Arsenic induces platelet shape change through altering focal adhesion kinase-mediated actin dynamics, contributing to increased platelet reactivity

Abhyankar, 2012, Arsenic exposure and hypertension: a systematic review, Environ. Health Perspect., 120, 494, 10.1289/ehp.1103988 Adams, 2008, Anti-thrombotic and vascular effects of AR246686, a novel 5-HT2A receptor antagonist, Eur. J. Pharmacol., 586, 234, 10.1016/j.ejphar.2007.11.056 Argos, 2011, A prospective study of arsenic exposure from drinking water and incidence of skin lesions in Bangladesh, Am. J. Epidemiol., 174, 185, 10.1093/aje/kwr062 Aslan, 2013, Rho GTPases in platelet function, J. Thromb. Haemost., 11, 35, 10.1111/jth.12051 Bae, 2007, Arsenite-enhanced procoagulant activity through phosphatidylserine exposure in platelets, Chem. Res. Toxicol., 20, 1760, 10.1021/tx700159y Bampalis, 2011, Effect of 5-HT2A receptor antagonists on human platelet activation in blood exposed to physiologic stimuli and atherosclerotic plaque, J. Thromb. Haemost., 9, 2112, 10.1111/j.1538-7836.2011.04476.x Cambien, 2004, A new role in hemostasis for the adhesion receptor P-selectin, Trends Mol. Med., 10, 179, 10.1016/j.molmed.2004.02.007 Carrim, 2014, Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation, PLoS One, 9, 10.1371/journal.pone.0113679 Chang, 2007, FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX, Mol. Biol. Cell, 18, 253, 10.1091/mbc.e06-03-0207 Chen, 1996, Dose-response relationship between ischemic heart disease mortality and long-term arsenic exposure, Arterioscler. Thromb. Vasc. Biol., 16, 504, 10.1161/01.ATV.16.4.504 Chen, 2002, Roles of rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells, J. Biol. Chem., 277, 33857, 10.1074/jbc.M204429200 Chen, 2011, Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study, BMJ., 342, d2431, 10.1136/bmj.d2431 Chiou, 1997, Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic, Stroke., 28, 1717, 10.1161/01.STR.28.9.1717 Davi, 2007, Platelet activation and atherothrombosis, N. Engl. J. Med., 357, 2482, 10.1056/NEJMra071014 EPA, 2002 Goggs, 2015, Platelet rho GTPases-a focus on novel players, roles and relationships, Biochem. J., 466, 431, 10.1042/BJ20141404 Hall, 2017, Hypertension among adults exposed to drinking water arsenic in northern Chile, Environ. Res., 153, 99, 10.1016/j.envres.2016.11.016 Hanna, 2013, Signaling networks of rho GTPases in cell motility, Cell. Signal., 25, 1955, 10.1016/j.cellsig.2013.04.009 Haseruck, 2004, The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors, Blood., 103, 2585, 10.1182/blood-2003-04-1127 Hsia, 2003, Differential regulation of cell motility and invasion by FAK, J. Cell Biol., 160, 753, 10.1083/jcb.200212114 Jackson, 2007, The growing complexity of platelet aggregation, Blood., 109, 5087, 10.1182/blood-2006-12-027698 Jones, 2009, Characterization of a novel focal adhesion kinase inhibitor in human platelets, Biochem. Biophys. Res. Commun., 389, 198, 10.1016/j.bbrc.2009.08.132 Karagas, 2001, Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study, Am. J. Epidemiol., 153, 559, 10.1093/aje/153.6.559 Kim, 2019, Arsenic may act as a pro-metastatic carcinogen through promoting tumor cell-induced platelet aggregation, Toxicol. Sci., 168, 18, 10.1093/toxsci/kfy247 Lee, 2002, Enhancement of platelet aggregation and thrombus formation by arsenic in drinking water: a contributing factor to cardiovascular disease, Toxicol. Appl. Pharmacol., 179, 83, 10.1006/taap.2001.9356 Liu, 2005, Focal adhesion kinase as a potential target in arsenic toxicity, Toxicol. Sci., 84, 212, 10.1093/toxsci/kfi111 