Anticancer drug resistance in primary human brain tumors

Brain Research Reviews - Tập 35 - Trang 161-204 - 2001
Markus Bredel1
1Department of General Neurosurgery, Neurocenter, University of Freiburg, Freiburg, Germany

Tài liệu tham khảo

Abe, 1994, Possible involvement of multidrug-resistance-associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells, Int. J. Cancer, 58, 860, 10.1002/ijc.2910580619 Abe, 1995, Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1, Br. J. Cancer, 72, 418, 10.1038/bjc.1995.348 Abe, 1998, Expression of multidrug resistance protein gene in patients with glioma after chemotherapy, J. Neurooncol., 40, 11, 10.1023/A:1005954406809 Abelson, 1978, Indentification of dihydrofolate reductase in human cental-nervous-system tumours, Lancet, 8057, 184, 10.1016/S0140-6736(78)90615-3 Aida, 1987, Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum (II) in human glial-derived cell lines, Cancer Res., 47, 1361 Aida, 1987, Inhibition of O6-alkylguanine-DNA-alkyltransferase activity potentiates cytotoxicity and induction of SCEs in human glioma cells resistant to 1,3-bis(2-chloroethyl)-1-nitrosouea, Carcinogenesis, 8, 1219, 10.1093/carcin/8.9.1219 Akinaga, 1996, G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and cdk-2, as well as induction of cdk inhibitor p21 in p53-mutated human carcinoma cells, Proc. Annu. Meet. Am. Assoc. Cancer Res., 37, A2888 Akinaga, 1994, Effect of UCN-01, a selective inhibitor of protein kinase C on the cell-cycle distribution of human epidermoid carcinoma, A431 cells, Cancer Chemother. Pharmacol., 33, 273, 10.1007/BF00685899 Ali-Osman, 1997, Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase-p gene variants, J. Biol. Chem., 272, 10004, 10.1074/jbc.272.15.10004 Ali-Osman, 1996, Buthionine sulfoximine induction of gamma-l-glutamyl-l-cysteine synthetase gene expression, kinetics of glutathione depletion and resynthesis, and modulation of carmustine-induced DNA-DNA cross-linking and cytotoxicitiy in human glioma cells, Mol. Pharmacol., 49, 1012 Ali-Osman, 1993, Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells, Cancer Res., 53, 5663 Ali-Osman, 1997, Prognostic significance of glutathione S-transferase p expression and subcellular localization in human gliomas, Clin. Cancer Res., 3, 2253 Ali-Osman, 1989, Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione, Cancer Res., 49, 5954 Ali-Osman, 1995, Formation and repair of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks inhuman glioma cells, Cancer Biochem. Biophys., 14, 231 Ali-Osman, 1990, DNA interstrand crosslinking and strand break repair human glioma cell lines of varying [1,3-bis(2-chloroethyl)-1-nitrosourea] resistance, Anticancer Res., 10, 677 Ali-Osman, 1990, Glutathione content and glutathione S-transferase expression in 1,3-bis(2-chloroehtyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines, Cancer Res., 50, 6976 Allalunis-Turner, 1991, Glutathione levels and chemosensitizing effects of buthionine sulfoximine in human malignant glioma cells, J. Neurooncol., 11, 157, 10.1007/BF02390175 Allikmets, 1996, Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database, Hum. Mol. Genet., 5, 1649, 10.1093/hmg/5.10.1649 Alt, 1978, Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells, J. Biol. Chem., 253, 1357, 10.1016/S0021-9258(17)34875-5 Amoureux, 1995, Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes, Biochem. Biophys. Res. Commun., 214, 639, 10.1006/bbrc.1995.2334 Anderson, 1991, The role of protein kinase C and phosphatidylinositol cycle in multidrug resistance in human ovarian cancer cells, Biochem. Pharmacol., 42, 1427, 10.1016/0006-2952(91)90455-E Andrews, 1997, Technetium-MIBI as a glioma imaging agent for the assessment of multidrug resistance, Neurosurgery, 40, 1323, 10.1097/00006123-199706000-00047 Angel, 1991, The role of jun, fos and the AP-1 complex in cell proliferation and transformation, Biochim. Biophys. Acta, 1072, 129 Arboix, 1997, Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis, J. Pharmacol. Exp. Ther., 281, 1226 Arita, 1991, Chemotherapy of malignant brain tumors-scientific basis for combination chemotherapy, Gan To Kagaku Ryoho, 18, 180 Baltuch, 1995, Protein kinase C isoform alpha overexpression in C6 glioma cells and its role in cell proliferation, J. Neurooncol., 24, 241, 10.1007/BF01052840 Baltuch, 1995, Protein kinase C and growth regulation of malignant gliomas, Can. J. Neurol. Sci., 22, 264, 10.1017/S0317167100039457 Bardot, 1994, Purine and pyrimidine metabolism in human gliomas: relation to chromosomal aberrations, Br. J. Cancer, 70, 212, 10.1038/bjc.1994.282 Baskin, 1975, Experimental chemotherapy of neuroblastoma. II. Increased thymidylate synthetase activity in a 5-fluorodeoxyuridine-resistant variant of mouse neuroblastoma, Mol. Pharmacol., 11, 105 Baskin, 1977, Altered thymidine kinase or thymidylate synthetase activities in 5-fluorodeoxyuridine resistant variants of mouse neuroblastoma, J. Neurochem., 29, 1031, 10.1111/j.1471-4159.1977.tb06506.x Baskin, 1975, A comparison of thymidylate synthetase activities from 5-fluorodeoxyuridine sensitive and resistant variants of mouse neuroblastoma, J. Neurochem., 25, 233, 10.1111/j.1471-4159.1975.tb06958.x Basu, 1991, Cellular sensitization to cis-diamminedichloroplatinum (II) by novel analogues of protein kinase C activator lyngbyatoxin A, Cancer Res., 51, 2511 Basu, 1992, Sensitization of human cervical carcinoma cells to cis-diamminedichloroplatinum (II) by bryostatin 1, Cancer Res., 52, 3119 Basu, 1990, Involvement of protein kinase C in phorbol ester-induced sensitization of HeLa cells to cis-diamminedichloroplatinum (II), J. Biol. Chem., 265, 8451, 10.1016/S0021-9258(19)38909-4 Bauman, 2000, Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas, Int. J. Radiat. Oncol. Biol. Phys., 48, 825, 10.1016/S0360-3016(00)00703-3 Baylin, 1998, Alterations in DNA methylation: a fundamental aspect of neoplasia, Adv. Cancer Res., 72, 141, 10.1016/S0065-230X(08)60702-2 Becker, 1991, The multidrug resistance gene MDR1 is