Antiphospholipid syndrome

Asherson, 1989, The “primary” antiphospholipid syndrome, Medicine (Baltimore), 68, 366, 10.1097/00005792-198911000-00004 Bick, 1994, Hypercoagulability and thrombosis, Med Clin North Am, 78, 635, 10.1016/S0025-7125(16)30151-1 Bick, 1997, Antiphospholipid thrombosis syndromes, Int J Hematol, 65, 193, 10.1016/S0925-5710(96)00550-6 Rand, 2003, The antiphospholipid syndrome, Annu Rev Med, 54, 409, 10.1146/annurev.med.54.101601.152412 Bick, 2001, Antiphospholipid thrombosis syndrome, Clin Appl Thromb Haemost, 7, 241, 10.1177/107602960100700401 Conley, 1952, A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus, J Clin Invest, 31, 621 Bowie, 1963, Thrombosis in systemic lupus erythematosus despite circulating anticoagulants, J Lab Clin Med, 62, 416 Feinstein, 1972, Acquired inhibitors of blood coagulation, Prog Hemost Thromb, 1, 75 Nilsson, 1975, Intrauterine death and circulating anticoagulant “antithromboplastin”, Acta Med Scand, 197, 153, 10.1111/j.0954-6820.1975.tb04897.x Hughes, 1985, The anticardiolipin syndrome [editorial], Clin Exp Rheumatol, 3, 285 Harris, 1987, Antiphospholipid antibodies, J Rheumatol, 13, 208 Levine, 2002, The antiphospholipid syndrome, N Engl J Med, 346, 752, 10.1056/NEJMra002974 Petri, 2000, Epidemiology of the antiphospholipid antibody syndrome, J Autoimmun, 15, 145, 10.1006/jaut.2000.0409 Schved, 1994, A prospective epidemiological study on the occurrence of antiphospholipid antibody, Hemostasis, 24, 175 Vila, 1994, Prevalence follow-up and clinical significance of the anticardiolipin antibodies in normal subjects, Thromb Haemost, 72, 209, 10.1055/s-0038-1648840 Bick, 1992, Deep vein thrombosis, Semin Thromb Hemost, 18, 267, 10.1055/s-2007-1002434 Merkel, 1996, The prevalence and clinical associations of anticardiolipin antibodies in a large inception cohort of patients with connective tissue diseases, Am J Med, 101, 576, 10.1016/S0002-9343(96)00335-X Cervera, 1993, Systemic lupus erythematosus, The European Working Party on Systemic Lupus Erythematosus. Medicine, 72, 113 Love, 1990, Antiphospholipid antibodies, Ann Intern Med, 112, 682, 10.7326/0003-4819-112-9-682 Alarcón-Segovia, 1992, Preliminary classification criteria for antiphospholipid syndrome within systemic lupus erytematosus, Semin Arthritis Rheum, 21, 275, 10.1016/0049-0172(92)90021-5 Bevers, 1992, Cofactors involved in the antiphospholipid syndrome [editorial], Lupus, 1, 51, 10.1177/096120339200100201 Permpikul, 1994, Functional and binding studies of the roles of prothrombin and beta-2-glycoprotein I in the expression of lupus anticoagulant activity, Blood, 83, 2878, 10.1182/blood.V83.10.2878.2878 Harris, 1983, Anticardiolipin antibodies, Lancet, 2, 1211, 10.1016/S0140-6736(83)91267-9 Goldstein, 1996, MHC studies of the primary antiphospholipid antibody syndrome and of antiphospholipid antibodies in systemic lupus erythematosus, J Rheumatol, 23, 1173 Meroni, 2000, Endothelial activation by aPL, J Autoimmun, 15, 237, 10.1006/jaut.2000.0412 Ames, 1994, Antiphospholipid antibodies, thrombosis and atherosclerosis in systemic lupus erythematosus, Lupus, 3, 371, 10.1177/096120339400300503 Oosting, 1993, Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S, Blood, 81, 2618, 10.1182/blood.V81.10.2618.2618 Kandiah, 1994, Beta-2-glycoprotein I, Lupus, 3, 207, 10.1177/096120339400300401 Long, 1991, The relationship of antiphospholipid antibodies to thromboembolic disease in systemic lupus erythematosus, Thromb Haemost, 66, 520, 10.1055/s-0038-1646452 Provenzale, 1998, Systemic thrombosis in patients with antiphospholipid antibodies, AJR Am J Roentgenol, 170, 285, 10.2214/ajr.170.2.9456930 Vianna, 1994, Comparison of the primary