Artocarpus nigrifolius: Cytotoxic and antibacterial constituents

Tran Minh Hoi1, Ha Van Anh1, Nguyen Thi Thanh Huong1, Nguyen Van Tuyen2, Le Thi Tu Anh2, Nguyen Thanh Tra2, Ba Thi Cham2, Nguyen Thi Thu Ha2, Pham Thuy Linh2, Doan Duy Tien2, Phan Van Kiem3, Ninh Khac Ban3, Lidziya Kukhareva4, Gill Tatiana4, Young Ho Kim5
1Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Caugiay, Hanoi, Vietnam
2Institute of Chemistry, Vietnam Academy of Science and Technology, Caugiay, Hanoi, Vietnam
3Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Caugiay, Hanoi, Vietnam
4Central Botanical Garden of the National Academy of Sciences of Belarus, Minsk, Republic of Belarus
5College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea

Tóm tắt

Six known compounds including α-amyrin 3-acetate (1), β-sitosterol (2), betulinic acid (3), friedelan-3-one (4), artochamin B (5), and 2-C-methyl-d-erythritol 4-O-α-d-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1–6 were evaluated. Results showed that artochamin B (5) possessed the highest cytotoxicity towards MCF7, Lu, HepG2, and KB cell lines with IC50 values of 4.59, 20.00, 3.60, and 1.18 μg/mL, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.

Tài liệu tham khảo

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