Appetite suppression caused by CCK is diet specific in VMH-lesioned rats
Tóm tắt
Intraperitoneal injections of the C-terminal octapeptide of cholecystokinin-pancreozymin (CCK) failed to inhibit 5.5-h-fasted feeding of a high-fat diet in rats with electrolytic lesions of the ventromedial hypothalamus. Similar injections significantly reduced the intake of a high-fat diet in sham-lesioned controls. These results are consistent with Powley’s (1977) cephalic phase hypothesis (CPH) and are interpreted to mean that rats with electrolytic lesions of the ventromedial hypothalamus, when given a highly palatable diet, demonstrate a prolonged cephalic reflex, which results in metabolic disturbances which may override the effect of CCK at the 40 U/kg dose.
Tài liệu tham khảo
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