Lopez-Vilchez, 2009, Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake, Cardiovasc. Res., 84, 309, 10.1093/cvr/cvp205 Machacek, 2009, Coordination of rho GTPase activities during cell protrusion, Nature., 461, 99, 10.1038/nature08242 Marshall, 2007, Fifty-year study of lung and bladder cancer mortality in Chile related to arsenic in drinking water, J. Natl. Cancer Inst., 99, 920, 10.1093/jnci/djm004 Merten, 2000, P-selectin expression on platelets determines size and stability of platelet aggregates, Circulation., 102, 1931, 10.1161/01.CIR.102.16.1931 Mitra, 2005, Focal adhesion kinase: in command and control of cell motility, Nat Rev Mol Cell Biol., 6, 56, 10.1038/nrm1549 Naujokas, 2013, The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem, Environ. Health Perspect., 121, 295, 10.1289/ehp.1205875 Navas-Acien, 2005, Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence, Am. J. Epidemiol., 162, 1037, 10.1093/aje/kwi330 Nimnual, 2003, Redox-dependent downregulation of rho by Rac, Nat. Cell Biol., 5, 236, 10.1038/ncb938 Nordstrom, 2002, Public health. Worldwide occurrences of arsenic in ground water, Science., 296, 2143, 10.1126/science.1072375 Oberoi, 2019, Global burden of cancer and coronary heart disease resulting from dietary exposure to arsenic, 2015, Environ. Res., 171, 185, 10.1016/j.envres.2019.01.025 Ohta, 2006, FilGAP, a rho- and ROCK-regulated GAP for Rac binds filamin a to control actin remodelling, Nat. Cell Biol., 8, 803, 10.1038/ncb1437 Parvez, 2010, A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the health effects of arsenic longitudinal study (HEALS), Thorax., 65, 528, 10.1136/thx.2009.119347 Radomski, 2005, Nanoparticle-induced platelet aggregation and vascular thrombosis, Br. J. Pharmacol., 146, 882, 10.1038/sj.bjp.0706386 Ren, 2000, Focal adhesion kinase suppresses rho activity to promote focal adhesion turnover, J. Cell Sci., 113, 3673, 10.1242/jcs.113.20.3673 Rodriguez, 2003, The effects of arsenic exposure on the nervous system, Toxicol. Lett., 145, 1, 10.1016/S0378-4274(03)00262-5 Rodriguez-Lado, 2013, Groundwater arsenic contamination throughout China, Science., 341, 866, 10.1126/science.1237484 Roy, 2018, Substantial evidences indicate that inorganic arsenic is a Genotoxic carcinogen: a review, Toxicol Res., 34, 311, 10.5487/TR.2018.34.4.311 Shin, 2017, Platelet shape changes and cytoskeleton dynamics as novel therapeutic targets for anti-thrombotic drugs, Biomol Ther (Seoul)., 25, 223, 10.4062/biomolther.2016.138 Simeonova, 2004, Arsenic and atherosclerosis, Toxicol. Appl. Pharmacol., 198, 444, 10.1016/j.taap.2003.10.018 Smith, 2011, Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis, Am. J. Epidemiol., 173, 414, 10.1093/aje/kwq383 Song, 2012, Procoagulant and prothrombotic effects of the herbal medicine, Dipsacus asper and its active ingredient, dipsacus saponin C, on human platelets, J Thromb Haemost., 10, 895, 10.1111/j.1538-7836.2012.04685.x Spiering, 2011, Dynamics of the rho-family small GTPases in actin regulation and motility, Cell Adhes. Migr., 5, 170, 10.4161/cam.5.2.14403 Tomasiak, 2007, Cyclosporine enhances platelet procoagulant activity, Nephrol. Dial. Transplant., 22, 1750, 10.1093/ndt/gfl836 WHO, 2006 Yancy, 2005, Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts, Toxicol. Sci., 84, 278, 10.1093/toxsci/kfi032 Yu, 2009, Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration, Mol. Biol. Cell, 20, 4706, 10.1091/mbc.e09-07-0548 Yuan, 2010, Kidney cancer mortality: fifty-year latency patterns related to arsenic exposure, Epidemiology., 21, 103, 10.1097/EDE.0b013e3181c21e46