Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles

Govind T. Vatassery1,2,3,4, Hung T. Quach1, W. Ed Smith1, Karen S. SantaCruz5, Sabita Roy6
1Research Service, VA Medical Center, Minneapolis, MN 55417, USA
2GRECC Program, VA Medical Center, Minneapolis, MN 55417, USA
3Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55455 USA
4Graduate Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA
5Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
6Department of Pharmacology, University of Minnesota, Medical School, Minneapolis, MN 55455 USA

Tài liệu tham khảo

Corder, 1993, Gene dose of apolipoprotein E allele and the risk of Alzheimer's disease in late onset families, Science, 261, 921, 10.1126/science.8346443 Farrer, 1997, ApoE and Alzheimer's disease meta analysis consortium, effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease, J. Am. Med. Assoc., 278, 1349, 10.1001/jama.1997.03550160069041 Mahley, 2006, Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease, Proc. Natl. Acad. Sci. U. S. A., 103, 5644, 10.1073/pnas.0600549103 Pratico, 1999, Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation, J. Neurochem., 73, 736, 10.1046/j.1471-4159.1999.0730736.x Shea, 2002, Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue, Free Radic. Biol. Med., 33, 1115, 10.1016/S0891-5849(02)01001-8 Sano, 1997, A controlled trial of seligiline, alpha tocopherol, or both as treatment for Alzheimer's disease, New Engl. J. Med., 336, 1216, 10.1056/NEJM199704243361704 Vatassery, 2006, Apolipoprotein E exerts selective and differential control over vitamin E concentrations in different areas of mammalian brain, J. Neurosci. Res., 84, 1335, 10.1002/jnr.21037 Franklin, 1997 Glowinski, 1966, Regional studies of catecholamines in the rat brain, J. Neurochem., 13, 655, 10.1111/j.1471-4159.1966.tb09873.x Vatassery, 1993, A liquid chromatographic method for the simultaneous determination of alpha tocopherol and tocopherolquinone in human red blood cells and other biological samples where tocopherol is easily oxidized during sample treatment., Anal. Biochem., 214, 426, 10.1006/abio.1993.1518 Markwell, 1978, A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples, Anal. Biochem., 87, 206, 10.1016/0003-2697(78)90586-9 Gallo-Torres, 1980, 193 Johanson, 2005, Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route, Pharm. Res., 22, 1011, 10.1007/s11095-005-6039-0 Abbott, 2004, Evidence for bulk flow of brain interstitial fluid: significance in physiology and pathology, Neurochem. Int., 45, 545, 10.1016/j.neuint.2003.11.006 Greitz, 1996, A proposed model of cerebrospinal fluid circulation: observations with radionuclide cisternography, Am. J. Neuroradiol., 17, 431 Roheim, 1979, Apolipoproteins in human cerebrospinal fluid, Proc. Natl. Acad. Sci. U. S. A., 76, 4646, 10.1073/pnas.76.9.4646 Pardridge, 1984, Transport of nutrients and hormones through the blood–brain barrier, Fed. Proc., 43, 201 LaDu, 1998, Nascent astrocyte particles differ from lipoproteins in CSF, J. Neurochem., 70, 2070, 10.1046/j.1471-4159.1998.70052070.x Mardones, 2002, Alpha tocopherol metabolism is abnormal in scavenger receptor class B type I (SR-B1)-deficient mice, J. Nutr., 132, 443, 10.1093/jn/132.3.443 Burton, 1990, Biokinetics of dietary RRR-alpha tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E, evidence that vitamin C does not spare vitamin E in vivo, Lipids, 25, 199, 10.1007/BF02535748