expressed in human glial tumors, Acta Neuropathol., 82, 516, 10.1007/BF00293387 Becker, 1992, New mechanisms of hormone secretion: MDR-like gene products as extrusion pumps for hormones?, Horm. Metab. Res., 24, 210, 10.1055/s-2007-1003295 Belanich, 1996, Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine, Cancer Res., 56, 783 Benzil, 1992, Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression, Cancer Res., 52, 2951 Berger, 1987, Thymidylate synthase overproduction and gene amplification in flurodeoxyuridine-resistant human cells, Mol. Pharmacol., 28, 461 Bhat, 1989, Role of protein kinase C in glial proliferation, J. Neurosci. Res., 22, 20, 10.1002/jnr.490220104 Bleehen, 1995, A phase II study of oral piritrexim in recurrent high-grade (III, IV) glioma, Br. J. Cancer, 72, 766, 10.1038/bjc.1995.407 Blobe, 1993, Selective regulation of expression of protein kinase C (PKC) isoenzymes in multi-drug resistant MCF-7 cells, J. Biol. Chem., 268, 658, 10.1016/S0021-9258(18)54202-2 Board, 1990, Genetic heterogneity of the human glutathione S-transferases: a complex of gene families, Pharmacol. Ther., 48, 357, 10.1016/0163-7258(90)90054-6 Bobola, 1995, Contribution of O6-methylguanine-DNA methyltransferase to resistance to 1,3-(chloroethyl)-1-nitrosourea in human brain tumor-derived cell lines, Mol. Carcinog., 13, 81, 10.1002/mc.2940130204 Bodell, 1986, Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, Carcinogenesis, 7, 879, 10.1093/carcin/7.6.879 Bodell, 1985, Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas, Environ. Health Perspect., 62, 119, 10.2307/3430103 Bodell, 1985, Investiation of resistance to DNA cross-linking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas, Cancer Res., 45, 3460 Bodell, 1985, Potentiation of 1,3-bis(chloroethyl)-1-nitrosourea (BCNU)-induced cytotoxicity in 9L cells by pretreatment with 6-thioguanine, Biochem. Pharmacol., 35, 515, 10.1016/0006-2952(85)90182-0 Bodell, 1984, Reduced level of DNA cross-links and sister chromatid exchanges in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant rat brain tumor cells, Cancer Res., 44, 3763 Bodell, 1988, Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea, Cancer Res., 48, 4489 Borst, 1997, DocMOAT (MRP2), other MRP homologues, and LRP play a role in MDR?, Semin. Cancer Biol., 8, 205, 10.1006/scbi.1997.0071 von Bossanyi, 1997, Immunohistochemical expression of P-glycoprotein and glutathione S-transferases in cerebral gliomas and response to chemotherapy, Acta Neuropathol., 94, 605, 10.1007/s004010050756 Bowles, 1990, Use of verapamil to enhance the antiproliferative activity of BCNU in human glioma cells: an in vitro and in vivo study, J. Neurosurg., 73, 248, 10.3171/jns.1990.73.2.0248 Brandes, 2000, Temozolomide in patients with high grade gliomas, Oncology, 59, 181, 10.1159/000012158 Brandt, 1997, Detection of DNA damage in transcriptionally active genes by RT-PCR and assessment of repair of cisplatin-induced damage in the glutathione S-transferase-pi gene in human glioblastoma cells, Toxicol. Appl. Pharmacol., 143, 22, 10.1006/taap.1996.8010 Bredel, 1999, The p21-Ras signal transduction pathway and growth regulation in high-grade gliomas, Brain Res. Brain Res. Rev., 29, 232, 10.1016/S0165-0173(98)00057-5 Bredel, 1997, The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy, Acta Neurochir., 139, 1000, 10.1007/BF01411552 Bredel, 1998, Inhibition of ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth, Neurosurgery, 43, 124, 10.1097/00006123-199807000-00081 Bredel, 1999, Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion, J. Neurooncol., 41, 9, 10.1023/A:1006047025425 Brent, 1984, Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphblasts, Cancer Res., 44, 1887 Britten, 1992, Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agents, J. Radiat. Oncol., 24, 527, 10.1016/0360-3016(92)91069-Y Broxterman, 1997, Transport proteins in drug resistance: detection and prognostic significance in acute myeloid leukemia, J. Intern. Med., 740, 147, 10.1111/joim.1997.242.s740.147 Broxterman, 1995, Pharmacology of drug transporter in multidrug resistant tumor cells, 67 Buchler, 1996, cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats, J. Biol. Chem., 271, 15091, 10.1074/jbc.271.25.15091 Bunch, 1996, Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor, Clin. Cancer Res., 2, 791 Burger, 1994, Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias, Leukemia, 8, 990 Cabral, 1986, A mechanism of cellular resistance to drugs that interfere with microtubule assembly, Ann. N.Y. Acad. Sci., 46, 748 Cairncross, 1998, Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas, J. Natl. Cancer Inst., 90, 1473, 10.1093/jnci/90.19.1473 Cardon-Cardo, 1990, Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissue, J. Histol. Cytochem., 38, 1277, 10.1177/38.9.1974900 Carlin, 1974, Quinazoline antifolates as inhibitors of growth, dihydrofolate reductase, and thymidylate synthetase of mouse neuroblastoma cells in culture, Mol. Pharmacol., 10, 194 Chambers, 1990, Correlation of protein kinase C translocation, P-glycoprotein phosphorylation and reduced drug accumulation in multidrug resistant human KB cells, Biochem. Biophys. Res. Commun., 169, 253, 10.1016/0006-291X(90)91461-Z Chambers, 1990, Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells, J. Biol. Chem., 265, 7679, 10.1016/S0021-9258(19)39168-9 Chan, 1991, P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma, New Engl. J. Med., 325, 1608, 10.1056/NEJM199112053252304 Chapman, 1994, The suppression of drug-induced apoptosis by activation of v-abl protein tyrosine kinase, Cancer Res., 54, 5131 Chaudhary, 1992, Activation of MDR 1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists, Oncol. Res., 4, 281 Chen, 1994, DNA topoisomerases: essential enzymes and lethal targets, Annu. Rev. Pharmacol. Toxicol., 34, 191, 10.1146/annurev.pa.34.040194.001203 Chen, 1986, Internal dublication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells, Cell, 47, 381, 10.1016/0092-8674(86)90595-7 Chen, 