Antifungal Drug Resistance in Aspergillus
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Denning, 1997, Itraconazole resistance in Aspergillus fumigatus, Antimicrob Ag Chemother, 41, 1364, 10.1128/AAC.41.6.1364
Denning, 1997, Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome ofAspergillus fumigatus infection, J Antimicrob Chemother, 40, 401, 10.1093/jac/40.3.401
Oakley, 1997, Efficacy of SCH-56592 in a temporarily neutropenic murine model of invasive aspergillosis with an itraconazole-susceptible and an itraconazole-resistant isolate of Aspergillus fumigatus, Antimicrob Ag Chemother, 41, 1504, 10.1128/AAC.41.7.1504
Oakley, 1997, In vitro activity of SCH-56592 and comparison with activities of amphotericin B and itraconazole againstAspergillus spp, Antimicrob Ag Chemother, 41, 1124, 10.1128/AAC.41.5.1124
Oakley, 1998, In-vitro activity of voriconazole against Aspergillus spp. and comparison with itraconazole and amphotericin B, J Antimicrob Chemother, 42, 91, 10.1093/jac/42.1.91
Lass-Flörl, 1998, In-vitro testing of susceptibility to amphotericin B is a reliable predictor of clinical outcome in invasive aspergillosis, J Antimicrob Chemother, 42, 497, 10.1093/jac/42.4.497
Johnson, 2000, Lack of correlation of in vitro amphotericin B susceptibility testing with outcome of in a murine model ofAspergillus infection, J Antimicrob Chemother, 45, 85, 10.1093/jac/45.1.85
Sterling, 1998, Resistance to amphotericin B: emerging clinical and microbiological patterns, Drug Resistance Updates, 1, 161, 10.1016/S1368-7646(98)80034-4
Vanden Bossche, 1998, Antifungal drug resistance in pathogenic fungi, Med Mycol, 36, 119
Sutton, 1999, In vitro amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole, J Clin Microbiol, 37, 2343, 10.1128/JCM.37.7.2343-2345.1999
Denning, 1992, In vitro susceptibility and synergy studies of Aspergillus species to conventional and new agents, Diagn Microbiol Infect Dis, 15, 21, 10.1016/0732-8893(92)90053-V
Espinel-Ingroff, 1998, Standardization of antifungal susceptibility and clinical relevance, Med Mycol, 36, 68
Verweij, 1998, Efficacy of LY303366 against amphotericin B-susceptible and -resistant Aspergillus fumigatus in a murine model of invasive aspergillosis, Antimicrob Ag Chemother, 42, 873, 10.1128/AAC.42.4.873
Oakley, 1999, Comparison of in vitro activity of liposomal nystatin against Aspergillus species with those of nystatin, amphotericin B (AB) deoxycholate, AB colloidal dispersion, liposomal AB, AB lipid complex, and itraconazole, Antimicrob Ag Chemother, 43, 1264, 10.1128/AAC.43.5.1264
Moore, 2000, In-vitro activity of terbinafine against Aspergillus species and comparison with itraconazole and amphotericin B [abstract WeP146], Clin Microbiol Infect, 6 (Suppl 1), 96
Denning, 1999, Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B, Antimicrob Ag Chemother, 43, 2592, 10.1128/AAC.43.11.2592
Christiansen, 1985, Distribution and activity of amphotericin B in humans, J Infect Dis, 152, 1037, 10.1093/infdis/152.5.1037
Manavathu, 1998, In-vitro isolation and antifungal susceptibility of amphotericin B-resistant mutants of Aspergillus fumigatus, J Antimicrob Chemother, 41, 615, 10.1093/jac/41.6.615
Vanden Bossche, 1994, Mechanisms and impact of antifungal drug resistance, J Med Vet Mycol, 32, 189, 10.1080/02681219480000821
Feigin, 1979, Role of the number and position of double bonds in the four ring sterol nucleus in reaction with polyene antibiotics, Biofizika, 24, 330
