Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

Oncogene - Tập 23 Số 16 - Trang 2934-2949 - 2004
Yves Pommier1, Olivier Sordet1, Smitha Antony1, Richard L. Hayward2, Kurt W. Kohn1
1Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, DHHS, Bethesda, USA
2Cancer Research United Kingdom, Western General Hospital, Edinburgh, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

Andjelkovic M, Maira S-M, Cron P, Parker PJ and Hemmings BA . (1999). Mol. Cell. Biol., 19, 5061–5072.

Antonsson B, Montessuit S, Sanchez B and Martinou JC . (2001). J. Biol. Chem., 276, 11615–11623.

Arch RH, Gedrich RW and Thompson CB . (2000). Biochem. Biophys. Res. Commun., 272, 936–945.

Arenzana-Seisdedos F, Turpin P, Rodriguez M, Thomas D, Hay RT, Virelizier JL and Dargemont C . (1997). J. Cell Sci., 110 (Part 3), 369–378.

Arlt A, Gehrz A, Muerkoster S, Vorndamm J, Kruse ML, Folsch UR and Schafer H . (2003). Oncogene, 22, 3243–3251.

Arsura M, Mercurio F, Oliver AL, Thorgeirsson SS and Sonenshein GE . (2000). Mol. Cell. Biol., 20, 5381–5391.

Bakker TR, Reed D, Renno T and Jongeneel CV . (1999). Int. J. Cancer, 80, 320–323.

Baldwin Jr AS . (1996). Annu. Rev. Immunol., 14, 649–683.

Baldwin AS . (2001). J. Clin. Invest., 107, 241–246.

Bartke T, Siegmund D, Peters N, Reichwein M, Henkler F, Scheurich P and Wajant H . (2001). Oncogene, 20, 571–580.

Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M and Piedrafita FJ . (2003). Mol. Cell. Biol., 23, 1061–1074.

Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM and Green DR . (2000). Nat. Cell Biol., 2, 469–475.

Beg AA and Baltimore D . (1996). Science, 274, 782–784.

Beg AA, Sha WC, Bronson RT, Ghosh S and Baltimore D . (1995). Nature, 376, 167–170.

Bessho R, Matsubara K, Kubota M, Kuwakado K, Hirota H, Wakazono Y, Lin YW, Okuda A, Kawai M, Nishikomori R and Heike T . (1994). Biochem. Pharmacol., 48, 1883–1889.

Bettaieb A, Dubrez-Daloz L, Launay S, Plenchette S, Rebe C, Cathelin S and Solary E . (2003). Curr. Med. Chem. Anti-Cancer Agents, 3, 307–318.

Bharti AC and Aggarwal BB . (2002). Biochem. Pharmacol., 64, 883–888.

Blume-Jensen P, Janknecht R and Hunter T . (1998). Curr. Biol., 8, 779–782.

Bouillet P and Strasser A . (2002). J. Cell Sci., 115, 1567–1574.

Brangi M, Litman T, Ciotti M, Nishiyama K, Kohlhagen G, Takimoto C, Robey R, Pommier Y, Fojo T and Bates SE . (1999). Cancer Res., 59, 5938–5946.

Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C, Gurbuxani S, Arrigo AP, Kroemer G, Solary E and Garrido C . (2000). Nat. Cell Biol., 2, 645–652.

Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME . (1999). Cell, 96, 857–868.

Budihardjo I, Oliver H, Lutter M, Luo X and Wang X . (1999). Annu. Rev. Cell Dev. Biol., 15, 269–290.

Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, Williams J, Lengauer C, Kinzler KW and Vogelstein B . (1999). J. Clin. Invest., 104, 263–269.

Burks DJ, Wang J, Towery H, Ishibashi O, Lowe D, Riedel H and White MF . (1998). J. Biol. Chem., 273, 31061–31067.

Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S and Reed JC . (1998). Science, 282, 1318–1321.

Cataldi A, Rapino M, Centurione L, Sabatini N, Grifone G, Garaci F and Rana R . (2003). J. Cell. Biochem., 89, 956–963.

Chan TA, Hermeking H, Lengauer C, Kinzler KW and Vogelstein B . (1999). Nature, 401, 616–620.

Chan TA, Hwang PM, Hermeking H, Kinzler KW and Vogelstein B . (2000). Genes Dev., 14, 1584–1588.

