia: a cross-sectional study in Indonesia. Front Public Health. 2020;8:381. Bell S, Clarke R, Mounier-Jack S, Walker JL, Paterson P. Parents’ and guardians’ views on the acceptability of a future COVID-19 vaccine: a multi-methods study in England. Vaccine. 2020;38(49):7789–98. https://doi.org/10.1016/j.vaccine.2020.10.02751. Leng A, Maitland E, Wang S, Nicholas S, Liu R, Wang J. Individual preferences for COVID-19 vaccination in China. Vaccine. 2021;39(2):247–54. https://doi.org/10.1016/j.vaccine.2020.12.00952. Detoc M, Bruel S, Frappe P, Tardy B, Botelho-Nevers E, Gagneux- BA. Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic. Vaccine. 2020;38(45):7002–6. https://doi.org/10.1016/j.vaccine.2020.09.04153. Gagneux-Brunon A, Detoc M, Bruel S, et al. Intention to get vaccinations against COVID-19 in French healthcare workers during the first pandemic wave: a cross-sectional survey. J Hosp Infect. 2021;108:168–73. https://doi.org/10.1016/j.jhin.2020.11.02054. Walkowiak MP, Walkowiak D. Predictors of COVID-19 vaccination campaign success: lessons learnt from the pandemic so far. A case study from Poland. Vaccines. 2021;9(10):1153. https://doi.org/10.3390/vaccines9101153. Biswas N, Mustapha T, Khubchandani J, Price JH. The nature and extent of COVID-19 vaccination hesitancy in healthcare workers. J Community Health. 2021;46:1244. Adane M, Ademas A, Kloos H. Knowledge, attitudes, and perceptions of COVID-19 vaccine and refusal to receive COVID-19 vaccine among healthcare workers in northeastern Ethiopia. BMC Public Health. 2022;22(1):1–4. Shahwan M, Suliman A, Jairoun AA, Alkhoujah S, Al-Hemyari SS, Al-Tamimi SK, Godman B, Mothana RA. Prevalence, knowledge and potential determinants of COVID-19 vaccine acceptability among university students in the United Arab Emirates: findings and implications. J Multidiscip Healthc. 2022;15:81. Cascini F, Pantovic A, Al-Ajlouni Y, Failla G, Ricciardi W. Attitudes, acceptance and hesitancy among the general population worldwide to receive the COVID-19 vaccines and their contributing factors: a systematic review. EClinicalMedicine. 2021;40:101113. Ahmed MH, Siraj SS, Klein J, Ali FY, Kanfe SG. Knowledge and attitude towards second COVID-19 vaccine dose among health professionals working at public health facilities in a low income country. Infect Drug Resist. 2021;14:3125. El-Elimat T, AbuAlSamen MM, Almomani BA, Al-Sawalha NA, Alali FQ. Acceptance and attitudes toward COVID-19 vaccines: a cross-sectional study from Jordan. PLoS ONE. 2021;16(4):e0250555. Lawshe CH. A quantitative approach to content validity. Pers Psychol. 1975;28:563–75. Polit DF, Beck CT, Owen SV. Is the CVI an acceptable indicator of content validity? Appraisal Recommend Res Nurs Health. 2007;30:459–67. Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N, Ke R. High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. Emerg Infect Dis. 2020;26(7):1470–7. Wong MCS, Wong ELY, Huang J, Cheung AWL, Law K, Chong MKC, et al. Acceptance of the COVID-19 vaccine based on the health belief model: a population-based survey in Hong Kong. Vaccine. 2021;39(7):1148–56. Abdullah AC, NA M, Rosliza AM. Predictors for inadequate knowledge and negative attitude towards childhood immunization among parents in Hulu Langat, Selangor, Malaysia. Malaysian J Public Heal Med. 2018;18(1):102–12. Ooi PL, Heng ZY, Boon KY. Factors influencing parents’awareness regarding childhood immunization: findings of cross-sectional study in northeast Penang Island District, Malaysia. Int J Public Heal Clin Sci. 2019;6(3):130–42. Mohamed NA, Solehan HM, Mohd Rani MD, Ithnin M, Che Isahak CI. Knowledge, acceptance and perception on COVID-19 vaccine among Malaysians: a web-based survey. PLoS ONE. 2021;16(8):e0256110. Geoghegan S, O’Callaghan KP, Offit PA. Vaccine safety: myths and misinformation. Front Microbiol. 