and secondary antiphospholipid syndrome, Am J Med, 96, 3, 10.1016/0002-9343(94)90108-2 Bick, 1992, Anticardiolipin antibodies and thrombosis, Hematol Oncol Clin North Am, 6, 1287, 10.1016/S0889-8588(18)30275-2 Bick, 1999, Antiphospholipid syndrome and thrombosis, Semin Thromb Hemost, 25, 333, 10.1055/s-2007-994935 Ginsburg, 1992, Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis, Ann Intern Med, 117, 997, 10.7326/0003-4819-117-12-997 Boey, 1983, Thrombosis in systemic lupus erythematosus, Br Med J, 287, 1021, 10.1136/bmj.287.6398.1021 Elias, 1984, Thromboembolism in patients with the “lupus-like”-type circulating anticoagulant, Arch Intern Med, 144, 510, 10.1001/archinte.1984.00350150102029 Hall, 1984, Occlusive retinal vascular disease in systemic lupus erytematosus, J Rheumatol, 11, 846 Girolami, 1996, Thromboembolic disease developing during oral contraceptive therapy in young females with antiphospholipid antibodies, Blood Coagulation Fibrinolysis, 7, 497, 10.1097/00001721-199606000-00011 Schutt, 1998, Familial coexistence of primary antiphospholipid syndrome and factor V Leiden, Lupus, 7, 176, 10.1191/096120398678919967 Poux, 1996, Renal infarction and thrombosis of the infrarenal aorta in a 35-year-old man with primary antiphospholipid syndrome, Am J Kidney Dis, 27, 721, 10.1016/S0272-6386(96)90109-2 Kojima, 1997, Antiphospholipid syndrome complicated by thrombosis of the superior mesenteric artery, Intern Med, 36, 528, 10.2169/internalmedicine.36.528 Brey, 1990, Antiphospholipid antibodies and cerebral ischemia in young people, Neurology, 40, 1190, 10.1212/WNL.40.8.1190 Toschi, 1998, High prevalence of antiphosphatidylinositol antibodies in young patients with cerebral ischemia of undetermined cause, Stroke, 29, 1759, 10.1161/01.STR.29.9.1759 Nencini, 1992, Lupus anticoagulant and anticardiolipin antibodies in young adults with cerebral ischemia, Stroke, 23, 189, 10.1161/01.STR.23.2.189 Briley, 1989, Neurological diseases associated with antiphospholipid antibodies, Ann Neurol, 25, 221, 10.1002/ana.410250303 Weingarten, 1997, The neuroimaging features of the cardiolipin antibody syndrome, Clin Imag, 21, 6, 10.1016/0899-7071(95)00044-5 Anticardiolipin antibodies are an independent risk factor for first ischemic stroke. The Antiphospholipid Antibodies in Stroke Study (APASS) Group. Neurology 1993;43:2069-73 Carhuapoma, 1997, Cerebral venous thrombosis and anticardiolipin antibodies, Stroke, 28, 2363, 10.1161/01.STR.28.12.2363 Asherson, 1989, Sneddon's syndrome, Neurology, 39, 1138, 10.1212/WNL.39.8.1138 Frampton, 1988, Severe Guillain-Barré syndrome, J Neuroimmunol, 19, 133, 10.1016/0165-5728(88)90042-2 Levin, 1987, The spectrum of neurologic disease associated with anticardiolipin antibodies, Arch Neurol, 44, 876, 10.1001/archneur.1987.00520200078024 Oppenheimer, 1986, Optic neuritis and myelopathy in systemic lupus erytematosus, Can Neurol Sci, 13, 129, 10.1017/S0317167100036064 Asherson, 1986, Arterial occlusion causing large bowel infarction, Clin Rheumatol, 5, 102, 10.1007/BF02030977 Hamilton, 1991, Superior mesenteric artery thrombosis associated with antiphospholipid syndrome, West J Med, 155, 174 Asherson, 1985, Aortic arch syndrome associated with anticardiolipin antibodies and the lupus anticoagulant, Arthritis Rheum, 28, 594, 10.1002/art.1780280525 Asherson, 1986, Arterial occlusion causing large bowel infarction, Clin Rheumatol, 5, 102, 10.1007/BF02030977 Asherson, 1986, Myocardial infarction in a young male with systemic lupus erythematosus, deep vein thrombosis and antiphospholipid antibodies, Br Heart J, 56, 190, 10.1136/hrt.56.2.190 Vaarala, 1998, Antiphospholipid antibodies and myocardial infarction, Lupus, 7, S132, 10.1177/096120339800700229 Gavaghan TP, Krilis SA, Daggard GE, Baron DW, Hickie JB, Chesterman CN. Anticardiolipin antibodies and occlusion of coronary artery bypass grafts. 