Asociación Mexicana de Hepatología A.C. Guía Clínica de Hepatitis B

Revista de Gastroenterologia de Mexico - Tập 86 - Trang 403-432 - 2021
F. Higuera-de-la-Tijera1, G.E. Castro-Narro2, J.A. Velarde-Ruiz Velasco3, E. Cerda-Reyes4, R. Moreno-Alcántar5, I. Aiza-Haddad6, M. Castillo-Barradas7, L.E. Cisneros-Garza8, M. Dehesa-Violante9, J. Flores-Calderón10, M.S. González-Huezo11, E. Márquez-Guillén2, L.E. Muñóz-Espinosa12, J.L. Pérez-Hernández1, M.V. Ramos-Gómez13, J. Sierra-Madero2, J.F. Sánchez-Ávila14, A. Torre-Delgadillo2, R. Torres15, E.R. Marín-López16
1Departamento de Gastroenterología, Hospital General de México «Dr. Eduardo Liceaga», Ciudad de México, México
2Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México
3Departamento de Gastroenterología, Hospital Civil de Guadalajara «Fray Antonio Alcalde», Guadalajara, Jalisco, México
4Departamento de Gastroenterología, Hospital Central Militar, Ciudad de México, México
5Departamento de Gastroenterología, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, México
6Clínica de Enfermedades Hepáticas, Hospital Ángeles Lomas, Ciudad de México, México
7Departamento de Gastroenterología, Hospital de Especialidades del Centro Médico Nacional «La Raza», IMSS, Ciudad de México, México
8Centro de Enfermedades Hepáticas, Hospital San José, Nuevo León, Monterrey, México
9Fundación Mexicana para la Salud Hepática A.C. (FUNDHEPA), Ciudad de México, México
10Departamento de Gastroenterología, Hospital de Pediatría del Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, México
11Servicio de Gastroenterología y Endoscopia Gastrointestinal, ISSSEMYM, Metepec, Estado de México, México
12Clínica de Hígado, Departamento de Medicina Interna, Hospital Universitario «Dr. José E. González», Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México
13Departamento de Gastroenterología, Centro Médico Nacional «20 de Noviembre», ISSSTE, Ciudad de México, México
14Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de México, México
15Hospital de Infectología del Centro Médico Nacional «La Raza», IMSS, Ciudad de México, México
16Hospital Ángeles Puebla, Puebla, México

Tài liệu tham khảo

Organización Mundial de la Salud. Hepatitis B [consultado 13 Dic 2019] Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/hepatitis-b; 19 de Julio de 2019 Marín-López, 2005, Primer consenso nacional de hepatitis B crónica, Rev Gastroenterol Mex, 70, 490 Manterola, 2014, Jerarquía de evidencia: Niveles de evidencia y grados de recomendación de uso actual, Rev Chilena Infectol, 31, 705, 10.4067/S0716-10182014000600011 Medina-Rojo, 2017, National prevalence of hepatitis C and B viruses in Mexican blood donors, 2000-2012, Rev Med Hosp Gen Mex, 80, 37 Panduro, 2011, Epidemiología de las hepatitis virales en México, Salud Publica Mex, 53, S37 Sanchez, 2002, Genotypes and S-gene variability of Mexican hepatitis B virus strains, J Med Virol, 68, 24, 10.1002/jmv.10166 Panduro, 2013, Distribution of HBV genotypes F and H in Mexico and Central America, Antivir Ther, 18, 475, 10.3851/IMP2605 Roman, 2013, HBV endemicity in Mexico is associated with HBV genotypes H and G, World J Gastroenterol, 19, 5446, 10.3748/wjg.v19.i33.5446 Roman, 2010, Occult Hepatitis B in the genotype H-infected Nahuas and Huichol native Mexican population, J Med Virol, 82, 1527, 10.1002/jmv.21846 Fierro, 2011, Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients, Mem Inst Oswaldo Cruz, 106, 1007, 10.1590/S0074-02762011000800018 Román, 2013, Hepatitis B virus genotype H and environmental factors associated to the low prevalence of hepatocellular carcinoma in Mexico, J Cancer Ther, 4, 367, 10.4236/jct.2013.42A044 Román, 2014, Hepatitis B virus infection in Latin America: A genomic medicine approach, World J Gastroenterol, 20, 7181, 10.3748/wjg.v20.i23.7181 Croagh, 2014, Natural history of chronic hepatitis B: Phases in a complex relationship, World J Gastroenterol, 20, 10395, 10.3748/wjg.v20.i30.10395 Schillie, 2018, Prevention of hepatitis B virus infection in the United States: Recommendations of the Advisory Committee on Immunization Practices, MMWR Recomm Rep, 67, 1, 10.15585/mmwr.rr6701a1 Ganem, 2004, Hepatitis B virus infection-natural history and clinical consequences, N Engl J Med, 350, 1118, 10.1056/NEJMra031087 Valdespino, 2007, Prevalencia en México de la infección y el estado de portador de la hepatitis B en adultos, Salud Publica Mex, 49, S404, 10.1590/S0036-36342007000900012 Zanella, 2020, Hepatitis B seroprevalence in the pediatric and adolescent population of Florence (Italy): An update 27 years after the implementation of universal vaccination, Vaccines (Basel), 8, 156, 10.3390/vaccines8020156 Gehring, 2016, The role of innate immunity in the immunopathology and treatment of HBV infection, J Hepatol, 64 Bertoletti, 2016, Adaptive immunity in HBV infection, J Hepatol, 64, S71, 10.1016/j.jhep.2016.01.026 Hoofnagle, 