Are Current Serum and Plasma Ferritin Cut-offs for Iron Deficiency and Overload Accurate and Reflecting Iron Status? A Systematic Review

Archives of Medical Research - Tập 49 - Trang 405-417 - 2018
Maria Nieves Garcia-Casal1, Sant-Rayn Pasricha2, Ricardo X. Martinez1, Lucero Lopez-Perez1, Juan Pablo Peña-Rosas1
1Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
2Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

Tài liệu tham khảo

Tussing-Humphreys, 2012, Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin, J Acad Nutr Diet, 112, 391, 10.1016/j.jada.2011.08.038 Low, 2016, Daily iron supplementation for improving anaemia, iron status and health in menstruating women, Cochrane Database Syst Rev, 4, CD009747 Verdon, 2003, Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial, BMJ, 326, 1124, 10.1136/bmj.326.7399.1124 Pasricha, 2014, Iron supplementation benefits physical performance in women of reproductive age: a systematic review and meta-analysis, J Nutr, 144, 906, 10.3945/jn.113.189589 Li, 1994, Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China, Am J Clin Nutr, 59, 908, 10.1093/ajcn/59.4.908 Lozoff, 2007, Iron deficiency and child development, Food Nutr Bull, 28, S560, 10.1177/15648265070284S409 Georgieff, 2011, Long-term brain and behavioral consequences of early iron deficiency, Nutr Rev, 69, S43, 10.1111/j.1753-4887.2011.00432.x Camaschella, 2015, Iron-deficiency anemia, N Engl J Med, 372, 1832, 10.1056/NEJMra1401038 Papagiannakis, 2013, The role of Helicobacter pylori infection in hematological disorders, Eur J Intern Med, 24, 685, 10.1016/j.ejim.2013.02.011 Spencer, 2013, Blood donor iron status: are we bleeding them dry?, Curr Opin Hematol, 20, 533, 10.1097/MOH.0b013e32836589f2 Brissot, 2009, Diagnosis and treatment of HFE-haemochromatosis Piga, 2009, Chapter 25: Evaluation and treatment of secondary iron overload Bacon, 2011, Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases, Hepatology, 54, 328, 10.1002/hep.24330 Baer, 1995, Hemochromatosis screening in asymptomatic ambulatory men 30 years of age and older, Am J Med, 98, 464, 10.1016/S0002-9343(99)80346-5 Phatak, 1998, Prevalence of hereditary hemochromatosis in 16031 primary care patients, Ann Intern Med, 129, 954, 10.7326/0003-4819-129-11_Part_2-199812011-00006 Weatherall, 2011, The inherited disorders of haemoglobin: an increasingly neglected global health burden, Indian J Med Res, 134, 493 Lorcerie, 2017, Diagnosis of hyperferritinemia in routine clinical practice, Presse Med, 46, e329, 10.1016/j.lpm.2017.09.028 Daru, 2017, Serum ferritin as an indicator of iron status: what do we need to know?, Am J Clin Nutr, 106, 1634S, 10.3945/ajcn.117.155960 World Health Organization, 1989 World Health Organization, 2011 Garcia-Casal, 2014, Rethinking ferritin cutoffs for iron deficiency and overload, Lancet Haematol, 1, e92, 10.1016/S2352-3026(14)00025-8 Garcia-Casal, 2015, Serum or plasma ferritin concentration as an index of iron deficiency and overload, Cochrane Database Syst Rev, 7, CD011817 Beutler, 1958, A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores, Ann Intern Med, 48, 60, 10.7326/0003-4819-48-1-60 Rao, 2013, Assessment of iron stores in bone marrow using an intensive grading method, Indian J Hematol Blood Transf, 29, 370 Riley, 2009, Bone marrow aspirate and biopsy II. Interpretation of the bone marrow aspirate and biopsy, J Clin Lab Anal, 23, 259, 10.1002/jcla.20305 Angelucci, 2000, Hepatic iron concentration and