2020;11:372. Banik R, Rahman M, Sikder MT, Rahman QM, Pranta MUR. Knowledge, attitudes, and practices related to the COVID-19 pandemic among Bangladeshi youth: a web-based cross-sectional analysis. J Public Health (Bangkok). 2021. https://doi.org/10.1007/s10389-020-01432-7. Chan EY-Y, Cheng CK-Y, Tam GCH, Huang Z, Lee PY. Willingness of future a/H7N9 influenza vaccine uptake: a cross-sectional study of Hong Kong community. Vaccine. 2015;33(38):4737–40. Islam M, Siddique AB, Akter R, Tasnim R, Sujan M, Hossain S, Ward PR, Sikder M. Knowledge, attitudes and perceptions towards COVID-19 vaccinations: a cross-sectional community survey in Bangladesh. BMC Public Health. 2021;21(1):1–1. Nor NA, Solehan HM, Mohamed NA, Hasan ZI, Umar NS, Sanip S, et al. Knowledge, attitude and practice (KAP) towards COVID-19 prevention (MCO): an online cross-sectional survey. Int J Res Pharm Sci. 2020;11(1):1458–68. Wang J, Jing R, Lai X, Zhang H, Lyu Y, Knoll MD, et al. Acceptance of COVID- 19 vaccination during the COVID-19 pandemic in China. Vaccines. 2020;8(3):482. Lazarus JV, Ratzan SC, Palayew A, et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med. 2021;27(2):225–8. https://doi.org/10.1038/s41591-020-1124-9. Sallam M, Dababseh D, Eid H, Al-Mahzoum K, Al-Haidar A, Taim D, Yaseen A, Ababneh NA, Bakri FG, Mahafzah A. High rates of COVID-19 vaccine hesitancy and its association with conspiracy beliefs: a study in Jordan and Kuwait among Other Arab countries. Vaccines. 2021;9(1):42. https://doi.org/10.3390/vaccines9010042. Maurer J, Uscher-Pines L, Harris KM. Perceived seriousness of seasonal and A(H1N1) influenzas, attitudes toward vaccination, and vaccine uptake among U.S. adults: does the source of information matter? Prev Med (Baltim). 2010;51:185–7. Islam MS, Kamal AH-M, Kabir A, Southern DL, Khan SH, Hasan SMM, et al. COVID-19 vaccine rumors and conspiracy theories: the need for cognitive inoculation against misinformation to improve vaccine adherence. PLoS ONE. 2021;16(5):e0251605. Barello S, Nania T, Dellafiore F, Graffigna G, Caruso R. ‘Vaccine hesitancy’ among university students in Italy during the COVID-19 pandemic. Eur J Epidemiol. 2020;35(8):781–3. https://doi.org/10.1007/s10654-020-00670-z13. Kanyike AM, Olum R, Kajjimu J, et al. Acceptance of the coronavirus disease-2019 vaccine among medical students in Uganda. Trop Med Health. 2021;49(1):37. https://doi.org/10.1186/s41182-021-00331-1. Riad A, Schünemann H, Attia S, et al. COVID-19 Vaccines Safety Tracking (CoVaST): protocol of a multi-center prospective cohort study for active surveillance of COVID-19 vaccines’ side effects. Int J Environ Res Public Health. 2021;18(15):7859. https://doi.org/10.3390/ijerph18157859. Riad A, Pokorná A, Klugarová J, et al. Side effects of mRNA-based COVID-19 vaccines among young adults (18–30 years old): an independent post-marketing study. Pharmaceuticals. 2021;14(10):1049. https://doi.org/10.3390/ph14101049. Jin Q, Raza SH, Yousaf M, Zaman U, Siang JMLD. Can communication strategies combat COVID-19 vaccine hesitancy with trade-off between public service messages and public skepticism? Experimental evidence from Pakistan. Vaccines. 