2009, Reactivation of hepatitis B, Hepatology., 49, S156, 10.1002/hep.22945 2012, EASL clinical practice guidelines: Management of chronic hepatitis B virus infection, J Hepatol., 57, 167, 10.1016/j.jhep.2012.02.010 2017, EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection, J Hepatol., 67, 370, 10.1016/j.jhep.2017.03.021 Bray, 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 68, 394, 10.3322/caac.21492 Baecker, 2018, Worldwide incident hepatocellular carcinoma cases attributable to major risk factors, Eur J Cancer Prev, 27, 205, 10.1097/CEJ.0000000000000428 Sun, 2012, Obesity, inflammation, and liver cancer, J Hepatol., 56, 704, 10.1016/j.jhep.2011.09.020 Tan, 2019, Type 2 diabetes mellitus increases the risk of hepatocellular carcinoma in subjects with chronic hepatitis B virus infection: A meta-analysis and systematic review, Cancer Manag Res, 11, 705, 10.2147/CMAR.S188238 Miele, 2015, Diabetes and insulin therapy, but not metformin, are related to hepatocellular cancer risk, Gastroenterol Res Pract, 2015, 570356, 10.1155/2015/570356 Bréchot, 1980, Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma, Nature, 286, 533, 10.1038/286533a0 Bréchot, 2004, Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms, Gastroenterology, 127, S56, 10.1053/j.gastro.2004.09.016 Murakami, 2005, Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas, Gut, 54, 1162, 10.1136/gut.2004.054452 Yang, 2002, Hepatitis B e antigen and the risk of hepatocellular carcinoma, N Engl J Med, 347, 168, 10.1056/NEJMoa013215 Chen, 2006, Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level, JAMA, 295, 65, 10.1001/jama.295.1.65 Tseng, 2012, High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load, Gastroenterology, 142, 1140, 10.1053/j.gastro.2012.02.007 Lin, 2018, Review article: The prevention of hepatitis B-related hepatocellular carcinoma, Aliment Pharmacol Ther, 48, 5, 10.1111/apt.14683 Papatheodoridis, 2011, Gut, 60, 1109, 10.1136/gut.2010.221846 Farinati, 2006, Diagnostic and prognostic role of a-fetoprotein in hepatocellular carcinoma: Both or neither?, Am J Gastroenterol, 101, 524, 10.1111/j.1572-0241.2006.00443.x Figueras, 2001, Selection criteria for liver transplantation in early-stage hepatocellular carcinoma with cirrhosis: Results of a multicenter study, Liver Transpl, 7, 877, 10.1053/jlts.2001.27856 Yao, 2001, Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival, Hepatology, 33, 1394, 10.1053/jhep.2001.24563 Coli, 2006, Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: A systemic review, Am J Gastroenterol, 101, 513, 10.1111/j.1572-0241.2006.00467.x Hemming, 2016, Hepatitis B and hepatocellular carcinoma, Clin Liv Dis, 20, 703, 10.1016/j.cld.2016.06.007 Iida-Ueno, 2017, Hepatitis B virus infection and alcohol consumption, World J Gastroenterol, 23, 2651, 10.3748/wjg.v23.i15.2651 Ribes, 2006, Cofactors associated with liver disease mortality in an HBsAg-positive Mediterranean cohort: 20 years of follow-up, Int J Cancer, 119, 687, 10.1002/ijc.21882 Rehm, 2010, Alcohol as a risk factor for liver cirrhosis: A systematic review and meta-analysis, Drug Alcohol Rev, 29, 437, 10.1111/j.1465-3362.2009.00153.x Jarcuska, 2016, Association between hepatitis B and metabolic syndrome: Current state of the art, World J Gastroenterol, 22, 155, 10.3748/wjg.v22.i1.155 Razi, 2017, Association of chronic hepatitis B infection with metabolic syndrome and its components: Meta-analysis of observational studies, Diabetes Metab Syndr, 11, S939, 10.1016/j.dsx.2017.07.020 Kasmari, 2017, Independent of cirrhosis, hepatocellular carcinoma risk is increased with diabetes and metabolic syndrome, Am J Med, 130, 746.e1, 10.1016/j.amjmed.2016.12.029 Reiss, 2004, Review article: Hepatitis vaccination in patients with chronic liver disease, Aliment Pharmacol Ther, 19, 715, 10.1111/j.1365-2036.2004.01906.x Rojas-Cordero, 2008, Cuantificación del virus de Hepatitis B por la técnica PCR tiempo real, Acta Med Costarricense, 50, 11 Iloeje, 2006, Predicting cirrhosis risk based on the level of circulating hepatitis B viral load, Gastroenterology, 130, 678, 10.1053/j.gastro.2005.11.016 Block, 2013, Chronic hepatitis B: What should be the goal for new therapies?, Antiviral Res, 98, 27, 10.1016/j.antiviral.2013.01.006 Hatzakis, 2011, The state of hepatitis B and C in Europe: Report from the hepatitis B and C summit conference, J Viral Hepat, 18, S1, 10.1111/j.1365-2893.2011.01499.x MacLachlan, 2012, Liver cancer is the fastest increasing cause of cancer death in Australians, Med J Aust, 197, 492, 10.5694/mja12.11481 Mitchell, 2010, Institute of Medicine recommendations for the prevention and control of hepatitis B and C, Hepatology, 51, 729, 10.1002/hep.23561 Perumalswami, 2013, Hepatitis outreach network: A practical strategy for hepatitis screening with linkage to care in foreign-born communities, J Hepatol, 58, 890, 10.1016/j.jhep.2013.01.004 