total body iron stores in thalassemia major, N Engl J Med, 343, 327, 10.1056/NEJM200008033430503 Barry, 1974, Liver iron co0ncentration, stainable iron, and total body storage iron, Gut, 15, 411, 10.1136/gut.15.5.411 Wood, 2014, Guidelines for quantifying iron overload, Hematology Am Soc Hematol Educ Program, 2014, 210, 10.1182/asheducation-2014.1.210 Liberati, 2009, The PRISMA statement for reporting systematic and meta-analyses of studies that evaluate interventions: explanation and elaboration, PLoS Med, 6, 1, 10.1371/journal.pmed.1000100 Hallberg, 1993, Screening for iron deficiency: an analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women, Br J Haematol, 85, 787, 10.1111/j.1365-2141.1993.tb03225.x Hanif, 2005, Evaluation of serum transferrin receptor concentration in diagnosing and differentiating iron deficiency anaemia from anaemia of chronic disorders, J Pak Med Assoc, 55, 13 Jacobs, 1972, Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload, Br Med J, 4, 206, 10.1136/bmj.4.5834.206 Jacobs, 1982, The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran, J Med, 13, 309 Jonker, 2014, Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian children, J Clin Pathol, 67, 717, 10.1136/jclinpath-2014-202291 Leyland, 1975, Immunoradiometric assay for ferritin in human serum, Scand J Haematol, 14, 385, 10.1111/j.1600-0609.1975.tb02711.x Lipschitz, 1974, A clinical evaluation of serum ferritin as an index of iron stores, N Engl J Med, 290, 1213, 10.1056/NEJM197405302902201 Milman, 1983, Serum ferritin in non-dialysis patients with chronic renal failure: Relation to bone marrow iron stores, Scand J Haematol, 30, 337, 10.1111/j.1600-0609.1983.tb01502.x Puolakka, 1980, Serum ferritin as a measure of iron stores during and after normal pregnancy with and without iron supplements, Acta Obstet Gynecol Scand, 95, 43, 10.3109/00016348009156379 Sorbie, 1975, Serum ferritin, cobalt excretion and body iron status, Can Med Assoc J, 112, 1173 Meira, 2005, Bone marrow features in children with HIV infection and peripheral blood cytopenias, J Trop Pediatr, 51, 114, 10.1093/tropej/fmh096 van den Broek, 1998, Iron status in pregnant women: which measurements are valid?, Br J Haematol, 103, 817, 10.1046/j.1365-2141.1998.01035.x Oluboyede, 1980, Iron studies in pregnant and non-pregnant women with haemoglobin SS or SC disease, Br J Obstet Gynaecol, 87, 989, 10.1111/j.1471-0528.1980.tb04463.x Rao, 1984, Iron stores in adults with sickle cell anemia, J Lab Clin Med, 103, 792 Ruivard, 2000, Ratio serum transferrin receptor/serum ferritin in the diagnosis of iron deficiency [Diagnostic de la carence en fer: Evaluation du rapport recepteur soluble de la transferrine/ferritine], Rev Med Interne, 21, 837, 10.1016/S0248-8663(00)00234-4 Solomon, 1981, Serum ferritin in refractory anemias, Acta Haematol, 66, 1, 10.1159/000207083 Kim, 2000, The usefulness of serum transferrin receptor in anemia with rheumatoid arthritis: comparison with bone marrow iron store, J Kor Rheum Assoc, 7, 360 Hansen, 1983, Serum ferritin and the assessment of iron deficiency in rheumatoid arthritis, Scand J Rheumatol, 12, 353, 10.3109/03009748309099740 Mulherin, 1996, The diagnosis of iron deficiency in patients with rheumatoid arthritis and anemia: an algorithm using simple laboratory measures, J Rheumatol, 23, 237 Nielsen, 1990, Anaemia of rheumatoid arthritis: serum erythropoietin concentrations and red cell distribution width in relation to iron status, Ann