Apoptosis, inflammatory response and parasite load in skin of Leishmania (Leishmania) chagasi naturally infected dogs: A histomorphometric analysis

Afonso, 2008, Interactions with apoptotic but not necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis, J. Leukoc. Biol., 8, 389, 10.1189/jlb.0108018

Baneth, 2008, Canine leishmaniasis – new concepts and insights on an expanding zoonosis: part one, Trends Parasitol., 24, 324, 10.1016/j.pt.2008.04.001

Carmen, 2007, Suicide prevention: disruption of apoptotic pathways by protozoan parasites, Mol. Microbiol., 64, 904, 10.1111/j.1365-2958.2007.05714.x

Carrero, 2004, Type I interferon sensitizes lymphocytes to apoptosis and reduce resistances to Listeria infection, J. Exp. Med., 200, 535, 10.1084/jem.20040769

Cochran, 1957

Cohen, 2002, Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase, J. Exp. Med., 196, 135, 10.1084/jem.20012094

Conceição-Silva, 1998, The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity, Eur. J. Immunol., 28, 237, 10.1002/(SICI)1521-4141(199801)28:01<237::AID-IMMU237>3.0.CO;2-O

Das, 1999, Leishmania donovani infection of a susceptible host results in CD4+ T-cell apoptosis and decreased Th1 cytokine production, Scand. J. Immunol., 49, 307, 10.1046/j.1365-3083.1999.00486.x

Das, 2001, Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes, J. Cell Sci., 114, 2461, 10.1242/jcs.114.13.2461

Deane, 1955, Leishmaniose visceral urbana (no cão e no homem) em Sobral, Ceará. O Hosp., 47, 75

Dos-Santos, 2004, Association between skin parasitism and granulomatous inflammatory pattern in canine visceral leishmaniasis, Parasitol. Res., 94, 84

Eda, 2004, Carbohydrate-mediated phagocytic recognition of early apoptotic cells undergoing transient capping of CD43 glycoprotein, J. Biol. Chem., 279, 5967, 10.1074/jbc.M310805200

Fadok, 1998, Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta PGE2, and PAF, J. Clin. Invest., 101, 890, 10.1172/JCI1112

Giunchetti, 2006, Relationship between canine visceral leishmaniasis and the Leishmania (Leishmania) chagasi burden in dermal inflammatory foci, J. Comp. Pathol., 135, 100, 10.1016/j.jcpa.2006.06.005

Gramiccia, 2005, The current status of zoonotic leishmaniasis and approaches to disease control, Int. J. Parasitol., 35, 1169, 10.1016/j.ijpara.2005.07.001

Huang, 1998, Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production, J. Immunol., 160, 4143, 10.4049/jimmunol.160.9.4143

Huynh, 2002, Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta 1 secretion and the resolution of inflammation, J. Clin. Invest., 109, 41, 10.1172/JCI0211638

Kerr, 1993, Definition of apoptosis and overview of its incidence, 1

Knight, 2002, The archaeology of apoptosis, Cell Death Differ., 9, 1, 10.1038/sj.cdd.4400980

Krysko, 2006, Macrophages use different internalization mechanisms to clear apoptotic and necrotic cells, Cell Death Differ., 18, 781

Lanzaro, 1995, Genetic variability in phlebotomine sandflies: possible implications for leishmaniasis epidemiology, Parasitol. Today, 11, 151, 10.1016/0169-4758(95)80137-5

Lee, 2002, Programmed cell death in the unicellular protozoan parasite Leishmania, Cell Death Differ., 9, 53, 10.1038/sj.cdd.4400952

Lindoso, 2004, Apoptosis of Leishmania (Leishmania) chagasi amastigotes in hamsters infected with visceral leishmaniasis, Int. J. Parasitol., 34, 1, 10.1016/j.ijpara.2003.09.010

Luna, 1968

Maderna, 2003, Phagocytosis of apoptotic cells and the resolution of inflammation, Biochim. Biophys. Acta, 1639, 141, 10.1016/j.bbadis.2003.09.004

Mauricio, 2000, The strange case of Leishmania chagasi, Parasitol. Today, 16, 188, 10.1016/S0169-4758(00)01637-9

Mikel, 1994

Moreira, 1996, Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis, J. Cell Physiol., 167, 305, 10.1002/(SICI)1097-4652(199605)167:2<305::AID-JCP15>3.0.CO;2-6