Vedio, 2013, Hepatitis B: Report of prevalence and access to healthcare among Chinese residents in Sheffield UK, J Infect Public Health, 6, 448, 10.1016/j.jiph.2013.05.004 Martinot-Peignoux, 2015, HBsAg quantification to optimize treatment monitoring in chronic hepatitis B patients, Liver Int, 35, S82, 10.1111/liv.12735 Seto, 2013, Reduction of hepatitis B surface antigen levels and hepatitis B surface antigen seroclearance in chronic hepatitis B patients receiving 10 years of nucleoside analogue therapy, Hepatology, 58, 923, 10.1002/hep.26376 Tian, 2016, Hepatitis B virus genotypes: Epidemiological and clinical relevance in Asia, Hepatol Int, 10, 854, 10.1007/s12072-016-9745-2 Yapali, 2014, Management of hepatitis B: Our practice and how it relates to the guidelines, Clin Gastroenterol Hepatol, 12, 16, 10.1016/j.cgh.2013.04.036 Agbim, 2019, Non-invasive assessment of liver fibrosis and prognosis: An update on serum and elastography markers, Expert Rev Gastroenterol Hepatol, 13, 361, 10.1080/17474124.2019.1579641 Park, 2019, Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study, World J Gastroenterol, 25, 3256, 10.3748/wjg.v25.i25.3256 Li, 2016, Systematic review with meta-analysis: The diagnostic accuracy of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B, Aliment Pharmacol Ther, 43, 458, 10.1111/apt.13488 Hako, 2019, Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B or C by contrast-enhanced magnetic resonance imaging, Can J Gastroenterol Hepatol, 2019, 3024630, 10.1155/2019/3024630 Shi, 2014, MR elastography for the assessment of hepatic fibrosis in patients with chronic hepatitis B infection: Does histologic necroinflammation influence the measurement of hepatic stiffness?, Radiology, 273, 88, 10.1148/radiol.14132592 Kim, 2016, Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients, J Hepatol, 64, 773, 10.1016/j.jhep.2015.11.012 Lemoine, 2016, The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa, Gut, 65, 1369, 10.1136/gutjnl-2015-309260 Wang, 2017, Development and validation of a model for staging hepatic fibrosis for chronic hepatitis B patients with E antigen-positive, Oncotarget, 8, 98812, 10.18632/oncotarget.22003 Lu, 2018, Assessment of liver fibrosis with the gamma-glutamyl transpeptidase to platelet ratio: A multicentre validation in patients with HBV infection, Gut, 67, 1903, 10.1136/gutjnl-2017-315299 Stasi, 2017, Non-invasive assessment of liver fibrosis in patients with HBV-related chronic liver disease undergoing antiviral treatment: A preliminary study, Eur J Pharmacol, 806, 105, 10.1016/j.ejphar.2017.03.063 Wang, 2017, A novel predictive model using routinely clinical parameters to predict liver fibrosis in patients with chronic hepatitis B, Oncotarget, 8, 59257, 10.18632/oncotarget.19501 Salkic, 2014, FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: A meta-analysis, Am J Gastroenterol, 109, 796, 10.1038/ajg.2014.21 Parikh, 2017, Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection, Ann Transl Med, 5, 40, 10.21037/atm.2017.01.28 2015, EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis, J Hepatol, 63, 237, 10.1016/j.jhep.2015.04.006 Mani, 2009, Liver biopsy findings in chronic hepatitis B, Hepatology, 49, S61, 10.1002/hep.22930 Tao, 2020, Present and future therapies for chronic hepatitis B, Adv Exp Med Biol, 1179, 137, 10.1007/978-981-13-9151-4_6 Tang, 2018, Chronic hepatitis B infection: A review, JAMA., 319, 1802, 10.1001/jama.2018.3795 Feld, 2009, Endpoints of therapy in chronic hepatitis B, Hepatology, 49, S96, 10.1002/hep.22977 Lok, 2017, Hepatitis B cure: From discovery to regulatory approval, J Hepatol, 67, 847, 10.1016/j.jhep.2017.05.008 Cornberg, 2020, Guidance for design and endpoints of clinical trials in chronic hepatitis B - Report from the 2019 EASL-AASLD HBV Treatment Endpoints Conference, J Hepatol, 72, 539, 10.1016/j.jhep.2019.11.003 Vlachogiannakos, 2018, Hepatitis B. Who and when to treat?, Liver Int, 38, S71, 10.1111/liv.13631 Peng, 2012, Hepatitis B virus-related decompensated liver cirrhosis: Benefits of antiviral therapy, J Hepatol, 57, 442, 10.1016/j.jhep.2012.02.033 Cholongitas, 2015, The impact of newer nucleos(t)ide analogues on patients with hepatitis B decompensated cirrhosis, Ann Gastroenterol, 28, 109 Lok, 2016, Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis, Hepatology, 63, 284, 10.1002/hep.28280 Jang, 2015, Long-term effect of antiviral therapy on disease course after decompensation in patients with hepatitis B virus-related cirrhosis, Hepatology, 61, 1809, 10.1002/hep.27723 Papatheodoridis, 2012, Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: A systematic review, J Hepatol, 57, 196, 10.1016/j.jhep.2011.11.030 Terrault, 2018, Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance, Hepatology, 67, 1560, 10.1002/hep.29800 Chu, 2007, HBsAg seroclearance in asymptomatic carriers of high endemic areas: Appreciably