Rheum Dis, 49, 349, 10.1136/ard.49.6.349 Porter, 1994, The use of serum ferritin estimation in the investigation of anaemia in patients with rheumatoid arthritis, Clin Exp Rheumatol, 12, 179 Ravindran, 2008, The differentiation of anaemia in rheumatoid arthritis: parameters of iron-deficiency in an Indian rheumatoid arthritis population, Rheumatol Int, 28, 507, 10.1007/s00296-007-0476-5 Shroff, 1991, Iron status in patients of rheumatoid arthritis with special reference to serum ferritin levels, J Assoc Physicians India, 39, 675 Smith, 1977, Serum ferritin levels in anemia of rheumatoid arthritis, J Rheumatol, 4, 389 Balaban, 1993, Evaluation of bone marrow iron stores in anemia associated with chronic disease: a comparative study of serum and red cell ferritin, Am J Hematol, 42, 177, 10.1002/ajh.2830420207 Intragumtornchai, 1998, The role of serum ferritin in the diagnosis of iron deficiency anaemia in patients with liver cirrhosis, J Intern Med, 243, 233, 10.1046/j.1365-2796.1998.00290.x Isa, 1988, Evaluation of iron stores in patients with alcoholic liver disease: role of red cell ferritin, Acta Haematol, 80, 85, 10.1159/000205608 Kalantar-Zadeh, 1995, Diagnosis of iron deficiency anemia in renal failure patients during the post-erythropoietin era, Am J Kidney Dis, 26, 292, 10.1016/0272-6386(95)90649-5 Krause, 1980, Serum ferritin and bone marrow biopsy iron stores. II. Correlation with low serum iron and Fe/TIBC ratio less than 15%, Am J Clin Pathol, 74, 461, 10.1093/ajcp/74.4.461 Nelson, 1978, Ferritin as an index of bone marrow iron stores, South Med J, 71, 1482, 10.1097/00007611-197812000-00011 Ali, 1978, Serum ferritin concentration and bone marrow iron stores: a prospective study, Can Med Assoc J, 118, 945 Harju, 1984, A comparison between serum ferritin concentration and the amount of bone marrow stainable iron, Scand J Clin Lab Invest, 44, 555, 10.1080/00365518409083610 Kotru, 2004, Evaluation of serum ferritin in screening for iron deficiency in tuberculosis, Ann Hematol, 83, 95, 10.1007/s00277-003-0788-9 Mast, 1998, Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations, Clin Chem, 44, 45, 10.1093/clinchem/44.1.45 Mazza, 1978, Usefulness of the serum ferritin concentration in the detection of iron deficiency in a general hospital, Can Med Assoc J, 119, 884 Means, 1999, Serum soluble transferrin receptor and the prediction of marrow aspirate iron results in a heterogeneous group of patients, Clin Lab Haematol, 21, 161, 10.1046/j.1365-2257.1999.00224.x Punnonen, 1998, Serum transferrin receptor, ferritin and TfR-F index in identification of latent iron deficiency, Eur J Haematol, 60, 135, 10.1111/j.1600-0609.1998.tb01011.x Witte, 1988, Predicting bone marrow iron stores in anemic patients in a community hospital using ferritin and erythrocyte sedimentation rate, Am J Clin Pathol, 90, 85, 10.1093/ajcp/90.1.85 Baillie, 2003, Soluble transferrin receptor: a discriminating assay for iron deficiency, Clin Lab Haematol, 25, 353, 10.1046/j.0141-9854.2003.00548.x Lindstedt, 1980, Serum-ferritin and iron-deficiency anaemia in hospital patients, Lancet, 1, 205, 10.1016/S0140-6736(80)90690-X Nanas, 2006, Etiology of anemia in patients with advanced heart failure, J Am Coll Cardiol, 48, 2485, 10.1016/j.jacc.2006.08.034 Punnonen, 1994, Iron-deficiency anemia is associated with high concentrations of transferrin receptor in serum, Clin Chem, 40, 774, 10.1093/clinchem/40.5.774 Punnonen, 