Antioxidant effect of ethanolic onion (Allium cepa) husk extract in ageing rats

Akash, 2014, Spice plant Allium cepa: Dietary supplement for treatment of type 2 diabetes mellitus, Nutrition, 30, 1128, 10.1016/j.nut.2014.02.011 Aremu, 2019, In vitro and in vivo antioxidant properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-induced hypertensive rats, Antioxidants, 8, 309, 10.3390/antiox8080309 Arora, 2017, Screening and evaluation of bioactive components of Cenchrus ciliaris L. by GC-MS analysis, Int. Res. J. Pharm., 8, 69, 10.7897/2230-8407.08699 Arung, 2011, Anti-melanogenesis properties of quercetin and its derivative-rich extract from Allium cepa, Food Chem., 124, 1024, 10.1016/j.foodchem.2010.07.067 Aversa, 2016, One can slow down the aging through antioxidants, Am. J. Eng. Appl. Sci., 9, 1112, 10.3844/ajeassp.2016.1112.1126 Beers, 1952, A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase, J. Biol. Chem., 195, 133, 10.1016/S0021-9258(19)50881-X Bardaweel, S.K., Gul, M., Alzweiri, M., Ishaqat, A., ALSalamat, H.A., Bashatwah, R.M., 2018. Reactive oxygen species: The dual role in physiological and pathological conditions of the human body. Eurasian J. Med. 50(3), 193–201. https://doi.org/10.5152/eurasianjmed.2018.17397. Bedrnícek, 2020, Onion peel powder as an antioxidant-rich material for sausages prepared from mechanically separated fish meat, Antioxidants, 9, 974, 10.3390/antiox9100974 Bedrníček, 2019, Onion waste as a rich source of antioxidants for meat products, Czech J. Food Sci., 37, 268, 10.17221/68/2018-CJFS Benítez, 2011, Characterization of Industrial Onion Wastes (Allium cepa L.): Dietary Fibre and Bioactive Compounds, Plant Foods Hum. Nutr., 66, 48, 10.1007/s11130-011-0212-x Benítez, 2012, Onion (Allium cepa L.) by-products as source of dietary fiber: Physicochemical properties and effect on serum lipid levels in high-fat fed rats, Eur. Food Res. Technol., 234, 617, 10.1007/s00217-012-1674-2 Benkeblia, 2005, Free-radical scavenging capacity and antioxidant properties of some selected onions (Allium cepa L.) and garlic (Allium sativum L.) extracts. Brazilian Arch, Biol. Technol., 48, 753, 10.1590/S1516-89132005000600011 Benzie, 1996, The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: The FRAP assay, Anal. Biochem., 239, 70, 10.1006/abio.1996.0292 Bondy, 1992, Ethanol toxicity and oxidative stress, Toxicol. Lett., 63, 231, 10.1016/0378-4274(92)90086-Y Brazhe, 2014, Studies of the blood antioxidant system and oxygen-transporting properties of human erythrocytes during 105-day isolation, Hum. Physiol., 40, 804, 10.1134/S0362119714070020 Burri, S.C.M., Ekholm, A., Håkansson, Å., Tornberg, E., Rumpunen, K., 2017. Antioxidant capacity and major phenol compounds of horticultural plant materials not usually used. J. Funct. Foods. 38(Part A), 119–127. https://doi.org/10.1016/j.jff.2017.09.003. Cui, 2020, Plant-derived antioxidants protect the nervous system from aging by inhibiting oxidative stress, Front. Aging Neurosci., 12, 209, 10.3389/fnagi.2020.00209 Ellman, 1959, Tissue sulfhydryl groups, Arch. Biochem. Biophys., 82, 70, 10.1016/0003-9861(59)90090-6 Freitas, 2017, Fatty acids, antioxidants and physical activity in brain aging, Nutrients., 9, 1263, 10.3390/nu9111263 FooDB. https://foodb.ca/ (accessed 30 November 2020). Galadari, 2017, Reactive oxygen species and cancer paradox: To promote