1993, Protein kinase C alpha, delta, epsilon and… in C6 glioma cells, FEBS Lett., 332, 169, 10.1016/0014-5793(93)80506-P Chen, 1995, Direction of p21-Ras generated signals towards cell growth or apoptosis is determined by protein kinase C and bcl-2, Oncogene, 11, 1487 Chen, 1998, Excision repair cross-complementing rodent deficiency gene 2 expression and chloroethylnitrosourea resistance in human glioma cell lines, Neurosurgery, 42, 1112, 10.1097/00006123-199805000-00094 Chou, 1996, Ependymomas in children express the multidrug resistance gene: immunohistochemical and molecular biologic study, Pediatr. Pathol. Lab. Med., 16, 551, 10.1080/107710496175499 Chou, 1995, Multidrug resistance gene expression in childhood medulloblastoma: correlation with clinical outcome and DNA ploidy in 29 patients, Pediatr. Neurosurg., 23, 283, 10.1159/000120984 Chu, 1996, Antifolates, 109 Chugani, 1993, Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex, J. Cell Sci., 106, 23, 10.1242/jcs.106.1.23 Citron, 1991, O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary, Cancer Res., 51, 4131 Citron, 1992, Detection of messenger RNA from O6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues, J. Natl. Cancer Inst., 84, 337, 10.1093/jnci/84.5.337 Clark, 1991, Characterization and differential distribution of the three major protein kinase C isozymes of the central nervous system in normal and Alzheimer’s disease brains, Lab. Invest., 64, 35 Clark, 1987, Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy, Cancer Treat. Rep., 71, 261 Cole, 1992, Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line, Science, 258, 1650, 10.1126/science.1360704 Cole, 1994, Pharmacological characterization of the multidrug resistant MRP-transfected human tumor cells, Cancer Res., 54, 5902 Colvin, 1993, Role of glutathione in cellular resistance to alkylating agents, Adv. Enzyme Regul., 33, 19, 10.1016/0065-2571(93)90006-Y Cordon-Cardo, 1989, Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood–brain barrier sites, Proc. Natl. Acad. Sci. USA, 86, 695, 10.1073/pnas.86.2.695 Couldwell, 1992, Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C, Neurosurgery, 31, 717, 10.1227/00006123-199210000-00015 Couldwell, 1994, Protein kinase C and growth regulation in malignant gliomas, Neurosurgery, 35, 1184, 10.1227/00006123-199412000-00029 Couldwell, 1994, Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines, FEBS Lett., 345, 43, 10.1016/0014-5793(94)00415-3 Couldwell, 1991, Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro, Neurosurgery, 29, 880, 10.1227/00006123-199112000-00013 Daneberg, 1977, Thymidylate synthase: a target enzyme in cancer chemotherapy, Biochim. Biophys. Acta, 473, 73 Danks, 1994, Subcellular distribution of the α and β topoisomerase II-DNA complexes stabilized by VM-26, Biochem. Pharmacol., 48, 1785, 10.1016/0006-2952(94)90465-0 Davies, 1988, Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins, J. Biol. Chem., 263, 17724, 10.1016/S0021-9258(19)77896-X Day, 1980, Defective repair of alkylated DNA by human tumor and SV40-transformed human cell strains, Nature, 288, 724, 10.1038/288724a0 Day, 1980, Human tumor cell strains defective in the repair of alkylation damage, Carcinogenesis, 1, 21, 10.1093/carcin/1.1.21 De Graeff, 1988, Resistance to cisplatin and analogues; mechanism and potential clinical implications, Cancer Chemother. Pharmacol., 22, 325, 10.1007/BF00254240 Denmeade, 1996, Programmed cell death (apoptosis) and cancer chemotherapy, Cancer Control, 3, 303, 10.1177/107327489600300401 De Tinguy-Moreaud, 1994, Relationships between DNA damage and growth inhibition induced by topoisomerase II-interfering drugs in doxorubicin-sensitive and resistant rat glioblastoma cells, Anticancer Res., 14, 99 Dive, 1994, Signal transduction events for the suppression of apoptosis, Br. J. Cancer, 71, A5 Doz, 1993, Metallothionein and anticancer agents: the role of metallothionein in cancer chemotherapy, J. Neurooncol., 17, 123, 10.1007/BF01050214 Duch, 1979, Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth, Cancer Res., 39, 487 Durmaz, 1999, The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme, Clin. Neurol. Neurosurg., 101, 238, 10.1016/S0303-8467(99)00061-X Earnshaw, 1985, Topoisomerase II is a structural component of mitotic chromosome scaffolds, J. Cell Biol., 100, 1706, 10.1083/jcb.100.5.1706 Earnshaw, 1985, Localization of topoiomerase II in mitotic chromosomes, J. Cell Biol., 100, 1716, 10.1083/jcb.100.5.1716 Ebadi, 1991, Metallothioneins and other zinc-binding proteins in brain, Methods Enzymol., 205, 363, 10.1016/0076-6879(91)05119-G Eid, 1988, Do metallothioneins affect the response to treatment in testis cancer?, J. Cancer Res. Clin. Oncol., 124, 31, 10.1007/s004320050130 El Rouby, 1993, p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression, Blood, 82, 3452, 10.1182/blood.V82.11.3452.3452 Endicott, 1989, The biochemistry of P-glycoprotein-mediated multidrug resistance, Annu. Rev. Biochem., 58, 137, 10.1146/annurev.bi.58.070189.001033 Erickson, 1991, The role of O6-methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibtion, Semin. Cancer Biol., 2, 257 Erickson, 1980, DNA cross-linking and monoadduct repair in nitrosourea-treated human tumor cells, Nature, 288, 727, 10.1038/288727a0 Esteller, 1999, Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promotor hyermethylation is a common event in primary human neoplasia, Cancer Res., 59, 793 Evans, 1995, Suppression of apoptosis by v-Abl protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haematopoietic cell line, J. Cell Sci., 108, 2591, 10.1242/jcs.108.7.2591 Evans, 1987, Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard, Cancer Res., 47, 2525 Evans, 1993, Multiple pathways to apoptosis, Cell Biol. Int., 17, 461, 10.1006/cbir.1993.1087 Fan, 1994, p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents, Cancer Res., 54, 5824 Feun, 1989, MDR1 gene expression in primary brain tumors (MBT), Proc. Am. Soc. Clin. Oncol., 8, 88 Feun, 1994, Drug resistance in brain