1997, Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency, Blood, 89, 1052, 10.1182/blood.V89.3.1052 van Zeben, 1990, Evaluation of microcytosis using serum ferritin and red blood cell distribution width, Eur J Haematol, 44, 106, 10.1111/j.1600-0609.1990.tb00359.x Joosten, 2002, Serum transferrin receptor in the evaluation of the iron status in elderly hospitalized patients with anemia, Am J Hematol, 69, 1, 10.1002/ajh.10014 Karlsson, 2015, Mass spectrometry evaluation of the hepcidin-25 assay in the differential diagnosis of iron deficiency anaemia with concurrent inflammation and anaemia of inflammation in elderly patients, Eur J Haematol, 95, 467, 10.1111/ejh.12518 Kis, 1998, Detecting iron deficiency in anemic patients with concomitant medical problems, J Gen Intern Med, 13, 455, 10.1046/j.1525-1497.1998.00134.x Sharma, 1984, Value of serum ferritin as an index of iron deficiency in elderly anaemic patients, Age Ageing, 13, 248, 10.1093/ageing/13.4.248 van Tellingen, 2001, Iron deficiency anaemia in hospitalised patients: value of various laboratory parameters. Differentiation between IDA and ACD, Neth J Med, 59, 270, 10.1016/S0300-2977(01)00169-3 Halliday, 1977, Serum-ferritin in diagnosis of haemochromatosis. A study of 43 families, Lancet, 2, 621, 10.1016/S0140-6736(77)92495-3 Holmström, 2002, Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls, Gut, 51, 723, 10.1136/gut.51.5.723 Jensen, 1994, The effect of iron overload and iron reductive treatment on the serum concentration of carbohydrate-deficient transferrin, Br J Haematol, 88, 56, 10.1111/j.1365-2141.1994.tb04977.x Kaltwasser, 1990, Non-invasive quantitation of liver iron-overload by magnetic resonance imaging, Br J Haematol, 74, 360, 10.1111/j.1365-2141.1990.tb02596.x Lawrence, 1996, Correlation of liver density by magnetic resonance imaging and hepatic iron levels. A noninvasive means to exclude homozygous hemochromatosis, J Clin Gastroenterol, 23, 113, 10.1097/00004836-199609000-00009 Leggett, 1990, Prevalence of haemochromatosis amongst asymptomatic Australians, Br J Haematol, 74, 525, 10.1111/j.1365-2141.1990.tb06345.x Lim, 2004, Hepatic iron loading in patients with compound heterozygous HFE mutations, Liver Int, 24, 631, 10.1111/j.1478-3231.2004.0953.x Lombard, 1989, Regulation of the hepatic transferrin receptor in hereditary hemochromatosis, Hepatology, 9, 1, 10.1002/hep.1840090102 Macfarlane, 1995, Idiopathic haemochromatosis: magnetic resonance signal intensity ratios permit non-invasive diagnosis of low levels of iron overload, Neth J Med, 47, 49, 10.1016/0300-2977(95)00038-O Olynyk, 1999, A population-based study of the clinical expression of the hemochromatosis gene, Magn Reson Imaging, 341, 718 Ortega, 2005, A computer-assisted morphometric quantitative analysis of iron overload in liver biopsies. A comparison with histological and biochemical methods, Pathol Res Pract, 201, 673, 10.1016/j.prp.2005.07.002 Pietrangelo, 1999, Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene, N Engl J Med, 341, 725, 10.1056/NEJM199909023411003 Rowe, 1977, amilial hemochromatosis: characteristics of the precirrhotic stage in a large kindred, Medicine, 56, 197, 10.1097/00005792-197705000-00002 Schöniger-Hekele, 2002, Liver pathology in compound heterozygous patients for hemochromatosis mutations, Liver, 22, 295, 10.1034/j.1600-0676.2002.01597.x Sham, 1997, Correlation between genotype and phenotype in hereditary hemochromatosis: analysis of 61 cases, Blood Cells Mol Dis, 