Antihypertensive Therapie bei kritischer Evidenzlage

Holzgreve H. Interventionsstudien bei Hypertonie. In: Rosenthal J, Kolloch R, Editors. Arterielle Hypertonie. 4th Edition ed. Berlin: Springer; 2004. p. 68-78 Beckett NS et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887-98 Amery A, et al. Mortality and morbidity results from the European Working Party on high blood pressure in the elderly trial. Lancet. 1985;1:1349-54 Benetos A et al. Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents. The PARTAGE Study. JAMA Intern Med. 2015;1175:989-95 Charlesworth CJ et al. Functional Status and Antihypertensive Therapy in Older Adults: A New Perspective on Old Data. Am J Hypertens. 2016;29:690-5 Odden MC et al. Rethinking the association of high blood pressure with mortality in elderly adults. Arch intern Med. 2012;172:1162-8 Oates JD et al. Blood pressure and survival in the oldest old. J Am Geriatr Soc. 2007;55;383-8 Williams B et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021-104 The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. New Engl J Med. 2015;373:2103-16 Streit S et al. Lower blood pressure during antihypertensive treatment is assodiated with higher all-cause mortality and accelerated cognitive decline in the oldest-old. Data from the Leiden 85-plus Study. Age Ageing. 2018;47:545-50