high rates during a long-term follow-up, Hepatology, 45, 1187, 10.1002/hep.21612 Yip, 2017, Impact of age and gender on risk of hepatocellular carcinoma after hepatitis B surface antigen seroclearance, J Hepatol, 67, 902, 10.1016/j.jhep.2017.06.019 Chayanupatkul, 2017, Hepatocellular carcinoma in the absence of cirrhosis in patients with chronic hepatitis B virus infection, J Hepatol, 66, 355, 10.1016/j.jhep.2016.09.013 Yu, 2017, Influence of metabolic risk factors on risk of hepatocellular carcinoma and liver-related death in men with chronic hepatitis B: A large cohort study, Gastroenterology, 153, 1006, 10.1053/j.gastro.2017.07.001 Yeo, 2000, Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: A prospective study of 626 patients with identification of risk factors, J Med Virol, 62, 299, 10.1002/1096-9071(200011)62:3<299::AID-JMV1>3.0.CO;2-0 Mori, 2015, Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations, World J Gastroenterol, 21, 10274, 10.3748/wjg.v21.i36.10274 Kanaan, 2012, Significant rate of hepatitis B reactivation following kidney transplantation in patients with resolved infection, J Clin Virol, 55, 233, 10.1016/j.jcv.2012.07.015 Block, 2017, Use of current and new endpoints in the evaluation of experimental hepatitis B therapeutics, Clin Infect Dis, 64, 1283, 10.1093/cid/cix129 Grek, 2016, Acute liver failure, AACN Adv Crit Care, 27, 420, 10.4037/aacnacc2016324 Wang, 2013, Advances in the management of acute liver failure, World J Gastroenterol, 19, 7069, 10.3748/wjg.v19.i41.7069 Lee, 2012, Acute liver failure, Semin Respir Crit Care Med, 33, 36, 10.1055/s-0032-1301733 Park, 2018, Tenofovir, entecavir, and lamivudine in patients with severe acute exacerbation and hepatic decompensation of chronic hepatitis B, Dig Liver Dis, 50, 163, 10.1016/j.dld.2017.10.002 Reshef, 2000, Lamivudine in the treatment of acute hepatitis B, N Engl J Med, 34, 1123, 10.1056/NEJM200010123431513 Torii, 2002, Effectiveness and long-term outcome of lamivudine therapy for acute hepatitis B, Hepatol Res, 24, 34, 10.1016/S1386-6346(02)00009-8 Kondili, 2004, The use of lamivudine for patients with acute hepatitis B (a series of cases), J Viral Hepat, 11, 427, 10.1111/j.1365-2893.2004.00504.x Lisotti, 2008, Lamivudine treatment for severe acute HBV hepatitis, Int J Med Sci, 5, 309, 10.7150/ijms.5.309 Schmilovitz-Weiss, 2004, Lamivudine treatment for acute severe hepatitis B: A pilot study, Liver Int, 24, 547, 10.1111/j.1478-3231.2004.0983.x Tillmann, 2006, Safety and efficacy of lamivudine in patients with severe acute or fulminant hepatitis B, a multicenter experience, J Viral Hepat, 13, 256, 10.1111/j.1365-2893.2005.00695.x Kumar, 2007, A randomized controlled trial of lamivudine to treat acute hepatitis B, Hepatology, 45, 97, 10.1002/hep.21486 Miyake, 2008, Lamivudine treatment improves the prognosis of fulminant hepatitis B, Intern Med, 47, 1293, 10.2169/internalmedicine.47.1061 Wang, 2014, Acute liver failure caused by severe acute hepatitis B: A case series from a multi-center investigation, Ann Clin Microbiol Antimicrob, 13, 23, 10.1186/1476-0711-13-23 Streinu-Cercel, 2016, Treatment with lamivudine and entecavir in severe acute hepatitis B, Indian J Med Microbiol, 34, 166, 10.4103/0255-0857.176837 García-Alonso, 2012, Pharmacological treatment of acute hepatitis B, Med Clin (Barc), 138, 633, 10.1016/j.medcli.2011.09.026 Cai, 2019, Comparison of the long-term efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naïve HBeAg-positive patients with chronic hepatitis B: A large, multicentre, randomized controlled trials, Medicine (Baltimore), 98, e13983, 10.1097/MD.0000000000013983 Lok, 2012, Efficacy of entecavir with or without tenofovir disoproxil fumarate for nucleos(t)ide-naïve patients with chronic hepatitis B, Gastroenterology, 143, 619, 10.1053/j.gastro.2012.05.037 Tenney, 2009, Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy, Hepatology, 49, 1503, 10.1002/hep.22841 Buti, 2020, Optimal management of chronic hepatitis B patients receiving nucleos(t)ide analogues, Liver Int, 40, S15, 10.1111/liv.14367 Callebaut, 2015, In vitro virology profile of tenofovir alafenamide, a novel oral prodrug of tenofovir with improved antiviral activity compared to that of tenofovir disoproxil fumarate, Antimicrob Agents Chemother, 59, 5909, 10.1128/AAC.01152-15 Childs-Kean, 2018, Tenofovir alafenamide for the treatment of chronic hepatitis B monoinfection, Pharmacotherapy, 38, 1051, 10.1002/phar.2174 Buti, 2016, Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: A randomised, double-blind, phase 3, non-inferiority trial, Lancet Gastroenterol Hepatol, 1, 196, 10.1016/S2468-1253(16)30107-8 Lampertico, 2020, Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: A randomised, double-blind, phase 3, multicentre non-inferiority study, Lancet Gastroenterol Hepatol, 5, 441, 10.1016/S2468-1253(19)30421-2 Yuen, 2018, Hepatitis B