Antifungal Activity of Alkaloids from the Seeds of Chimonanthus praecox

Wiley - Tập 6 Số 6 - Trang 838-845 - 2009
Jiwen Zhang1,2, Jin‐Ming Gao3,1,2, Tian Xu1,2, Xingchang Zhang4, Ya‐Tuan Ma3,1,2, Suwatchai Jarussophon3,5, Yasuo Konishi3
1Research Centre for Natural Medicinal Chemistry, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China, (phone: +86-29-87092335
2fax: +86-29-87092335)
3Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Que., H4P 2R2 Canada
4Institute of Soil & Water Conservation, Chinese Academy of Science, Yangling, Shaanxi 712100, P. R. China
5National Nanotechnology Center, National Science and Technology Development Agency, 30 Thailand Science Park, Paholyothin Rd., Klong Luang, Pathumthani 12120 Bangkok, Thailand

Tóm tắt

Abstractmagnified imageTwo alkaloids, D‐calycanthine (1) and L‐folicanthine (2), were isolated from the active MeOH extract of the seeds of Chimonanthus praecox Link. The structures of the two compounds were established by 1H‐ and 13C‐NMR, and MS (FAB, ESI) analyses. In the in vitro tests, compounds 1 and 2 showed significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium, among which B. maydis was found to be the most susceptible to 1 with an EC50 value of 29.3 μg/ml, followed by S. sderotiorum to 2 with an EC50 value of 61.2 μg/ml. To our knowledge, this is the first report of isolation and LC/MS/MS identification as well as of antifungal properties of these alkaloids from the seeds of this plant.

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Wiley

Tập 6 Số 6

838-845

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