Antimuscarinics for the treatment of overactive bladder: A review of central nervous system effects

Current Bladder Dysfunction Reports - Tập 2 Số 4 - Trang 227-233 - 2007
Klausner, Adam P.1, Steers, William D.
1Division of Urology, Virginia Commonwealth University School of Medicine, Richmond, USA

Tóm tắt

Antimuscarinic drugs commonly used to treat overactive bladder are often associated with central nervous system (CNS) side effects including cognitive dysfunction, memory impairment, dizziness, fatigue, and headache. New agents show reduced CNS penetrance and better selectivity for the M3 muscarinic receptor. However, changes associated with aging may lead to alterations in blood-brain barrier permeability. Therefore, use of antimuscarinics in the elderly or in patients with Alzheimer’s disease presents a significant challenge. This review highlights muscarinic receptor distribution and function in the CNS, provides a description and incidence of CNS side effects with therapy, offers information specific to currently available agents, and describes the use of antimuscarinics in special populations including children, the elderly, and patients with Alzheimer’s disease.

Tài liệu tham khảo

citation_journal_title=Neurourol Urodyn; citation_title=The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society; citation_author=P. Abrams, L. Cardozo, M. Fall; citation_volume=21; citation_publication_date=2002; citation_pages=167-178; citation_doi=10.1002/nau.10052; citation_id=CR1 citation_journal_title=Eur Urol; citation_title=Prevalence of the overactive bladder syndrome by applying the International Continence Society definition; citation_author=C. Temml, S. Heidler, A. Ponholzer, S. Madersbacher; citation_volume=48; citation_publication_date=2005; citation_pages=622-627; citation_doi=10.1016/j.eururo.2005.04.026; citation_id=CR2 citation_journal_title=World J Urol; citation_title=Prevalence and burden of overactive bladder in the United States; citation_author=W.F. Stewart, J.B. Rooyen, G.W. Cundiff; citation_volume=20; citation_publication_date=2003; citation_pages=327-336; citation_id=CR3 citation_journal_title=BJU Int; citation_title=The impact on health-related quality of life of stress, urge and mixed urinary incontinence; citation_author=K.S. Coyne, Z. Zhou, C. Thompson, E. Versi; citation_volume=92; citation_publication_date=2003; citation_pages=731-735; citation_doi=10.1046/j.1464-410X.2003.04463.x; citation_id=CR4 citation_journal_title=Pharmacotherapy; citation_title=Costs associated with the management of overactive bladder and related comorbidities; citation_author=T. Darkow, C.L. Fontes, T.E. Williamson; citation_volume=25; citation_publication_date=2005; citation_pages=511-519; citation_doi=10.1592/phco.25.4.511.61033; citation_id=CR5 Nabi G, Cody JD, Ellis G, et al.: Anticholinergic drugs versus placebo for overactive bladder syndrome in adults. Cochrane Database Syst Rev 2006, CD003781. Sanctura (trospium chloride) 20 mg tablets prescribing information. Available at http://www.sanctura.com/pdf/sanctura_pi.pdf . Accessed February 1, 2007. Detrol LA tolterodine tartrate extended release capsules: prescribing information. Available at http://www.detrolla.com/cwpb/appmanager/detrolLA/detrolLADesktop?_nfpb=true&_pageLabel=detrolLA_prescribingInformation . Accessed February 1, 2007. citation_journal_title=Eur Urol; citation_title=Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study; citation_author=D.E. Irwin, I. Milsom, S. Hunskaar; citation_volume=50; citation_publication_date=2006; citation_pages=1306-1314; citation_doi=10.1016/j.eururo.2006.09.019; citation_id=CR9 citation_journal_title=Arch Intern Med; citation_title=Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts; citation_author=D.M. Fick, J.W. Cooper, W.E. Wade; citation_volume=163; citation_publication_date=2003; citation_pages=2716-2724; citation_doi=10.1001/archinte.163.22.2716; citation_id=CR10 citation_journal_title=Curr Urol Rep; citation_title=Muscarinic receptors: what we know; citation_author=H.M. Scarpero, R.R. Dmochowski; citation_volume=4; citation_publication_date=2003; citation_pages=421-428; citation_doi=10.1007/s11934-003-0021-3; citation_id=CR11 citation_journal_title=Br J Pharmacol; citation_title=Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder; citation_author=P. Abrams, K.E. Andersson, J.J. Buccafusco; citation_volume=148; citation_publication_date=2006; citation_pages=565-578; citation_doi=10.1038/sj.bjp.0706780; citation_id=CR12 citation_journal_title=Nature; citation_title=Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean; citation_author=M. Yamada, T. Miyakawa, A. Duttaroy; citation_volume=410; citation_publication_date=2001; citation_pages=207-212; citation_doi=10.1038/35065604; citation_id=CR13 citation_journal_title=Eur