Chen C, Edelstein LC and Gelinas C . (2000). Mol. Cell. Biol., 20, 2687–2695.

Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T and Korsmeyer SJ . (2001). Mol. Cell, 8, 705–711.

Chinnaiyan AM, O’Rourke K, Tewari M and Dixit VM . (1995). Cell, 81, 505–512.

Chipuk JE, Bhat M, Hsing AY, Ma J and Danielpour D . (2001). J. Biol. Chem., 276, 26614–26621.

Cho S, Urata Y, Iida T, Goto S, Yamaguchi M, Sumikawa K and Kondo T . (1998). Biochem. Biophys. Res. Commun., 253, 104–108.

Cox MM . (2001). Proc. Natl. Acad. Sci. USA, 98, 8173–8180.

Cusack Jr JC, Liu R and Baldwin Jr AS . (2000). Cancer Res., 60, 2323–2330.

Cusack Jr JC, Liu R, Houston M, Abendroth K, Elliott PJ, Adams J and Baldwin Jr AS . (2001). Cancer Res., 61, 3535–3540.

Cusack JC . (2003). Cancer Treat. Rev., 21–31.

D’Acquisto F, Ialenti A, Ianaro A, Di Vaio R and Carnuccio R . (2000). Gene Therapy, 7, 1731–1737.

Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW and Krystal G . (1996). Proc. Natl. Acad. Sci. USA, 93, 1689–1693.

Datta SR, Brunet A and Greenberg ME . (1999). Genes Dev., 13, 2905–2927.

Debatin KM, Poncet D and Kroemer G . (2002). Oncogene, 21, 8786–8803.

Derenne S, Monia B, Dean NM, Taylor JK, Rapp MJ, Harousseau JL, Bataille R and Amiot M . (2002). Blood, 100, 194–199.

Desai AA, Innocenti F and Ratain MJ . (2003). Oncogene, 22, 6621–6628.

Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS and Reed JC . (1998). EMBO J., 17, 2215–2223.

Deveraux QL, Stennicke HR, Salvesen GS and Reed JC . (1999). J. Clin. Immunol., 19, 388–398.

el-Deiry WS . (1998). Semin. Cancer Biol., 8, 345–357.

Epinat JC and Gilmore TD . (1999). Oncogene, 18, 6896–6909.

Flynn Jr V, Ramanitharan A, Moparty K, Davis R, Sikka S, Agrawal KC and Abdel-Mageed AB . (2003). Int. J. Oncol., 23, 317–323.

Frantz B and O’Neill EA . (1995). Science, 270, 2017–2019.

Fu WN, Bertoni F, Kelsey SM, McElwaine SM, Cotter FE, Newland AC and Jia L . (2003). Oncogene, 22, 451–455.

Fujita N, Sato S, Ishida A and Tsuruo T . (2002). J. Biol. Chem., 277, 10346–10353.

Fujita N and Tsuruo T . (2003). Cancer Chemother Pharmacol., 52 (Suppl 1), S24–S28.

Garg A and Aggarwal BB . (2002). Leukemia, 16, 1053–1068.

Giri DK and Aggarwal BB . (1998). J. Biol. Chem., 273, 14008–14014.

Gottesman MM . (2002). Annu. Rev. Med., 53, 615–627.

Gross A, McDonnell JM and Korsmeyer SJ . (1999). Genes Dev., 13, 1899–1911.

Gupta M, Fan S, Zhan Q, Kohn KW, O'Connor PM and Pommier Y . (1997). Clin. Cancer Res., 3, 1653–1660.

Habib AA, Chatterjee S, Park S-K, Ratan RR, Lefebvre S and Vartanian T . (2001). J. Biol. Chem., 276, 8865–8874.

Hacker H and Karin M . (2002). Cancer Cell, 2, 431–433.

Han Z, Wei W, Dunaway S, Darnowski JW, Calabresi P, Sedivy J, Hendrickson EA, Balan KV, Pantazis P and Wyche JH . (2002). J. Biol. Chem., 277, 17154–17160.

Hayward RL, Macpherson JS, Cummings J, Monia BP, Smyth JF and Jodrell DI . (2003). Clin. Cancer Res., 9, 2856–2865.

Hermeking H . (2003). Nat. Rev. Cancer, 3, 941–943.

Hill MM and Hemmings BA . (2002). Pharmacol. Ther., 93, 243–251.

