Assembly and mechanosensory function of focal contacts

Current Opinion in Cell Biology - Tập 13 - Trang 584-592 - 2001
Benjamin Geiger1, Alexander Bershadsky1
1Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel

Tài liệu tham khảo

Adams, 2001, Cell-matrix contact structures, Cell Mol Life Sci, 58, 371, 10.1007/PL00000864 Abercrombie, 1975, Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy, Exp Cell Res, 92, 57, 10.1016/0014-4827(75)90636-9 Heath, 1978, Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system A correlated interference-reflexion and high-voltage electron-microscope study, J Cell Sci, 29, 197, 10.1242/jcs.29.1.197 Bershadsky, 1999, Cytoskeleton-associated anchor and signal transduction proteins. Introduction, 3 Critchley, 2000, Focal adhesions — the cytoskeletal connection, Curr Opin Cell Biol, 12, 133, 10.1016/S0955-0674(99)00067-8 Petit, 2000, Focal adhesions: structure and dynamics, Biol Cell, 92, 477, 10.1016/S0248-4900(00)01101-1 Sastry, 2000, Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics, Exp Cell Res, 261, 25, 10.1006/excr.2000.5043 Zamir E, Geiger B: Molecular diversity of actin-integrin adhesion complexes. J Cell Sci 2001, in press. In this review, the authors highlight the molecular complexity and heterogeneity of focal adhesion and related matrix adhesions. Parsons, 2000, Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement, Oncogene, 19, 5606, 10.1038/sj.onc.1203877 Daniels, 1999, p21-activated protein kinase: a crucial component of morphological signaling?, Trends Biochem Sci, 24, 350, 10.1016/S0968-0004(99)01442-5 Michaelson, 2001, Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding, J Cell Biol, 152, 111, 10.1083/jcb.152.1.111 Nobes, 1995, Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, 81, 53, 10.1016/0092-8674(95)90370-4 Clark, 1998, Integrin-mediated signals regulated by members of the rho family of GTPases, J Cell Biol, 142, 573, 10.1083/jcb.142.2.573 Rottner, 1999, Interplay between rac and rho in the control of substrate contact dynamics, Curr Biol, 9, 640, 10.1016/S0960-9822(99)80286-3 Kiosses, 2001, Rac recruits high affinity integrin αvβ3 to lamellipodia in endothelial cell migration, Nat Cell Biol, 3, 316, 10.1038/35060120 Beningo, 2001, Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts, J Cell Biol, 153, 881, 10.1083/jcb.153.4.881 del Pozo, 2000, Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK, EMBO J, 19, 2008, 10.1093/emboj/19.9.2008 Kraynov, 2000, Localized rac activation dynamics visualized in living cells, Science, 290, 333, 10.1126/science.290.5490.333 Borisy, 2000, Actin machinery: pushing the envelope, Curr Opin Cell Biol, 12, 104, 10.1016/S0955-0674(99)00063-0 Tolias, 2000, Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly, Curr Biol, 10, 153, 10.1016/S0960-9822(00)00315-8 Machesky, 1999, Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex, Proc Natl Acad Sci USA, 96, 3739, 10.1073/pnas.96.7.3739 Miki, 2000, IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling, Nature, 408, 732, 10.1038/35047107 Edwards, 1999, Activation of LIM kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics, Nat Cell Biol, 1, 253, 10.1038/12963 Yang, 1998, Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization, Nature, 393, 809, 10.1038/31735 Turner, 1999, Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling, J Cell Biol, 145, 851, 10.1083/jcb.145.4.851 Hashimoto, 2001, Interaction of paxillin with p21-activated kinase (PAK) association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3, J Biol Chem, 276, 6037, 10.1074/jbc.M005854200 Chong, 2001, The mechanism of PAK activation: auto-phosphorylation events in both regulatory and kinase domains control activity, J Biol Chem, 276, 17347, 10.1074/jbc.M009316200 Sells, 2000, Temporal and spatial distribution of activated Pak1 in fibroblasts, J Cell Biol, 151, 1449, 10.1083/jcb.151.7.1449 Bishop, 2000, Rho GTPases and their effector proteins, Biochem J, 348 Pt 2, 241, 10.1042/0264-6021:3480241 Watanabe, 1999, Cooperation between mDia1 and ROCK in Rho-induced actin reorganization, Nat Cell Biol, 1, 136, 10.1038/11056 Afshar, 2000, Functional analysis of the Drosophila diaphanous FH protein in early embryonic development, Development, 127, 1887, 10.1242/dev.127.9.1887 Ozaki-Kuroda, 2001, Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae, Mol Cell Biol, 21, 827, 10.1128/MCB.21.3.827-839.2001 Chang, 2000, Microtubule and actin-dependent movement of the formin cdc12p in fission yeast, Microsc Res Tech, 49, 161, 10.1002/(SICI)1097-0029(20000415)49:2<161::AID-JEMT8>3.0.CO;2-2 Watanabe, 1997, p140mDia, a mammalian homolog of <>Drosophila<> diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin, EMBO J, 16, 3044, 10.1093/emboj/16.11.3044 Nakano, 1999, Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells, Mol Biol Cell, 10, 2481, 10.1091/mbc.10.8.2481 Tominaga, 2000, Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling, Mol Cell, 5, 13, 10.1016/S1097-2765(00)80399-8 Alberts, 2001, Identification of a carboxy-terminal diaphanous related formin homology protein autoregulatory domain, J Biol Chem, 276, 2824, 10.1074/jbc.M006205200 Fujiwara, 2000, Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2, Biochem Biophys Res Commun, 271, 626, 10.1006/bbrc.2000.2671 Lee, 1999, Control of mitotic spindle position by the <>Saccharomyces cerevisiae<> formin Bni1p, J Cell Biol, 144, 947, 10.1083/jcb.144.5.947 Ishizaki, 2001, Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1, Nat Cell Biol, 3, 8, 10.1038/35050598 Riveline D, Zamir E, Balaban NQ, Schwarz U, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by a mDia1-dependent and ROCK-independent mechanism, J Cell Biol 2001, 153. Direct application of local force to individual small focal contacts induces their growth even in conditions when ROCK activity and myosin II-driven contractility are blocked. This paper suggests that focal contacts behave as mechanosensors, responding to external forces and to forces induced by cell contractility. When Rho activity is blocked, Dia1 is sufficient to restore the ability of focal contacts to grow upon force application. Amano, 2000, Regulation and functions of Rho associated kinase, Exp Cell Res, 261, 44, 10.1006/excr.2000.5046 Maekawa, 1999, Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase, Science, 285, 895, 10.1126/science.285.5429.895 Ohashi, 2000, Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop, J Biol Chem, 275, 3577, 10.1074/jbc.275.5.3577 Sumi, 2001, Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase, J Biol Chem, 276, 670, 10.1074/jbc.M007074200 Amano, 2001, LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505, Biochem J, 354, 149, 10.1042/0264-6021:3540149 Matsui, 1998, Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association, J Cell Biol, 140, 647, 10.1083/jcb.140.3.647 Fukata, 2001, Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells, Trends Pharmacol Sci, 22, 32, 10.1016/S0165-6147(00)01596-0 Somlyo, 2000, Signal transduction by G-proteins, rho kinase and protein phosphatase to smooth muscle and non-muscle myosin II, J Physiol, 522 Pt, 2, 177 Totsukawa, 2000, Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts, J Cell Biol, 150, 797, 10.1083/jcb.150.4.797 Volberg, 