Antimicrobial Peptides Human β-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines

Aarbiou, 2002, Human neutrophil defensins induce lung epithelial cell proliferation in vitro, J Leukoc Biol, 72, 167, 10.1189/jlb.72.1.167

Aarbiou, 2004, Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro, Am J Respir Cell Mol Biol, 30, 193, 10.1165/rcmb.2002-0267OC

Ali, 2001, Expression of the peptide antibiotics human β-defensin-1 and human β-defensin-2 in normal human skin, J Invest Dermatol, 117, 106, 10.1046/j.0022-202x.2001.01401.x

Andl, 2004, EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes, Am J Physiol Gastrointest Liver Physiol, 287, G1227, 10.1152/ajpgi.00253.2004

Befus, 1999, Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action, J Immunol, 163, 947, 10.4049/jimmunol.163.2.947

Cha, 1996, Enhanced modulation of keratinocyte motility by transforming growth factor-α (TGF-α) relative to epidermal growth factor (EGF), J Invest Dermatol, 106, 590, 10.1111/1523-1747.ep12345083

Chaly, 2000, Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells, Eur Cytokine Netw, 11, 257

Chen, 2005, Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli, J Dermatol Sci, 40, 123, 10.1016/j.jdermsci.2005.03.014

Chertov, 1996, Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils, J Biol Chem, 271, 2935, 10.1074/jbc.271.6.2935

Clapham, 1995, Calcium signaling, Cell, 80, 259, 10.1016/0092-8674(95)90408-5

Dorschner, 2001, Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus, J Invest Dermatol, 117, 91, 10.1046/j.1523-1747.2001.01340.x

Frank, 1999, Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling, Nat Med, 5, 444, 10.1038/7445

Frohm, 1999, The human cationic antimicrobial protein (hCAP-18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6, Infect Immun, 67, 2561, 10.1128/IAI.67.5.2561-2566.1999

Fulton, 1997, Expression of natural peptide antibiotics in human skin, Lancet, 350, 1750, 10.1016/S0140-6736(05)63574-X

García, 2001, Identification of a novel, multifunctional β-defensin (human β-defensin-3) with specific antimicrobial activity: Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction, Cell Tissue Res, 306, 257, 10.1007/s004410100433

García, 2001, Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity, FASEB J, 15, 1819, 10.1096/fj.00-0865fje

Harder, 1997, A peptide antibiotic from human skin, Nature, 387, 861, 10.1038/43088

Harder, 2001, Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic, J Biol Chem, 276, 5707, 10.1074/jbc.M008557200

Harder, 2004, Differential gene induction of human β-defensins (hBD-1, -2, -3, and -4) in keratinocytes is inhibited by retinoic acid, J Invest Dermatol, 123, 522, 10.1111/j.0022-202X.2004.23234.x

Heilborn, 2003, The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium, J Invest Dermatol, 120, 379, 10.1046/j.1523-1747.2003.12069.x

Hou, 2004, In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl) amino) hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions, J Pharmacol Exp Ther, 309, 697, 10.1124/jpet.103.060574

Huh, 2002, Dynamic alteration of human β-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin, J Mol Med, 80, 678, 10.1007/s00109-002-0373-z

Jia, 2001, Discovery of new human β-defensins using a genomics-based approach, Gene, 263, 211, 10.1016/S0378-1119(00)00569-2

Kehrl, 1998, Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins, Immunity, 8, 1, 10.1016/S1074-7613(00)80453-7

Kijima, 2002, STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo, Cell Growth Differ, 13, 355

Knall, 1998, G-protein regulatory pathways: rocketing into the twenty-first century, J Cell Biochem Suppl, 30/31, 137, 10.1002/(SICI)1097-4644(1998)72:30/31+<137::AID-JCB18>3.0.CO;2-L

Koczulla, 2003, An angiogenic role for the human peptide antibiotic LL-37/hCAP-18, J Clin Invest, 111, 1665, 10.1172/JCI17545

Lehrer, 1999, Antimicrobial peptides in mammalian and insect host defense, Curr Opin Immunol, 11, 23, 10.1016/S0952-7915(99)80005-3

Li, 2004, Signals that initiate, augment, and provide directionality for human keratinocyte motility, J Invest Dermatol, 123, 622, 10.1111/j.0022-202X.2004.23416.x

Liu, 2002, Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentation, J Invest Dermatol, 118, 275, 10.1046/j.0022-202x.2001.01651.x

Niyonsaba, 2001, Evaluation of the effects of peptide antibiotics human β-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells, Eur J Immunol, 31, 1066, 10.1002/1521-4141(200104)31:4<1066::AID-IMMU1066>3.0.CO;2-#

Niyonsaba, 2002, Epithelial cell-derived human β-defensin-2 acts as chemotaxin for mast cells through a pertussis toxin-sensitive and phospholipase C-dependent pathway, Int Immunol, 14, 421, 10.1093/intimm/14.4.421

Niyonsaba, 2002, A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis, Immunology, 106, 20, 10.1046/j.1365-2567.2002.01398.x

Niyonsaba, 2004, Human β-defensin-2 functions as a chemotactic agent for tumour necrosis factor-α-treated human neutrophils, Immunology, 111, 273, 10.1111/j.0019-2805.2004.01816.x

Niyonsaba, 2005, The human β-defensins (hBD-1, -2, -3, -4) and cathelicidin LL-37 induce interleukin-18 secretion through p38 and ERK MAPK activation in primary human keratinocytes, J Immunol, 175, 1776, 10.4049/jimmunol.175.3.1776

Ong, 2002, Endogenous antimicrobial peptides and skin infections in atopic dermatitis, New Engl J Med, 347, 1151, 10.1056/NEJMoa021481

Oppenheim, 2003, Roles of antimicrobial peptides such as defensins in innate and adaptive immunity, Ann Rheum Dis, 62, 17, 10.1136/ard.62.suppl_2.ii17

Oren, 2003, In human epidermis, β-defensin 2 is packaged in lamellar bodies, Exp Mol Pathol, 74, 180, 10.1016/S0014-4800(02)00023-0

Sano, 1999, Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis, EMBO J, 18, 4657, 10.1093/emboj/18.17.4657

Shaykhiev, 2005, The human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure, Am J Physiol Lung Cell Mol Physiol, 289, L842, 10.1152/ajplung.00286.2004

Sørensen, 1997, The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils, Blood, 90, 2796, 10.1182/blood.V90.7.2796

Sørensen, 2005, Differential regulation of β-defensin expression in human skin by microbial stimuli, J Immunol, 174, 4870, 10.4049/jimmunol.174.8.4870

Tokumaru, 2005, Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37, J Immunol, 175, 4662, 10.4049/jimmunol.175.7.4662

Yang, 1999, defensins: linking innate and adaptive immunity through dendritic and T cell CCR6, Science, 286, 525, 10.1126/science.286.5439.525

Yang, 2000, LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells, J Exp Med, 192, 1069, 10.1084/jem.192.7.1069

Zahm, 2000, Mitogenic effect of recombinant HGF on airway epithelial cells during the in vitro wound repair of the respiratory epithelium, J Cell Physiol, 185, 447, 10.1002/1097-4652(200012)185:3<447::AID-JCP16>3.0.CO;2-D

Zanetti, 1995, Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain, FEBS Lett, 374, 1, 10.1016/0014-5793(95)01050-O

Zhang, 2001, Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion, Am J Physiol Lung Cell Mol Physiol, 280, L947, 10.1152/ajplung.2001.280.5.L947