virus infection, Nat Rev Dis Primers, 4, 18035, 10.1038/nrdp.2018.35 Lam, 2017, Seven-year treatment outcome of entecavir in a real-world cohort: Effects on clinical parameters HBsAg and HBcrAg levels, Clin Transl Gastroenterol, 8, e125, 10.1038/ctg.2017.51 Buti, 2015, Seven-year efficacy and safety of treatment with tenofovir disoproxil fumarate for chronic hepatitis B virus infection, Dig Dis Sci, 60, 1457, 10.1007/s10620-014-3486-7 Jeon, 2017, Efficacy of tenofovir-based rescue therapy for chronic hepatitis B patients with resistance to lamivudine and entecavir, Clin Mol Hepatol, 23, 230, 10.3350/cmh.2017.0003 Lee, 2017, Tenofovir versus tenofovir plus entecavir for chronic hepatitis B with lamivudine resistance and entecavir resistance, J Viral Hepat, 24, 141, 10.1111/jvh.12623 Cho, 2015, Tenofovir-based rescue therapy in chronic hepatitis B patients with suboptimal responses to adefovir with prior lamivudine resistance, J Med Virol, 87, 1532, 10.1002/jmv.24201 Corsa, 2014, No resistance to tenofovir disoproxil fumarate through 96 weeks of treatment in patients with lamivudine-resistant chronic hepatitis B, Clin Gastroenterol Hepatol, 12, 2106, 10.1016/j.cgh.2014.05.024 Leemans, 2008, Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: Successful rescue therapy with tenofovir, Eur J Gastroenterol Hepatol, 20, 773, 10.1097/MEG.0b013e3282f793d6 Guo, 2018, Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study, Int J Antimicrob Agents, 52, 201, 10.1016/j.ijantimicag.2018.04.002 Liu, 2016, Hepatitis B: Treatment choice and monitoring for response and resistance, Expert Rev Gastroenterol Hepatol, 10, 697, 10.1586/17474124.2016.1145547 Park, 2019, Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients, J Hepatol, 70, 1093, 10.1016/j.jhep.2019.02.006 Yim, 2018, Switching to tenofovir vs continuing entecavir for hepatitis B virus with partial virologic response to entecavir: A randomized controlled trial, J Viral Hepat, 25, 1321, 10.1111/jvh.12934 Gish, 2012, Selection of chronic hepatitis B therapy with high barrier to resistance, Lancet Infect Dis, 12, 341, 10.1016/S1473-3099(11)70314-0 Buster, 2009, Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa, Gastroenterology, 137, 2002, 10.1053/j.gastro.2009.08.061 Bonino, 2007, Predicting response to peginterferon-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B, Gut, 56, 699, 10.1136/gut.2005.089722 Lampertico, 2013, Randomised study comparing 48 and 96 weeks peginterferon a-2a therapy in genotype D HBeAg-negative chronic hepatitis B, Gut, 62, 290, 10.1136/gutjnl-2011-301430 Chen, 2014, Extended peginterferon alfa-2a (Pegasys) therapy in Chinese patients with HBeAg-negative chronic hepatitis B, J Med Virol, 86, 1705, 10.1002/jmv.24013 Sonneveld, 2013, Response-guided peginterferon therapy in hepatitis B e antigen-positive chronic hepatitis B using serum hepatitis B surface antigen levels, Hepatology, 58, 872, 10.1002/hep.26436 Rijckborst, 2010, Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitis B using HBsAg and HBV DNA levels, Hepatology, 52, 454, 10.1002/hep.23722 Thio, 2002, HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS), Lancet, 360, 1921, 10.1016/S0140-6736(02)11913-1 Avihingsanon, 2010, Efficacy of tenofovir disoproxil fumarate/emtricitabine compared with emtricitabine alone in antiretroviral-naive HIV-HBV coinfection in Thailand, Antivir Ther, 15, 917, 10.3851/IMP1645 De Clercq, 2018, Role of tenofovir alafenamide (TAF) in the treatment and prophylaxis of HIV and HBV infections, Biochem Pharmacol, 153, 2, 10.1016/j.bcp.2017.11.023 Matthews, 2009, Combination HBV. therapy is linked to greater HBV. suppression in a cohort of lamivudine-experienced DNA HIV/HBV. coinfected individuals, AIDS, 23, 1707, 10.1097/QAD.0b013e32832b43f2 Benhamou, 1999, Long-term incidence of hepatitis B virus resistance to lamivudine in human immunodeficiency virus-infected patients, Hepatology, 30, 1302, 10.1002/hep.510300525 Lacombe, 2008, Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients, Antivir Ther, 13, 705, 10.1177/135965350801300510 Yang, 2015, Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients, World J Gastroenterol, 21, 2746, 10.3748/wjg.v21.i9.2746 Jia, 2018, High prevalence of HBV lamivudine-resistant mutations in HBV/HIV co-infected patients on antiretroviral therapy in the area with the highest prevalence of HIV/HBV Co-Infection in China, Intervirology, 61, 123, 10.1159/000493797 McMahon, 2007, The HBV drug entecavir - Effects on HIV-1 replication and resistance, N Engl J Med, 356, 2614, 10.1056/NEJMoa067710 Pessôa, 2008, Efficacy and safety of entecavir for chronic HBV in HIV/HBV coinfected patients receiving lamivudine as part of antiretroviral therapy, AIDS, 22, 1779, 10.1097/QAD.0b013e32830b3ab5 Gish, 2017, Reactivation of Hepatitis B Virus After Treatment with Direct Acting Antivirals for Hepatitis C: What You Need to Know Liu, 