Readio, 1982, Equilibrium binding of amphotericin B and its methyl ester and borate complex to sterols, Biochim Biophys Acta, 685, 219, 10.1016/0005-2736(82)90103-1
Bolard, 1986, How do the polyene macrolide antibiotics affect the cellular membrane properties?, Biochim Biophys Acta, 864, 257, 10.1016/0304-4157(86)90002-X
Sandhu, 1979, Effect of amphotericin B on the metabolism of Aspergillus fumigatus, Mycopathologia, 68, 23, 10.1007/BF00490387
Kotler-Brajtburg, 1974, Characterization of the binding of amphotericin B to Saccharomyces cerevisiae and relationship to the antifungal effects, Antimicrob Ag Chemother, 6, 770, 10.1128/AAC.6.6.770
Joseph-Horne, 1996, Nonsterol related resistance in Ustilago maydis to the polyene antifungals, amphotericin B and nystatin, Phytochemistry, 42, 637, 10.1016/0031-9422(96)00037-4
Pierce, 1978, Lipid composition and polyene antibiotic resistance of Candida albicans mutants, Can J Biochem, 56, 135, 10.1139/o78-023
Coulon, 1986, Action de l'amphotericine B sur la composition en sterols de Kluyveromyces bulgaricus et Kluyveromyces lactis, Can J Microbiol, 32, 738, 10.1139/m86-134
Broughton, 1991, Polyene resistance in ergosterol producing strains of Candida albicans, Mycoses, 34, 75, 10.1111/j.1439-0507.1991.tb00623.x
Hsu Chen, 1974, Two types of resistance to polyene antibiotics in Candida albicans, Nature, 251, 656, 10.1038/251656a0
Sokol-Anderson, 1986, Amphotericin B-induced oxidative damage and killing of Candida albicans, J Infect Dis, 154, 76, 10.1093/infdis/154.1.76
Sokol-Anderson, 1988, Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B, Antimicrob Ag Chemother, 32, 702, 10.1128/AAC.32.5.702
Brajtburg, 1990, Amphotericin B: current understanding of mechanisms of action, Antimicrob Ag Chemother, 34, 183, 10.1128/AAC.34.2.183
Lamy-Freund, 1985, Mechanism of inactivation of the polyene antibiotic amphotericin B, Br J Antibiotics, 38, 753, 10.7164/antibiotics.38.753
Kagan, VE, Lipid Peroxidation in Biomembranes, Florida, CRC Press Inc. 1988
Brajtburg, 1985, Involvement of oxidative damage in erythrocyte lysis induced by amphotericin B, Antimicrob Ag Chemother, 27, 172, 10.1128/AAC.27.2.172
Miller, 1997, Role of oxidants in microbial pathophysiology, Clin Microbiol Rev, 10, 1, 10.1128/CMR.10.1.1
Osaka, 1997, Amphotericin B protects cis-parinaric acid against peroxyl radical-induced oxidation: Amphotericin B as an antioxidant, Antimicrob Ag Chemother, 41, 743, 10.1128/AAC.41.4.743
Tokamura, 1995, A family of phospholipid autacoids: Occurrence, metabolism and bioactions, Prog Lipid Res, 34, 151, 10.1016/0163-7827(95)00001-G
Hansberg, 1993, Reactive oxygen species associated with cell differentiation in Neurospora crassa, Free Radical Biol and Med, 14, 287, 10.1016/0891-5849(93)90025-P
Hipler, U-C, Wollina, U, Denning, DW, Fluorescence analysis of reactive oxygen species generated by six isolates of Aspergillus fumigatus [abstract 97], 1999, 48
Holdom, 1996, The Cu, Zn superoxide dismutases of Aspergillus flavus, Aspergillus niger, Aspergillus nidulans, Aspergillus terreus: purification and biochemical comparison with the Aspergillus fumigatus Cu, Zn superoxide dismutase, Infect Immun, 64, 3326, 10.1128/IAI.64.8.3326-3332.1996
Takasuka, 1999, Aspergillus fumigatus catalases: cloning of an Aspergillus nidulans catalase B homologue and evidence for at least three catalases, FEMS Immunol Med Microbiol, 23, 125, 10.1111/j.1574-695X.1999.tb01231.x
Waring, 1995, Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling, Biochem Pharmacol, 49, 1195, 10.1016/0006-2952(95)00039-3
