Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine

Springer Science and Business Media LLC - Tập 5 Số 1-2 - Trang 21-31 - 2011
Maryam Amidi1, Markus de Raad1, Daan J.A. Crommelin1, Wim E. Hennink1, Enrico Mastrobattista1
1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands

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Abdulhaqq SA, Weiner DB (2008) DNA vaccines: developing new strategies to enhance immune responses. Immunol Res 42(1–3):219–232. doi: 10.1007/s12026-008-8076-3

Amidi M, Pellikaan HC, Hirschberg H, de Boer AH, Crommelin DJ, Hennink WE, Kersten G, Jiskoot W (2007) Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs. Vaccine 25(37–38):6818–6829

Amidi M, de Raad M, de Graauw H, van Ditmarsch D, Hennink WE, Crommelin DJ, Mastrobattista E (2010) Optimization and quantification of protein synthesis inside liposomes. J Liposome Res 20(1):73–83. doi: 10.3109/08982100903402954

Beebe ET, Makino SI, Nozawa A, Matsubara Y, Frederick RO, Primm JG, Goren MA, Fox BG (2010) Robotic large-scale application of wheat cell-free translation to structural studies including membrane proteins. N Biotechnol. doi: 10.1016/j.nbt.2010.07.003

Berrier C, Park KH, Abes S, Bibonne A, Betton JM, Ghazi A (2004) Cell-free synthesis of a functional ion channel in the absence of a membrane and in the presence of detergent. Biochemistry 43(39):12585–12591

Bollag DM, Edelstein SJ (1991) Protein methods. Wiley-Liss Publications, New York

Canton B, Labno A, Endy D (2008) Refinement and standardization of synthetic biological parts and devices. Nat Biotech 26(7):787–793. doi: http://www.nature.com/nbt/journal/v26/n7/suppinfo/nbt1413_S1.html

Coutelier JP, van der Logt JT, Heessen FW, Warnier G, Van Snick J (1987) Igg2a restriction of murine antibodies elicited by viral infections. J Exp Med 165(1):64–69

DesRoches C, Blendon R, Benson J (2005) Americans’ responses to the 2004 influenza vaccine shortage. Health Aff 24(3):822

Foged C, Brodin B, Frokjaer S, Sundblad A (2005) Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm 298(2):315–322

Gissmann L (2009) Hpv vaccines: preclinical development. Arch Med Res 40(6):466–470

Goren MA, Nozawa A, Makino S, Wrobel RL, Fox BG (2009) Cell-free translation of integral membrane proteins into unilamelar liposomes. Methods Enzymol 463:647–673. doi: 10.1016/S0076-6879(09)63037-8

Henderson MP, Billen LP, Kim PK, Andrews DW (2007) Cell-free analysis of tail-anchor protein targeting to membranes. Methods 41(4):427–438. doi: 10.1016/j.ymeth.2006.07.004

Hinman AR, Orenstein WA, Santoli JM, Rodewald LE, Cochi SL (2006) Vaccine shortages: history, impact, and prospects for the future. Annu Rev Public Health 27:235–259

Ho GY, Studentsov Y, Hall CB, Bierman R, Beardsley L, Lempa M, Burk RD (2002) Risk factors for subsequent cervicovaginal human papillomavirus (HPV) infection and the protective role of antibodies to HPV-16 virus-like particles. J Infect Dis 186(6):737–742. doi: 10.1086/342972

Hocart MJ, Mackenzie JS, Stewart GA (1989) The immunoglobulin g subclass responses of mice to influenza a virus: the effect of mouse strain, and the neutralizing abilities of individual protein a-purified subclass antibodies. J Gen Virol 70(Pt 9):2439–2448

Hovden AO, Cox RJ, Madhun A, Haaheim LR (2005) Two doses of parenterally administered split influenza virus vaccine elicited high serum igg concentrations which effectively limited viral shedding upon challenge in mice. Scand J Immunol 62(4):342–352. doi: 10.1111/j.1365-3083.2005.01666.x

Ishihara G, Goto M, Saeki M, Ito K, Hori T, Kigawa T, Shirouzu M, Yokoyama S (2005) Expression of g protein coupled receptors in a cell-free translational system using detergents and thioredoxin-fusion vectors. Protein Expr Purif 41(1):27–37

Ishikawa K, Sato K, Shima Y, Urabe I, Yomo T (2004) Expression of a cascading genetic network within liposomes. FEBS Lett 576(3):387–390

Jewett MC, Calhoun KA, Voloshin A, Wuu JJ, Swartz JR (2008) An integrated cell-free metabolic platform for protein production and synthetic biology. Mol Syst Biol 4:220. doi: 10.1038/msb.2008.57

Junge F, Haberstock S, Roos C, Stefer S, Proverbio D, Dotsch V, Bernhard F (2010) Advances in cell-free protein synthesis for the functional and structural analysis of membrane proteins. N Biotechnol. doi: 10.1016/j.nbt.2010.07.002

