Aqueous Extracts of Fructus Ligustri Lucidi Enhance the Sensitivity of Human Colorectal Carcinoma DLD-1 Cells to Doxorubicin-Induced Apoptosis via Tbx3 Suppression

Integrative Cancer Therapies - Tập 10 Số 1 - Trang 85-91 - 2011
Jinfang Zhang1, Ming‐Liang He2, Qi Dong2, Weidong Xie3, Yangchao Chen2, Marie C.M. Lin4, Ping‐Chung Leung2, Yaou Zhang3, Hsing-Jien Kung5
1Tsinghua University, Beijing, People's Republic of China, Tsinghua University, Shenzhen, People's Republic of China, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China
2The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China
3Tsinghua University, Shenzhen, People's Republic of China
4The University of Hong Kong, Hong Kong SAR, People’s Republic of China
5Tsinghua University, Shenzhen, People's Republic of China? , The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China

Tóm tắt

Chemoresistance has imposed a great challenge for cancer therapy. Fructus Ligustri Lucidi (FLL) is one of the commonest Chinese herbs that has been used for thousand years. This study shows that the aqueous extract of FLL (AFLL) enhanced the sensitivity of DLD-1 colon cancer cells to doxorubicin-induced apoptosis. Furthermore, Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated. Therefore, reduction of Tbx3 rescued the dysregulated P14ARF-P53 signaling, which in turn contributed to the sensitivity of DLD-1 cells to doxorubicin-induced apoptosis. As a conclusion, the findings suggest that FLL has a potential of being an appealing agent for auxiliary chemotherapy in treatment of human colorectal carcinoma.

Từ khóa


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Thông tin xuất bản

Integrative Cancer Therapies

Tập 10 Số 1

85-91

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