Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Ji-Chun Zhang1, Jin Wu1, Yūkō Fujita1, Wei Yao1, Qian Ren1, Chun Yang1, Su‐Xia Li1, Yukihiko Shirayama1, Kenji Hashimoto2
1Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama).
2Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan (Drs Zhang, Wu, Yao, Ren, Yang, Li, Shirayama, Hashimoto, and Ms Fujita); National Institute of Drug Dependence, Peking University, Beijing, China (Dr Li); Department of Psychiatry, Teikyo University Chiba Medical Center, Chiba, Japan (Dr Shirayama). [email protected].

Tóm tắt

Từ khóa


Tài liệu tham khảo

Adachi, (2008), Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy, Biol Psychiatry, 63, 642, 10.1016/j.biopsych.2007.09.019

Andero, (2011), Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning, Am J Psych, 168, 163, 10.1176/appi.ajp.2010.10030326

Autry, (2011), NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses, Nature, 475, 91, 10.1038/nature10130

Berton, (2006), Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress, Science, 311, 864, 10.1126/science.1120972

Castrén, (2014), Neurotrophins and psychiatric disorders, Handb Exp Pharmacol, 220, 461, 10.1007/978-3-642-45106-5_17

Cazorla, (2011), Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice, J Clin Invest, 121, 1846, 10.1172/JCI43992

Chaudhury, (2013), Rapid regulation of depression-related behaviors by control of midbrain dopamine neurons, Nature, 493, 532, 10.1038/nature11713

Dantzer, (2008), From inflammation to sickness and depression: when the immune system subjugates the brain, Nat Rev Neurosci, 9, 46, 10.1038/nrn2297

de Paiva, (2010), Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice, Behav Brain Res, 215, 146, 10.1016/j.bbr.2010.07.015

Dowlati, (2010), A meta-analysis of cytokines in major depression, Biol Psychiatry, 67, 446, 10.1016/j.biopsych.2009.09.033

Duman, (2012), Synaptic dysfunction in depression: Potential therapeutic targets, Science, 338, 68, 10.1126/science.1222939

Duman, (2012), Signaling pathways underlying the rapid antidepressant actions of ketamine, Neuropharmacology, 62, 35, 10.1016/j.neuropharm.2011.08.044

Duman, (2006), Neurotrophic model for stress-related mood disorders, Biol Psychiatry, 59, 1116, 10.1016/j.biopsych.2006.02.013

Dwivedi, (2003), Altered gene expression of brain-derived neurotrophic factor and receptor tyrosin kinase B in postmortem brain of suicide subjects, Arch Gen Psychiatry, 60, 804, 10.1001/archpsyc.60.8.804

Eisch, (2003), Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression, Biol Psychiatry, 54, 994, 10.1016/j.biopsych.2003.08.003

Govindarajan, (2006), Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects, Proc Natl Acad Sci USA, 103, 13208, 10.1073/pnas.0605180103

Guan, (2006), Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats, Brain Behav Immun, 20, 64, 10.1016/j.bbi.2005.04.005

Guo, (2014), Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice, Neuroscience, 263, 1, 10.1016/j.neuroscience.2014.01.008

Hashimoto, (2009), Emerging role of glutamate in the pathophysiology of major depressive disorder, Brain Res Brain Res Rev, 61, 105, 10.1016/j.brainresrev.2009.05.005

Hashimoto, (2010), Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions, Psychiatry Clin Neurosci, 64, 341, 10.1111/j.1440-1819.2010.02113.x

Hashimoto, (2011), Role of mTOR signaling pathway in the rapid antidepressant action of ketamine, Expert Rev Neurother, 11, 33, 10.1586/ern.10.176

Hashimoto, (2013), Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression, Prog Neurobiol, 100, 15, 10.1016/j.pneurobio.2012.09.001

Hashimoto, (2013), Therapeutic implications for NMDA receptors in mood disorders, Expert Rev Neurother, 13, 735, 10.1586/14737175.2013.811894

Hashimoto, (2014), Serum brain-derived neurotrophic factor as a predictor of incident dementia, JAMA Neurol, 71, 653, 10.1001/jamaneurol.2013.6414

Hashimoto, (2014), BDNF and proBDNF as biomarkers for bipolar disorder, Bri J Psychiatry, 205, 410, 10.1192/bjp.205.5.410

Hashimoto, (2004), Critical role of brain-derived neurotrophic factor in mood disorders, Brain Res Brain Res Rev, 45, 104, 10.1016/j.brainresrev.2004.02.003

Hyman, (2001), Addiction and the brain: The neurobiology of compulsion and its persistence, Nat Rev Neurosci, 2, 695, 10.1038/35094560

Jang, (2010), A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone, Proc Natl Acad Sci USA, 107, 2687, 10.1073/pnas.0913572107

Karege, (2005), Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs, Brain Res Mol Brain Res, 136, 29, 10.1016/j.molbrainres.2004.12.020

