Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV

EBioMedicine - Tập 81 - Trang 104090 - 2022
Marta Calvet-Mirabent1,2, Ildefonso Sánchez-Cerrillo1,2, Noa Martín-Cófreces1,3, Pedro Martínez-Fleta1, Hortensia de la Fuente1,3, Ilya Tsukalov2, Cristina Delgado-Arévalo1,2, María José Calzada2, Ignacio de los Santos4,5, Jesús Sanz4,5, Lucio García-Fraile4,5, Francisco Sánchez-Madrid1,2,3, Arantzazu Alfranca1, María Ángeles Muñoz-Fernández6, Maria J. Buzón7, Enrique Martín-Gayo1,2,5
1Immunology Unit from Hospital Universitario de La Princesa and Instituto de Investigación Sanitaria Princesa, Madrid, Spain
2Universidad Autónoma de Madrid, Madrid, Spain
3Centro de Investigación Biomédica en Red Cardiovascular, CIBERCV, 28029 Madrid, Spain
4Infectious Diseases Unit from Hospital Universitario de La Princesa, Madrid, Spain
5Centro de Investigación Biomédica en Red Infecciosas, CIBERINF, 28029 Madrid, Spain
6Immunology Section, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Hospital General Universitario Gregorio Marañón, Madrid, Spain
7Infectious Diseases Department, Institut de Recerca Hospital Univesritari Vall d'Hebrón (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain

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