Kanter G, Yang J, Voloshin A, Levy S, Swartz JR, Levy R (2007) Cell-free production of scfv fusion proteins: an efficient approach for personalized lymphoma vaccines. Blood 109(8):3393–3399. doi: 10.1182/blood-2006-07-030593

Kita H, Matsuura T, Sunami T, Hosoda K, Ichihashi N, Tsukada K, Urabe I, Yomo T (2008) Replication of genetic information with self-encoded replicase in liposomes. Chembiochem 9(15):2403–2410. doi: 10.1002/cbic.200800360

Klinman DM, Klaschik S, Sato T, Tross D (2009) Cpg oligonucleotides as adjuvants for vaccines targeting infectious diseases. Adv Drug Deliv Rev 61(3):248–255

Knight T (2003) Idempotent vector design for standard assembly of biobricks. MIT Artificial Intelligence Laboratory; MIT Synthetic Biology Working Group. http://hdl.handle.net/1721.1/21168

Kohyama S, Ohno S, Suda T, Taneichi M, Yokoyama S, Mori M, Kobayashi A, Hayashi H, Uchida T, Matsui M (2009) Efficient induction of cytotoxic t lymphocytes specific for severe acute respiratory syndrome (sars)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a. Antiviral Res 84(2):168–177

Kuruma Y, Suzuki T, Ueda T (2010) Production of multi-subunit complexes on liposome through an e.Coli cell-free expression system. Methods Mol Biol 607:161–171. doi: 10.1007/978-1-60327-331-2_14

Liu MA, Ulmer JB (2005) Human clinical trials of plasmid DNA vaccines. Adv Genet 55:25–40. doi: 10.1016/S0065-2660(05)55002-8

Lu S (2008) Immunogenicity of DNA vaccines in humans: it takes two to tango. Hum Vaccin 4(6):449–452

Mastrobattista E, Taly V, Chanudet E, Treacy P, Kelly BT, Griffiths AD (2005) High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions. Chem Biol 12(12):1291–1300

Matsui M, Kohyama S, Suda T, Yokoyama S, Mori M, Kobayashi A, Taneichi M, Uchida T (2010) A ctl-based liposomal vaccine capable of inducing protection against heterosubtypic influenza viruses in hla-a*0201 transgenic mice. Biochem Biophys Res Commun 391(3):1494–1499

Montefiori DC, Mascola JR (2009) Neutralizing antibodies against hiv-1: Can we elicit them with vaccines and how much do we need? Curr Opin HIV AIDS 4(5):347–351. doi: 310.1097/COH.1090b1013e32832f32834a32834d

Montefiori D, Sattentau Q, Flores J, Esparza J, Mascola J, Va WGCGH (2007) Antibody-based hiv-1 vaccines: recent developments and future directions. PLoS Med 4(12):1867–1871. doi: 10.1371/journal.pmed.0040348

Moritani Y, Nomura SI, Morita I, Akiyoshi K (2010) Direct integration of cell-free-synthesized connexin-43 into liposomes and hemichannel formation. FEBS J. doi: 10.1111/j.1742-4658.2010.07736.x

Murtas G, Kuruma Y, Bianchini P, Diaspro A, Luisi PL (2007) Protein synthesis in liposomes with a minimal set of enzymes. Biochem Biophys Res Commun 363(1):12–17. doi: 10.1016/j.bbrc.2007.07.201

Naito S, Horino A, Nakayama M, Nakano Y, Nagai T, Mizuguchi J, Komuro K, Uchida T (1996) Ovalbumin-liposome conjugate induces igg but not ige antibody production. Int Arch Allergy Immunol 109(3):223–228

Nozawa A, Nanamiya H, Tozawa Y (2010) Production of membrane proteins through the wheat-germ cell-free technology. Methods Mol Biol 607:213–218. doi: 10.1007/978-1-60327-331-2_17

Oberholzer T, Nierhaus KH, Luisi PL (1999) Protein expression in liposomes. Biochem Biophys Res Commun 261(2):238–241

Ohno S, Kohyama S, Taneichi M, Moriya O, Hayashi H, Oda H, Mori M, Kobayashi A, Akatsuka T, Uchida T, Matsui M (2009) Synthetic peptides coupled to the surface of liposomes effectively induce sars coronavirus-specific cytotoxic t lymphocytes and viral clearance in hla-a*0201 transgenic mice. Vaccine 27(29):3912–3920

Poland G, Ovsyannikova I, Jacobson R (2008) Personalized vaccines: the emerging field of vaccinomics. Expert Opin Biol Ther 8(11):1659–1667

Reckel S, Sobhanifar S, Durst F, Lohr F, Shirokov VA, Dotsch V, Bernhard F (2010) Strategies for the cell-free expression of membrane proteins. Methods Mol Biol 607:187–212. doi: 10.1007/978-1-60327-331-2_16

Rosenberg SA, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth LR, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, White DE (2003) Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen. Hum Gene Ther 14(8):709–714. doi: 10.1089/104303403765255110