1987;2:977-8 Morton, 1986, Coronary artery bypass graft failure, Lancet, 2, 1353, 10.1016/S0140-6736(86)92004-0 Ludia, 1998, Antiphospholipid antibodies, Autoimmunity, 27, 141, 10.3109/08916939809003861 Galve, 1992, Valvular heart disease in primary antiphospholipid syndrome, Ann Intern Med, 116, 293, 10.7326/0003-4819-116-4-293 Chartash, 1989, Aortic insufficiency and mitral regurgitation in patients with systemic lupus erythematosus and the antiphospholipd syndrome, Am J Med, 86, 407, 10.1016/0002-9343(89)90337-9 Chartash, 1989, Aortic insufficiency and mitral regurgitation in patients with systemic lupus erythematosus and the antiphospholipid syndrome, Am J Med, 86, 407, 10.1016/0002-9343(89)90337-9 Leung, 1990, Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus, Am J Med, 89, 411, 10.1016/0002-9343(90)90368-N Nesher, 1997, Valvular dysfunction in antiphospholipid syndrome, Semin Arthritis Rheum, 27, 27, 10.1016/S0049-0172(97)80034-0 Bulckaen, 2003, Antiphospholipid antibodies and the risk of thromboembolic events in valvular heart disease, Mayo Clin Proc, 78, 294, 10.4065/78.3.294 Nzerue, 2002, “Black swan in the kidney:”, Kidney Int, 62, 733, 10.1046/j.1523-1755.2002.00500.x Isom, 2002, Nephrological and obstetric complications of the antiphospholipid syndrome, Expert Opin Investig Drugs, 11, 819, 10.1517/13543784.11.6.819 Nochy, 2002, Antiphospholipid syndrome nephropathy, J Nephrol, 15, 446 Luzzana, 2002, Up-date on the antiphospholipid syndrome, J Nephrol, 15, 342 Karmochkine, 1996, High prevalence of antiphospholipid antibodies in precapillary pulmonary hypertension, J Rheumatol, 23, 286 Miyashita, 1996, Asymptomatic pulmonary hypertension complicated with antiphospholipid syndrome case, Intern Med, 35, 912, 10.2169/internalmedicine.35.912 Kerr, 1997, Antiphospholipid antibody syndrome presenting as a refractory noninflammatory pulmonary vasculopathy, Chest, 112, 1707, 10.1378/chest.112.6.1707 Lee, 1997, Mesenteric and portal venous obstruction associated with primary antiphospholipid antibody syndrome, J Gastroenterol Hepatol, 12, 822, 10.1111/j.1440-1746.1997.tb00378.x Biron, 1998, Prevalence of antiphospholipid antibodies in patients with chronic liver disease related to alcohol or hepatitis C virus, J Lab Clin Med, 131, 243, 10.1016/S0022-2143(98)90096-8 Vivaldi, 1997, Severe bleeding due to acquired hypoprothrombinemia-lupus anticoagulant syndrome, Haematologica, 82, 345 Hudson, 1997, Catastrophic haemorrhage in a case of paediatric primary antiphospholipid syndrome and factor II deficiency, Lupus, 6, 68, 10.1177/096120339700600110 Cuadrado, 1997, Thrombocytopenia in the antiphospholipid syndrome, Ann Rheum Dis, 56, 194, 10.1136/ard.56.3.194 Macchi, 1997, Anti-platelet antibodies in patients with systemic lupus erythematosus and the primary antiphospholipid antibody syndrome, Br J Haematol, 98, 336, 10.1046/j.1365-2141.1997.2243038.x Asherson, 1986, Anticardiolipin antibodies, Postgrad Med J, 62, 1081, 10.1136/pgmj.62.734.1081 Weinstein, 1987, Livido reticularis associated with increased titers of anticardiolipin antibodies in systemic lupus erythematosus, Arch Dermatol, 123, 596, 10.1001/archderm.1987.01660290064017 Eng, 1994, Cutaneous expressions of antiphospholipid syndrome, Semin Thromb Heamost, 20, 71, 10.1055/s-2007-1001891 Wolf, 1991, Widespread cutaneous necrosis in a patient with rheumatoid arthritis associated with anticardiolipin antibodies, Arch Dermatol, 127, 1739, 10.1001/archderm.1991.01680100143034 Lockwood, 1994, The