tumors, J. Neurooncol., 20, 165, 10.1007/BF01052726 Fields, 1990, Role of nuclear protein kinase C in the mitogenic response to platelet-derived growth factor, J. Cell Sci., 96, 107, 10.1242/jcs.96.1.107 Fine, 1988, Phorbol esters induce multidrug resistance in human breast cancer cells, Proc. Natl. Acad. Sci. USA, 85, 582, 10.1073/pnas.85.2.582 Flens, 1994, Immunohistochemical detection of the multidrug resistance-associated protein (MRP) in human multidrug-resistant tumor cells by monoclonal antibodies, Cancer Res., 54, 4557 Flens, 1996, Tissue distribution of the multidrug resistance protein, Am. J. Pathol., 148, 1237 Fornace, 1990, Expression of the O6-methylguanine DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells, Cancer Res., 50, 7908 Friedman, 1992, Cyclophosphamide resistance in medulloblastoma, Cancer Res., 52, 5373 Friedman, 2000, Temozolomide and treatment of malignant glioma, Clin. Cancer Res., 6, 2585 Friedman, 1998, DNA mismatchrepair and O6-alkylguanine-DNA-alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma, J. Clin. Oncol., 16, 3851, 10.1200/JCO.1998.16.12.3851 Froelich-Ammon, 1995, Topoisomerase poisons: harnessing the dark side of enzyme mechanism, J. Biol. Chem., 270, 21429, 10.1074/jbc.270.37.21429 Fry, 1991, Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines, Cancer Res., 51, 6592 Fujiwara, 1994, Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene, Cancer Res., 54, 2287 Gasparini, 1995, Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer, Clin. Cancer Res., 1, 189 Ge, 1997, Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine, Int. J. Cancer, 71, 675, 10.1002/(SICI)1097-0215(19970516)71:4<675::AID-IJC26>3.0.CO;2-9 Geddes, 1994, Detection multidrug resistance gene product (P-glycoprotein) expression in ependymomas, Neuropathol. Appl. Neurobiol., 20, 118, 10.1111/j.1365-2990.1994.tb01170.x Gerlach, 1986, Multidrug resistance, Cancer Survey, 5, 25 Germann, 1996, P-glycoprotein — a mediator of multidrug resistance in tumour cells, Eur. J. Cancer, 32A, 927, 10.1016/0959-8049(96)00057-3 Gerosa, 1983, Improved treatment of a brain-tumor model: Part 2. Sequential therapy with BCNU and 5-fluorouracil, J. Neurosurg., 58, 368, 10.3171/jns.1983.58.3.0368 Gjerset, 1995, Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53, Mol. Carcinog., 14, 275, 10.1002/mc.2940140408 Goldie, 1979, A mathematical model for relating the drug sensitivity of tumors to their spontaneous mutation rate, Cancer Treat. Pep., 63, 1727 Goldstein, 1989, Expression of a multidrug-resistance gene in human cancer, J. Natl. Cancer Inst., 81, 116, 10.1093/jnci/81.2.116 Goldstein, 1992, Multidrug resistance in human cancer, Crit. Rev. Oncol. Hematol., 12, 243, 10.1016/1040-8428(92)90057-W Gomez-Manzano, 1997, Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis, J. Natl. Cancer Inst., 89, 1036, 10.1093/jnci/89.14.1036 Gomi, 1997, Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells, Biochem. Biophys. Res. Commun., 239, 51, 10.1006/bbrc.1997.7423 Gomi, 1997, Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea in human glioma cells, Cancer Res., 57, 5292 Gomi, 1996, Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea, Biochem. Biophys. Res. Commun., 227, 558, 10.1006/bbrc.1996.1545 Grant, 1994, Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs, Cancer Res., 54, 357 Grant, 1995, Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma, J. Neurooncol., 25, 1, 10.1007/BF01054717 Grogan, 1993, P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy, Blood, 81, 490, 10.1182/blood.V81.2.490.490 Gros, 1986, Isolation and expression of a complementary DNA that confers multidrug resistance, Nature, 323, 728, 10.1038/323728a0 Gutin, 1983, Surgery, radiation, and chemotherapy in the treatment of malignant brain tumors, 67 Haas-Kogan, 1999, p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors, Int. J. Radiat. Oncol. Biol. Phys., 43, 399, 10.1016/S0360-3016(98)00393-9 Hamada, 1998, Accumulation of class I mutant p53 and apoptosis induced by carboplatin in a human glioma cell line, Brain Tumor Pathol., 15, 77, 10.1007/BF02478887 Hara, 1993, Identification of placental form of glutathione S-transferase in ACNU-resistant murine glioma cell lines, J. Neurooncol., 17, 205, 10.1007/BF01049976 Hara, 1993, Localization of the placental form of glutathione S-transferase messenger ribonucleic acid in human glioma cell lines, Neurosurgery, 33, 100, 10.1227/00006123-199307000-00016 Hara, 1993, Expression of the placental form of glutathione S-transferase in pediatric gliomas, Child’s Nerv. Syst., 9, 142, 10.1007/BF00272262 Hara, 1993, Immunoblot analysis of the placental form of glutathione S-transferase in protein extracted from paraffin-embedded human glioma tissue, J. Cancer Res. Clin. Oncol., 119, 493, 10.1007/BF01215931 Hara, 1990, Immunohistochemical demonstration of the placental form of glutathione S-transferase, a detoxifying enzyme in human gliomas, Cancer, 66, 2563, 10.1002/1097-0142(19901215)66:12<2563::AID-CNCR2820661219>3.0.CO;2-A Harris, 1991, Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene, Nucleic Acids Res., 19, 6163, 10.1093/nar/19.22.6163 Hayes, 1995, The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance, Crit. Rev. Biochem. Mol. Biol., 30, 445, 10.3109/10409239509083491 He, 1992, Expression of O6-methylguanine-DNA methyltransferase in six human medulloblastoma cell lines, Cancer Res., 52, 1144 Heck, 1988, Differential expression of DNA topoisomerase I and II during the eukaryotic cell cycle, Proc. Natl. Acad. Sci. USA, 85, 1086, 10.1073/pnas.85.4.1086 Hegemann, 1992, Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells, Cancer Res., 52, 6969 Hellemans, 1995, Immunohistochemical study of topoisomerase IIa expression in primary ductal carcinoma of the breast, J. Clin. Pathol., 48, 147, 10.1136/jcp.48.2.147 Henson, 1992, P-glycoprotein expression in brain tumors, J. Neurooncol., 14, 37, 10.1007/BF00170943 Herzog, 1995, Expression of topoisomerase II, bcl-2, and p53 in three human brain tumor cell lines and