Antifungal Activity of Coumarins

Zeitschrift fur Naturforschung - Section C Journal of Biosciences - Tập 63 Số 1-2 - Trang 21-28 - 2008
Cristina Montagner1, Simone Machado de Souza1, Cláudia Groposo1, Franco Delle Monachè2, Elza F. A. Smânia1, Artur Smânia1
1Departamento de Microbiologia e Parasitologia, Centro de Ciências Biológicas da Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil
2Centro Chimica dei Recettori (CNR), Universitá Cattolica del Sacro Cuore, Largo Francesco Vito, 1, Roma 00168, Italy

Tóm tắt

The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 μg/ml for Fusarium solani and 250 μg/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

Từ khóa


Tài liệu tham khảo

Thông tin
Thông tin xuất bản

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Tập 63 Số 1-2

21-28

Thông tin tác giả