Sattentau Q (2008) Correlates of antibody-mediated protection against hiv infection. Curr Opin HIV AIDS 3(3):368–374. doi: 10.1097/COH.0b013e3282f9ae79

Shimizu Y, Inoue A, Tomari Y, Suzuki T, Yokogawa T, Nishikawa K, Ueda T (2001) Cell-free translation reconstituted with purified components. Nat Biotech 19 (8):751–755. doi: http://www.nature.com/nbt/journal/v19/n8/suppinfo/nbt0801_751_S1.html

Simpson ML (2006) Cell-free synthetic biology: a bottom-up approach to discovery by design. Mol Syst Biol 2. doi: 6910.1038/msb4100104

Smith LA (2009) Botulism and vaccines for its prevention. Vaccine 27(Suppl 4):D33–D39

Sunami T, Sato K, Matsuura T, Tsukada K, Urabe I, Yomo T (2006) Femtoliter compartment in liposomes for in vitro selection of proteins. Anal Biochem 357(1):128–136. doi: 10.1016/j.ab.2006.06.040

Sunami T, Matsuura T, Suzuki H, Yomo T (2010) Synthesis of functional proteins within liposomes. Methods Mol Biol 607:243–256. doi: 10.1007/978-1-60327-331-2_20

Tabata Y, Inoue Y, Ikada Y (1996) Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres. Vaccine 14(17–18):1677–1685

Takagi A, Matsui M, Ohno S, Duan HY, Moriya O, Kobayashi N, Oda H, Mori M, Kobayashi A, Taneichi M, Uchida T, Akatsuka T (2009) Highly efficient antiviral cd8(+) t-cell induction by peptides coupled to the surfaces of liposomes. Clin Vaccine Immunol 16(10):1383–1392. doi: 10.1128/Cvi.00116-09

Taneichi M, Ishida H, Kajino K, Ogasawara K, Tanaka Y, Kasai M, Mori M, Nishida M, Yamamura H, Mizuguchi J, Uchida T (2006a) Antigen chemically coupled to the surface of liposomes are cross-presented to cd8 + t cells and induce potent antitumor immunity. J Immunol 177(4):2324–2330

Taneichi M, Tanaka Y, Kasai M, Mori M, Nishida M, Yamamura H, Mizuguchi J, Uchida T (2006b) Induction of differential t-cell epitope by plain- and liposome-coupled antigen. Bioconj Chem 17(4):899–904. doi: 10.1021/bc060024g

Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, Pardoll D, Wu TC (2009) A phase i trial of a human papillomavirus DNA vaccine for hpv16 + cervical intraepithelial neoplasia 2/3. Clin Cancer Res 15(1):361–367. doi: 10.1158/1078-0432.CCR-08-1725

Tsuboi T, Takeo S, Iriko H, Jin L, Tsuchimochi M, Matsuda S, Han ET, Otsuki H, Kaneko O, Sattabongkot J, Udomsangpetch R, Sawasaki T, Torii M, Endo Y (2008) Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates. Infect Immun 76(4):1702–1708. doi: 10.1128/IAI.01539-07

Tsuboi T, Takeo S, Arumugam TU, Otsuki H, Torii M (2010a) The wheat germ cell-free protein synthesis system: a key tool for novel malaria vaccine candidate discovery. Acta Trop 114(3):171–176. doi: 10.1016/j.actatropica.2009.10.024

Tsuboi T, Takeo S, Sawasaki T, Torii M, Endo Y (2010b) An efficient approach to the production of vaccines against the malaria parasite. Methods Mol Biol 607:73–83. doi: 10.1007/978-1-60327-331-2_8

Uchida T, Taneichi M (2008) Clinical application of surface-linked liposomal antigens. Mini Rev Med Chem 8(2):184–192

Ulmer JB, Valley U, Rappuoli R (2006) Vaccine manufacturing: challenges and solutions. Nat Biotechnol 24(11):1377–1383. doi: 10.1038/nbt1261

Xiang SD, Scholzen A, Minigo G, David C, Apostolopoulos V, Mottram PL, Plebanski M (2006) Pathogen recognition and development of particulate vaccines: does size matter? Methods 40(1):1–9

Yamaji K, Kanai T, Nomura SM, Akiyoshi K, Negishi M, Chen Y, Atomi H, Yoshikawa K, Imanaka T (2009) Protein synthesis in giant liposomes using the in vitro translation system of thermococcus kodakaraensis. IEEE Trans Nanobioscience 8(4):325–331. doi: 10.1109/TNB.2009.2035278

Yoshida M, Babensee JE (2006) Molecular aspects of microparticle phagocytosis by dendritic cells. J Biomater Sci Polym Ed 17(8):893–907

Zichel R, Mimran A, Keren A, Barnea A, Steinberger-Levy I, Marcus D, Turgeman A, Reuveny S (2010) Efficacy of a potential trivalent vaccine based on hc fragments of botulinum toxins a, b, and e produced in a cell-free expression system. Clin Vaccine Immunol 17(5):784–792. doi: 10.1128/CVI.00496-09