Antitumor effects of different Ganoderma lucidum spore powder in cell- and zebrafish-based bioassays

Zhao, 2018, The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network, Sci Rep, 8, 12680, 10.1038/s41598-018-30881-0 Pérez-Herrero, 2015, Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy, Eur J Pharm Biopharm, 93, 52, 10.1016/j.ejpb.2015.03.018 Ongnok, 2020, Doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions, Exp Neurol, 324, 10.1016/j.expneurol.2019.113118 Chen, 2019, Protective effect of Ganoderma (Lingzhi) on radiation and chemotherapy, Adv Exp Med Biol, 1182, 119, 10.1007/978-981-32-9421-9_4 Ruan, 2015, Distinct responses of cytotoxic Ganoderma lucidum triterpenoids in human carcinoma cells, Phytother Res, 29, 1744, 10.1002/ptr.5426 Ma, 2015, Anti-diabetic effects of Ganoderma lucidum, Phytochemistry, 114, 109, 10.1016/j.phytochem.2015.02.017 Qi, 2012, The anti-tumor mechanism of Ganderma lucidam: a review of the literature, Zhongguo Yao Xue Za Zhi, 11, 1781 Pan, 2013, Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities, Int J Biol Macromol, 55, 301, 10.1016/j.ijbiomac.2013.01.022 Zheng, 2012, Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells, Oncol Lett, 3, 613, 10.3892/ol.2011.515 Zhang, 2016, Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses, Food Funct, 7, 1872, 10.1039/C5FO01628B Sanodiya, 2009, Ganoderma lucidum: a potent pharmacological macrofungus, Curr Pharm Biotechnol, 10, 717, 10.2174/138920109789978757 Zhu, 2018, Synthesis and evaluation of herbal chitosan from Ganoderma lucidum spore powder for biomedical applications, Sci Rep, 8, 14608, 10.1038/s41598-018-33088-5 Zhao, 2014, Investigation of ice-assisted sonication on the microstructure and chemical quality of Ganoderma lucidum spores, J Food Sci, 79, E2253, 10.1111/1750-3841.12681 Xu, 2019, Researches and application of Ganoderma spores powder, Adv Exp Med Biol, 1181, 157, 10.1007/978-981-13-9867-4_6 Li, 2020, Screening immunoactive compounds of Ganoderma lucidum spores by mass spectrometry molecular networking combined with in vivo zebrafish assays, Front Pharmacol, 11, 287, 10.3389/fphar.2020.00287 Chinese Pharmacopoeia Commission, 2015, 188 Tang JQ, Feng N, Liu W, Wang JY, Zhou S, Zhang SJ, et al. A method for quantification of seventeen triterpenoids in Ganoderma lucidum. CN108181396A. 2018-06-19 [Chinese]. Zhang H, Li ZH, Fan XH. UPLC fingerprint combined with quantitative analysis of multi-components by single marker for quality assessment of Danshen Injection. Zhongguo Zhong Yao Za Zhi 2019;44(17):3724–31 [Chinese]. Pan, 2019, Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation, Cell Death Dis, 10, 456, 10.1038/s41419-019-1653-7 Smina, 2017, Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals, Mutat Res, 813, 45, 10.1016/j.mrgentox.2016.11.010 Spitsbergen, 2000, Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylhenz[a]anthracene by two exposure routes at different developmental stages, Toxicol Pathol, 28, 705, 10.1177/019262330002800511 Nicoli, 2007, The zebrafish/tumor xenograft angiogenesis assay, Nat Protoc, 2, 2918, 10.1038/nprot.2007.412 Brown, 2017, Zebrafish xenograft models of cancer and metastasis for drug discovery, Expert Opin Drug Discov, 12, 379, 10.1080/17460441.2017.1297416 Zhu, 2016, Closantel suppresses angiogenesis and cancer growth in zebrafish models, Assay Drug Dev Technol, 14, 282, 10.1089/adt.2015.679 Cabezas-Sainz, 2018, Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool, BMC Cancer, 18, 3, 10.1186/s12885-017-3919-8 Cör, 2018, Antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides: a review, Molecules, 23, 649, 10.3390/molecules23030649 Shen, 2019, Production of triterpenoid compounds from Ganoderma lucidum spore powder using ultrasound-assisted extraction, Prep Biochem Biotechnol, 22, 1 Li, 2017, The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo, Oncol Rep, 38, 2803, 10.3892/or.2017.6010 Xia, 2014, A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp, Molecules, 19, 17478, 10.3390/molecules191117478 Weng, 2008, Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1, Carcinogenesis, 29, 147, 10.1093/carcin/bgm261 Chen, 2010, Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression, Pharmacol Rep, 62, 150, 10.1016/S1734-1140(10)70252-8 Li, 2020, Purification, structural characterization, and immunomodulatory activity of the polysaccharides from Ganoderma lucidum, Int J Biol Macromol, 143, 806, 10.1016/j.ijbiomac.2019.09.141 Wu, 2013, Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum—a review, Expert Opin Invest Drugs, 22, 981, 10.1517/13543784.2013.805202 Sohretoglu, 2018, Ganoderma lucidum polysaccharides as an anti-cancer agent, Anticancer Agents Med Chem, 18, 667, 10.2174/1871520617666171113121246 Sliva, 2003, Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells, J Altern Complement Med, 9, 491, 10.1089/107555303322284776 Sliva, 2002, Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells, Biochem Biophys Res Commun, 298, 603, 10.1016/S0006-291X(02)02496-8 Yang W, Zhang YL, Niu KW. Effects of Ganoderma lucidum essence powder and Ganoderma lucidum spore powder on immune function of mice with Lewis lung cancer. Zhongguo Sheng Wu Zhi Pin Xue Za Zhi. 2012;25(9):1171–5 [Chinese]. Lin SR, Du S, Zheng HX. Research on the cellular immune function of glossy Ganoderma spores powder to the Lewis mice. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi 2005; 11(6): 428–33 [Chinese]. Stanley, 2005, Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-β1 from prostate cancer cells, Biochem Biophys Res Commun, 330, 46, 10.1016/j.bbrc.2005.02.116 Jiao, 2020, Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9, J Ethnopharmacol, 247, 10.1016/j.jep.2019.112256 Yeh, 2010, Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes, J Agric Food Chem, 58, 8535, 10.1021/jf100914m Liang, 2012, Recombinant LZ-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells, Oncol Rep, 27, 1079, 10.3892/or.2011.1593