immunobiology and obstetrical consequences of antiphospholipid antibodies, Obstet Gynecol Surv, 49, 432, 10.1097/00006254-199406000-00026 Greaves, 2000, Guidelines on the investigation and management of the antiphospholipid syndrome, Br J Haematol, 109, 704, 10.1046/j.1365-2141.2000.02069.x Arkel, 2001, Thrombophilia and pregnancy, Clin Appl Thromb Hemost, 7, 259, 10.1177/107602960100700402 Erkan, 2002, The relation between antiphospholipid syndrome-related pregnancy morbidity and non-gravid vascular thrombosis, Curr Rheumatol Rep, 4, 379, 10.1007/s11926-002-0081-2 Branch, 2003, Antiphospholipid syndrome, Obstet Gynecol, 101, 1333, 10.1016/S0029-7844(03)00363-6 Lockshin, 1985, Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus, N Engl J Med, 313, 152, 10.1056/NEJM198507183130304 Oshiro, 1996, Antiphospholipid antibodies and fetal death, Obstet Gynecol, 87, 489, 10.1016/0029-7844(95)00498-X Harris, 1991, Should anticardiolipin tests be performed in otherwise healthy pregnant women?, Am J Obstet Gynecol, 165, 1272, 10.1016/S0002-9378(12)90741-3 Feinstein, 1992, Lupus anticoagulant, anticardiolipin antibodies, fetal loss and systemic lupus erythematosus, Blood, 80, 859, 10.1182/blood.V80.4.859.859 di Somone, 2000, Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta 2-glycoprotein I, Arthritis Rheum, 43, 140, 10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P Rand, 1997, Pregnancy loss in the antiphospholipid-antibody syndrome, N Engl J Med, 337, 154, 10.1056/NEJM199707173370303 Donohoe, 2000, Ontogeny of beta2-glycoprotein I and annexin V in villous placenta of normal and antiphospholipid pregnancies, Thromb Haemost, 84, 32, 10.1055/s-0037-1613963 Asherson, 1998, The catastrophic antiphospholipid syndrome, 1998, Lupus, 7, S55, 10.1177/096120339800700214 Asherson, 1998, Catastrophic antiphospholipid syndrome, Medicine (Baltimore), 77, 195, 10.1097/00005792-199805000-00005 Westney, 2002, Catastrophic antiphospholipid syndrome in the intensive care unit, Crit Care Clin, 18, 805, 10.1016/S0749-0704(02)00026-X Espinosa, 2003, Adrenal involvement in the antiphospholipid syndrome, Medicine, 82, 106, 10.1097/00005792-200303000-00005 Kitchens, 1998, Thrombotic storm, Am J Med, 104, 381, 10.1016/S0002-9343(98)00061-8 Intrator, 1988, Anticardiolipin antibodes in HIV infected patients with or without immune thrombocytopenic purpura, Br J Haematol, 67, 269, 10.1111/j.1365-2141.1988.tb06206.x Asherson, 2003, Human immunodeficiency virus infection, antiphospholipid antibodies, and the antiphospholipid syndrome [editorial], J Rheumatol, 30, 214 Canoso, 1987, Anticardiolipin antibodies associated with HTLV-III infection, Br J Haematol, 65, 495, 10.1111/j.1365-2141.1987.tb04157.x Panzer, 1989, Anticardiolipin antibodies are elevated in HIV-1 infected haemophiliacs but do not predict for disease progression, Thromb Haemost, 61, 81, 10.1055/s-0038-1646531 Stimmler, 1989, Anticardiolipin antibodies in acquired immune deficiency syndrome, Arch intern Med, 149, 1833, 10.1001/archinte.1989.00390080091020 Vaarala, 1986, Anticardiolipin response in acute infections, Clin Immunol Immunopathol, 41, 8, 10.1016/0090-1229(86)90046-2 Violi, 1990, Dilute aPTT prolongation by antiphospholipid antibodies in patients with liver cirrhosis, Thromb Haemost, 63, 183, 10.1055/s-0038-1645192 Harrison, 1987, Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use, Arch Pathol Lab Med, 111, 719 Lillicrap, 1990, Heterogeneity of laboratory test results for antiphospholipid antibodies in patients treated with chlorpromazine and other phenothiazines, Am J Clin Pathol, 93, 771, 10.1093/ajcp/93.6.771 Wilson, 1999, International consensus statement on preliminary classification