2018, Efficacy of ledipasvir and sofosbuvir treatment of HCV infection in patients coinfected with HBV, Gastroenterology, 154, 989, 10.1053/j.gastro.2017.11.011 Tyson, 2013, Prevalence and predictors of hepatitis B virus coinfection in a United States cohort of hepatitis C virus-infected patients, Hepatology, 58, 538, 10.1002/hep.26400 Bini, 2010, Hepatitis B virus infection among American patients with chronic hepatitis C virus infection: Prevalence, racial/ethnic differences, and viral interactions, Hepatology, 51, 759 Bersoff-Matcha, 2017, Hepatitis B virus reactivation associated with direct-acting antiviral therapy for chronic hepatitis C virus: A review of cases reported to the U.S. Food and Drug Administration Adverse Event Reporting System, Ann Intern Med, 166, 792, 10.7326/M17-0377 Wang, 2017, Hepatitis due to reactivation of hepatitis B virus in endemic areas among patients with hepatitis C treated with direct-acting antiviral agents, Clin Gastroenterol Hepatol, 15, 132, 10.1016/j.cgh.2016.06.023 Gane, 2016, Ledipasvir and sofosbuvir for HCV infection in patients coinfected with HBV, Antivir Ther, 21, 605, 10.3851/IMP3066 Tamori, 2017, Low incidence of hepatitis B virus reactivation and subsequent hepatitis in patients with chronic hepatitis C receiving direct-acting antiviral therapy, J Viral Hepat, 25, 608, 10.1111/jvh.12840 Reddy, 2015, American Gastroenterological Association Institute guideline on the prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy, Gastroenterology, 148, 215, 10.1053/j.gastro.2014.10.039 Muñóz-Espinosa, 1997, Prevalencia de hepatitis D en una población del Noreste de México y su relación con otros virus, Rev Gastroenterol Mex, 62, 246 Trépo, 2014, Hepatitis B virus infection, Lancet, 384, 2053, 10.1016/S0140-6736(14)60220-8 Organización Mundial de la Salud. Hepatitis D [consultado 3 Ene 2020] Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/hepatitis-d; 8 Julio 2019 Wedemeyer, 2010, Epidemiology, pathogenesis and management of hepatitis D: Update and challenges ahead, Nat Rev Gastroenterol Hepatol, 7, 31, 10.1038/nrgastro.2009.205 Rizzetto, 2012, Epidemiology of hepatitis D, Semin Liver Dis, 32, 211, 10.1055/s-0032-1323626 Gilman, 2019, Chronic hepatitis delta: A state-of-the-art review and new therapies, World J Gastroenterol, 25, 4580, 10.3748/wjg.v25.i32.4580 Alter, 2003, Epidemiology of hepatitis B in Europe and worldwide, J Hepatol, 39, S64, 10.1016/S0168-8278(03)00141-7 Noureddin, 2014, Hepatitis delta: Epidemiology, diagnosis and management 36 years after discovery, Curr Gastroenterol Rep, 16, 365, 10.1007/s11894-013-0365-x Heidrich, 2013, Treatment options for hepatitis delta virus infection, Curr Infect Dis Rep, 15, 31, 10.1007/s11908-012-0307-z Heidrich, 2014, Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta, Hepatology, 60, 87, 10.1002/hep.27102 Castelnau, 2006, Efficacy of peginterferon alpha-2b in chronic hepatitis delta: Relevance of quantitative RTPCR for follow-up, Hepatology, 44, 728, 10.1002/hep.21325 Erhardt, 2006, Treatment of chronic hepatitis delta with pegylated interferon- alpha2b, Liver Int, 26, 805, 10.1111/j.1478-3231.2006.01279.x Niro, 2006, Pegylated interferon alpha-2b as monotherapy or in combination with ribavirin in chronic hepatitis delta, Hepatology, 44, 713, 10.1002/hep.21296 Wedemeyer, 2011, Peginterferon plus adefovir versus either drug alone for hepatitis delta, N Engl J Med, 364, 322, 10.1056/NEJMoa0912696 Wranke, 2017, Antiviral treatment and liver-related complications in hepatitis delta, Hepatology, 65, 414, 10.1002/hep.28876 Yurdaydin, 2008, Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon, J Viral Hepat, 15, 314, 10.1111/j.1365-2893.2007.00936.x Goyal, 2015, Prolonged use of tenofovir and entecavir in hepatitis B virus-related cirrhosis, Indian J Gastroenterol, 34, 286, 10.1007/s12664-015-0576-1 Wang, 2016, Entecavir for patients with hepatitis B decompensated cirrhosis in China: A meta-analysis, Sci Rep, 6, 32722, 10.1038/srep32722 Zhang, 2015, The efficacy and safety of entecavir in patients with chronic hepatitis B- associated liver failure: A meta-analysis, Ann Hepatol, 14, 150, 10.1016/S1665-2681(19)30776-8 Miquel, 2013, Efficacy and safety of entecavir and/or tenofovir in hepatitis B compensated and decompensated cirrhotic patients in clinical practice, Ann Hepatol, 12, 205, 10.1016/S1665-2681(19)31358-4 Oh, 2017, Can we trust safety of tenofovir disoproxil in patients with decompensated cirrhosis?, Gut Liver, 11, 743, 10.5009/gnl17401 Singal, 2012, Meta-analysis: Oral antiviral agents in adults with decompensated hepatitis B virus cirrhosis, Aliment Pharmacol Ther, 35, 674, 10.1111/j.1365-2036.2011.04990.x Liaw, 2011, Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease, Hepatology, 53, 62, 10.1002/hep.23952 Lee, 2017, Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis, World J Gastroenterol, 23, 2396, 