their possible relationship to intrinsic resistance to etoposide, Clin. Cancer Res., 1, 1391 Hickman, 1996, Apoptosis and chemotherapy resistance, Eur. J. Cancer, 32, 921, 10.1016/0959-8049(96)00080-9 Higgins, 1992, ABC transporters: from microorganisms to man, Annu. Rev. Cell Biol., 8, 67, 10.1146/annurev.cb.08.110192.000435 Hill, 1975, Microsomal metabolism of nitrosoureas, Cancer Res., 35, 296 Hipfner, 1994, Detection of the Mr 190,000 multidrug resistance protein, MRP, with monoclonal antibodies, Cancer Res., 54, 5788 Hishikawa, 1997, Overexpression of metallothionein correlates with chemoresistance to cisplatin and prognosis in esophageal cancer, Oncology, 54, 342, 10.1159/000227714 Hitchins, 1988, Identification of a multidrug resistance associated antigen (P-glycoprotein) in human normal tissues, Eur. J. Cancer Clin. Oncol., 24, 449, 10.1016/S0277-5379(98)90015-3 Hiura, 1998, Immunohistochemical analysis of metabollothionein in astrocytic tumors in relation to tumor grade, proliferative potential, and surival, Cancer, 83, 2361, 10.1002/(SICI)1097-0142(19981201)83:11<2361::AID-CNCR16>3.0.CO;2-N Holden, 1995, Immunohistochemical staining for DNA topoisomerase II in non-Hodgkin’s lymphomas, Am. J. Clin. Pathol., 104, 54, 10.1093/ajcp/104.1.54 Holden, 1992, The distribution of immunoreactive topoisomerase II protein in human tissues and neoplasms, Oncol Res., 4, 157 Holden, 1994, Immunohistochemical staining for DNA topoisomerase II in frozen and formalin-fixed paraffin-embedded human tissues, Mod. Pathol., 8, 829 Holden, 1999, DNA topoisomerase II-alpha as a proliferation marker in astrocytic neoplasms of the central nervous system: correlation with MIB1 expression and patient survival, Mod. Pathol., 12, 1094 Holm, 1994, Coming undone: how to untangle a chromosome, Cell, 77, 955, 10.1016/0092-8674(94)90433-2 Hongeng, 1997, O-6-methylguanine-DNA methyltransferase protein levels in pediatric brain tumors, Clin. Cancer Res., 3, 2459 Horie, 1987, Specific induction of ACNU-resistance in V79 Chinese hamster cells and C6 rat glioma cells, J. Neurosurg., 67, 553, 10.3171/jns.1987.67.4.0553 Hotta, 1994, 06-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications, J. Neurooncol., 21, 135, 10.1007/BF01052897 Houlbrook, 1995, Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines, Br. J. Cancer, 72, 1454, 10.1038/bjc.1995.529 Huet, 1992, P-glycoprotein overexpression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines, Br. J. Cancer, 65, 538, 10.1038/bjc.1992.111 Husemann, 1999, Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors, J. Neuropathol. Exp. Neurol., 58, 1041, 10.1097/00005072-199910000-00002 Iida, 1997, Effect of glutathione-modulating compounds on hydrogen peroxide-induced cytotoxicity in human glioblastoma and glioma cell lines, J. Cancer Res. Clin. Oncol., 123, 619, 10.1007/s004320050115 Ikemoto, 1995, Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor, J. Neurosurg., 83, 1008, 10.3171/jns.1995.83.6.1008 Ino, 2000, Long survival and therapeutic responses in patients with histologically disparate high-grade gliomas demonstrating chromosome 1p loss, J. Neurosurg., 92, 983, 10.3171/jns.2000.92.6.0983 Islam, 1989, Chromosomal localization of human glutathione transferase genes of classes alpha, mu, and pi, Hum. Genet., 82, 338, 10.1007/BF00273994 Ito, 1997, Immunohistochemical study of Ki-67 and DNA topooisomerase II in human endometrium, Mod. Pathol., 10, 289 Iwadate, 1996, Association of p53 gene muation with decreased chemosensitivity in human malignant gliomas, Int. J. Cancer, 69, 236, 10.1002/(SICI)1097-0215(19960621)69:3<236::AID-IJC14>3.0.CO;2-5 Iwasaki, 1995, Inhibitory effects of tamoxifen and tumor necrosis factor alpha on human glioblastoma cells, Cancer Immunol. Immunother., 40, 228, 10.1007/BF01519896 Izquierdo, 1996, Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors, Am. J. Pathol., 148, 877 Izquierdo, 1996, Major vault protein LRP-related multidrug resistance, Eur. J. Cancer, 32A, 979, 10.1016/0959-8049(96)00053-6 Izquierdo, 1996, Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs, Cytotechnology, 19, 191, 10.1007/BF00744212 Izquierdo, 1995, Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma, J. Natl. Cancer Inst., 87, 1230, 10.1093/jnci/87.16.1230 Izumu, 1993, Characterization and chemosensitivity of two cell lines derived from human glioblastomas, J. Neurooncol., 17, 111, 10.1007/BF01050213 Jackson, 1977, Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofolate reductase, Eur. J. Cancer, 13, 567, 10.1016/0014-2964(77)90118-9 Järvinen, 1996, Expression of topoisomerase IIa is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer, Am. J. Pathol., 148, 2073 Jasani, 1997, Significance of metallothionein overexpression in human tumours, Histopathology, 31, 211, 10.1046/j.1365-2559.1997.2140848.x Jedlitschky, 1994, ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein, Cancer Res., 54, 4833 Jenh, 1985, Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines, Mol. Pharmacol., 28, 80 Johnston, 1992, Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines, Cancer Res., 52, 4306 Johnston, 1994, The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer, J. Clin. Oncol., 12, 2640, 10.1200/JCO.1994.12.12.2640 Juliano, 1976, A surface glycoprotein in modulating drug permeability in Chinese hamster ovary cell mutants, Biochim. Biophys. Acta, 455, 152, 10.1016/0005-2736(76)90160-7 Kartner, 1983, Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines, Science, 221, 1285, 10.1126/science.6137059 Kaufmann, 1994, Topoisomerase II levels and drug sensitivity in adult myelogenous leukemia, Blood, 83, 517, 10.1182/blood.V83.2.517.517 Kedersha, 1986, Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA, J. Cell Biol., 103, 699, 10.1083/jcb.103.3.699 Keith, 1993, Co-amplification of erbB2, topoisomerase IIa and retinoid acid receptor genes in breast cancer and allelic loss at topoisomerase I on chromosome 20, Eur. J. Cancer, 29A, 1469, 10.1016/0959-8049(93)90022-8 Keller, 1998, Translational