or to suppress?, Free Radic. Biol. Med., 104, 144, 10.1016/j.freeradbiomed.2017.01.004 Gharib, 2008, Antispasmodic Activity of Onion (Allium cepa L.) Peel Extract on Rat Ileum, Iran. J. Pharm. Res., 7, 155 Go, 2017, Redox theory of aging: Implications for health and disease, Clin. Sci., 131, 1669, 10.1042/CS20160897 Hariharapura, 2014, Investigation of the Antioxidant and Hepatoprotective Potential of Hypericum mysorense, Antioxidants., 3, 526, 10.3390/antiox3030526 Hayes, 2020, Oxidative stress in cancer, Cancer Cell., 38, 167, 10.1016/j.ccell.2020.06.001 Helen, 2000, Antioxidant effect of onion oil (Allium cepa. Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol, Toxicol. Lett., 116, 61, 10.1016/S0378-4274(00)00208-3 Hernández, 2016, Lipids and oxidative stress associated with ethanol-induced neurological damage, Oxid. Med. Cell. Longev., 2016, 1543809, 10.1155/2016/1543809 Hollman, 2000, Flavonols, flavones and flavanols - Nature, occurrence and dietary burden, J. Sci. Food Agric., 80, 1081, 10.1002/(SICI)1097-0010(20000515)80:7<1081::AID-JSFA566>3.0.CO;2-G Ige, 2020, Allium Cepa remediates oxidative stress-mediated hepatic DNA damage in cadmium-exposed rats through enhanced p53 expression and inhibition of Bcl2, Int. J. Biomed. Sci., 16, 11, 10.59566/IJBS.2020.16011 Kim, 2007, Effects of onion (Allium cepa) skin extract on pancreatic lipase and body weight-related parameters, Food Sci. Biotechnol., 16, 434 Kim, 2010, Antioxidant activity and α-glucosidase inhibitory potential of onion (Allium cepa L.) extracts, Food Sci. Biotechnol., 19, 159, 10.1007/s10068-010-0022-1 Kotenkova, 2019, Comparative antioxidant study of onion and garlic waste and bulbs, IOP Conf. Ser. Earth Environ. Sci., 333, 10.1088/1755-1315/333/1/012031 Kupaeva, 2019, Search for alternative sources of natural plant antioxidants for food industry, Food Syst., 2, 17, 10.21323/2618-9771-2019-2-3-17-19 Kwak, 2017, Variation of quercetin glycoside derivatives in three onion (Allium cepa L.) varieties. Saudi, J. Biol. Sci., 24, 1387 Liguori, 2018, Oxidative stress, aging, and diseases, Clin. Interv. Aging., 13, 757, 10.2147/CIA.S158513 Lubrano, 2015, Enzymatic antioxidant system in vascular inflammation and coronary artery disease, World J. Exp. Med., 5, 218, 10.5493/wjem.v5.i4.218 Malfa, 2020, The antioxidant activities of Betula etnensis Rafin. Ethanolic extract exert protective and anti-diabetic effects on streptozotocin-induced diabetes in rats, Antioxidants, 9, 847, 10.3390/antiox9090847 Malta, 2014, Analyses of total phenolics, total flavonoids, and total antioxidant activities in foods and dietary supplements, 305 Marklund, 1974, Involment of the Superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase, Eur. J. Biochem., 47, 469, 10.1111/j.1432-1033.1974.tb03714.x Marrelli, 2019, Biological properties and bioactive components of Allium cepa L.: Focus on potential benefits in the treatment of obesity and related comorbidities, Molecules., 24, 119, 10.3390/molecules24010119 Meng, 2017, The decay of redox-stress response capacity is a substantive characteristic of aging: revising the redox theory of aging, Redox Biol., 11, 365, 10.1016/j.redox.2016.12.026 Mittler, 2017, ROS Are Good, Trends Plant Sci., 22, 11, 10.1016/j.tplants.2016.08.002 Namdev, 2015, Herbal green tea formulation using Withania somniferastems, Terminalia arjuna bark, Cinnamon