Kathol, (1989), Pathophysiology of HPA axis abnormalities in patients with major depression: an update, Am J Psych, 146, 311, 10.1176/ajp.146.3.311

Krishnan, (2007), Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions, Cell, 131, 391, 10.1016/j.cell.2007.09.018

Krystal, (2013), Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond, Biol Psychiatry, 73, 1133, 10.1016/j.biopsych.2013.03.026

Li, (2010), mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists, Science, 329, 959, 10.1126/science.1190287

Li, (2011), Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure, Biol Psychiatry, 69, 754, 10.1016/j.biopsych.2010.12.015

Lindholm, (2014), Mice with altered BDNF signaling as models for mood disorders and antidepressant effects, Front Behav Neurosci, 8, 143, 10.3389/fnbeh.2014.00143

Liu, (2010), A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect, J Med Chem, 53, 8274, 10.1021/jm101206p

Liu, (2012), Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse modelsof depression, J Med Chem, 55, 8524, 10.1021/jm301099x

Magariños, (2011), Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons, Hippocampus, 21, 253, 10.1002/hipo.20744

Martinowich, (2007), New insights into BDNF function in depression and anxiety, Nat Neurosci, 10, 1089, 10.1038/nn1971

McEwen, (2007), Physiology and neurobiology of stress and adaptation: central role of the brain, Physiol Rev, 87, 873, 10.1152/physrev.00041.2006

Milatovic, (2010), Morphometric analysis in neurodegenerative disorders, Curr Protoc Toxicol Chapter, 12, 1

Miller, (2009), Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression, Biol Psychiatry, 65, 732, 10.1016/j.biopsych.2008.11.029

Monteggia, (2004), Essential role of brain-derived neurotrophic factor in adult hippocampal function, Proc Natl Acad Sci USA, 101, 10827, 10.1073/pnas.0402141101

Monteggia, (2007), Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors, Biol Psychiatry, 61, 187, 10.1016/j.biopsych.2006.03.021

Nestler, (2002), Neurobiology of depression, Neuron, 34, 13, 10.1016/S0896-6273(02)00653-0

Nestler, (2006), The mesolimbic dopamine reward circuit in depression, Biol Psychiatry, 59, 1151, 10.1016/j.biopsych.2005.09.018

O’Connor, (2009), Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice, Mol Psychiatry, 14, 511, 10.1038/sj.mp.4002148

Ohgi, (2013), Effects of antidepressants on alternations in serum cytokines and depressive-like behavior in mice after lipopolysaccharide administration, Pharmacol Biochem Behav, 103, 856, 10.1016/j.pbb.2012.12.003

Pariante, (2001), Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment, Biol Psychiatry, 49, 391, 10.1016/S0006-3223(00)01088-X

Paxinos, (1998), The mouse brain in stereotaxic coordinates, 4

Raison, (2010), Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression, Arch Gen Psychiatry, 67, 1211, 10.1001/archgenpsychiatry.2010.161

Ren, (2013), Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine, Pharmacol Biochem Behav, 106, 124, 10.1016/j.pbb.2013.03.016

Ren, (2014), Protective effects of TrkB agonist 7,8-dihydroxyflavone on the behavioral changes and neurotoxicity in mice after administration of methamphetamine, Psychopharmacology, 231, 159, 10.1007/s00213-013-3221-7

Rantamäki, (2007), Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain, Neuropsychopharmacology, 32, 2152, 10.1038/sj.npp.1301345

Saarelainen, (2003), Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects, J Neurosci, 23, 349, 10.1523/JNEUROSCI.23-01-00349.2003

Sanacora, (2008), Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders, Nat Rev Drug Discov, 7, 426, 10.1038/nrd2462

Shelton, (2011), Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression, Mol Psychiatry, 16, 751, 10.1038/mp.2010.52

Shirayama, (2006), Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents, Curr Neuropharmacol, 4, 277, 10.2174/157015906778520773

Shirayama, (2002), Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression, J Neurosci, 22, 3251, 10.1523/JNEUROSCI.22-08-03251.2002

Sun, (2013), Epigenetics of the depressed brain: role of histone acetylation and methylation, Neuropsychopharmacology, 38, 124, 10.1038/npp.2012.73

Taliaz, (2013), Altered brain-derived neurotrophic factor expression in the ventral tegmental area, but not in the hippocampus, is essential for antidepressant-like effects of electroconvulsive therapy, Biol Psychiatry, 74, 305, 10.1016/j.biopsych.2012.07.025

Tanaka, (2008), Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines, Science, 319, 1683, 10.1126/science.1152864

Walsh, (2014), Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway, Nat Neurosci, 17, 27, 10.1038/nn.3591

Yu, (2012), Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants, J Neurosci, 32, 4092, 10.1523/JNEUROSCI.5048-11.2012

Zarate, (2010), Glutamatergic modulators: the future of treating mood disorders?, Harv Rev Psychiatry, 18, 293, 10.3109/10673229.2010.511059