10.3748/wjg.v23.i13.2396 Verna, 2018, Updated hepatitis B guidance: Implications for liver transplant patients, Liver Transpl, 24, 465, 10.1002/lt.25037 2012, EASL-EORTC Clinical practice guidelines: Management of hepatocellular carcinoma, J Hepatol., 56, 908, 10.1016/j.jhep.2011.12.001 Montoliu, 2010, Incidence and prognosis of different types of functional renal failure in cirrhotic patients with ascites, Clin Gastroenterol Hepatol, 8, 616, 10.1016/j.cgh.2010.03.029 Patel, 2015, Bone disease in cirrhosis, Clin Liv Dis (Hoboken), 6, 96, 10.1002/cld.498 Custodio, 2016, Pharmacokinetics and safety of tenofovir alafenamide in HIV-uninfected subjects with severe renal impairment, Antimicrob Agents Chemother, 60, 5135, 10.1128/AAC.00005-16 Arribas, 2017, Brief Report: Randomized, double-blind comparison of tenofovir alafenamide (TAF) vs tenofovir disoproxil fumarate (TDF), each coformulated with elvitegravir, cobicistat, and emtricitabine (E/C/F) for initial HIV-1 treatment: Week 144 results, J Acquir Immune Defic Synd, 75, 211, 10.1097/QAI.0000000000001350 Raffi, 2017, Brief report: Long-term (96-week) efficacy and safety after switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) in HIV-infected, virologically suppressed adults, J Acquir Immune Defic Syndr, 75, 226, 10.1097/QAI.0000000000001344 Chan, 2016, Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: A randomised, double-blind, phase 3, non-inferiority trial, Lancet Gastroenterol Hepatol, 1, 185, 10.1016/S2468-1253(16)30024-3 Agarwal, 2018, 96?weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection, J Hepatol, 68, 672, 10.1016/j.jhep.2017.11.039 Seto, 2018, Improved bone safety of tenofovir alafenamide compared to tenofovir disoproxil fumarate over 2 years in patients with chronic HBV infection, Clin Gastroenterol Hepatol, S1542–3565, 30633 Fox, 2011, Individualizing hepatitis B infection prophylaxis in liver transplant recipients, J Hepatol, 55, 507, 10.1016/j.jhep.2011.04.002 2016, EASL Clinical Practice Guidelines: Liver transplantation, J Hepatol., 64, 433, 10.1016/j.jhep.2015.10.006 Samuel, 1991, Passive immunoprophylaxis after liver transplantation in HBsAg-positive patients, Lancet, 337, 813, 10.1016/0140-6736(91)92515-4 McGory, 1996, Improved outcome of orthotopic liver transplantation for chronic hepatitis B cirrhosis with aggressive passive immunization, Transplantation, 61, 1358, 10.1097/00007890-199605150-00013 Terrault, 1996, Prophylaxis in liver transplant recipients using a fixed dosing schedule of hepatitis B immunoglobulin, Hepatology, 24, 1327, 10.1002/hep.510240601 Devlin, 1994, Impact of immunoprophylaxis and patient selection on outcome of transplantation for HBsAg-positive liver recipients, J Hepatol, 21, 204, 10.1016/S0168-8278(05)80396-4 Lauchart, 1987, Long-term immunoprophylaxis of hepatitis B virus reinfection in recipients of human liver allografts, Transplant Proc, 19, 4051 Roche, 2015, Rational basis for optimizing short and long-term hepatitis B virus prophylaxis post liver transplantation: Role of hepatitis B immune globulin, Transplantation, 99, 1321, 10.1097/TP.0000000000000777 Anselmo, 2002, New era of liver transplantation for hepatitis B: A 17-year single-center experience, Ann Surg, 235, 611, 10.1097/00000658-200205000-00002 Zheng, 2006, Prevention of hepatitis B recurrence after liver transplantation using lamivudine or lamivudine combined with hepatitis B Immunoglobulin prophylaxis, Liver Transpl, 12, 253, 10.1002/lt.20701 Akyildiz, 2007, Adefovir dipivoxil therapy in liver transplant recipients for recurrence of hepatitis B virus infection despite lamivudine plus hepatitis B immunoglobulin prophylaxis, J Gastroenterol Hepatol, 22, 2130, 10.1111/j.1440-1746.2006.04609.x Gane, 2007, Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation, Gastroenterology, 132, 931, 10.1053/j.gastro.2007.01.005 Jiang, 2013, prophylaxis using lamivudine and individualized low-dose hepatitis B immunoglobulin in living donor liver transplantation, Transplant Proc, 45, 2326, 10.1016/j.transproceed.2013.03.028 Xi, 2009, The role of entecavir in preventing hepatitis B recurrence after liver transplantation, J Dig Dis, 10, 321, 10.1111/j.1751-2980.2009.00403.x Jiang, 2010, Prophylaxis against hepatitis B recurrence post-transplantation using lamivudine and individualized low-dose hepatitis B immunoglobulin, Am J Transplant, 10, 1861, 10.1111/j.1600-6143.2010.03208.x Cai, 2012, Clinical study on prevention of HBV re-infection by entecavir after liver transplantation, Clin Transplant, 26, 208, 10.1111/j.1399-0012.2011.01448.x Di Costanzo, 2013, Safety and efficacy of subcutaneous hepatitis B immunoglobulin after liver transplantation: An open single-arm prospective study, Am J Transplant, 13, 348, 10.1111/j.1600-6143.2012.04319.x Hu, 2014, Section 14 Combination of entecavir plus low-dose on-demand hepatitis B immunoglobulin is