Apigenin inhibits NF-κB and Snail signaling, EMT and metastasis in human hepatocellular carcinoma

Oncotarget - Tập 7 Số 27 - Trang 41421-41431 - 2106
Yuan Qin1,2, Dong Zhao1,2, Honggang Zhou1,2, Xinghui Wang3, Weilong Zhong1,2, Shuang Chen2, Wenguang Gu1,2, Wei Wang1,2, Chunhong Zhang1,2, Yanrong Liu2, Huijuan Liu2, Qiang Zhang1,2, Yuan Guo1,2, Tao Sun1,2, Cheng Yang1,2
1State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China
2Tianjin Key Laboratory of Molecular Drug Research, Nankai University and Tianjin International Joint Academy of Biomedicine, Tianjin, China
3Department of Pathology, The People's Hospital of Shouguang City, Shouguang, Shandong Province, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Blay, 2013, Apigenin and its impact on gastrointestinal cancers, Mol Nutr Food Res, 57, 126, 10.1002/mnfr.201200424

Seth, 2015, Ethnomedicinal review of Usnakantaka (Echinops echinatus Roxb.), Pharmacogn Rev, 9, 149, 10.4103/0973-7847.162138

Katan, 1998, Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from anand a dietary supplement study, Am J Clin Nutr, 67, 255, 10.1093/ajcn/67.2.255

Xie, 2015, Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer, Mol Med Rep, 11, 1004, 10.3892/mmr.2014.2801

Xie, 2015, Apigenin inhibits the proliferation and invasion of osteosarcoma cells by suppressing the Wnt/beta-catenin signaling pathway, Oncol Rep, 34, 1035, 10.3892/or.2015.4022

Xuegang, 2013, Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT, J Nutr Biochem, 24, 1766, 10.1016/j.jnutbio.2013.03.006

Xie, 2013, Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells, Cancer Cell Int, 13, 54, 10.1186/1475-2867-13-54

Zhang, 2011, Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns, Phytomedicine, 18, 366, 10.1016/j.phymed.2010.08.006

Mukhtar, 2015, Dietary agents for prevention and treatment of lung cancer, Cancer Lett, 359, 155, 10.1016/j.canlet.2015.01.038

Andreeva, 2015, Apigenin Inhibits Growth of Breast Cancer Cells: The Role of ERalpha and HER2/neu, Acta Naturae, 7, 133, 10.32607/20758251-2015-7-3-133-139

Liu, 2015, Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3derived sphere-forming cells, Mol Med Rep, 11, 2221, 10.3892/mmr.2014.2974

Lim, 2016, Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress, Int J Oncol, 48, 399, 10.3892/ijo.2015.3243

Mikulits, 2011, A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression, Mol Cancer Ther, 10, 850, 10.1158/1535-7163.MCT-10-0917

Christofori, 2012, EMT as the ultimate survival mechanism of cancer cells, Semin Cancer Biol, 22, 194, 10.1016/j.semcancer.2012.02.013

Sen, 2014, Extracellular matrix density promotes EMT by weakening cell-cell adhesions, Mol Biosyst, 10, 838, 10.1039/C3MB70431A

Liu, 2011, Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: a study of hepatocellular carcinoma, Hepatology, 54, 1690, 10.1002/hep.24543

Jia, 2014, MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X, BMC Cancer, 14, 393, 10.1186/1471-2407-14-393

Albert, 2014, Network modeling of TGFbeta signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint sonic hedgehog and Wnt pathway activation, Cancer Res, 74, 5963, 10.1158/0008-5472.CAN-14-0225

Sun, 2015, Doxycycline reverses epithelial-to-mesenchymal transition and suppresses the proliferation and metastasis of lung cancer cells, Oncotarget, 6, 40667, 10.18632/oncotarget.5842

Giaccone, 2015, EMT is associated with, but does not drive resistance to ALK inhibitors among EML4-ALK non-small cell lung cancer, Mol Oncol

Alahari, 2009, Molecular mechanisms controlling E-cadherin expression in breast cancer, Biochem Biophys Res Commun, 384, 6, 10.1016/j.bbrc.2009.04.051

Sun, 2010, Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry, Hepatology, 51, 545, 10.1002/hep.23311

Peng, 2016, N-cadherin promotes epithelial-mesenchymal transition and cancer stem cell-like traits via ErbB signaling in prostate cancer cells, Int J Oncol, 48, 595, 10.3892/ijo.2015.3270

Zhou, 2010, Snail: More than EMT, Cell Adh Migr, 4, 199, 10.4161/cam.4.2.10943

Kitahara, 2016, Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells, Oncol Rep, 35, 261, 10.3892/or.2015.4348

Nieto, 2002, The snail superfamily of zinc-finger transcription factors, Nat Rev Mol Cell Biol, 3, 155, 10.1038/nrm757

Fang, 2013, Curcumin inhibits LPS-induced EMT through downregulation of NF-kappaB-Snail signaling in breast cancer cells, Oncol Rep, 29, 117, 10.3892/or.2012.2080

Garcia de Herreros, 2004, Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells, Oncogene, 23, 7345, 10.1038/sj.onc.1207990