Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection

Clinical and Laboratory Standards Institute, 2012. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, approved standards, ninth edition, M07-A9CLSI, Wayne, PA. Crandon, 2010, Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model, Antimicrob. Agents Chemother., 54, 5115, 10.1128/AAC.00062-10 Enright, 2000, Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus, J. Clin. Microbiol., 38, 1008, 10.1128/JCM.38.3.1008-1015.2000 Garcia-Roca, 2006, Linezolid diminishes inflammatory cytokine production from human peripheral blood mononuclear cells, Arch. Med. Res., 37, 31, 10.1016/j.arcmed.2005.05.022 Grundmann, 2006, Emergence and resurgence of methicillin-resistant Staphylococcus aureus as a public-health threat, Lancet, 368, 874, 10.1016/S0140-6736(06)68853-3 Gu, 2013, The emerging problem of linezolid-resistant Staphylococcus, J. Antimicrob. Chemother., 68, 4, 10.1093/jac/dks354 Harada, 2013, In vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection, Antimicrob. Agents Chemother., 57, 2841, 10.1128/AAC.02331-12 Holzknecht, 2010, Changing epidemiology of methicillin-resistant Staphylococcus aureus in Iceland from 2000 to 2008: a challenge to current guidelines, J. Clin. Microbiol., 48, 4221, 10.1128/JCM.01382-10 Kaku, 2014, Immunomodulatory effect of linezolid on methicillin-resistant Staphylococcus aureus supernatant-induced MUC5AC overexpression in human airway epithelial cells, Antimicrob. Agents Chemother., 58, 4131, 10.1128/AAC.02811-13 Kihara, 2009, Potency of SMP-601 a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus, Antimicrob. Agents Chemother., 52, 2164 Lambers, 2010, Early immunomodulatory effects of linezolid in a human whole blood endotoxin model, Int. J. Clin. Pharmacol., 48, 419, 10.5414/CPP48419 Lepak, 2012, Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model, Antimicrob. Agents Chemother., 56, 5916, 10.1128/AAC.01303-12 Liu, 2012, Infectious Diseases Society of America: clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children, Clin. Infect. Dis., 52, e18, 10.1093/cid/ciq146 Locke, 2014, Tedizolid for management of human infections: in vitro characteristics, Clin. Infect. Dis., 58, S35, 10.1093/cid/cit616 Locke, 2014, Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center, Antimicrob. Agents Chemother., 58, 6949, 10.1128/AAC.03380-14 Moran, 2014, Tedizolid for 6days versus linezolid for 10days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomized double-blind phase3, non-inferiority trial, Lancet Infect. Dis., 14, 696, 10.1016/S1473-3099(14)70737-6 Motoshima, 2010, Genetic diagnosis of community-acquired MRSA: a multiplex real-time PCR method for staphylococcal cassette chromosome mec typing and detecting toxin genes, Tohoku J. Exp. Med., 220, 165, 10.1620/tjem.220.165 Popovich, 2008, Are community-associated Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?, Clin. Infect. Dis., 46, 787, 10.1086/528716 Prokocimer, 2013, Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial, JAMA, 309, 559, 10.1001/jama.2013.241 Rodvold, 2014, Methicillin-resistant Staphylococcus aureus therapy: past, present, and future, Clin. Infect. Dis., 58, S20, 10.1093/cid/cit614 Sawai, 1997, Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads, Infect. Immun., 65, 466, 10.1128/IAI.65.2.466-471.1997 Sham, 2015, Results of the surveillance of tedizolid activity and resistance program: in vitro susceptibility of gram-positive pathogens collected in 2011 and 2012 from the United States and Europe, Diagn. Microbiol. Infect. Dis., 81, 112, 10.1016/j.diagmicrobio.2014.08.011 Sharma-Kuinkel, 2013, Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model, PLoS One, 8, e60463, 10.1371/journal.pone.0060463 Shor, 2015, Analysis of the phase 3 ESTABLISH trials of tedizolid versus linezolid in acute bacterial skin and skin structure infections, Antimicrob. Agents Chemother., 59, 864, 10.1128/AAC.03688-14 Takahashi, 2010, Effect of linezolid on cytokine production capacity and plasma endotoxin levels in response to lipopolysaccharide stimulation of whole blood, J. Infect. Chemother., 16, 94, 10.1007/s10156-009-0012-5 Tessier, 2012, Comparative in vivo efficacies of epithelial lining fluid exposures of tedizolid linezolid, and vancomycin for methicillin-resistant Staphylococcus aureus in a mouse pneumonia model, Antimicrob. Agents Chemother., 56, 2342, 10.1128/AAC.06427-11 Yanagihara, 2002, Efficacy of linezolid against methicillin-resistant or vancomycin-insensitive Staphylococcus aureus in a model of hematogenous pulmonary infection, Antimicrob. Agents Chemother., 46, 3288, 10.1128/AAC.46.10.3288-3291.2002 Yanagihara, 2008, Subinhibitory concentrations of telithromycin, clarithromycin and azithromycin reduce methicillin-resistant Staphylococcus aureus coagulase in vitro and in vivo, J. Antimicrob. Chemother., 61, 647, 10.1093/jac/dkm507 Yanagihara, 2009, Efficacy of linezolid against panton-valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) in a mouse model of hematogenous pulmonary infection, Int. J. Antimicrob. Agnets, 34, 477, 10.1016/j.ijantimicag.2009.06.024 Yoshizawa, 2012, Virulence-suppressing effects of linezolid on methicillin-resistant Staphylococcus aureus: possible contribution to early defervescence, Antimicrob. Agents Chemother., 56, 1744, 10.1128/AAC.05430-11 Zarogoulidis, 2012, Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases, Eur. J. Clin. Pharmacol., 68, 479, 10.1007/s00228-011-1161-x