Urol; citation_title=Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder; citation_author=F. Haab, L. Stewart, P. Dwyer; citation_volume=45; citation_publication_date=2004; citation_pages=420-429; citation_doi=10.1016/j.eururo.2004.01.008; citation_id=CR14 citation_journal_title=Clin Ther; citation_title=Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: the VESIcare Open-Label Trial (VOLT); citation_author=A.D. Garely, J.M. Kaufman, P.K. Sand; citation_volume=28; citation_publication_date=2006; citation_pages=1935-1946; citation_doi=10.1016/j.clinthera.2006.11.010; citation_id=CR15 citation_journal_title=J Urol; citation_title=Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder; citation_author=L. Cardozo, M. Lisec, R. Millard; citation_volume=172; citation_publication_date=2004; citation_pages=1919-1924; citation_doi=10.1097/01.ju.0000140729.07840.16; citation_id=CR16 citation_title=Darifenacin is selective for the human recombinant M3 receptor subtype [abstract 445]; citation_inbook_title=Presented at the International Continence Society annual meeting; citation_publication_date=2002; citation_id=CR17; citation_author=C. Napier; citation_author=P. Gupta; citation_publisher=Heidelberg citation_journal_title=Naunyn Schmiedebergs Arch Pharmacol; citation_title=M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland; citation_author=K. Ikeda, S. Kobayashi, M. Suzuki; citation_volume=366; citation_publication_date=2002; citation_pages=97-103; citation_doi=10.1007/s00210-002-0554-x; citation_id=CR18 citation_journal_title=Mayo Clin Proc; citation_title=Prospective randomized controlled trial of extended-release oxybutynin chloride and tolterodine tartrate in the treatment of overactive bladder: results of the OBJECT Study; citation_author=R.A. Appell, P. Sand, R. Dmochowski; citation_volume=76; citation_publication_date=2001; citation_pages=358-363; citation_doi=10.4065/76.4.358; citation_id=CR19 citation_journal_title=Urology; citation_title=Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladder; citation_author=P. Kerrebroeck, K. Kreder, U. Jonas; citation_volume=57; citation_publication_date=2001; citation_pages=414-421; citation_doi=10.1016/S0090-4295(00)01113-4; citation_id=CR20 citation_journal_title=Eur Urol; citation_title=Differential effects of the antimuscarinic agents darifenacin and oxybutynin ER on memory in older subjects; citation_author=G. Kay, T. Crook, L. Rekeda; citation_volume=50; citation_publication_date=2006; citation_pages=317-326; citation_doi=10.1016/j.eururo.2006.03.057; citation_id=CR21 citation_journal_title=Urol Res; citation_title=Oxybutynin disrupts learning and memory in the rat passive avoidance response; citation_author=T. Sugiyama, Y.C. Park, T. Kurita; citation_volume=27; citation_publication_date=1999; citation_pages=393-395; citation_doi=10.1007/s002400050169; citation_id=CR22 citation_journal_title=Arch Neurol; citation_title=Tolterodine and memory: dry but forgetful; citation_author=K.B. Womack, K.M. Heilman; citation_volume=60; citation_publication_date=2003; citation_pages=771-773; citation_doi=10.1001/archneur.60.5.771; citation_id=CR23 citation_journal_title=J Clin Pharm Ther; citation_title=In vivo age-related changes in hepatic drug-oxidizing capacity in humans; citation_author=E. Tanaka; citation_volume=23; citation_publication_date=1998; citation_pages=247-255; citation_doi=10.1046/j.1365-2710.1998.00164.x; citation_id=CR24 citation_journal_title=Clin Drug Investig; citation_title=Psychotic disorder induced by oxybutynin: presentation of two cases; citation_author=M. Gulsun, M. Pinar, U. Sabanci; citation_volume=26; citation_publication_date=2006; citation_pages=603-606; citation_doi=10.2165/00044011-200626100-00007; citation_id=CR25 citation_journal_title=N Engl J Med; citation_title=Transient memory impairment and hallucinations associated with tolterodine use; citation_author=J.W. Tsao, K.M. Heilman; citation_volume=349; citation_publication_date=2003; citation_pages=2274-2275; citation_doi=10.1056/NEJM200312043492325; citation_id=CR26 citation_journal_title=J Neurosci; citation_title=Nicotinic acetylcholine receptors interact with dopamine in induction of striatal long-term depression; citation_author=J.G. Partridge, S. Apparsundaram, G.A. Gerhardt; citation_volume=22; citation_publication_date=2002; citation_pages=2541-2549; citation_id=CR27 citation_journal_title=J Clin Pharmacol; citation_title=Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system; citation_author=A. Todorova, B. Vonderheid-Guth, W. Dimpfel; citation_volume=41; citation_publication_date=2001; citation_pages=636-644; citation_doi=10.1177/00912700122010528; citation_id=CR28 Once-a-day Ditropan XL (oxybutynin chloride) extended-release tablets 5, 10, 15 mg. Full U.S. prescribing information. Available at http://www.ditropanxl.com/html/pdxl/prescribing_consumer.jsp;jsessionid=UYLZTKGIQK2EOCQPCCFTC0YKB2IIQNSC ? Accessed February 1, 2007. citation_journal_title=World J Urol; citation_title=Transdermal oxybutynin in the treatment of adults with overactive bladder: combined results of two randomized clinical trials; citation_author=R.R. Dmochowski, V. Nitti, D. Staskin; citation_volume=23; citation_publication_date=2005; citation_pages=263-270; citation_doi=10.1007/s00345-005-0012-8; citation_id=CR30 Enablex (darifenacin) extended release tablets: prescribing information. Available at http://www.enablex.com/info/tools/pi.jsp . Accessed February 1, 2007. VESIcare (solifenacin succinate) tablets. Available at http://www.astellas.us/docs/vesicare.pdf . Accessed February 1, 2007. citation_journal_title=Clin Drug Investig; citation_title=Randomized, double-blind study of the effects of oxybutynin, tolterodine, trospium chloride and placebo on sleep in heathy young volunteers; citation_author=K. Diefenback, F. Donath, A. Maurer; citation_volume=23; citation_publication_date=2003; citation_pages=395-404; citation_doi=10.2165/00044011-200323060-00003; citation_id=CR33 citation_journal_title=BMJ; citation_title=Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study; citation_author=M.L. Ancelin, S. Artero, F. Portet; citation_volume=332; citation_publication_date=2006; citation_pages=455-459; citation_doi=10.1136/bmj.38740.439664.DE; citation_id=CR34 citation_journal_title=Acta Neurochir (Wien); citation_title=Influence of aging on blood-brain barrier permeability and free radical formation following experimental brain cold injury; citation_author=P. Erdincler, S. Tuzgen, U.D. Erdincler; citation_volume=144; citation_publication_date=2002; citation_pages=195-199; citation_doi=10.1007/s007010200024; citation_id=CR35 citation_journal_title=Neurobiol Dis; citation_title=Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome; citation_author=A. Abdel-Rahman, A.K. Shetty, M.B. Abou-Donia; citation_volume=10; citation_publication_date=2002; citation_pages=306-326; citation_doi=10.1006/nbdi.2002.0524; citation_id=CR36 citation_journal_title=J Urol; citation_title=The effect of oxybutynin treatment on cognition in children with diurnal incontinence; citation_author=B.R. Sommer, R. O’Hara, N. Askari; citation_volume=173; citation_publication_date=2005; citation_pages=2125-2127; citation_doi=10.1097/01.ju.0000157685.83573.79; citation_id=CR37 citation_journal_title=Lancet; citation_title=Alzheimer’s disease; citation_author=K. Blennow, M.J. Leon, H. Zetterberg; citation_volume=368; citation_publication_date=2006; citation_pages=387-403; citation_doi=10.1016/S0140-6736(06)69113-7; citation_id=CR38 citation_journal_title=Clin Pharmacol Ther; citation_title=Treatment of urinary incontinence with anticholinergics in patients taking cholinesterase inhibitors for dementia; citation_author=E.L. Siegler, M. Reidenberg; citation_volume=75; citation_publication_date=2004; citation_pages=484-488; citation_doi=10.1016/j.clpt.2004.01.015; citation_id=CR39 citation_journal_title=Ann Neurol; citation_title=Increased Alzheimer pathology in Parkinson’s disease related to antimuscarinic drugs; citation_author=E.K. Perry, L. Kilford, A.J. Lees; citation_volume=54; citation_publication_date=2003; citation_pages=235-238; citation_doi=10.1002/ana.10639; citation_id=CR40 citation_journal_title=Neurobiol Dis; citation_title=Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease; citation_author=M. Garcia-Alloza, E.M. Robbins, S.X. Zhang-Nunes; citation_volume=24; citation_publication_date=2006; citation_pages=516-524; citation_doi=10.1016/j.nbd.2006.08.017; citation_id=CR41 citation_journal_title=J Neuropathol Exp Neurol; citation_title=Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease; citation_author=J.L. Jankowsky, G. Xu, D. Fromholt; citation_volume=62; citation_publication_date=2003; citation_pages=1220-1227; citation_id=CR42 citation_journal_title=J Urol; citation_title=Does oxybutynin alter amyloid beta peptides in a mouse model of Alzheimer’s Disease; citation_author=A.P. Klausner, S. Fletcher, S.K. Yang; citation_volume=173; citation_publication_date=2005; citation_pages=41; citation_id=CR43 citation_journal_title=J Urol; citation_title=The effect of oxybutynin on plaques, amyloid beta peptides, and behavior in mouse and human cybrid models of Alzheimer’s Disease [abstract]; citation_author=S. Sharma, A.P. Klausher, S. Fletcher; citation_volume=175; citation_publication_date=2006; citation_pages=55; citation_id=CR44 citation_journal_title=Neuroscience; citation_title=Role of hippocampal M2 muscarinic receptors in the estrogen-induced enhancement of working memory; citation_author=J.M. Daniel, J.L. Hulst, C.D. Lee; citation_volume=132; citation_publication_date=2005; citation_pages=57-64; citation_doi=10.1016/j.neuroscience.2005.01.002; citation_id=CR45