Hong SY, Yoon WH, Park JH, Kang SG, Ahn JH and Lee TH . (2000). J. Biol. Chem., 275, 18022–18028.

Hopkins-Donaldson S, Cathomas R, Simoes-Wust AP, Kurtz S, Belyanskya L, Stahel RA and Zangemeister-Wittke U . (2003). Int. J. Cancer, 106, 160–166.

Hu Y, Benedict MA, Ding L and Nunez G . (1999). EMBO J., 18, 3586–3595.

Hu Y, Benedict MA, Wu D, Inohara N and Nunez G . (1998). Proc. Natl. Acad. Sci. USA, 95, 4386–4391.

Huang DC and Strasser A . (2000). Cell, 103, 839–842.

Huang H, Cheville JC, Pan Y, Roche PC, Schmidt LJ and Tindall DJ . (2001). J. Biol. Chem., 276, 38830–38836.

Huang S, DeGuzman A, Bucana CD and Fidler IJ . (2000). Clin. Cancer Res., 6, 2573–2581.

Jia W, Yu C, Rahmani M, Krystal G, Sausville EA, Dent P and Grant S . (2003). Blood, 102, 1824–1832.

Jiang Z, Zheng X and Rich KM . (2003). J. Neurochem., 84, 273–281.

Jobin C, Hellerbrand C, Licato LL, Brenner DA and Sartor RB . (1998). Gut, 42, 779–787.

Jones DR, Broad RM, Madrid LV, Baldwin Jr AS and Mayo MW . (2000). Ann. Thorac. Surg., 70, 930–936 discussion 936–937.

Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC and Burrows FJ . (2003). Nature, 425, 407–410.

Kamesaki S, Kamesaki H, Jorgensen TJ, Tanizawa A, Pommier Y and Cossman J . (1993). Cancer Res., 53, 4251–4256.

Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY and Karin M . (2000). J. Biol. Chem., 275, 36062–36066.

Karin M and Ben-Neriah Y . (2000). Annu. Rev. Immunol., 18, 621–663.

Karin M, Cao Y, Greten FR and Li ZW . (2002). Nat. Rev. Cancer, 2, 301–310.

Karin M and Lin A . (2002). Nat. Immunol., 3, 221–227.

Karin M, Yamamoto Y and Wang QM . (2004). Nat. Rev. Drug Discov., 3, 17–26.

Karpinich NO, Tafani M, Rothman RJ, Russo MA and Farber JL . (2002). J. Biol. Chem., 277, 16547–16552.

Kasibhatla S, Genestier L and Green DR . (1999). J. Biol. Chem., 274, 987–992.

Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC and Lorenzi MV . (2001). Oncogene, 20, 7965–7975.

Katsuyama K, Shichiri M, Marumo F and Hirata Y . (1998). Arterioscler. Thromb. Vasc. Biol., 18, 1796–1802.

Kohn KW . (1999). Mol. Biol. Cell, 10, 2703–2734.

Kohn KW . (2001). CHAOS, 11, 84–97.

Kohn KW, Aladjem MI, Pasa S, Parodi S and Pommier Y . (2004). Nat. Encyclopedia Human Genome, 1, 457–474.

Korsmeyer SJ . (1999). Cancer Res., 59, 1693s–1700s.

Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D and Courtois G . (2003). Nature, 424, 801–805.

Krikos A, Laherty CD and Dixit VM . (1992). J. Biol. Chem., 267, 17971–17976.

Kroemer G . (1999). Biochem. Soc. Symp., 66, 1–15.

Kunstle G, Laine J, Pierron G, Kagami Si S, Nakajima H, Hoh F, Roumestand C, Stern MH and Noguchi M . (2002). Mol. Cell. Biol., 22, 1513–1525.

Lai EC . (2003). J. Cell Biol., 162, 365–370.

Larochette N, Decaudin D, Jacotot E, Brenner C, Marzo I, Susin SA, Zamzami N, Xie Z, Reed J and Kroemer G . (1999). Exp. Cell Res., 249, 413–421.

Lassus P, Opitz-Araya X and Lazebnik Y . (2002). Science, 297, 1352–1354.

Levkau B, Scatena M, Giachelli CM, Ross R and Raines EW . (1999). Nat. Cell Biol., 1, 227–233.

