Application of crosslinkers to dentin collagen enhances the ultimate tensile strength

Journal of Biomedical Materials Research - Part B Applied Biomaterials - Tập 80B Số 1 - Trang 268-272 - 2007
Ana K. Bedran‐Russo1, Patricia N R Pereira2,3, Wagner Rodrigues Duarte2,4, James L. Drummond1, Mitsuo Yamauchi2,4
1Department of Restorative Dentistry, College of Dentistry, University of Illinois, Chicago, Illinois
2Dental Research Center, University of North Carolina, Chapel Hill, North Carolina
3Department of Operative Dentistry, University of North Carolina Dental School, Chapel Hill, North Carolina
4Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina

Tóm tắt

AbstractThe stabilization of dentin collagen with biocompatible crosslinking agents may be of clinical importance to improve dentin bond strength. The present study aimed to evaluate the effect of three collagen crosslinking agents on the ultimate tensile strength (UTS) of undemineralized and demineralized dentin. Ten freshly extracted sound molars were sectioned into 0.5 × 0.5 mm2 thick beams. The beams were either demineralized or kept undemineralized. Then, specimens were subdivided into four groups according to treatments—PBS solution (control), 5% glutaraldehyde (GD), 0.5% proanthocyanidin PBS solution (PA), and 0.625% genipin PBS solution (GE). Specimens were kept in their respective solutions for either 4 or 40 h. To assess UTS, specimens were subjected to tensile forces at a crosshead speed of 1 mm/min. Statistical analysis was performed using two‐way ANOVA and Fisher's PLSD test (p < 0.05). Statistically significant increases in UTS were observed for demineralized dentin after PA and GE dentin treatment, when compared with those of the control group. Dentin treated with GD showed no statistically significant differences in UTS when compared with that the control. Undemineralized dentin revealed no significant differences as compared to that of the control, regardless of the collagen crosslinkers. The application of two naturally occurring crosslinkers, i.e., PA and GE, to dentin collagen significantly improves UTS, indicating its potential value in restorative dentistry. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

Từ khóa


Tài liệu tham khảo

10.1002/ar.1092240206

10.1007/s002230020047

10.1177/10454411010120040401

Nakabayashi N, 1985, Bonding of restorative materials to dentine: The present status in Japan, Int Dent J, 35, 145

10.1002/jbm.a.10460

10.1002/(SICI)1097-4636(199911)47:2<116::AID-JBM2>3.0.CO;2-J

10.1016/S0142-9612(99)00069-1

10.1002/(SICI)1097-4636(19990915)46:4<520::AID-JBM10>3.0.CO;2-9

Nimni ME, 1988, 1

10.1016/S0142-9612(98)00242-7

10.3109/03008209909005276

10.1002/jbm.a.10346

10.1034/j.1600-0722.2001.00088.x

Yoshiyama M, 2003, Resin adhesion to carious dentin, Am J Dent, 16, 47

Yamauchi M, 2002, 455

10.1177/154405910408301014

10.2174/1389201013378725

Fine AM, 2000, Oligomeric proanthocyanidin complexes: History, structure, and phytopharmaceutical applications, Altern Med Rev, 5, 144

10.1042/bj1120609

10.1016/0076-6879(74)31057-9

10.1007/BF01024600

10.1080/10826079408013541

Thông tin
Thông tin xuất bản

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Tập 80B Số 1

268-272

Thông tin tác giả