inhibition of messenger RNA of the human pi class glutathione S-transferase by antisense oligodeoxyribonucleotides, Chem. Biol. Interact., 111–112, 307, 10.1016/S0009-2797(97)00168-3 Kelley, 1988, Overexpression of the metallothionein confers resistance to anticancer drugs, Science, 241, 1813, 10.1126/science.3175622 Keppler, 1997, Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver, FASEB J., 11, 509, 10.1096/fasebj.11.7.9212074 Kerr, 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer, 26, 239, 10.1038/bjc.1972.33 Kickhoefer, 1994, The sequence of a cDNA encoding the major vault protein from Rattus norvegicus, Gene, 151, 257, 10.1016/0378-1119(94)90667-X Kikuchi, 1993, Induction of metallothionein in a human astrocytoma cell line by interleukin-1 and heavy metals, FEBS Lett., 317, 22, 10.1016/0014-5793(93)81483-G Kikuchi, 1998, cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3), FEBS Lett., 433, 149, 10.1016/S0014-5793(98)00899-0 Kiley, 1995, Intracellular targeting of protein kinase C isoenzymes, functional implications, Biochem. Soc. Trans., 23, 601, 10.1042/bst0230601 Kodera, 1994, Expression of glutathione S-transferases α and π in gastric cancer: a correlation with cisplatin resistance, Cancer Chemother. Pharmacol., 34, 203, 10.1007/BF00685078 Koike, 1996, Overexpression of multidrug resistance protein gene in human cancer cell lines selected for drug resistance to epipodophyllotoxins, Jpn. J. Cancer Res., 87, 765, 10.1111/j.1349-7006.1996.tb00290.x Kondo, 1995, MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis, Oncogene, 10, 2001 Kondo, 1996, Mdm2 gene mediates the expression of Mdr1 gene and P-glycoprotein in a human glioblastoma cell line, Br. J. Cancer, 74, 1263, 10.1038/bjc.1996.527 Kondo, 1998, Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis, Oncogene, 16, 2243, 10.1038/sj.onc.1201754 Kool, 1997, Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines, Cancer Res., 57, 3537 Korshunov, 1999, Prognostic value of the immunoexpression of chemoresistance-related proteins in cerebral glioblastomas: an analysis of 168 cases, Neuropathololgy, 19, 143, 10.1046/j.1440-1789.1999.00228.x Kroes, 1995, The role of mRNA stability and transcription in O6-methylguanine-DNA methyltransferase (MGMT) expression in Mer- human tumor cell lines, Carcinogenesis, 16, 2255, 10.1093/carcin/16.9.2255 Kudo, 1990, Qunatitative analysis of glutathione in human brain tumors, J. Neurosurg., 72, 610, 10.3171/jns.1990.72.4.0610 Kupczyk-Subotkowska, 1997, Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate, J. Med. Chem., 40, 1726, 10.1021/jm960592p Kuriyama, 1997, Induction of resistance to etoposide and adriamycin in a human glioma cell line treated with antisense oligonucleotide complementary to the messenger ribonucleic acid of deoxyribonucleic acid topoisomerase II alpha, Neurol. Med.-Chir., 37, 655, 10.2176/nmc.37.655 Kurpad, 1997, Intraarterial O-6-benzylguanine enables the specific therapy of notrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea, Cancer Chemother. Pharmacol., 39, 307, 10.1007/s002800050577 Lasorella, 1995, Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations in apoptosis and drug resistance, Cancer Res., 55, 4711 Lavin, 1996, Role of protein kinase activity in apoptosis, Experientia, 52, 979, 10.1007/BF01920107 Lee, 1998, Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter, Cancer Res., 58, 2741 Lee, 1992, Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells, Cancer Res., 52, 3750 Lefebvre, 1993, Induction of O6-methylguanine-DNA-methyltransferase and N3-methyladenine-DNA-glycosylase in human cells exposed to DNA-damaging agents, DNA Cell Biol., 12, 233, 10.1089/dna.1993.12.233 Lehnert, 1994, Multidrug resistance in human cancer, J. Neurooncol., 22, 239, 10.1007/BF01052927 Leier, 1994, The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates, J. Biol. Chem., 29, 27807, 10.1016/S0021-9258(18)46856-1 Levin, 1972, Uptake and distribution of 3H-methotrexate by the murine ependymoblastoma, J. Natl. Cancer Inst., 48, 875 Levin, 1978, BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors, Cancer Treat. Rep., 62, 2071 Levin, 1992, Treatment of recurrent gliomas and metastatic brain tumors with a polydrug protocol designed to combat nitrosourea resistance, J. Clin. Oncol., 10, 766, 10.1200/JCO.1992.10.5.766 Leweke, 1998, Multidrug resistance in glioblastoma. Chemosensitivity resting and immunohistochemical demonstration of p-glycoprotein, Pathol. Res. Pract., 194, 149, 10.1016/S0344-0338(98)80015-0 Lewis, 1988, Gluthatione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects, Carcinogenesis, 9, 1283, 10.1093/carcin/9.7.1283 Liang, 1996, Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines, J. Neurooncol., 29, 149, 10.1007/BF00182138 Lincke, 1991, Structure of the human MDR3 and physical mapping of the human MDR locus, J. Biol. Chem., 266, 5303, 10.1016/S0021-9258(19)67788-4 List, 1997, Non-P-glycoprotein drug export mechanisms of multidrug resistance, Semin. Hematol., 34, 20 List, 1996, Role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia, Leukemia, 10, 937 List, 1996, The role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia, Leukemia, 10, 36 List, 1996, Overexpression of the major vault protein transporter lung-resistance protein predicts treatment outcome in acute myeloid leukemia, Blood, 87, 2464, 10.1182/blood.V87.6.2464.bloodjournal8762464 Lo, 1998, Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1*C, cloned from a glioblastoma multiforme cell line, Chem. Biol. Interact., 112, 91, 10.1016/S0009-2797(97)00153-1 Lo, 1997, Genomic cloning of hGSTP1*C, an allelic Pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements, J. Biol. Chem., 272, 32743, 10.1074/jbc.272.52.32743 Loe, 1996, Biology of the multidrug resistance-associated protein, MRP. Eur. J. Cancer, 32A, 945, 10.1016/0959-8049(96)00046-9 Lowe, 1994, p53 status and the efficacy of cancer chemotherapy in vitro, Science, 266, 807, 10.1126/science.7973635 Lowe, 1993, p53-dependent apoptosis modulates the