Li H, Zhu H, Xu CJ and Yuan J . (1998). Cell, 94, 491–501.

Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES and Wang X . (1997). Cell, 91, 479–489.

Li X and Stark GR . (2002). Exp. Hematol., 30, 285–296.

Lin YZ, Yao SY, Veach RA, Torgerson TR and Hawiger J . (1995). J. Biol. Chem., 270, 14255–14258.

Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR and Thompson CB . (2000). Mol. Cell, 6, 1389–1399.

Ling MT, Wang X, Ouyang XS, Xu K, Tsao SW and Wong YC . (2003). Oncogene, 22, 4498–4508.

Luo X, Budihardjo I, Zou H, Slaughter C and Wang X . (1998). Cell, 94, 481–490.

Lutz RJ . (2000). Biochem. Soc. Trans., 28, 51–56.

Madrid LV, Mayo MW, Reuther JY and Baldwin Jr AS . (2001). J. Biol. Chem., 276, 18934–18940.

Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M and Hemmings BA . (2001). Science, 294, 374–380.

Manna SK, Zhang HJ, Yan T, Oberley LW and Aggarwal BB . (1998). J. Biol. Chem., 273, 13245–13254.

Marinovich M, Viviani B, Corsini E, Ghilardi F and Galli CL . (1996). Exp. Cell Res., 226, 98–104.

McNulty SE, Tohidian NB and Meyskens Jr FL : Pigment Cell Res., 14, 456–465.

Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH and Peter ME . (1997). EMBO J., 16, 2794–2804.

Micheau O, Lens S, Gaide O, Alevizopoulos K and Tschopp J . (2001). Mol. Cell. Biol., 21, 5299–5305.

Micheau O, Solary E, Hammann A and Dimanche-Boitrel MT . (1999). J. Biol. Chem., 274, 7987–7992.

Micheau O, Solary E, Hammann A, Martin F and Dimanche-Boitrel MT . (1997). J. Natl. Cancer Inst., 89, 783–789.

Muerkoster S, Arlt A, Witt M, Gehrz A, Haye S, March C, Grohmann F, Wegehenkel K, Kalthoff H, Folsch UR and Schafer H . (2003). Int. J. Cancer, 104, 469–476.

Muller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, Li-Weber M, Friedman SL, Galle PR, Stremmel W, Oren M and Krammer PH . (1998). J. Exp. Med., 188, 2033–2045.

Nakashio A, Fujita N, Rokudai S, Sato S and Tsuruo T . (2000). Cancer Res., 60, 5303–5309.

Nieves-Neira W and Pommier Y . (1999). Int. J. Cancer, 82, 396–404.

Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H and Tsujimoto Y . (2003). J. Biol. Chem., 278, 2058–2065.

Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM and Donner DB . (1999). Nature, 401, 82–85.

Pahl HL . (1999). Oncogene, 18, 6853–6866.

Paillard F . (1999). Hum. Gene Ther., 10, 1–3.

Pandey P, Saleh A, Nakazawa A, Kumar S, Srinivasula SM, Kumar V, Weichselbaum R, Nalin C, Alnemri ES, Kufe D and Kharbanda S . (2000). embo J., 19, 4310–4322.

Parcellier A, Gurbuxani S, Schmitt E, Solary E and Garrido C . (2003). Biochem. Biophys. Res. Commun., 304, 505–512.

Pieper GM and Riaz ul HRS . (1997). J. Cardiovasc. Pharmacol., 30, 528–532.

Poulaki V, Mitsiades CS, Joussen AM, Lappas A, Kirchhof B and Mitsiades N . (2002). Am. J. Pathol., 161, 2229–2240.

Puthalakath H and Strasser A . (2002). Cell Death Differ., 9, 505–512.

Ravagnan L, Marzo I, Costantini P, Susin SA, Zamzami N, Petit PX, Hirsch F, Goulbern M, Poupon MF, Miccoli L, Xie Z, Reed JC and Kroemer G . (1999). Oncogene, 18, 2537–2546.

Ravagnan L, Roumier T and Kroemer G . (2002). J. Cell. Physiol., 192, 131–137.

Ray RB, Meyer K, Steele R, Shrivastava A, Aggarwal BB and Ray R . (1998). J. Biol. Chem., 273, 2256–2259.

Reed JC . (1999). J. Clin. Oncol., 17, 2941–2953.