Wong, 1989, Increased amounts of the Aspergillus metabolite D-mannitol in tissue and serum of rats with experimental aspergillosis, J Infect Dis, 160, 95, 10.1093/infdis/160.1.95
Wallace, 1997, Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice, Antimicrob Ag Chemother, 41, 2238, 10.1128/AAC.41.10.2238
National Committee for Clinical Laboratory Standards, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, Wayne, PA, NCCLS, 1997
National Committee for Clinical Laboratory Standards, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Conidium-forming Filamentous Fungi, Wayne, PA, NCCLS, 1998
Dannaoui, 1999, in-vivo itraconazole resistance of Aspergillus fumigatus in systemic murine aspergillosis, J Med Microbiol, 48, 1087, 10.1099/00222615-48-12-1087
Espinel-Ingroff, 1998, In vitro activity of the new triazole voriconazole (UK-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens, J Clin Microbiol, 36, 198, 10.1128/JCM.36.1.198-202.1998
Johnson, 1998, In-vitro activity of voriconazole, itraconazole and amphotericin B against filamentous fungi, J Antimicrob Chemother, 42, 741, 10.1093/jac/42.6.741
Marco, 1998, Antifungal activity of a new triazole, voriconazole (UK-109,496), compared with three other antifungal agents tested against clinical isolates of filamentous fungi, Med Mycol, 36, 433, 10.1080/02681219880000691
Dannaoui, 1999, In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole, J Antimicrob Chemother, 44, 553, 10.1093/jac/44.4.553
Rath, 1998, Susceptibility of Aspergillus strains from culture collections to amphotericin B and itraconazole, J Antimicrob Chemother, 41, 567, 10.1093/jac/41.5.567
Murphy, 1997, Activity of voriconazole (UK-109,496) against clinical isolates of Aspergillus species and its effectiveness in an experimental model of invasive pulmonary aspergillosis, Antimicrob Ag Chemother, 41, 696, 10.1128/AAC.41.3.696
Cuenca-Estrella, 1998, Comparison of the In-vitro activity of voriconazole (UK-109,496), itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus, J Antimicrob Chemother, 42, 531, 10.1093/jac/42.4.531
Moore, 2000, In vitro activity of the new triazole BMS-207147 against Aspergillus species in comparison with itraconazole and amphotericin B, Antimicrob Ag Chemother, 44, 441, 10.1128/AAC.44.2.441-443.2000
Chryssanthou, 1997, In vitro susceptibility of respiratory isolates of Aspergillus species to itraconazole and amphotericin B. Acquired resistance to itraconazole, Scand J Infect Dis, 29, 509, 10.3109/00365549709011864
Abraham, 1999, In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B, Diagn Microbiol Infect Dis, 33, 7, 10.1016/S0732-8893(98)00102-3
Al-Hedaithy, 1998, Antifungal susceptibility testing of Aspergilli isolated from confirmed aspergillosis infections, Biomed Res, 9, 103
Verweij, 1998, In-vitro activities of amphotericin B, itraconazole and voriconazole against 150 clinical and environmentalAspergillus fumigatus isolates, J Antimicrob Chemother, 42, 389, 10.1093/jac/42.3.389
Myoken, 1999, Antifungal susceptibility of Aspergillus species isolated from invasive oral infection in neutropenic patients with hematologic malignancies, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 87, 174, 10.1016/S1079-2104(99)70269-6
Espinel-Ingroff, 1995, Comparative and collab-orative evaluation of standardization of antifungal susceptibility testing for filamentous fungi, Antimicrob Ag Chemother, 39, 314, 10.1128/AAC.39.2.314