1994, Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system, Cell Motil Cytoskeleton, 29, 321, 10.1002/cm.970290405 Chrzanowska-Wodnicka, 1996, Rho-stimulated contractility drives the formation of stress fibers and focal adhesions, J Cell Biol, 133, 1403, 10.1083/jcb.133.6.1403 Helfman, 1999, Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions, Mol Biol Cell, 10, 3097, 10.1091/mbc.10.10.3097 Wei, 2000, Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells, Mol Biol Cell, 11, 3617, 10.1091/mbc.11.10.3617 Balaban, 2001, Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates, Nat Cell Biol, 3, 466, 10.1038/35074532 Kiosses, 1999, A role for p21-activated kinase in endothelial cell migration, J Cell Biol, 147, 831, 10.1083/jcb.147.4.831 Pelham, 1997, Cell locomotion and focal adhesions are regulated by substrate flexibility, Proc Natl Acad Sci USA, 94, 13661, 10.1073/pnas.94.25.13661 Lo, 2000, Cell movement is guided by the rigidity of the substrate, Biophys J, 79, 144, 10.1016/S0006-3495(00)76279-5 Kaverina, 1998, Targeting, capture, and stabilization of microtubules at early focal adhesions, J Cell Biol, 142, 181, 10.1083/jcb.142.1.181 Kaverina, 1999, Microtubule targeting of substrate contacts promotes their relaxation and dissociation, J Cell Biol, 146, 1033, 10.1083/jcb.146.5.1033 Elbaum, 1999, Microtubule involvement in regulating cell contractility and adhesion-dependent signalling: a possible mechanism for polarization of cell motility, Biochem Soc Symp, 65, 147 Bershadsky, 1996, Involvement of microtubules in the control of adhesion-dependent signal transduction, Curr Biol, 6, 1279, 10.1016/S0960-9822(02)70714-8 Liu, 1998, Microtubule depolymerization induces stress fibers, focal adhesions, and DNA synthesis via the GTP-binding protein Rho, Cell Adhes Commun, 5, 249, 10.3109/15419069809040295 Kaverina, 2000, Enforced polarisation and locomotion of fibroblasts lacking microtubules, Curr Biol, 10, 739, 10.1016/S0960-9822(00)00544-3 Ballestrem, 2000, Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration, Mol Biol Cell, 11, 2999, 10.1091/mbc.11.9.2999 Small, 1999, Cytoskeleton cross-talk during cell motility, FEBS Lett, 452, 96, 10.1016/S0014-5793(99)00530-X Pankov, 2000, Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis, J Cell Biol, 148, 1075, 10.1083/jcb.148.5.1075 Zamir, 2000, Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts, Nat Cell Biol, 2, 191, 10.1038/35008607 Liddington, 2000, The structural basis of dynamic cell adhesion: heads, tails, and allostery, Exp Cell Res, 261, 37, 10.1006/excr.2000.5058 Shaub, 1999, Unravelling the extracellular matrix, Nat Cell Biol, 1, E173, 10.1038/15608 Hamill, 2001, Molecular basis of mechanotransduction in living cells, Physiol Rev, 81, 685, 10.1152/physrev.2001.81.2.685 Ren, 1999, Regulation of the small GTP binding protein Rho by cell adhesion and the cytoskeleton, EMBO J, 18, 578, 10.1093/emboj/18.3.578 Ren, 2000, Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover, J Cell Sci, 113, 3673, 10.1242/jcs.113.20.3673 Arthur, 2000, Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism, Curr Biol, 10, 719, 10.1016/S0960-9822(00)00537-6 Wang, 2000, Focal adhesion kinase (FAK) is involved in mechanical sensing during fibroblast migration, Mol Biol Cell, 11, 398a Choquet, 1997, Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages, Cell, 88, 39, 10.1016/S0092-8674(00)81856-5 Galbraith, 1999, Concentration of vinculin at small fibronectin beads requires force, Mol Biol Cell, 10, 65a Palazzo, 2001, mDia mediates Rho-regulated formation and orientation of stable microtubules, Nat Cell Biol, 3, 723, 10.1038/35087035