Moro, 2004, Determination of the minimal representative number of microscopic fields to quantify apoptosis in canine lymph nodes, Arq. Bras. Med. Vet. Zootech., 56, 408, 10.1590/S0102-09352004000300020

Peters, 2008, In vivo imaging revealed an essential role for neutrophils in leishmaniasis transmitted by sand flies, Science, 321, 970, 10.1126/science.1159194

Piarroux, 1993, Isolation and characterization of a repetitive DNA sequence from Leishmania infantum: development of s visceral leishmaniasis Polymerase Chain Reaction, Am. J. Trop. Med. Hyg., 49, 364, 10.4269/ajtmh.1993.49.364

Pozio, 1981, Leishmaniasis in Tuscany (Italy): VI. Canine leishmaniasis in the focus of Monte Argentario (Grosseto), Acta Trop., 38, 383

Reed, 1996, Diagnosis of leishmaniasis, Clin. Dermatol., 14, 471, 10.1016/0738-081X(96)00038-7

Reynolds, 1963, The use of lead citrate at high pH as an electron opaque stain in electron microscopy, J. Cell Biol., 17, 208, 10.1083/jcb.17.1.208

Ribeiro-Gomes, 2005, Macrophage interactions with neutrophils regulate Leishmania major infection, J. Immunol., 172, 454

Rousseau, 2001, In vivo involvement of polymorphonuclear neutrophils in Leishmania infantum infection, BMC Microbiol., 1

Savill, 2002, A blast from the past: clearance of apoptotic cells regulates immune responses, Nat. Rev. Immunol., 2, 965, 10.1038/nri957

Solano-Gallego, 2004, Histological and immunohistochemical study of clinically normal skin of Leishmania infantum-infected dogs, J. Comp. Pathol., 130, 7, 10.1016/S0021-9975(03)00063-X

Solano-Gallego, 2001, Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology, J. Clin. Microbiol., 39, 560, 10.1128/JCM.39.2.560-563.2001

Tacchini-Cottier, 2000, An immunomodulatory function for neutrophils during the induction of a CD4_Th2 response in BALB/c mice infected with Leishmania major, J. Immunol., 165, 26, 10.4049/jimmunol.165.5.2628

Tafuri, 2004, An alternative immunohistochemical method for detecting Leishmania amastigotes in paraffin-embedded canine tissues, J. Immunol. Method, 292, 17, 10.1016/j.jim.2004.05.009

Van Zandbergen, 2006, Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum, Proc. Natl. Acad. Sci., 103, 13837, 10.1073/pnas.0600843103

Van Zandbergen, 2004, Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages, J. Immunol., 173, 6521, 10.4049/jimmunol.173.11.6521

Verçosa, 2008, Transmission potential, skin inflammatory response and parasitism of symptomatic and asymptomatic dogs with visceral leishmaniasis, BMC Vet. Res., 4, 1, 10.1186/1746-6148-4-45

Verçosa, 2011, Inflammatory response, parasite load and AgNOR expression in ear skin of symptomatic and asymptomatic Leishmania (Leishmania) chagasi infected dogs, J. Venom. Anim. Toxins Incl. Trop. Dis., 17, 308, 10.1590/S1678-91992011000300011

Wanderley, 2009, Cooperation between apoptotic and viable metacyclics enhances the pathogenesis of leishmaniasis, PLoS One, 4, 1, 10.1371/journal.pone.0005733

Watson, 1958, Staining of tissue sections for electron microscopy with heavy metals, J. Biophys. Biochem. Cytol., 4, 475, 10.1083/jcb.4.4.475

Weinrauch, 1999, The induction of apoptosis by bacterial pathogens, Annu. Rev. Microbiol., 53, 155, 10.1146/annurev.micro.53.1.155

Welburn, 1997, Control of 473 Trypanosoma brucei brucei infections in tse-tse, Glossina morsitans, Med. Vet. Entomol., 11, 286, 10.1111/j.1365-2915.1997.tb00408.x

Xavier, 2006, Comparison of paraffin-embedded skin biopsies from different anatomical regions as sampling methods for detecting Leishmania infection in dogs using histological, immunohistochemical and PCR methods, BMC Vet. Res., 2, 17, 10.1186/1746-6148-2-17