Antineoplastic effects of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, on lung adenocarcinoma (A549) cells

Nuñez, 1998, Caspases: the proteases of the apoptotic pathway, Oncogene, 17, 3237, 10.1038/sj.onc.1202581 Kaufmann, 2000, Induction of apoptosis by cancer chemotherapy, Exp Cell Res, 256, 42, 10.1006/excr.2000.4838 Hammer, 1993, Tapping an Amazônian plethora: four medicinal plants of Marajó Island, Pará (Brazil), J Ethanopharmocol, 40, 53, 10.1016/0378-8741(93)90089-N Sankar, 2001, Antiinflammatory activity of Elephantopus scaber in albino rats, Indian J Pharm Sci, 63, 523 Daisy, 2010, Hypolipidemic and renal functionality potentials of the hexane extract fractions of Elephantopus scaber Linn, Int J Biomed Sci, 6, 241 Rajesh, 2001, Hepatoprotection by Elephantopus scaber Linn. in CCl4-induced liver injury, Indian J Physiol Pharmacol, 45, 481 Daisy, 2009, A novel steroid from Elephantopus scaber L. an ethanomedicinal plant with antidiabetic activity, Phytomedicine, 16, 252, 10.1016/j.phymed.2008.06.001 Geetha, 2010, Evaluation of Elephantopus scaber on the inhibition of chemical carcinogenesis and tumor development in mice, Pharm Biol, 48, 342, 10.3109/13880200903133845 Singh, 2005, Wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn, Indian J Pharmacol, 37, 238, 10.4103/0253-7613.16570 Geetha, 2012, Sesquiterpene lactones isolated from Elephantopus scaber L. inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitro, J Biomed Biotechnol, 2012, 721285, 10.1155/2012/721285 Huang, 2010, Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice, Br J Pharmacol, 159, 856, 10.1111/j.1476-5381.2009.00581.x Su, 2009, Antiproliferative activities of five Chinese medicinal herbs and active compounds in Elephantopus scaber, Nat Prod Commun, 4, 1025 Than, 2005, Sesquiterpene lactones from Elephantopus scaber, Z Naturforsch, 60b, 200, 10.1515/znb-2005-0212 Su, 2011, Deoxyelephantopin from Elephantopus scaber L. induces cell-cycle arrest and apoptosis in the human nasopharyngeal cancer CNE cells, Biochem Biophys Res Commun, 411, 342, 10.1016/j.bbrc.2011.06.144 Katz, 2008, Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening, Biotechniques, 44, ix, 10.2144/000112757 Liu, 2004, Potential synergy of phytochemicals in cancer prevention: mechanism of action, J Nutr, 134, 3479S, 10.1093/jn/134.12.3479S Xu, 2006, Antitumor activities of the four sesquiterpene lactones from Elephantopus scaber L, Exp Oncol, 28, 106 Lee, 2012, Deoxyelephantopin impedes mammary adenocarcinoma cell motility by inhibiting calpain-mediated adhesion dynamics and inducing reactive oxygen species and aggresome formation, Free Radic Biol Med, 52, 1423, 10.1016/j.freeradbiomed.2012.01.020 Zhang, 2005, Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms, Curr Med Chem Anticancer Agents, 5, 239, 10.2174/1568011053765976 Varalakshmi, 2011, In vitro safety assessment of effect of five medicinal plants on human peripheral lymphocytes, Trop J Pharm Res, 10, 33, 10.4314/tjpr.v10i1.66539 Aithal, 2009, Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells, Cell Biol Int, 33, 1039, 10.1016/j.cellbi.2009.06.018 Budihardjo, 1999, Biochemical pathways of caspase activation during apoptosis, Annu Rev Cell Dev Biol, 15, 269, 10.1146/annurev.cellbio.15.1.269 Robertson, 2002, Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis, J Biol Chem, 277, 29803, 10.1074/jbc.M204185200 Li, 1997, Activation of caspase-2 in apoptosis, J Biol Chem, 272, 21010, 10.1074/jbc.272.34.21010 Lavrik, 2006, Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis, Blood, 108, 559, 10.1182/blood-2005-07-007096 Nicholson, 1995, Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis, Nature, 376, 37, 10.1038/376037a0 Carnero, 2002, Targeting the cell cycle for cancer therapy, Br J Cancer, 87, 129, 10.1038/sj.bjc.6600458 Hartwell, 1989, Checkpoints: controls that ensure the order of cell cycle events, Science, 246, 629, 10.1126/science.2683079 Lewin, 1990, Driving the cell cycle: M phase kinases, its partners, and substrates, Cell, 61, 743, 10.1016/0092-8674(90)90181-D Makin, 2000, Apoptosis and cancer chemotherapy, Cell Tissue Res, 301, 143, 10.1007/s004419900160