cytotoxicity of anticancer agents, Cell, 74, 957, 10.1016/0092-8674(93)90719-7 Lynch, 1997, Human DNA topoisomerase II-alpha: a new marker of proliferation in invasive breast cancer, Hum. Pathol, 28, 1180, 10.1016/S0046-8177(97)90256-2 Ma, 1991, Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine, J. Biol. Chem., 266, 5593, 10.1016/S0021-9258(19)67636-2 Maier, 1997, Metallothionein overexpression in human brain tumors, Acta Neuropathol., 94, 599, 10.1007/s004010050755 Malayeri, 1996, Multidrug resistance in leukemias and its reversal, Leuk. Lymphoma, 23, 451, 10.3109/10428199609054853 Mannervik, 1992, Nomenclature for human glutathione transferases, Biochem. J., 282, 305, 10.1042/bj2820305 Mannervik, 1988, Gluthione transferases. Stucture and catalytic activity, CRC Crit. Rev. Biochem. Mol. Biol., 23, 283, 10.3109/10409238809088226 Marathi, 1994, Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo, Biochem. Pharmacol., 48, 2127, 10.1016/0006-2952(94)90514-2 Marquardt, 1990, Mechanisms of multidrug resistance in HL-60 cells: Detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the reduced sequence of P-glycoprotein, Cancer Res., 50, 1426 Martinchick, 1997, Human DNA topoisomerase II-alpha: immunohistochemical staining for enzyme protein in tumors of ovarian origin, Int. J. Oncol., 10, 1229 Masliah, 1990, Differential involvement of protein kinase C isozymes in Alzheimer’s disease, J. Neurosci., 10, 2113, 10.1523/JNEUROSCI.10-07-02113.1990 Matsumara, 1994, Topoisomerase II deletion as well as amplification associated with erbB2 amplification in breast cancer, Proc. Am. Assoc. Cancer Res., 35, A2708 Matsumoto, 1990, Amplification and expression of a multidrug resistance gene in human glioma cell lines, J. Neurosurg., 72, 96, 10.3171/jns.1990.72.1.0096 Matsumoto, 1991, Expression of P-glycoprotein in human glioma cell lines and surgical glioma specimens, J. Neurosurg., 74, 460, 10.3171/jns.1991.74.3.0460 Matsumoto, 1995, Determinants of drug response in camptothecin-11-resistant glioma cell lines, J. Neurooncol., 23, 1, 10.1007/BF01058453 Matsumoto, 1999, Increased phosphorylation of DNA topoisomerase II in etoposide resistant mutants of human glioma cell line, J. Neurooncol., 45, 37, 10.1023/A:1006346624083 Matsumoto, 1992, Quantitative analysis of glutathione and glutathione S-transferase in human brain tumors, C6 rat glioma cells and drug resistant C6 cells, No Shinkei Geka, 20, 1069 Mauritz, 1998, Ex vivo activity of methorexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells, Clin. Cancer Res., 4, 2399 May, 1994, Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis, J. Biol. Chem., 269, 26865, 10.1016/S0021-9258(18)47099-8 McPake, 1998, Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status, Oncol. Res., 10, 235 Meisenhelder, 1989, Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro, Cell, 57, 1109, 10.1016/0092-8674(89)90048-2 Meyerson, 1992, A family of human cdc2-related protein kinases, EMBO J., 11, 2909, 10.1002/j.1460-2075.1992.tb05360.x Mineura, 1994, O6-methylguanine-DNA methyltransferase activity in cerebral gliomas. A guidance for nitrosourea treatment?, Acta Oncol., 33, 29, 10.3109/02841869409098371 Mineura, 1994, Enhancement of ACNU cytotoxicity by pretreatment with O6-methylguanine in ACNU-resistant brain tumors, J. Neurooncol., 19, 51, 10.1007/BF01051048 Mineura, 1993, Influence of O6-methylguanine-DNA mehyltransferase activity on chloroethylnitrosourea chemotherapy in brain tumors, Int. J. Cancer, 55, 76, 10.1002/ijc.2910550115 Mineura, 1991, O6-alkylguanine-DNA alkyltransferase activity in human brain tumors, Tohoku J. Exp. Med., 165, 223, 10.1620/tjem.165.223 Mineura, 1996, Quantification of O6-methylguanine-DNA methyltransferase mRNA in human brain tumors, Biochem. Biophys. Acta, 1289, 105, 10.1016/0304-4165(95)00123-9 Mineura, 1996, Human brain tumor O[6]-methylguanine-DNA methyltransferase mRNA and its significance as an indicator of selective chloroethylnitrosourea chemotherapy, Int. J. Cancer, 69, 420, 10.1002/(SICI)1097-0215(19961021)69:5<420::AID-IJC12>3.0.CO;2-6 Misra-Press, 1992, Protein kinase C isoforms in human glioblastoma cells, Glia, 6, 188, 10.1002/glia.440060306 Miyamoto, 1992, Reversal of vinblastine resistance by a new staurosporine derivate, NA-382 in P388/ADR cells, Cancer Lett., 64, 177, 10.1016/0304-3835(92)90079-B Monden, 1997, Prognostic significance of the expression of metallothionein, glutathione S-transferase pi and P-glycoprotein in curatively resected gastric cancer, Onocology, 54, 391, 10.1159/000227725 Montaudon, 1997, Differential stabilization of topoisomerase-II-DNA cleavable complexes by doxorubicin and etoposide in doxorubicin-resistant rat glioblastoma cells, Eur. J. Biochem., 245, 307, 10.1111/j.1432-1033.1997.00307.x Morrow, 1990, Cowan K. Glutathione S-transferases and drug resistance, Cancer Cells, 2, 15 Mousseau, 1993, A study of the expression of four chemoresistance-related genes in human primary and metastatic brain tumors, Eur. J. Cancer, 29A, 753, 10.1016/S0959-8049(05)80361-2 Müller, 1994, Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport, Proc. Natl. Acad. Sci. USA, 91, 13033, 10.1073/pnas.91.26.13033 Murphy, 1987, Phorbol ester stimulates the proliferation of astrocytes in primary culture, Brain Res. Dev. Brain Res., 31, 133, 10.1016/0165-3806(87)90091-5 Nabors M.W., Griffin C.A., Zehnbauer B.A., Hruban R.H., Phillips P.C., Grossman S.A., Brem H., Colvin O.M. Multidrug-resistance gene (MDR1) expression in human brain tumors. J. Neurosurg. 