Reed JC . (2002). Nat. Rev. Drug Discov., 1, 111–121.

Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y and Weinstein JN . (2003). Cancer Res., 63, 1000–1011.

Reuther JY and Baldwin Jr AS . (1999). J. Biol. Chem., 274, 20664–20670.

Romashkova JA and Makarov SS . (1999). Nature, 401, 86–90.

Ryan KM, Phillips AC and Vousden KH . (2001). Curr. Opin. Cell Biol., 13, 332–337.

Sachdev S, Hoffmann A and Hannink M . (1998). Mol. Cell. Biol., 18, 2524–2534.

Saga Y, Mizukami H, Suzuki M, Kohno T, Urabe M, Ozawa K and Sato I . (2002). Clin. Cancer Res., 8, 1248–1252.

Saleh A, Srinivasula SM, Acharya S, Fishel R and Alnemri ES . (1999). J. Biol. Chem., 274, 17941–17945.

Saleh A, Srinivasula SM, Balkir L, Robbins PD and Alnemri ES . (2000). Nat. Cell Biol., 2, 476–483.

Salvesen GS and Dixit VM . (1999). Proc. Natl. Acad. Sci. USA, 96, 10964–10967.

Sarto C, Binz PA and Mocarelli P . (2000). Electrophoresis, 21, 1218–1226.

Sato S, Fujita N and Tsuruo T . (2000). Proc. Natl. Acad. Sci. USA, 97, 10832–10837.

Sato S, Fujita N and Tsuruo T . (2002a). Oncogene, 21, 1727–1738.

Sato S, Fujita N and Tsuruo T . (2002b). J. Biol. Chem., 277, 39360–39367.

Sato T, Odagiri H, Ikenaga SK, Maruyama M and Sasaki M . (2003). Cancer Sci., 94, 467–472.

Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH and Peter ME . (1998). EMBO J., 17, 1675–1687.

Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM and Lowe SW . (2002a). Cancer Cell, 1, 289–298.

Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM and Lowe SW . (2002b). Cell, 109, 335–346.

Schmitt CA and Lowe SW . (2002). J. Mol. Med., 80, 137–146.

Schmitt CA, Rosenthal CT and Lowe SW . (2000). Nat. Med., 6, 1029–1035.

Schott AF, Apel IJ, Nunez G and Clarke MF . (1995). Oncogene, 11, 1389–1394.

Shao RG, Cao CX, Nieves-Neira W, Dimanche-Boitrel MT, Solary E and Pommier Y . (2001). Oncogene, 20, 1852–1859.

Singh S and Aggarwal BB . (1995). J. Biol. Chem., 270, 24995–25000.

Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR and Martin SJ . (1999). J. Cell Biol., 144, 281–292.

Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X, McCombie R, Herman JG, Gerald WL, Lazebnik YA, Cordon-Cardo C and Lowe SW . (2001). Nature, 409, 207–211.

Soengas MS and Lowe SW . (2003). Oncogene, 22, 3138–3151.

Solary E, Bettaieb A, Dubrez-Daloz L and Corcos L . (2003). Leukemia Lymphoma, 44, 563–574.

Sordet O, Khan Q, Kohn KW and Pommier Y . (2003). Curr. Med. Chem. Anticancer Agents, 3, 271–290.

Sordet O, Rebe C, Leroy I, Bruey JM, Garrido C, Miguet C, Lizard G, Plenchette S, Corcos L and Solary E . (2001). Blood, 97, 3931–3940.

Srinivasula SM, Ahmad M, Fernandes-Alnemri T and Alnemri ES . (1998). Mol. Cell, 1, 949–957.

Staal FJ, Roederer M, Raju PA, Anderson MT, Ela SW and Herzenberg LA . (1993). AIDS Res. Hum. Retroviruses, 9, 299–306.

Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP and Mak TW . (1998). Cell, 95, 29–39.

Stroh C, Held J, Samraj AK and Schulze-Osthoff K . (2003). Oncogene, 22, 5367–5373.

Sunwoo JB, Chen Z, Dong G, Yeh N, Crowl Bancroft C, Sausville E, Adams J, Elliott P and Van Waes C . (2001). Clin. Cancer Res., 7, 1419–1428.

Tang D, Okada H, Ruland J, Liu L, Stambolic V, Mak TW and Ingram AJ . (2001a). J. Biol. Chem., 276, 30461–30466.