criteria for definitive antiphospholipid syndrome, Atrhritis Rheum, 42, 1309, 10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F Brandt, 1995, Criteria for the diagnosis of lupus anticoagulants, On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost, 74, 1185 Alarcón-Segovia, 1989, Antiphospholipid antibodies and antiphospholipid syndrome in systemic lupus erythematosus, Medicine (Baltimore), 68, 353, 10.1097/00005792-198911000-00003 Alarcón-Segovia, 1989, Primary antiphospholipid syndrome, J Rheumatol, 16, 482 Hughson, 1995, Spectrum of vascular pathology affecting patients with antiphospholipid syndrome, Hum Pathol, 26, 716, 10.1016/0046-8177(95)90218-X Lie, 1996, Pathology of antiphospholipid syndrome, 89 Laflan, 1995, Investigation of hemostasis, 298 Hathaway, 1993 Galli, 1998, Prothrombin as cofactor for antiphospholipids, Lupus, 7, S37, 10.1177/096120339800700209 Galli, 1995, Kaolin clotting time and dilute Russell's viper venom time distinguish between prothrombin-dependent and beta 2-glycoprotein I-dependent antiphospholipid antibodies, Blood, 86, 617, 10.1182/blood.V86.2.617.bloodjournal862617 Arnout, 1994, Optimization of the dilute prothrombin time for the detection of lupus anticoagulant by use of a recombinant human tissue thromboplastin, Br J Heamatol, 87, 94, 10.1111/j.1365-2141.1994.tb04876.x Liu, 1989, The reappraisal of dilute tissue thromboplastin inhibition test in the diagnosis of lupus anticoagulant, Br J Haematol, 72, 229, 10.1111/j.1365-2141.1989.tb07687.x Forastiero, 1994, Evaluation of recently described tests for detection of the lupus anticoagulant, Thromb Haemost, 72, 728, 10.1055/s-0038-1648949 Sanmarco, 1997, Prevalence and clinical significance of IgG isotype anti-beta 2-glycoprotein I antibodies in antiphospholipid syndrome, J Lab Clin Med, 129, 499, 10.1016/S0022-2143(97)90004-4 Zanon E, Prandoni P, Vianello F, Saggiorato G, Carraro G, Bagatella P, et al. Anti-beta2-glycoprotein I antibodies in patients with acute venous thromboembolism: prevalence and association with recurrent thromboembolism. Thromb Res 1999;96:269-74 Hajjar KA, Jacovina AT, Chacko J. An endothelial cell receptor for plasminogen/tissue plasminogen activator. I: Identity with annexin II. J Biol Chem 1994;269:21191-7 Cesarman GM, Guevara CA, Hajjar KA. An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II: Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J Biol Chem 1994;269:21198-203 Lenzi, 1986, Anticardiolipin antibodies in pregnant patients with systemic lupus erythematosus [letter], N Engl J Med, 314, 1392, 10.1056/NEJM198605223142118 McCrae, 1996, Antiphospholipid antibody associated thrombosis, Lupus, 5, 560, 10.1177/096120339600500602 Urfer, 1996, Antiphospholipid antibodies syndrome, Schweiz Med Wochenschr, 126, 2136 Erkan, 2001, High thrombosis rate after fetal loss in antiphospholipid syndrome, Arthritis Rheum, 44, 1466, 10.1002/1529-0131(200106)44:6<1466::AID-ART242>3.0.CO;2-C Petri, 1996, Hydroxychloroquine use in the Baltimore Lupus Cohort, Lupus, 5, S16, 10.1177/096120339600500105 Wallace, 1996, The use of chloroquine and hydroxychloroquine for non-infectious conditions other than rheumatoid arthritis or lupus, Lupus, 5, S59, 10.1177/096120339600500113 Khamashta, 1995, The management of thrombosis in the antiphospholipid-antibody syndrome, N Engl J Med, 332, 993, 10.1056/NEJM199504133321504 Rosove, 1992, Antiphospholipid thrombosis, Ann Intern Med, 117, 303, 10.7326/0003-4819-117-4-303 Derksen, 1993, Patients with antiphospholipid antibodies and venous thrombosis should receive long term anticoagulant treatment, Ann Rheum Dis, 52, 689, 10.1136/ard.52.9.689 Ginsberg, 1995, Antiphospholipid antibodies