bark and Tinospora cordifolia stems and nutritional & phytochemical analysis, J. Pharmacogn. Phytochem., 4, 282 National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/ (accessed 30 November 2020). National Institute of Standards and Technology. https://www.nist.gov/ (accessed 30 November 2020). Obanda, 1997, Flavanol composition and caffeine content of green leaf as quality potential indicators of Kenyan black teas, J. Sci. Food Agric., 74, 209, 10.1002/(SICI)1097-0010(199706)74:2<209::AID-JSFA789>3.0.CO;2-4 Ogbuagu, 2019, Prophylactic propensity of methanolic extract of Vernonia amygdalina leaves against acute ethanol-induced oxidative stress in wistar rats, J. BioSci. Biotechnol., 11, 37 Ojieh, 2015, Hypoglycemic and hypolipidaemic effect of Allium Cepa in streptozotocin-induced diabetes, Int. J. Sci. Eng. Res., 6, 23 Okoro, 2019, Ameliorative effects of Allium cepa extract on carbon tetrachloride neurotoxicity in rat, Thai J. Pharm. Sci., 43, 14 Oyewole, 2014, Comparing the effects of mitochondrial targeted and localized antioxidants with cellular antioxidants in human skin cells exposed to UVA and hydrogen peroxide, FASEB J., 28, 485, 10.1096/fj.13-237008 Piechowiak, 2020, Optimization of extraction process of antioxidant compounds from yellow onion skin and their use in functional bread production, LWT., 117, 10.1016/j.lwt.2019.108614 Pohl, 2018, The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: In vitro, in vivo and clinical trials, Molecules., 23, 3283, 10.3390/molecules23123283 Prasad, 2017, Telomere shortening during aging: Attenuation by antioxidants and anti-inflammatory agents, Mech. Ageing Dev., 164, 61, 10.1016/j.mad.2017.04.004 Ren, 2020, Effect of storage, food processing and novel extraction technologies on onions flavonoid content: A review, Food Res. Int., 132, 10.1016/j.foodres.2019.108953 Sadowska-Bartosz, 2014, Effect of antioxidants supplementation on aging and longevity, BioMed Res. Int., 2014, 10.1155/2014/404680 Saravanan, 2005, Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats, BMC Complement. Altern. Med., 5, 14, 10.1186/1472-6882-5-14 Siddeeg, A., AlKehayez, N.M., Abu-Hiamed, H.A., Al-Sanea, E.A., AL-Farga, A.M. 2021. Mode of action and determination of antioxidant activity in the dietary sources: An overview. Saudi J. Biol. Sci. 28, 1633–1644. https://doi.org/10.1016/j.sjbs.2020.11.064. Sidhu, 2019, Onion (Allium cepa L.) is potentially a good source of important antioxidants, J. Food Sci. Technol., 56, 1811, 10.1007/s13197-019-03625-9 Teshika, 2019, Traditional and modern uses of onion bulb (Allium cepa L.): a systematic review, Crit. Rev. Food Sci. Nutr., 59, S39, 10.1080/10408398.2018.1499074 Vaiserman, 2020, Nanodelivery of natural antioxidants: an anti-aging perspective, Front. Bioeng. Biotechnol., 7, 447, 10.3389/fbioe.2019.00447 Yegorov, 2020, Healthy aging: antioxidants, uncouplers and/or telomerase?, Mol. Biol., 54, 311, 10.1134/S002689332003005X Zaki, 2019, Evaluation of antioxidant and anti-lipid peroxidation potentials of Nigella sativa and onion extract on nicotine-induced lung damage, Folia Morphol., 78, 554, 10.5603/FM.a2018.0117 Zhao, 2016, Protective effects of Genistein and Puerarin against chronic alcohol-induced liver injury in mice via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, J. Agric. Food Chem., 64, 7291, 10.1021/acs.jafc.6b02907