Tang G, Yang J, Minemoto Y and Lin A . (2001b). Mol. Cell, 8, 1005–1016.

Theodorakis P, Lomonosova E and Chinnadurai G . (2002). Cancer Res., 62, 3373–3376.

Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R and Dedhar S . (2003). J. Biol. Chem., 278, 22374–22378.

Tsujimoto Y . (2003). J. Cell. Physiol., 195, 158–167.

Tzung SP, Kim KM, Basanez G, Giedt CD, Simon J, Zimmerberg J, Zhang KY and Hockenbery DM . (2001). Nat. Cell Biol., 3, 183–191.

Usami I, Kubota M, Bessho R, Kataoka A, Koishi S, Watanabe K, Sawada M, Lin YW, Akiyama Y and Furusho K . (1998). Biochem. Pharmacol., 55, 185–191.

Vanhaesebroeck B and Alessi DR . (2000). Biochem J., 346 (Part 3), 561–576.

Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P and Wallach D . (1998). Immunity, 9, 267–276.

Vaux DL and Silke J . (2003). Biochem. Biophys. Res. Commun., 304, 499–504.

Vermeulen L, De Wilde G, Notebaert S, Vanden Berghe W and Haegeman G . (2002). Biochem. Pharmacol., 64, 963–970.

Vieira HL, Boya P, Cohen I, El Hamel C, Haouzi D, Druillenec S, Belzacq AS, Brenner C, Roques B and Kroemer G . (2002). Oncogene, 21, 1963–1977.

Vivanco I and Sawyers CL . (2002). Nat. Rev. Cancer, 2, 489–501.

Walczak H, Bouchon A, Stahl H and Krammer PH . (2000). Cancer Res., 60, 3051–3057.

Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B and Williams J . (1997). Nat. Med., 3, 1034–1036.

Walton MI, Whysong D, O’Connor PM, Hockenbery D, Korsmeyer SJ and Kohn KW . (1993). Cancer Res., 53, 1853–1861.

Wan X, Yokoyama Y, Shinohara A, Takahashi Y and Tamaya T . (2002). Cell Death Differ., 9, 414–420.

Wang CY, Cusack Jr JC, Liu R and Baldwin Jr AS . (1999). Nat. Med., 5, 412–417.

Wang CY, Mayo MW and Baldwin Jr AS . (1996). Science, 274, 784–787.

Wang JL, Zhang ZJ, Choksi S, Shan S, Lu Z, Croce CM, Alnemri ES, Korngold R and Huang Z . (2000). Cancer Res., 60, 1498–1502.

Wang Y, Cui H, Schroering A, Ding JL, Lane WS, McGill G, Fisher DE and Ding HF . (2002). Nat. Cell Biol., 4, 888–893.

Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB and Korsmeyer SJ . (2000). Genes Dev., 14, 2060–2071.

Wei MC, Zong W-X, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB and Korsmeyer SJ . (2001). Science, 292, 727–730.

Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ and Harper JW . (1999). Genes Dev., 13, 270–283.

Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P and Clarkson B . (1999). Blood, 93, 2707–2720.

Wu H, Goel V and Haluska FG . (2003). Oncogene, 22, 3113–3122.

Yasui H, Adachi M and Imai K . (2003). Cancer, 97, 1412–1420.

Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry WS, Lowe SW, Goeddel DV and Mak TW . (1998). Science, 279, 1954–1958.

Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L and Downing JR . (2002). Cancer Cell, 1, 133–143.

Yu J, Zhang L, Hwang PM, Kinzler KW and Vogelstein B . (2001). Mol. Cell, 7, 673–682.

Yuan XJ and Whang YE . (2002). Oncogene, 21, 319–327.

Zandi E, Chen Y and Karin M . (1998). Science, 281, 1360–1363.

Zandi E, Rothwarf DM, Delhase M, Hayakawa M and Karin M . (1997). Cell, 91, 243–252.

Zha J, Harada H, Osipov K, Jockel J, Waksman G and Korsmeyer SJ . (1997). J. Biol. Chem., 272, 24101–24104.

Zhang L, Yu J, Park BH, Kinzler KW and Vogelstein B . (2000). Science, 290, 989–992.

Zhou G and Kuo MT . (1997). J. Biol. Chem., 272, 15174–15183.