2021;9(7):757. https://doi.org/10.3390/vaccines9070757. Wang P-W, Ahorsu DK, Lin C-Y, et al. Motivation to have COVID-19 vaccination explained using an extended protection motivation theory among university students in china: the role of information sources. Vaccines. 2021;9(4):380. https://doi.org/10.3390/vaccines9040380. Faasse K, Newby J. Public perceptions of COVID-19 in Australia: perceived risk, knowledge, health-protective behaviors, and vaccine intentions. Psychol. 2020;11:551004. Lataifeh L, Al-Ani A, Lataifeh I, Ammar K, AlOmary A, Al-Hammouri F, Al-Hussaini M. Knowledge, attitudes, and practices of healthcare workers in jordan towards the COVID-19 vaccination. Vaccines. 2022;10(2):263. Ssentongo P, Ssentongo AE, Heilbrunn ES, Ba DM, Chinchilli VM. Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: a systematic review and metaanalysis. PLoS ONE. 2020;15(8):e0238215. Chew NWS, Cheong C, Kong G, Phua K, Ngiam JN, Tan BYQ, et al. An Asia-Pacific study on healthcare worker’s perception and willingness to receive COVID-19 vaccination. Int J Infect Dis. 2021;106:52–60. Sun Y, Chen X, Cao M, Xiang T, Zhang J, Wang P, et al. Will healthcare workers accept a COVID-19 vaccine when it becomes available? A cross-sectional study in China. Front Public Health. 2021;9:1–8. Huynh G, Tran TT, Nguyen HTN, Pham LA. COVID-19 vaccination intention among healthcare workers in Vietnam. Asian Pac J Trop Med. 2021;14(4):159–64. Al-Metwali BZ, Al-Jumaili AA, Al-Alag ZA, Sorofman B. Exploring the acceptance of COVID-19 vaccine among healthcare workers and general population using health belief model. J Eval Clin Pract. 2021:1–11. Gadoth A, Halbrook M, Matine-Blais R, Gray A, Tobin NH, Ferbas KG, Adrovandi GMRA. Cross-sectional assessment of COVID-19 vaccine acceptance among healthcare workers in Los Angeles. Ann Internal Med. 2021. https://doi.org/10.7326/M20-7580. Shekhar R, Sheikh AB, Upadhyay S, Singh M, Kottewar S, Mir H, et al. COVID-19 vaccine acceptance among health care workers in the United States. Vaccines. 2021;9(2):1–18. Agyekum MW, Afrifa-Anane GF, Kyei-Arthur F, Addo B. Acceptability of COVID-19 vaccination among healthcare workers in Ghana. Adv Public Health. 2021. Paudel S, Palaian S, Subedi N. Risk perception and hesitancy toward COVID-19 vaccination among healthcare workers and staff at a medical college in Nepal. Risk Manag Health Policy. 2021;14:2253–61. Kabamba Nzaji M, Kabamba Ngombe L, Ngoie Mwamba G, Banza Ndala DB, Mbidi Miema J, Luhata Lungoyo C, et al. Acceptability of vaccination against COVID-19 among healthcare workers in the Democratic Republic of the Congo. Pragmatic Obs Res. 2020;11:103–9. Fares S, Elmnyer MM, Mohamed SS, Elsayed R. COVID-19 vaccination perception and attitude among healthcare workers in Egypt. J Prim Care Community Health. 2021;12:215013272110133. Tobin EA, Okonofua M, Azeke A, Ajekweneh V, Akpede G. Willingness to acceptance a covid-19 vaccine in Nigeria: a population-based cross-sectional study. J Med Res. 2021;5(2):1–6. Qattan AMN, Alshareef N, Alsharqi O, Al Rahahleh N, Chirwa GC, Al- Hanawi MK. Acceptability of a COVID-19 vaccine among healthcare workers in the Kingdom of Saudi Arabia. Front Med. 2021;8:1–12. Karafillakis E, Dinca I, Apfel F, Cecconi S, Wurz A, Takacs J, Suk J, Celentano LP, Kramarz P, Larson HJ. Vaccine hesitancy among Healthcare Workers in Europe: a qualitative study. Vaccine. 2016;34:5013–20. Ciardi F, Menon V, Jensen JL, Shariff MA, Pillai A, Venugopal U, Kasubhai M, Dimitrov V, Kanna B, Poole BD. Knowledge, attitudes and perceptions of COVID-19 vaccination among Healthcare Workers of an Inner-City Hospital in New York. Vaccines. 2021;9:516.