Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Đánh giá Gel Nanoemulsion Dạng Nước Trong Dầu Của Selegiline HCl Để Quản Lý Hiệu Quả Bệnh Parkinson: Nghiên Cứu Dược Lực, Dược Động Học, Và Hóa Sinh
Tóm tắt
Trong nghiên cứu hiện tại, tiềm năng của gel nanoemulsion transdermal của selegiline hydrochloride trong việc điều trị bệnh Parkinson đã được điều tra. Nanoemulsion nước trong dầu đã được phát triển bằng cách so sánh các phương pháp năng lượng thấp và cao và đã trải qua các bài kiểm tra độ ổn định nhiệt động, thẩm thấu in vitro và các nghiên cứu đặc trưng. Các nghiên cứu in vitro cho thấy rằng các thành phần của nanoemulsion hoạt động như những chất tăng cường khả năng thẩm thấu với dòng thẩm thấu cao nhất đạt 3.531 ± 1.94 μg/cm2/h từ nanoemulsion SB6 chứa 0.5 mg selegiline hydrochloride, 3% nước cất, 21% S mix (Span 85, Tween 80, PEG 400), và 76% isopropyl myristate theo trọng lượng. SB6 có kích thước giọt nhỏ nhất là 183.4 ± 0.35 nm, chỉ số phân bố đa dạng là 0.42 ± 0.06 với pH là 5.9 ± 0.32 và độ nhớt là 22.42 ± 0.14 cps đã được chuyển đổi thành gel nanoemulsion NEGS4 (độ nhớt = 22,200 ± 400 cps) bằng cách thêm Viscup160® để thuận tiện khi sử dụng và được đánh giá về khả năng thẩm thấu, độ an toàn và hồ sơ dược động học trong chuột Wistar. Nó cung cấp tỷ lệ tăng cường cao gấp 3.69 lần so với gel truyền thống. NEGS4 cho thấy sự tăng trưởng 6.56 và 5.53 lần trong sinh khả dụng so với viên nén và gel truyền thống, tương ứng, cùng với hiệu ứng duy trì. Do đó, gel nanoemulsion nước trong dầu đã được phát triển hứa hẹn sẽ là phương tiện hiệu quả cho việc cung cấp selegiline hydrochloride qua da.
Từ khóa
#nanoemulsion #selegiline #bệnh Parkinson #dược động học #thẩm thấu qua daTài liệu tham khảo
Gourie-Devi M. Epidemiology of neurological disorders in India: review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors. Neurol India. 2014;62:588–98.
Connolly BS, Lang AE. Pharmacological treatment of Parkinson disease: a review. JAMA. 2014;311:1670–83.
Bhowmik D, Pusupoleti KR, Duraivel S, Kumar KPS. Recent approaches in transdermal drug delivery system. The Pharma Innovation. 2013;2:99–108.
Shakeel F, Ramadan W. Transdermal delivery of anticancer drug caffeine from water-in-oil nanoemulsions. Colloids Surf B Biointerfaces. 2010;75:356–62.
Elnaggar YSR, El-Massik MA, Abdallah OY. Sildenafil citrate nanoemulsion vs. self-nanoemulsifying delivery systems: rational development and transdermal permeation. Int J Nanoetech. 2011;8:749–76.
Singh BP, Kumar B, Jain SK, Shafaat K. Development and characterization of a nanoemulsion gel formulation for transdermal delivery of carvedilol. Int J Drug Dev Res. 2012;4:151–61.
Varshosaz J, Andalib S, Tabbakhian M, Ebrahimzadeh N. Development of lecithin nanoemulsion based organogels for permeation enhancement of metoprolol through rat skin. J Nanomater. 2013;2013:1–10.
Abdelaziz AE, Elmowafy M, Salama A, Samy A, Kassem A, Raslan MA, et al. Development and transdermal efficacy assessment of indomethacin nanoemulsion formulation. Int J Pharma Sci. 2014;4:611–21.
Suciati T, Aliyandi A, Satrialdi. Development of transdermal nanoemulsion formulation for simultaneous delivery of protein vaccine and artin-m adjuvant. Int J Pharm Pharm Sci. 2014;6:536–46.
Rachmawati H, Budiputra DK, Mauludin R. Curcumin nanoemulsion for transdermal application: formulation and evaluation. Drug Dev Ind Pharm. 2015;41:560–6.
Sampathi S, Mankala SK, Wankar J, Dodoala S. Nanoemulsion based hydrogels of Itraconazole for transdermal drug delivery. J Sci Ind Res. 2015;74:88–92.
