Arylsulfone-Based HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

10.1126/science.6189183

10.1126/science.6601823

10.1016/j.antiviral.2009.10.007

10.1093/cid/cir936

10.1177/095632029800900301

10.1016/j.antiviral.2009.10.016

10.3390/v3040347

10.1124/pr.111.005553

Barrish JC ZahlerR. Antiviral Agents. In: Annual Reports in Medicinal Chemistry. Bristol JA (Ed.). Academic Press Inc. NY USA 131–140 (1993).

10.1016/j.antiviral.2009.09.008

10.1002/cbdv.200490012

10.1016/j.antiviral.2009.10.003

10.1016/j.bmc.2007.09.010

10.1023/A:1008629608556

10.1038/3293

10.1016/j.antiviral.2009.07.022

10.1097/COH.0b013e328322402e

10.1016/j.antiviral.2009.11.004

10.1016/j.clinthera.2008.10.012

10.1016/j.antiviral.2009.10.002

10.1038/nrd2563

Saag MS . New and investigational antiretroviral drugs for HIV infection: mechanisms of action and early research findings.Topics Antivir. Med.20(5), 162–167 (2012).

10.1007/s11030-012-9417-7

10.1073/pnas.88.23.10895

10.1126/science.1377403

10.1073/pnas.90.13.6320

10.1016/S0021-9258(18)61637-0

10.1016/S0021-9258(18)98737-5

10.1006/jmbi.1994.1665

10.1128/AAC.37.4.754

10.1002/ardp.19953280304

10.1021/jm950568w

10.1021/jm9901125

10.1016/S0968-0896(00)00333-3

10.1177/095632029600700504

10.1021/jm0004906

10.1021/jm0004906

10.3891/acta.chem.scand.06-0667

10.1016/0968-0896(96)00075-2

Silvestri R , ArticoM, PagnozziE, StefancichG, MassaS, la Colla P. Synthesis and anti-HIV activity of 10, 11-dihydropyrrolo[1,2-b][1,2,5]benzothiadiazepine-11-acetic acid 5, 5-dioxide derivatives and related compounds. Farmaco51, 425–430 (1996).

Artico M , StefancichG, SilvestriRet al. Pyrrolobenzothiazepines: a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors. Med. Chem. Res. 4, 283–290 (1994).

10.1021/jm00061a022

10.1021/jm0211063

10.1055/s-1988-27615

10.1016/0960-894X(95)00059-3

10.1021/jm040854k

10.1177/095632020601700202

10.1021/jm0004906

10.1021/jm0512490

10.1021/jm801470b

10.1021/jm031147e

Beressi A , SunheimerRL, HuishS, KinckC, PincusMR. Acute severe rhabdomyolysis in a human immunodeficiency virus seropositive patient associated with rising anti-Coxsackie B viral titers.Ann. Clin. Lab. Sci.24, 278–281 (1994).

Neves O , SteinCM, ThomtonC, GangaidzoI, ThomasJE. Rhabdomyolysis associated with immunodeficiency virus (HIV) infection.Cent. Afr. J. Med.37, 387–388 (1991).

10.1016/S0079-6468(08)70082-1

10.1177/135965359900403S01

10.1128/AAC.43.12.2893

10.1016/S0960-894X(99)00565-X

10.1021/jm990580e

10.1021/jm070488f

10.1016/j.antiviral.2008.09.008

10.1128/AAC.49.11.4546-4554.2005

10.3851/IMP1607

Robinson B . The Fischer Indole Synthesis. John Wiley and Sons Chichester UK (1982).

Silvestri R , ArticoM, la Regina G, de Martino G. Synthetic approaches to difluoroindole carboxylic acid ethyl esters. ARKIVOC5, 26–31 (2004).

10.1039/JR9650007185

10.1080/00304940209355772

10.1021/op1001808

10.1080/00304940809458086

10.1021/co100015b

10.1021/co200165j

10.1016/S0960-894X(01)00411-5

10.1021/jm9707030

10.1021/jm9707028

10.1016/j.bmcl.2007.11.085

10.1021/jm101614j

10.3851/IMP1855

10.1021/jm300477h

10.1021/ja034308c

10.1021/ja3092642

10.1021/jm301294g

10.1021/jm030558s

10.1006/jmbi.1996.0698

10.1021/jm990192c

10.1021/ja042289g

10.1016/S0969-2126(00)00513-X

10.1021/jm1002233

10.1016/S0960-894X(01)00510-8

GlaxoSmithKline and Idenix Pharmaceuticals sign worldwide license agreement for IDX899 a novel NNRTI for the treatment of HIV. Idenix Pharmaceuticals Inc. MA USA (2009).

10.1021/jm040840e

Jakubik J , SeiferM, GrayLet al. IDX12899 Anti-HIV-1 activity and resistance profile is superior to efavirenz. Antivir. Ther. 12(Suppl. 1), S32 (2007).

Kilby JM , SaagMS. Is there a role for non-nucleoside reverse transcriptase inhibitors in the treatment of HIV infection?Antiinfective Agents Dis.3, 313–323 (1994).

Artico M Massa S Silvestri R Loi AG De Montis A La Colla P: WO96/33171 (1996).

Williams TA Ciccarone TM Saari WS et al.: EP0530907A1 (1992).

Williams TA Ciccarone TM Greenlee WJ et al.: WO94/19321 (1994).

la Colla P Artico M Sommadossi JP: US10/122252 (2002).

Storer R Alexandre FR Dousson C Moussa AM Bridges E: WO2008/042240 (2008).

Artico M Silvestri R Massa S Loi AG la Colla P: MI95A000812 (1995).

UNAIDS 2012 Global Report UNAIDS. www.amfar.org

US FDA. Antiretroviral drugs used in the treatment of HIV infection. www.fda.gov/ForConsumers/byAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm118915.htm