Artificial Triterpenoid Fatty Acid Ester Isolated From the Leaves of Phytolacca icosandra L

Natural Products and Bioprospecting - 2020
Elier Galarraga1, Andersson Mavares1, Neudo Urdaneta1, Rafael E. Rodríguez-Lugo1,2, Juan M. Amaro‐Luis3
1Departamento de Química. Edificio de Química Y Procesos, Universidad Simón Bolívar (USB), Venezuela, USA
2Laboratorio de Química Bioinorgánica, Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC), Venezuela, USA
3Laboratorio de Productos Naturales, Departamento de Química. Facultad de Ciencias, Universidad de Los Andes (ULA), Mérida, Venezuela-5101, USA

Tóm tắt

Abstract The methanol extract form the leaves of Phytolacca icosandra L., afforded the unprecedented artificial triterpenoid fatty acid ester 1 derived from the new natural triterpenoid phytolaccagenic acid 3-O-myristate (1a), along with the three known triterpenoids serjanic, acinosolic and phytolaccagenic acid (2 – 4). Their structures were stablished by HR-EI-MS, 1D and 2D NMR techniques. The possible mechanistic formation of 1 is proposed, and the in vitro toxicity of all compounds was assessed using the brine shrimp lethality assay (BSLA). Graphic Abstract

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