Are Stem Cells the Magical Medical Therapy of the Future?

Yu, 2007, Induced pluripotent stem cell lines derived from human somatic cells, Science, 318, 1917, 10.1126/science.1151526 Takahashi, 2007, Induction of pluripo-tent stem cells from adult human fibroblasts by defined factors, Cell, 131, 861, 10.1016/j.cell.2007.11.019 Kirschstein R, Skirboll LR. Stem Cells: Scientific Progress and Future Research Directions. Report prepared by the National Institutes of Health, 2001. Sanchez-Ramos, 2002, Neural cells derived from adult bone marrow and umbilical cord blood, J Neurosci Res, 69, 880, 10.1002/jnr.10337 Mitchell, 2003, Matrix cells from Wharton's jelly form neurons and glia, Stem Cells, 21, 50, 10.1634/stemcells.21-1-50 Berger, 2006, Differentiation of umbilical cord blood-derived multilineage progenitor cells into respiratory epithelial cells, Cytotherapy, 8, 480, 10.1080/14653240600941549 Lee, 2004, Isolation of multipotent mesenchymal stem cells from umbilical cord blood, Blood, 103, 1669, 10.1182/blood-2003-05-1670 Wang, 2004, Mesenchymal stem cells in the Wharton's Jelly of the human umbilical cord, Stem Cells, 22, 1330, 10.1634/stemcells.2004-0013 Yen, 2008, Placenta-derived multipo-tent cells differentiate into neuronal and glial cells in vitro, Tissue Engineering, 14, 9, 10.1089/ten.2006.0352 Yen, 2004, Isolation of multipotent cells from human term placenta, Stem Cells, 23, 3, 10.1634/stemcells.2004-0098 Shackleton, 2006, Generation of a functional mammary gland from a single stem cell, Nature, 439, 84, 10.1038/nature04372 Yusta-Boyo, 2004, Absence of hematopoiesis from transplanted olfactory bulb neural stem cells, Eur J Neurosci, 19, 505, 10.1111/j.1460-9568.2004.03140.x Aust, 2004, Yield of human adipose-derived adult stem cells from liposuction aspirates, Cytotherapy, 6, 7, 10.1080/14653240310004539 Morizono, 2003, Multilineage cells from adipose tissue as gene delivery vehicles, Hum Gene Ther, 14, 59, 10.1089/10430340360464714 Urbanek, 2003, Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy, Proc Natl Acad Sci USA, 100, 10440, 10.1073/pnas.1832855100 Svendsen, 1999, Human neural stem cells: isolation, expansion and transplantation, Brain Pathol, 9, 499, 10.1111/j.1750-3639.1999.tb00538.x Dotto, 2005, Developmental biology. Rac1 up for epidermal stem cells, Science, 309, 890, 10.1126/science.1117192 Benitah, 2005, Stem cell depletion through epidermal deletion of Rac1, Science, 309, 933, 10.1126/science.1113579 Koizumi, 2001, Cultivated corneal epithelial stem cells transplantation in ocular surface disorders, Ophthalmology, 108, 1569, 10.1016/S0161-6420(01)00694-7 Tropepe, 2000, Retinal stem cells in the adult mammalian eye, Science, 287, 2032, 10.1126/science.287.5460.2032 Chen, 2006, Trans-differentiation of mouse BM cells into hepatocyte-like cells, Cytotherapy, 8, 381, 10.1080/14653240600735800 Tomita, 2002, Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina, Stem Cells, 20, 279, 10.1634/stemcells.20-4-279 Gronthos, 2000, Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo, Proc Natl Acad Sci USA, 97, 13625, 10.1073/pnas.240309797 Miura, 2003, SHED: stem cells from human exfoliated deciduous teeth, Proc Natl Acad Sci USA, 100, 5807, 10.1073/pnas.0937635100 Le Blanc, 2005, Mesenchymal stem cells: progress toward promise, Cytotherapy, 7, 36, 10.1016/S1465-3249(05)70787-8 Cai, 2007, Transplantation of embryonic stem cell-derived cardiomyocytes improves cardiac function in infracted rat hearts, Cytotherapy, 9, 286, 10.1080/14653240701247838 Orlic, 2001, Bone marrow cells regenerate infracted myocardium, Nature, 410, 701, 10.1038/35070587 Henning, 2004, Human umbilical cord blood mononuclear cells for the treatment of acute myocardial infraction, Cell Transplant, 114, 729, 10.3727/000000004783983477 