Kumar D, Ali J, Baboota S. Omega 3 fatty acid-enriched nanoemulsion of thiocolchicoside for transdermal delivery: formulation, characterization and absorption studies. Drug Deliv. 2016;23:591–600.
El-Aasser MS, Sudol ED. Miniemulsion: overview of research and application. J Coat Technol Res. 2014;1:20–31.
Anton N, Vandamme TF. Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm Res. 2011;28:978–85.
Setya S, Negi P, Razdan BK, Talegaonkar S. Design, development and in vitro investigation of water in oil nanoemulsion for transdermal delivery. WJPPS. 2014;3:1495–512.
Lovelyn C, Attama AA. Current state of nanoemulsions in drug delivery. J BiomaterNanobiotechnol. 2011;2:626–39.
Wessel K, Szelenyi I. Selegiline—an overview of its role in the treatment of Parkinson’s disease. ClinInvestig. 1992;70:459–62.
Knoll J. The possible mechanisms of action of (−) deprenyl in Parkinson’s disease. J Neural Transm. 1978;43:177–98.
Mahmood I. Clinical pharmacokinetics and pharmacodynamics of selegiline. Clin Pharmacokinet. 1997;33:91–102.
Lew MF, Pahwa R, Leehey M, Bertoni J, Kricorian G, Zydis Selegiline Study Group. Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of “off” episodes in patients with Parkinson's disease. Curr Med Res Opin. 2007;23:741–50.
Deleu D, Northway MG, Hanssens Y. Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson’s disease. Clin Pharmacokinet. 2002;41:261–309.
Azzaro AJ, Ziemniak J, Kemper E, Campbell BJ, VanDenBerg C. Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules. J Clin Pharmacol. 2007;47:1256–67.
Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Nanoemulsion components screening and selection: a technical note. AAPS PharmSciTech. 2009;10:69–76.
Dhingani A, Patel J, Garala K, Patel H, Dharamsi A. Formulation and development of w/o type microemulsion based transdermal systems for verapamil hydrochloride. Inventi Impact- NDDS. 2013;4:294–306.
Shinde PB. Component screening of miconazole nitrate nanoemulsion. Asian J Pharm Sci. 2011;3:33–40.
Porras M, Solans C, Gonzalez C, et al. Studies of formation of w/o nano-emulsions. Colloids Surf A Physicochem Eng Asp. 2004;249:115–8.
Koteswari P, Krishna SR, Reddy VP, Narasu LM. Formulation and preparation of felodipine nanoemulsions. Asian J Pharm Clin Res. 2011;4:116–7.
Setya S, Razdan BK, Talegaonkar S. Development and validation of RPHPLC method of tacrine hydrochloride in nanoemulsion gel. J Adv Pharm Edu Res. 2014;4:435–9.
Talegaonkar S, Tariq M, Alabood RM. Design and development of o/w nanoemulsion for the transdermal delivery of ondansetron. Bull Pharm Res. 2011;1:18–30.
Lala RR, Awari NG. Nanoemulsion-based gel formulations of COX-2 inhibitors for enhanced efficacy in inflammatory conditions. Appl Nanosci. 2014;4:143–51.
Setya S, Razdan BK, Talegaonkar S. RP-HPLC method development and validation of selegiline hydrochloride in nanoemulsion formulation. WJPS. 2015;3:737–42.
Malgope A, Murthy PN, Ramani R, Dey S. Development of nanoemulsion as carrier for transdermal delivery of valsartan. Int J Pharm Chem Sci. 2013;2:1655–65.
Dhingani A, Patel J, Garala K, Raval M, Dharamsi A. Quality by design approach for development of w/o type microemulsion-based transdermal systems for atenolol. J DisperSci Technol. 2014;35:619–40.
Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S. Design, development and evaluation of novel nanoemulsion formulation for transdermal potential of celecoxib. Acta Pharma. 2007;57:315–32.
Eid AM, Elmarzugi NA, El-Enshasy HA. Development of avocado oil nanoemulsion hydrogel using sucrose ester stearate. J Applied Pharm Sci. 2013;3:145–7.
Makhmalzadeh BS, Torabi S, Azarpanah A. Optimization of ibuprofen delivery through rat skin from traditional and novel nanoemulsion formulations. Iran J Pharm Res. 2012;11:47–58.