and venous thromboembolism, Blood, 86, 3685, 10.1182/blood.V86.10.3685.bloodjournal86103685 Schulman, 1998, Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy, Duration of Anticoagulation Study Group. Am J Med, 104, 332 Douketis, 1999, The effects of low-intensity warfarin on coagulation activation in patients with antiphospholipid antibodies and systemic lupus erythematosus, Thromb Haemost, 82, 1028, 10.1055/s-0037-1614324 Finazzi, 1996, Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies, Am J Med, 100, 530, 10.1016/S0002-9343(96)00060-5 Moll, 1997, Monitoring warfarin therapy in patients with lupus anticoagulants, Ann Intern Med, 127, 177, 10.7326/0003-4819-127-3-199708010-00001 Della Valle, 1996, Potential failure of the international normalized ratio (INR) system in the monitoring of oral anticoagulation in patients with lupus anticoagulants, Ann Med Interne (Paris), 147, 10 Le, 1994, The international normalized ratio (INR) for monitoring warfarin therapy, Ann Intern Med, 120, 552, 10.7326/0003-4819-120-7-199404010-00004 Ciavarella, 1980, Multicenter evaluation of a new chromogenic factor X assay in plasma of patients on oral anticoagulants, Thromb Res, 19, 493, 10.1016/0049-3848(80)90022-5 Lind, 1997, Plasma levels of factors II, VII and X and their relationship to the international normalized ratio during chronic warfarin therapy, Blood Coagulation Fibrinoloysis, 8, 48, 10.1097/00001721-199701000-00008 Camps Garcia, 1996, Fibrinolytic treatment in primary antiphospholipid syndrome, Lupus, 5, 627, 10.1177/096120339600500613 Julkunen H, Hedman C, Kauppi M. Thrombolysis for acute ischemic stroke in the primary antiphospholipid syndrome. J Rheumatol 24:181-3 Ho, 1996, Successful treatment of acute myocardial infarction by thrombolytic therapy in a patient with primary antiphospholipid antibody syndrome, Cardiology, 87, 354, 10.1159/000177119 Cowchock, 1992, Repeated fetal losses associated with antiphospholipid antibodies, Am J Obstet Gynecol, 166, 1318, 10.1016/0002-9378(92)91596-3 Kutteh, 1996, Antiphospholipid antibody-associated recurrent pregnancy loss, Am J Obstet Gynecol, 174, 1584, 10.1016/S0002-9378(96)70610-5 Rai, 1997, Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies), BMJ, 314, 253, 10.1136/bmj.314.7076.253 Pattison, 2000, Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome?, a randomized controlled trial. Am J Obstet Gynecol, 183, 1008, 10.1067/mob.2000.106754 Ginsberg, 2001, Use of antithrombotic agents during pregnancy, Chest, 119, S122, 10.1378/chest.119.1_suppl.122S Sanson, 1999, Safety of low-molecular-weight heparin in pregnancy, Thromb Haemost, 81, 668, 10.1055/s-0037-1614550 Ginsberg, 1989, Risks to the fetus of anticoagulant therapy during pregnancy, Thromb Haemost, 61, 197, 10.1055/s-0038-1646558 Ginsberg, 1989, Heparin therapy during pregnancy, Arch Intern Med, 149, 2233, 10.1001/archinte.1989.00390100059015 Dulitzki, 1996, Low molecular weight heparin during pregnancy and delivery, Obstet Gynecol, 87, 380, 10.1016/0029-7844(95)00452-1 Casele, 1999, Changes in the pharmacokinetics of the low molecular weight heparin enoxaparin sodium during pregnancy, Am J Obstet Gynecol, 181, 1113, 10.1016/S0002-9378(99)70091-8 Hunt, 1997, Thromboprophylaxis with low molecular weight heparin (Fragmin) in high risk pregnancies, Thromb Haemost, 77, 39, 10.1055/s-0038-1655903 Blomback, 1998, Thromboprophylaxis with low molecular mass heparin, “Fragmin” (dalteparin), during pregnancy, Blood Coagulation Fibrinolysis, 9, 1 Cowchock, 1997, Do low-risk pregnant women with antiphospholipid antibodies need to be treated?, Organizing Group of the Antiphospholipid Antibody Treatment Trial. Am J Obstet Gynecol, 176, 1099