Antigen presenting cells may be able to distinguish between normal and radiated Schistosoma japonicum cercaria: an in vitro observation

King, 2009, Toward the elimination of schistosomiasis, N Engl J Med, 360, 106, 10.1056/NEJMp0808041 McManus, 2008, Current status of vaccines for schistosomiasis, Clin Microbiol, 21, 225, 10.1128/CMR.00046-07 Yang, 2009, Schistosoma japonicum: proteomics analysis of differentially expressed proteins from ultraviolet-attenuated cercariae compared to normal cercariae, Parasitol Res, 105, 237, 10.1007/s00436-009-1387-z Zhu, 2005, Gene transcription profile in mice vaccinated with ultraviolet-attenuated cercariae of Schistosoma japonicum reveals molecules contributing to elevated IFN-gamma levels, Acta Biochim Biophys Sin (Shanghai), 37, 254, 10.1111/j.1745-7270.2005.00038.x Hall, 2004, Schistosoma mansoni: antigen-presenting cells emigrating from skin exposed to attenuated cercariae activate lymphoid cells and transfer protection in C57B1/6 mice, J Parasitol, 90, 733, 10.1645/GE-209 Jenkins, 2005, Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and - independent pathways, Int Immunol, 17, 1409, 10.1093/intimm/dxh319 Menson, 1989, Lung-phase immunity to Schistosoma mansoni. Flow cytometric analysis of macrophage activation states in vaccinated mice, J Immunol, 143, 2342, 10.4049/jimmunol.143.7.2342 James, 1986, Activated macrophages as effector cells of protective immunity to schistosomiasis, Immunol Res, 5, 139, 10.1007/BF02917588 James, 1998, Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance, Infect Immun, 66, 3510, 10.1128/IAI.66.8.3510-3518.1998 Dean, 1996, Homologous and heterologous protective immunity to Egyptian strains of Schistosoma mansoni and S. haematobium induced by ultraviolet-irradiated cercariae, Parasite Immunol, 18, 403, 10.1046/j.1365-3024.1996.d01-129.x Shi, 1990, Schistosoma japonicum: an ultraviolet-attenuated cercarial vaccine applicable in the field for water buffaloes, Exp Parasitol, 71, 100, 10.1016/0014-4894(90)90012-2 Moloney, 1985, The induction of specific immunity against Schistosoma japonicum by exposure of mice to ultraviolet-attenuated cercariae, Parasitology, 90, 313, 10.1017/S0031182000051015 Takeda, 2005, Toll-like receptors in innate immunity, Int Immunol, 17, 1, 10.1093/intimm/dxh186 Areschoug, 2008, Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands, Contrib Microbiol, 15, 45, 10.1159/000135685 Paveley, 2009, Fluorescent imaging of antigen released by a skin-invading helminth reveals differential uptake and activation profiles by antigen presenting cells, PLoS Negl Trop Dis, 3, e528, 10.1371/journal.pntd.0000528 Incani, 1984, Histopathological and ultrastructural studies of cutaneous reactions elicited in naive and chronically infected mice by invading schistosomula of Schistosoma mansoni, Int J Parasitol, 14, 259, 10.1016/0020-7519(84)90077-8 Riengrojpitak, 1998, Induction of immunity to Schistosoma mansoni: interaction of schis-tosomula with accessory leucocytes in murine skin and draining lymph nodes, Parasitology, 117, 301, 10.1017/S0031182098003187 Hogg, 2003, Interleukin-12 p40 secretion by cutaneous CD11c+ and F4/80+ cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni, Infect Immun, 71, 3563, 10.1128/IAI.71.6.3563-3571.2003 Jing, 2003, Prostaglandin E2 inhibits production of the inflammatory chemokines CCL3 and CCL4 in dendritic cells, J Leukoc Biol, 868, 10.1189/jlb.0303116 Balto, 2001, Interleukin-6 deficiency increases inflammatory bone destruction, Infect Immun, 69, 744, 10.1128/IAI.69.2.744-750.2001 Nagabhushanam, 2003, Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma, J Immunol, 171, 4750, 10.4049/jimmunol.171.9.4750 Redpath, 1999, Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10, J Immunol, 162, 6701, 10.4049/jimmunol.162.11.6701 Wilson, 2009, Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages, Infect Immun, 77, 4953, 10.1128/IAI.00844-09 Couper, 2008, IL-10: the master regulator of immunity to infection, J Immunol, 180, 5771, 10.4049/jimmunol.180.9.5771 Kumar, 1999, Vaccination with irradiated cercariae of Schistosoma mansoni preferentially induced the accumulation of interferon-gamma producing T cells in the skin and skin draining lymph nodes of mice, Parasitol Int, 48, 109, 10.1016/S1383-5769(99)00008-2 Ramaswamy, 2000, A role for parasite-induced PGE2 in IL-10-mediated host immunoregulation by skin stage schistosomula of Schistosoma mansoni, J Immunol, 165, 4567, 10.4049/jimmunol.165.8.4567 Hogg, 2003, IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine, Int Immunol, 15, 1451, 10.1093/intimm/dxg142 Hoffmann, 1999, Studies with double cytokine-deficient mice reveal that highly polarized Th1-and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni, J Immunol, 163, 927, 10.4049/jimmunol.163.2.927 Treffkorn, 2004, PGE2 exerts its effect on the LPS-induced release of TNF-alpha, ET-1, IL-1alpha, IL-6 and IL-10 via the EP2 and EP4 receptor in rat liver macrophages, Prostaglandins Other Lipid Mediat, 74, 113, 10.1016/j.prostaglandins.2004.07.005 Smythies, 1992, Monoclonal antibody to IFN-gamma modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae, J Immunol, 149, 3654, 10.4049/jimmunol.149.11.3654 Wilson, 1996, Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-gamma receptor gene exposed to the irradiated Schistosoma mansoni vaccine, Immunology, 87, 275, 10.1046/j.1365-2567.1996.465550.x