Azeem A, Talegaonkar S, Negi LM, Ahmad FJ, Khar RK, Iqbal Z. Oil based nanocarrier system for transdermal delivery of ropinirole: a mechanistic, pharmacokinetic and biochemical investigation. Int J Pharm. 2011;422:436–44.
Ali MS, Alama MS, Alamb N, Siddiqui MR. Preparation, characterization and stability study of dutasteride loaded nanoemulsion for treatment of benign prostatic hypertrophy. Iran J Pharm Res. 2014;13:1125–40.
Akhter S, Jain GK, Ahmad FJ, Khar RK, Jain N. Iqbal Z investigation of nanoemulsion system for transdermal delivery of domperidone: ex-vivo and in vivo studies. Curr Nanosci. 2008;4:381–90.
Abbe NJV, Nicholas P, Boon E. Exaggerated exposure in topical irritancy and sensitization testing. J SocCosmet Chem. 1975;26:173–87.
Azeem A, Ahmad FJ, Khar RK, Talegaonkar S. Nanocarrier for the transdermal delivery of an antiparkinsonian drug. AAPS PharmSciTech. 2009;10:1093–103.
Ghosh MN. Fundamentals of experimental pharmacology. 3rd ed. Kolkata: Hilton and company; 2005.
Paxinos G, Watson C. The rat brain stereotaxic coordinates. 2nd ed. Sydney: Academic; 1986.
Zafar KS, Siddiqui A, Sayeed I, Ahmad M, Saleem S, Islam F. Protective effect of adenosine in rat model of Parkinson’s disease: neurobehavioral and neurochemical evidences. J ChemNeuroanat. 2003;26:143–51.
Borlongan CV, Sanberg PR. Elevated body swing test: a new behavioral parameters for rats with 6-hydroxydopamine-induced hemiparkinsonism. J Neurosci. 1995;15:5372–8.
Fernagut PO, Diguet E, Labattu B, Tison F. A simple method to measure stride length as an index of nigrostriatal dysfunction in mice. J Neurosci Meth. 2002;113:123–30.
Catalase LH. In: Bergmeyer HO, editor. Methods of enzymatic analysis. New York: Academic; 1971. p. 855–93.
Goverdhan P, Sravanthi A, Mamatha T. Neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress. Int J Alzheimers Dis. 2012;2012:1–8.
Bouchemal K, Briançon S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int J Pharm. 2004;280:241–51.
Peng LC, Liu CH, Kwan CC, Hunag KF. Optimization of water-in-oil nanoemulsions by mixed surfactants. Colloids Surf A Physicochem Eng Asp. 2010;370:136–42.
Yadav Y, Singh D, Poddar SK. Influence of components of nanoemulsion system for transdermal drug delivery of nimodipine. Asian J Pharm Clin Res. 2012;5:119–24.
Lawrence MJ, Rees GD. Microemulsion based media as novel drug delivery systems. Adv Drug Deliver Rev. 2000;45:89–121.
Porras M, Solans C, Gonzalez C, Gutiérrez JM. Properties of water-in-oil nano-emulsions prepared by a low-energy emulsification method. Colloids Surf A Physicochem Eng Asp. 2008;324:181–8.
Noor El-Din MR, El-Hamouly SH, Mohamed HM, Mishrif MR, Ragab AM. Water-in-diesel fuel nanoemulsions: preparation, stability and physical properties. Egypt J Petroleum. 2013;22:517–30.
Delmas T, Piraux H, Couffin AC, Texier I, Vinet F, Poulin P, et al. How to prepare and stabilize very small nanoemulsions. Langmuir. 2011;27:1683–92.
Nokhodchi A, Shokri J, Dashbolaghi A, Hassan-Zadeh D, Ghafourian T, Barzegar-Jalali M. The enhancement effect of surfactants on the penetration of lorazepan through rat skin. Int J Pharm. 2003;250:359–69.
Cappel MJ, Kreut J. Effect of nonionic surfactants on transdermal drug delivery: I. Polysorbates. Int J Pharm. 1991;69:143–53.
Malakar J, Nayak AK, Basu A. Ondansetron HCl microemulsions for transdermal delivery: formulation and in vitro skin permeation. ISRN Pharm. 2012;2012:1–6.
Thakkar PJ, Madan P, Lin S. Transdermal delivery of diclofenac using water-in-oil microemulsion: formulation and mechanistic approach of drug skin permeation. Pharm Dev Technol. 2014;19:373–84.
Schober A. Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP. Cell Tissue Res. 2014;318:215–24.