Manavathu, 1996, A comparative study of the broth micro- and macro-dilution techniques for the determination of the in vitro susceptibility of Aspergillus fumigatus, Can J Microbiol, 42, 960, 10.1139/m96-123
Espinel-Ingroff, A, Bartlett, M, Chaturvedi, V, et al., Optimal susceptibility testing conditions to detect azole resistance of Aspergillus spp. [abstract 154], San Francisco, CA, Washington, DC, American Society for Microbiology, 1999, 544
Gehrt, 1995, Effect of increasing inoculum sizes of pathogenic filamentous fungi on MICs of antifungal agents by broth microdilution method, J Clin Microbiol, 33, 1302, 10.1128/JCM.33.5.1302-1307.1995
Mosquera, 2000, Invalidation of In-vitro susceptibility testing of Aspergillus flavus with itraconazole and amphotericin B using a murine model. [abstract MoO17], Clin Microbiol Infect, 6 (Suppl 1), 113
Bezjak, 1985, Standardization of a hyphal inoculum of Aspergilli for amphotericin B susceptibility testing, J Clin Microbiol, 21, 509, 10.1128/JCM.21.4.509-512.1985
Manavathu, 1999, Comparative study of susceptibilities of germinated and ungerminated conidia of Aspergillus fumigatus to various antifungal agents, J Clin Microbiol, 37, 858, 10.1128/JCM.37.3.858-861.1999
Espinel-Ingroff, 1991, Spectrophotometric method of inoculum preparation for the in vitro susceptibility testing of filamentous fungi, J Clin Microbiol, 29, 393, 10.1128/JCM.29.2.393-394.1991
Espinel-Ingroff, 1997, Multicenter evaluation of proposed standardised procedure for antifungal susceptibility testing of filamentous fungi, J Clin Microbiol, 35, 139, 10.1128/JCM.35.1.139-143.1997
Llop, 2000, Comparison of three methods of determining MICs for filamentous fungi using different end point criteria and incubation periods, Antimicrob Ag Chemother, 44, 239, 10.1128/AAC.44.2.239-242.2000
Jahn, 1996, Colorimetric susceptibility testing for Aspergillus fumigatus: comparison of menadione-augmented 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide and Alamar Blue tests, J Clin Microbiol, 34, 2039, 10.1128/JCM.34.8.2039-2041.1996
Joseph-Horne, 1997, Molecular mechanisms of azole resistance in fungi, FEMS Microbiol Lett, 149, 141, 10.1111/j.1574-6968.1997.tb10321.x
White, 1998, Clinical, cellular and molecular factors that contribute to antifungal drug resistance, Clin Microbiol Rev, 11, 382, 10.1128/CMR.11.2.382
Kelly, 1995, Mode of action and resistance to azole antifungals associated with the formation of 14α-methylergosta-8,24(28)-dien-3β,6α-diol, Biochem Biophys Res Comm, 207, 910, 10.1006/bbrc.1995.1272
Kelly, 1997, Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta (5, 6) desaturation, FEBS Lett, 400, 80, 10.1016/S0014-5793(96)01360-9
Shimokawa, 1992, Increased sensitivity of Candida albicans cells accumulating 14α-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents, Antimicrob Agents Chemother, 36, 1626, 10.1128/AAC.36.8.1626
White, 1997, Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance inCandida albicans isolates from a patient infected with human immunodeficiency virus, Antimicrob Agents Chemother, 41, 1482, 10.1128/AAC.41.7.1482
Lamb, 1997, The mutation T315A in Candida albicans sterol 14α-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity, J Biol Chem, 272, 5682, 10.1074/jbc.272.9.5682
Sanglard, 1998, Amino acid substitutionsin the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistantCandida albicans clinical isolates contribute to resistance to azole antifungal agents, Antimicrob Ag Chemother, 42, 241, 10.1128/AAC.42.2.241