23, 314, 10.1006/bcmd.1997.0148 Smith, 1997, Prevalence of hereditary hemochromatosis in a Massachusetts corporation: is Celtic origin a risk factor?, Hepatology, 25, 1439, 10.1002/hep.510250622 Summers, 1990, Identification of homozygous hemochromatosis subjects by measurement of hepatic iron index, Hepatology, 12, 20, 10.1002/hep.1840120105 Thomsen, 1992, Identification of patients with hereditary haemochromatosis by Magnetic Resonance Imaging and spectroscopic relaxation time measurements, Magn Reson Imaging, 10, 867, 10.1016/0730-725X(92)90440-B Wands, 1976, Normal serum ferritin concentrations in precirrhotic hemochromatosis, N Engl J Med, 294, 302, 10.1056/NEJM197602052940603 Chapman, 1982, Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis, Dig Dis Sci, 27, 909, 10.1007/BF01316575 Harada, 1992, Comparative study of magnetic resonance imaging, computed tomography and histology in the assessment of liver iron overload, Intern Med, 31, 180, 10.2169/internalmedicine.31.180 Niederau, 1998, Screening for hemochromatosis and iron deficiency in employees and primary care patients in Western Germany, Ann Intern Med, 128, 337, 10.7326/0003-4819-128-5-199803010-00001 Pascoe, 1999, Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation, Gut, 45, 301, 10.1136/gut.45.2.301 Sebastiani, 2012, Hepatic iron overload is common in chronic hepatitis B and is more severe in patients coinfected with hepatitis D virus, J Viral Hepat, 19, 170, 10.1111/j.1365-2893.2011.01508.x Villeneuve, 1996, Variability in hepatic iron concentration measurement from needle-biopsy specimens, Hepatology, 25, 172, 10.1016/S0168-8278(96)80070-5 Walsh, 2006, The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis, Clin Gastroenterol Hepatol, 4, 1403, 10.1016/j.cgh.2006.07.009 Guyader, 2007, Liver iron is a surrogate marker of severe fibrosis in chronic hepatitis C, J Hepatol, 46, 587, 10.1016/j.jhep.2006.09.021 Sebastiani, 2006, Hepatic iron, liver steatosis and viral genotypes in patients with chronic hepatitis C, J Viral Hepat, 13, 199, 10.1111/j.1365-2893.2005.00662.x Thorburn, 2002, The role of iron and haemochromatosis gene mutations in the progression of liver disease in chronic hepatitis C, Gut, 50, 248, 10.1136/gut.50.2.248 Maliken, 2012, Room-temperature susceptometry predicts biopsy-determined hepatic iron in patients with elevated serum ferritin, Ann Hepatol, 11, 77, 10.1016/S1665-2681(19)31489-9 Guyatt, 1990, Diagnosis of iron-deficiency anemia in the elderly, Am J Med, 88, 205, 10.1016/0002-9343(90)90143-2 Namaste, 2017, Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project, Am J Clin Nutr, 106, 359S, 10.3945/ajcn.116.141762 Engle-Stone, 2012, J Nutr, 143, 369, 10.3945/jn.112.167775 Righetti, 2013, Effects of inflammation and Plasmodium falciparum infection on soluble transferrin receptor and plasma ferritin concentration in different age groups: a prospective longitudinal study in Cote d’Ivoire, Am J Clin Nutr, 97, 1364, 10.3945/ajcn.112.050302 Thurnham, 2011, Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis, Am J Clin Nutr, 92, 546, 10.3945/ajcn.2010.29284 Thurnham, 2015, The use of adjustment factors to address the impact of inflammation on vitamin A and iron status in humans, J Nutr, 145, 1137S, 10.3945/jn.114.194712 Bain, 2011, Pitfalls in obtaining and interpreting bone marrow aspirates: to err is human, J Clin Pathol, 64, 373, 10.1136/jcp.2010.080820 World Health Organization, 2001 World Health Organization, 2017