Apoferritin nanoparticle based dual-antigen influenza conjugate vaccine with potential cross-protective efficacy against heterosubtypic influenza virus

Aumiller, 2018, Protein cage assembly across multiple length scales, Chemical Society Reviews, 47, 3433, 10.1039/C7CS00818J Corbett, 2019, Design of nanoparticulate group 2 influenza virus hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages, MBio, 10, e02810, 10.1128/mBio.02810-18 Ekiert, 2009, Antibody recognition of a highly conserved influenza virus epitope, Science, 324, 246, 10.1126/science.1171491 Falvo, 2013, Antibody-drug conjugates: Targeting melanoma with cisplatin encapsulated in protein-cage nanoparticles based on human ferritin, Nanoscale, 5, 12278, 10.1039/c3nr04268e Frietze, 2016, Engineering virus-like particles as vaccine platforms, Current Opinion in Virology, 18, 44, 10.1016/j.coviro.2016.03.001 Harrison, 1996, The ferritins: Molecular properties, iron storage function and cellular regulation, Biochimica Biophysica Acta, 1275, 161, 10.1016/0005-2728(96)00022-9 Hoare, 1975, Structure of horse-spleen apoferritin at 6-a resolution, Nature, 255, 653, 10.1038/255653a0 Huang, 2013, PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine, Journal of Controlled Release, 172, 382, 10.1016/j.jconrel.2013.03.008 Ionescu, 2006, Pharmaceutical and immunological evaluation of human papillomavirus virus like particle as an antigen carrier, Journal of Pharmaceutical Sciences, 95, 70, 10.1002/jps.20493 Jegerlehner, 2002, A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses, Vaccine, 20, 3104, 10.1016/S0264-410X(02)00266-9 Kanekiyo, 2013, Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies, Nature, 499, 102, 10.1038/nature12202 Kolpe, 2017, M2-based influenza vaccines: Recent advances and clinical potential, Expert Review of Vaccines, 16, 123, 10.1080/14760584.2017.1240041 Li, 2006, Ferritin nanoparticle technology: A new platform for antigen presentation and vaccine development, Industrial Biotechnology, 2, 143, 10.1089/ind.2006.2.143 MaHam, 2009, Protein-based nanomedicine platforms for drug delivery, Small, 5, 1706, 10.1002/smll.200801602 Mougin, 2011, Hybrid capsules via self-assembly of thermoresponsive and interfacially active bionanoparticle-polymer conjugates, Advanced Functional Materials, 21, 2470, 10.1002/adfm.201002315 NIH, 2019 Qi, 2018, Intranasal nanovaccine confers homo- and hetero-subtypic influenza protection, Small, 14, e1703207, 10.1002/smll.201703207 Thong, 2019, Thermally-responsive virus-like particle for targeted delivery of cancer drug, Scientific Reports, 9, 3945, 10.1038/s41598-019-40388-x WHO, 2011 Xu, 2019, Development of meningococcal polysaccharide conjugate vaccine that can elicit long-lasting and strong cellular immune response with hepatitis B core antigen virus-like particles as a novel carrier protein, Vaccine, 37, 956, 10.1016/j.vaccine.2018.12.073 Yewdell, 1985, Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes, Proceedings of the National Academy of Sciences of the United States of America, 82, 1785, 10.1073/pnas.82.6.1785 Zhang, 2011, Self-assembly in the ferritin nano-cage protein superfamily, International Journal of Molecular Sciences, 12, 5406, 10.3390/ijms12085406 Zheng, 2014, Development of universal influenza vaccines based on influenza virus M and NP genes, Infection, 42, 251, 10.1007/s15010-013-0546-4