Delye, 1997, A mutation in the 14α-demethylase gene of Uncinular necator that correlates with resistance to a sterol biosynthesis inhibitor, Appl Environ Microbiol, 63, 2966, 10.1128/AEM.63.8.2966-2970.1997
Joseph-Horne, 1995, Altered P450 specificity associated with direct selection for fungal azole resistance, FEBS Lett, 374, 174, 10.1016/0014-5793(95)01102-K
De Waard, 1996, Molecular genetics of resistance in fungi to azole fungicides, ACS Symposium Series, 645, 62, 10.1021/bk-1996-0645.ch007
Kelly, 1996, Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients, Lancet, 348, 1523, 10.1016/S0140-6736(05)65949-1
Nolte, 1997, Isolation and characterisation of fluconazole and amphotericin B-resistant Candida albicans from blood of two patients with leukemia, Antimicrob Agents Chemother, 41, 196, 10.1128/AAC.41.1.196
Geber, 1995, Deletion of the Candida glabrata ERG3 and ERG11 genes – effect on cell viability, cell growth, sterol composition, and antifungal susceptibility, Anti-microb Ag Chemother, 39, 2708, 10.1128/AAC.39.12.2708
Henry, 1989, Laboratory-induced fungicide resistance to benzimidazole and azole fungicides in Cercospora beticola, Pestic Biochem Physiol, 35, 89, 10.1016/0048-3575(89)90106-5
Marichal, 1997, Molecular biological characterisation of an azole-resistant Candida glabrata isolate, Antimicrob Ag Chemother, 41, 2229, 10.1128/AAC.41.10.2229
Higgins, 1992, ABC transporters: from microorganisms to man, Ann Rev Cell Biol, 8, 67, 10.1146/annurev.cb.08.110192.000435
De Waard, 1979, Mechanism of resistance to fenarimol in Aspergillus nidulans, Pestic Biochem Physiol, 10, 219, 10.1016/0048-3575(79)90025-7
De Waard, 1980, An energy dependent efflux mechanism for fenarimol in a wild-type strain and fenarimol-resistant mutants ofAspergillus nidulans, Pestic Biochem Physiol, 13, 255, 10.1016/0048-3575(80)90124-8
De Waard, 1984, Differential accumulation of fenarimol by a wild-type isolate and fenarimol resistant isolates of Penicillium italicum, Neth J Pl Path, 90, 143, 10.1007/BF02006477
De Waard, 1988, Accumulation of SBI fungicides in wild-type and fenarimol-resistant isolates of Penicillium italicum, Pestic Sci, 22, 371, 10.1002/ps.2780220409
Nakaune, 1998, A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum, Appl Environ Microbiol, 64, 3983, 10.1128/AEM.64.10.3983-3988.1998
Del Sorbo, 1997, Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters, Mol Gen Genet, 254, 417, 10.1007/s004380050434
Pereira, 1998, The gene that determines resistance to tioconazole and to acridine derivatives in Aspergillus nidulans may have a corresponding gene in Trichophyton rubrum, Mycopathologia, 143, 71, 10.1023/A:1006919009621
Kalamarakis, 1991, Resistance to fenarimol in Nectria haematococca var. cucurbitae, Pestic Biochem Physiol, 40, 212, 10.1016/0048-3575(91)90092-Z
Sanglard, 1995, Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters, Antimicrob Agents Chemother, 39, 2378, 10.1128/AAC.39.11.2378
Sanglard, 1997, Cloning of Candida albicans genes conferring resistance to azole antifungal agents: charac-terization ofCDR2 , a new multidrug ABC transporter gene, Microbiology, 143, 405, 10.1099/00221287-143-2-405
Sanglard, 1998, Multiple resistance mechanisms to azole antifungals in yeast clinical isolates, Drug Resistance Updates, 1, 255, 10.1016/S1368-7646(98)80006-X
Prasad, 1995, Molecular cloning and characterisation of a novel gene of Candida albicans CDR1, conferring multiple resistance to drugs and antifungals, Curr Genet, 27, 320, 10.1007/BF00352101
