Antimicrobial agents

Folia Microbiologica - Tập 16 - Trang 472-475 - 1971
A. Čapek1, A. Šimek1
1Institute of Pharmacy and Biochemistry, Prague 3

Tóm tắt

The adaptation of dermatophytes to antimycotics leads to the development of two independent processes—the induction of degrading enzyme systems detoxicating the antimycotic to less active or completely inactive derivatives, and temporary resistance, accompanied by increasing loss of sensitivity of the dermatophytes to the given antimycotics. These processes can both be regarded as part of the defences of the microbial cell.

Tài liệu tham khảo

Čapek, A., Šimek, A., Němcová, D., Janata, V.:Antimicrobial agents. V. Antimycotic activity of quaternary ammonium salts. Fol. microbiol. 15: 54, 1970a. Čapek, A., Šimek, A., Leiner, J., Weichet, J.:Antimicrobial agents. VII. Microbial degradation of the antifungal agent 2-chloro-4-nitrophenol (Nitrofungin). Fol. microbiol. 15: 350, 1970b. Čapek, A., Šimek, A.:Antimicrobial agents. XI. Microbial degradation of fungicidin. Fol. microbiol. 16: 364, 1971. Perlman, D., Čapek, A.:Microbial transformation of peptidea tibiotics. n II. Site ofactinomycin degradation in Actinoplanes missouriensis. Hind. Antibiotics Bull. 10: 270, 1968a. Perlman, D., Čapek, A.:Microbial transformation of peptide antibiotics. III. Relation of inducer structure to induction of actinomycin degrading enzymes in Actinoplanes missouriensis. J. Antibiotics 21: 421, 1968b. Szybalski, W., Bryson, V.:Genetic studies on microbial cross resistance to toxic agents. I. Cross resistance of Escherichia coli to fifteen antibiotics. J. Bacteriol. 64: 489, 1952.