Hirata, 2005, Human umbilical cord blood cells improve cardiac function after myocardial infraction, Biochem Biophys Res Commun, 327, 609, 10.1016/j.bbrc.2004.12.044 Rosenzweig, 2006, Cardiac cell therapy-mixed results from mixed cells, N Engl J Med, 355, 1274, 10.1056/NEJMe068172 Vendrame, 2004, Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume, Stroke, 35, 2390, 10.1161/01.STR.0000141681.06735.9b Taguchi, 2004, Administration of CD34+ cells after stroke enhances neurogenesis via angio-genesis in a mouse model, J Clin Invest, 114, 330, 10.1172/JCI200420622 Deng, 2006, Implantation of BM mesen-chymal stem cells into injured spinal cord elicits de novo neurogenesis and functional recovery: evidence from a study in rhesus monkeys, Cytotherapy, 8, 210, 10.1080/14653240600760808 Kang, 2005, A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study, Cytotherapy, 7, 368, 10.1080/14653240500238160 Yu, 2007, BM stem cell transplantation rescues pathologic features of aged destrophic mdx muscle, Cytotherapy, 9, 44, 10.1080/14653240601114815 Gussoni, 1999, Dystrophin expression in the mdx mouse restored by stem cell transplantation, Nature, 401, 390, 10.1038/43919 Ikehara, 1985, Prevention of type I diabetes in nonobese diabetic mice by allogeneic bone marrow transplantation, Proc Natl Acad Sci USA, 82, 7743, 10.1073/pnas.82.22.7743 Voltarelli, 2007, Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus, JAMA, 297, 1568, 10.1001/jama.297.14.1568 Ende, 2004, Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice, Biochem Biophy Res Commun, 325, 665, 10.1016/j.bbrc.2004.10.091 Santana, 2006, Insulin-producing cells derived from stem cells: recent progress and future directions, J Cell Mol Med, 10, 866, 10.1111/j.1582-4934.2006.tb00531.x Elkin, 2004, Prevention of diabetes in nonobese diabetic mice by nonmyeloablative allogeneic bone marrow transplantation, Exp Hematol, 32, 579, 10.1016/j.exphem.2004.03.007 Urbán, 2008, Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes, Stem Cells, 26, 244, 10.1634/stemcells.2007-0267 Wang, 2007, Stem cells transplantation: a promising therapy for Parkinson's disease, J Neuroimmune Pharmacol, 2, 243, 10.1007/s11481-007-9074-2 Baier, 2004, Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after transplantation of differentiated mouse embryonic stem cells without morphological integration, Stem Cells, 22, 396, 10.1634/stemcells.22-3-396 Parish, 2005, Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease, Stem Cells, 23, 471, 10.1634/stemcells.2004-0294 Kim, 2006, Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease, Neuropathology, 26, 129, 10.1111/j.1440-1789.2006.00688.x Bianco, 2001, Stem cells in tissue engineering, Nature, 414, 118, 10.1038/35102181 Temple, 2001, The development of neural stem cells, Nature, 414, 112, 10.1038/35102174 Tsai, 2000, Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells, N Engl J Med, 343, 86, 10.1056/NEJM200007133430202 Pellegrini, 1997, Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium, Lancet, 349, 990, 10.1016/S0140-6736(96)11188-0 Kvalheim, 2005, Stem cell therapy still not here, Cytotherapy, 7, 456, 10.1080/14653240500319267 Murry, 2004, Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infracts, Nature, 428, 664, 10.1038/nature02446 Balsam, 2004, Haematopoietic stem cells adopt mature haematopoietic fates in ischemic myocardium, Nature, 428, 668, 10.1038/nature02460 Hanna, 2007, Treatment of sickle cell anemia mouse model with iPS cells generate from autologous skin, Science, 318, 1920, 10.1126/science.1152092 Vogel, 2005, Ready or not? Human ES cells head toward the clinic, Science, 308, 1534, 10.1126/science.308.5728.1534 Brickman, 2002, Pluripotency and tumorigenicity, Nature Genetics, 32, 557, 10.1038/ng1202-557