Albertson, 1996, Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance, Antimicrob Ag Chemother, 40, 2835, 10.1128/AAC.40.12.2835
Sanglard, 1996, Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors, Antimicrob Ag Chemother, 40, 2300, 10.1128/AAC.40.10.2300
Tobin, 1997, Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus, Gene, 200, 11, 10.1016/S0378-1119(97)00281-3
Angermayr, 1999, Expression of atrC– encoding a novel member of the ATP binding cassette transporter family inAspergillus nidulans – is sensitive to cycloheximide, Biochim Biophys Acta, 1453, 304, 10.1016/S0925-4439(98)00107-0
Del Sorbo, 2000, Fungal transporters involved in efflux of natural toxic compounds and fungicides, Fungal Genetics Biol, 30, 1, 10.1006/fgbi.2000.1206
Slaven, JW, Anderson, MJ, Sanglard, D, et al., Induced expression of a novel Aspergillus fumigatus putative drug efflux gene in response to itraconazole [abstract 447], San Francisco, CA, Washington, DC, American Society for Microbiology, 1999, 550
Manavathu, 1999, Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent, Int J Antimicrob Agents, 12, 213, 10.1016/S0924-8579(98)00102-2
Brent, KJ, Fungicide resistance in crop pathogens: how can it be managed?, 1995
De Waard, 1997, Characterization of fenarimol-resistant mutants of Aspergillus nidulans, Neth J Pl Path, 83 (Suppl 1), 177
Pombeiro, 1990, Genetic study of a triadimefon-resistant mutant of Aspergillus nidulans, Rev Brasil Genet, 13, 653
De Waard, 1982, Laboratory resistance to fungicides which inhibit ergosterol biosynthesis in Penicillium italicum, Neth J Pl Path, 88, 99, 10.1007/BF01976357
De Waard, 1990, Stepwise development of laboratory resistance to DMI-fungicides in Penicillium italicum, Neth J Pl Path, 96, 321, 10.1007/BF01998780
Mikami, 1995, In vitro emergence of resistant fungal strains after serial subculturing on gradiently increasing concentrations of five different antifungal agents, Japan J Chemother, 43, 634
Brent, KJ, Hollomon, DW, Fungicide resistance: the assessment of risk?, 1998
Groll, 1998, Clinical pharmacology of systemic antifungal agents: a comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development, Adv Pharmacol, 44, 343, 10.1016/S1054-3589(08)60129-5
Hitchcock, CA, Pye, GW, Oliver, GP, Troke, PF, UK-109,496, anovel, wide-spectrum triazole derivative for the treatment offungal infections: antifungal activity and selectivity in vitro [abstract F72], San Francisco, CA, Washington, DC, American Society for Microbiology, 1995, 125
Martin, 1997, Comparison of voriconazole (UK-109,496) and itraconazole in prevention and treatment of Aspergillus fumigatus endocarditis in guinea pigs, Antimicrob Ag Chemother, 41, 13, 10.1128/AAC.41.1.13
Dupont, B, Denning, DW, Lode, H, Yonren, S, Troke, P, Sarantis, N, UK- 109,496, a novel, wide spectrum triazole derivative for the treatment of fungal infections. Clinical efficacy in chronic invasive aspergillosis [abstract F81], San Francisco, CA, Washington, DC, American Society for Microbiology, 1995, 127
Denning, DW, Del Favero, A, Gluckman, E, et al., The efficacy and tolerability of UK 109,496 (voriconazole) in the treatment of invasive aspergillosis (IA) [abstract P552), Parma, Italy, 1997, 217
Kotoyiannis, DP
Munayyer, H, Shaw, KJ, Hare, RS, et al., SCH56592 is a potent inhibitor of sterol C14 demethylation in fungi [abstract F92], New Orleans, LA, Washington, DC, American Society for Microbiology, 1996, 115
Hata, 1996, Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis and cryptococcosis, Antimicrob Ag Chemother, 40, 2243, 10.1128/AAC.40.10.2243