Arsenic trioxide induces programmed cell death through stimulation of ER stress and inhibition of the ubiquitin–proteasome system in human sarcoma cells

Skubitz, 2007, Sarcoma, Mayo Clin. Proc, 82, 1409, 10.4065/82.11.1409 Chakraborty, 2009, Chemoprotection and enhancement of cancer chemotherapeutic efficacy of cyclophosphamide in mice bearing Ehrlich ascites carcinoma by diphenylmethyl selenocyanate, Cancer Chemother. Pharmacol, 64, 971, 10.1007/s00280-009-0950-8 Adachi, 2012, Radiation-induced fibrosarcoma after radiotherapy for osteosarcoma in the mandibular condyle, J. Craniofac. Surg, 23, e619, 10.1097/SCS.0b013e31826cf893 Longhi, 2006, Primary bone osteosarcoma in the pediatric age: state of the art, Cancer Treat. Rev, 32, 423, 10.1016/j.ctrv.2006.05.005 Marina, 2004, Biology and therapeutic advances for pediatric osteosarcoma, Oncologist, 9, 422, 10.1634/theoncologist.9-4-422 Bielack, 2008, State-of-the-art approach in selective curable tumors: bone sarcoma, Ann. Oncol, 19, vii155, 10.1093/annonc/mdn436 Shen, 1997, Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients, Blood, 89, 3354, 10.1182/blood.V89.9.3354 Ma, 2011, Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-kappaB, Cancer Lett, 301, 75, 10.1016/j.canlet.2010.10.022 Pettersson, 2009, Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells, Mol. Cancer Ther, 8, 160, 10.1158/1535-7163.MCT-08-0595 Cai, 2000, Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia, Leukemia, 14, 262, 10.1038/sj.leu.2401650 Miller, 2002, Mechanisms of action of arsenic trioxide, Cancer Res, 62, 3893 Yu, 2014, Anti-apoptotic and apoptotic pathway analysis of arsenic trioxide induced apoptosis in human gastric cancer SGC-7901 cells, Oncol. Rep, 32, 973, 10.3892/or.2014.3276 Kanzawa, 2003, Induction of autophagic cell death in malignant glioma cells by arsenic trioxide, Cancer Res, 63, 2103 Chiu, 2011, Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin, J. Mol. Med. (Berl.), 89, 927, 10.1007/s00109-011-0763-1 Kanzawa, 2005, Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3, Oncogene, 24, 980, 10.1038/sj.onc.1208095 Nedelsky, 2008, Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection, Biochim. Biophys. Acta, 1782, 691, 10.1016/j.bbadis.2008.10.002 Cybulsky, 2013, The intersecting roles of endoplasmic reticulum stress, ubiquitin-proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease, Kidney Int, 84, 25, 10.1038/ki.2012.390 Korennykh, 2009, The unfolded protein response signals through high-order assembly of Ire1, Nature, 457, 687, 10.1038/nature07661 Li, 2012, Study on the effect of IRE1a on cell growth and apoptosis via modulation PLK1 in ER stress response, Mol. Cell. Biochem, 365, 99, 10.1007/s11010-012-1248-4 Cheng, 2011, Survival and death of endoplasmic-reticulum-stressed cells: role of autophagy, World J. Biol. Chem, 2, 226, 10.4331/wjbc.v2.i10.226 Xu, 2005, Endoplasmic reticulum stress: cell life and death decisions, J. Clin. Invest, 115, 2656, 10.1172/JCI26373 Chou, 1984, Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors, Adv. Enzyme Regul, 22, 27, 10.1016/0065-2571(84)90007-4 Chiu, 2010, Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis, Autophagy, 6, 353, 10.4161/auto.6.3.11229 Peng, 2008, Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death, Int. J. Radiat. Oncol. Biol. Phys, 70, 529, 10.1016/j.ijrobp.2007.08.034 Drexler, 2009, Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors, PLoS ONE, 4, e4161, 10.1371/journal.pone.0004161 Maria, 2013, A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production, Invest. New Drugs, 31, 493, 10.1007/s10637-012-9871-1 Isomura, 2013, Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism, Toxicol. Appl. Pharmacol, 272, 137, 10.1016/j.taap.2013.05.026 Paglin, 2001, A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles, Cancer Res, 61, 439 Schleicher, 2010, Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: implications for future therapeutic approaches, Drug Resist. Updat, 13, 79, 10.1016/j.drup.2010.04.002 Darling, 2014, The role of MAPK signalling pathways in the response to endoplasmic reticulum stress, Biochim. Biophys. Acta, 1843, 2150, 10.1016/j.bbamcr.2014.01.009 Hung, 2004, Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase, J. Biol. Chem, 279, 46384, 10.1074/jbc.M403568200 Li, 2004, Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress, Exp. Gerontol, 39, 735, 10.1016/j.exger.2004.02.008 Hoyer-Hansen, 2007, Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium, Cell Death Differ, 14, 1576, 10.1038/sj.cdd.4402200 Chauhan, 2010, A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma, Blood, 116, 4906, 10.1182/blood-2010-04-276626 Shapovalov, 2010, Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma, Int. J. Cancer, 127, 67, 10.1002/ijc.25024 Fribley, 2004, Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells, Mol. Cell. Biol, 24, 9695, 10.1128/MCB.24.22.9695-9704.2004 Nawrocki, 2005, Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis, Cancer Res, 65, 11658, 10.1158/0008-5472.CAN-05-2370 Ge, 2009, Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells, J. Proteome Res, 8, 3006, 10.1021/pr9001004 Nagelkerke, 2014, The unfolded protein response as a target for cancer therapy, Biochim. Biophys. Acta, 1846, 277 Kim, 2010, Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells, Oncogene, 29, 3241, 10.1038/onc.2010.74 Ledoux, 2003, Glucose depletion enhances P-glycoprotein expression in hepatoma cells: role of endoplasmic reticulum stress response, Cancer Res, 63, 7284 Rouschop, 2010, The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5, J. Clin. Invest, 120, 127, 10.1172/JCI40027 Rzymski, 2010, Regulation of autophagy by ATF4 in response to severe hypoxia, Oncogene, 29, 4424, 10.1038/onc.2010.191 Chaachouay, 2011, Autophagy contributes to resistance of tumor cells to ionizing radiation, Radiother. Oncol, 99, 287, 10.1016/j.radonc.2011.06.002 Apel, 2008, Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy, Cancer Res, 68, 1485, 10.1158/0008-5472.CAN-07-0562 Mukubou, 2010, The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation, Int. J. Oncol, 37, 821 De Duve, 1966, Functions of lysosomes, Annu. Rev. Physiol, 28, 435, 10.1146/annurev.ph.28.030166.002251 Zou, 2012, Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells, Autophagy, 8, 1798, 10.4161/auto.22110 Rubinsztein, 2012, Mechanisms of autophagosome biogenesis, Curr. Biol, 22, R29, 10.1016/j.cub.2011.11.034 Kim, 2013, Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy, Cell, 152, 290, 10.1016/j.cell.2012.12.016 Inoki, 2003, TSC2 mediates cellular energy response to control cell growth and survival, Cell, 115, 577, 10.1016/S0092-8674(03)00929-2 Gwinn, 2008, AMPK phosphorylation of raptor mediates a metabolic checkpoint, Mol. Cell, 30, 214, 10.1016/j.molcel.2008.03.003 Kim, 2011, AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1, Nat. Cell Biol, 13, 132, 10.1038/ncb2152