Antiviral and immunological activity of zinc and possible role in COVID-19

British Journal of Nutrition - Tập 127 Số 8 - Trang 1172-1179 - 2022
Dilina do Nascimento Marreiro1, Kyria Jayanne Clímaco Cruz1, Ana Raquel Soares de Oliveira1, Jennifer Beatriz Silva Morais1, Betânia de Jesus e Silva de Almendra Freitas1, Stéfany Rodrigues de Sousa Melo1, Loanne Rocha dos Santos1, Bruna Emanuele Pereira Cardoso1, Thaline Milany da Silva Dias1
1Departament of Nutrition, Federal University of Piaui, Campus Minister Petrônio Portela, Teresina, PI, Brasil

Tóm tắt

Abstract

Zn deficiency compromises its biological functions, its effect on the immune system and its antiviral activity, increasing vulnerability to infectious diseases. This narrative review aims at presenting and discussing functional aspects and possible mechanisms involved in the potential role of Zn in the immune response and antiviral activity for coronavirus infectious disease-19 (COVID-19) prevention and control. The searches were conducted in PubMed and Science Direct databases, using clinical trials, experimental studies in animals and humans, case–control studies, case series, letters to the editor, and review articles published in English, without restrictions on year of publication. Search approach was based on using the terms: ‘zinc’, ‘COVID-19’, ‘antiviral agents’, ‘immunologic factors’ and ‘respiratory tract infections’. Literature shows the importance of Zn as an essential mineral immunomodulator with relevant antiviral activity in the body. Thus, although there is still a scarcity of studies evaluating Zn supplementation in patients with COVID-19, the results on the topic show the necessity of controlling Zn mineral deficiency, as well as maintaining its homoeostasis in the body in order to strengthen the immune system and improve the prevention of highly complex viral infections, such as that of the COVID-19.

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British Journal of Nutrition

Tập 127 Số 8

1172-1179

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