effective with very low hepatitis B recurrence after liver transplantation, Transplantation, 97, S53, 10.1097/01.tp.0000446278.43804.f9 Fung, 2017, Long-term outcomes of entecavir monotherapy for chronic hepatitis B after liver transplantation: Results up to 8 years, Hepatology, 66, 1036, 10.1002/hep.29191 Buti, 2003, A randomized study comparing lamivudine monotherapy after a short course of hepatitis B immune globulin (HBIg) and lamivudine with long-term lamivudine plus HBIg in the prevention of hepatitis B virus recurrence after liver transplantation, J Hepatol, 38, 811, 10.1016/S0168-8278(03)00087-4 Nath, 2006, prophylaxis post-liver transplant without maintenance hepatitis B immunoglobulin therapy, Clin Transplant, 20, 206, 10.1111/j.1399-0012.2005.00467.x Buti, 2007, Adherence to Lamivudine after an early withdrawal of hepatitis B immune globulin plays an important role in the long-term prevention of hepatitis B virus recurrence, Transplantation, 84, 650, 10.1097/01.tp.0000277289.23677.0a Wong, 2007, Low risk of hepatitis B virus recurrence after withdrawal of long-term hepatitis B immunoglobulin in patients receiving maintenance nucleos(t)ide analogue therapy, Liver Transpl, 13, 374, 10.1002/lt.21041 Neff, 2007, Combination therapy in liver transplant recipients with hepatitis B virus without hepatitis B immune globulin, Dig Dis Sci, 52, 2497, 10.1007/s10620-006-9658-3 Angus, 2008, A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis, Hepatology., 48, 1460, 10.1002/hep.22524 Saab, 2011, Posttransplantation hepatitis B prophylaxis with combination oral nucleoside and nucleotide analog therapy, Am J Transplant, 11, 511, 10.1111/j.1600-6143.2010.03416.x Lenci, 2011, Safety of complete and sustained prophylaxis withdrawal in patients liver-transplanted for HBV-related cirrhosis at low risk of HBV recurrence, J Hepatol, 55, 587, 10.1016/j.jhep.2010.12.036 Teperman, 2013, Randomized trial of emtricitabine/tenofovir disoproxil fumarate after hepatitis B immunoglobulin withdrawal after liver transplantation, Liver Transpl, 19, 594, 10.1002/lt.23628 Gane, 2013, Combination lamivudine plus adefovir without HBIG is safe and effective prophylaxis against HBV recurrence in HBsAg+ liver transplant candidates, Liver Transpl, 19, 268, 10.1002/lt.23600 Yi, 2013, Post-transplantation sequential entecavir monotherapy following 1-year combination therapy with hepatitis B immunoglobulin, J Gastroenterol, 48, 1401, 10.1007/s00535-013-0761-x Tanaka, 2014, One year of hepatitis B immunoglobulin plus tenofovir therapy is safe and effective in preventing recurrent hepatitis B post-liver transplantation, Can J Gastroenterol Hepatol, 28, 41, 10.1155/2014/839014 Aygen, 2018, Immunosuppressive therapy and the risk of hepatitis B reactivation: Consensus report, Turk J Gastroenterol, 29, 259, 10.5152/tjg.2018.18263 Perrillo, 2015, Hepatitis B reactivation from immunosuppressive drug therapy: A global menace, Clin Liver Dis (Hoboken), 5, 39, 10.1002/cld.448 Perrillo, 2015, American Gastroenterological Association Institute technical review on prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy, Gastroenterology, 148, 221, 10.1053/j.gastro.2014.10.038 Huang, 2013, Randomized controlled trial of entecavir prophylaxis for rituximab associated hepatitis B virus reactivation in patients with lymphoma and resolved hepatitis B, J Clin Oncol, 31, 2765, 10.1200/JCO.2012.48.5938 Tran, 2016, Hepatitis B in pregnancy, Clin Infect Dis, 62, S314, 10.1093/cid/ciw092 Lee, 2006, Hepatitis B immunisation for newborn infants of hepatitis B surface antigen-positive mothers, Cochrane Database Syst Rev, CD004790 Nelson, 2014, Prevention of perinatal hepatitis B virus transmission, J Pediatric Infect Dis Soc, 3, S7, 10.1093/jpids/piu064 Schillie, 2013, Seroprotection after recombinant hepatitis B vaccination among newborn infants: A review, Vaccine, 31, 2506, 10.1016/j.vaccine.2012.12.012 Pan, 2012, An algorithm for risk assessment and intervention of mother to child transmission of hepatitis B virus, Clin J Gastroenterol Hepatol, 10, 452, 10.1016/j.cgh.2011.10.041 Pan, 2016, Tenofovir to prevent hepatitis B transmission in mothers with high viral load, N Engl J Med, 374, 2324, 10.1056/NEJMoa1508660 Terrault, 2016, AASLD guidelines for treatment of chronic hepatitis B, Hepatology, 63, 261, 10.1002/hep.28156 Wong, 2018, Review article: Long-term safety of oral anti-viral treatment for chronic hepatitis B, Aliment Pharmacol Ther, 47, 730, 10.1111/apt.14497 Han, 2017, The efficacy and safety comparison between tenofovir and entecavir in treatment of chronic hepatitis B and HBV related cirrhosis: A systematic review and Meta-analysis, Int Immunopharmacol, 42, 168, 10.1016/j.intimp.2016.11.022 Viganò, 2019, Effectiveness and safety of switching to entecavir hepatitis B patients developing kidney dysfunction during tenofovir, Liver Int, 39, 484, 10.1111/liv.14017