75 (1991) 941-946. Nagane, 1997, Application of antisense ribonucleic acid complementary to O6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant gliomas, Neurosurgery, 41, 434, 10.1097/00006123-199708000-00021 Nagane, 1992, Expression of O6-methylguanine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors, Jpn. J. Clin. Oncol., 22, 143 Nagane, 1998, Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases, Proc. Natl. Acad. Sci. USA, 95, 5724, 10.1073/pnas.95.10.5724 Nagane, 1995, Investigation of chemoresistance-related genes mRNA expression for selecting anticancer agents in successful adjuvant chemotherapy for a case of recurrent glioblastoma, Surg. Neurol., 44, 462, 10.1016/0090-3019(95)00299-5 Naidu, 1993, Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon, Anticancer Res., 13, 1469 Naidu, 1993, Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma, J. Neurooncol., 16, 1, 10.1007/BF01324828 Nakamura, 1997, Retinoblastoma protein expression and MIB-1 correlate with survival of patients with malignant astrocytoma, Cancer, 80, 242, 10.1002/(SICI)1097-0142(19970715)80:2<242::AID-CNCR12>3.0.CO;2-U Nakamura, 1990, Immunohistochemical study of placental form of glutathione S-transferase in human brain tumors and fetal brains, No To Shinkei, 42, 965 Nakatsu, 1997, Induction of apoptosis in multi-drug resistant (MDR) human glioblastoma cells by SN-38, a metabolite of the camptothecin derivative CPT-11, Cancer Chemother. Pharmacol., 39, 417, 10.1007/s002800050592 Nano, 1990, Qualitative and quantitative histochemical evaluation of the dehydrogenase actitvity in human glioblastoma cells treated with beta-interferon, Boll. Soc. Ital. Biol. Sper., 66, 279 Naumann, 1999, p27 modulates cell cycle progression and chemosensitivity in human malignant glioma, Biochem. Biophys. Res. Commun., 261, 890, 10.1006/bbrc.1999.1126 Nevaldine, 1999, Differential sensitivity of double minute chromosomes to hydroxyurea treatment in cultured methotrexate-resistant mouse cells, Mutat. Res., 406, 55 Newcomb, 1995, P53 gene mutations in lymphoid diseases an their possible relevance to drug resistance, Leuk. Lymphoma, 17, 211, 10.3109/10428199509056825 Nigg, 1991, Vertebrate cdc2 kinase its regulation by phosphorylation and its mitotic targets, Cold Spring Harbor Symp. Quant. Biol., 56, 539, 10.1101/SQB.1991.056.01.061 Nishizuka, 1992, Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C, Science, 258, 607, 10.1126/science.1411571 Nishizuka, 1988, The molecular heterogenity of protein kinase C and its implications for cellular regulation, Nature, 334, 661, 10.1038/334661a0 Nishizuka, 1984, The role of protein kinase C in cell surface signal transduction and tumor promotion, Nature, 308, 693, 10.1038/308693a0 Nitiss, 1996, Antitopoisomerase drug action and resistance, Eur. J. Cancer, 32A, 958, 10.1016/0959-8049(96)00056-1 Nitiss, 1992, Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II, Cancer Res., 52, 4467 Nooter, 1995, Constitutive expression of the c-H-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line, Br. J. Cancer, 71, 556, 10.1038/bjc.1995.109 Norris, 1996, Association between high levels of expression of the multidrug resistance-associated protein (MRP) and poor outcome in primary human neuroblastoma, New Eng. J. Med., 344, 231, 10.1056/NEJM199601253340405 Nutt, 1995, O6-methylguanine-DNA mehyltransferase in tumors and cells of the oligodendrocyte lineage, Can. J. Neurol. Sci., 22, 111, 10.1017/S0317167100040178 Nutt, 2000, Differential expression of drug resistance genes and chemosensitivity in glial cell lineages correlate with differential response of oligodendrogliomas and astrocytomas to chemotherapy, Cancer Res., 60, 4812 Oberc-Greenwood, 1990, Selective cytoplasmic and membrane changes induced by cisplatinum, J. Neurooncol., 9, 191, 10.1007/BF02341149 O’Brien, 1996, Glutathione and related enzymes in multidrug resistance, Eur. J. Cancer, 32A, 967, 10.1016/0959-8049(96)00051-2 Ostrowski, 1991, Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines, Carcinogenesis, 12, 1739, 10.1093/carcin/12.9.1739 Paleologos, 1999, Neoadjuvant procarbazine, CCNU, and vincristine for anaplastic and aggressive oligodendroglioma, Neurology, 53, 1141, 10.1212/WNL.53.5.1141 Pastan, 1987, Multiple-drug resistance in human cancer, New Engl. J. Med., 316, 1388, 10.1056/NEJM198705283162207 Pegg, 1990, Mammalian O6-alkylguanine-DNA alkyltransferase regulation and importance in response to alkylating carcinogenic and therapeutic agents, Cancer Res., 50, 6119 Pestalozzi, 1997, Prognostic importance of thymidylate synthase expression in early breast cancer, J. Clin. Oncol., 15, 1923, 10.1200/JCO.1997.15.5.1923 Pickett, 1989, Glutathione S-transferases, gene structure, regulations, biological function, Annu. Rev. Biochem., 58, 743, 10.1146/annurev.bi.58.070189.003523 Pieper, 1990, Comparison of O6-methylguanine-DNA methyltransferase gene (MGMT) mRNA levels in MER+ and MER− human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique, Cancer Commun., 2, 13, 10.3727/095535490820874812 Pohl, 1999, Homozygous deletions of the CDKN2C/p18INK4C gene on the short arm of chromosome 1 in anaplastic oligodendroglioma, Brain Pathol., 9, 639, 10.1111/j.1750-3639.1999.tb00545.x Pollack, 1994, Patterns of growth factor, growth factor receptor and second messenger expression in pediatric brain tumors, J. Neurosurg., 80, A400 Pollack, 1996, Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor, J. Neurosurg., 84, 1024, 10.3171/jns.1996.84.6.1024 Pollack, 1990, Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways, J. Neurosurg., 73, 98, 10.3171/jns.1990.73.1.0098 Pongracz, 1995, Changes in protein kinase C isoenzyme expression associated with apoptosis in U937 myelomonocytic cells, Exp. Cell Res., 218, 430, 10.1006/excr.1995.1176 Posada, 1989, Human multidrug resistant KB cells overexpress protein kinase C: involvement in drug resistance, Cancer Commun., 1, 285, 10.3727/095535489820874922 Posada, 1989, Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells, Cancer Res., 49, 6634 Pourquier, 1998, Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells: role of c-jun in drug resistance and cell death, Biochem. Pharmacol., 55, 1963, 10.1016/S0006-2952(98)00006-9 Preuss, 1995, O6-methylguanine-DNA methyltransferase activity in breast and brain tumors, Int. J. Cancer, 61, 321, 10.1002/ijc.2910610308 Pu, 1996, Study of the antioxidant enzymes in human brain tumors, J. Neurooncol., 29, 121, 10.1007/BF00182134 Raaphorst, 1998, Evaluation of apoptosis in four human tumour cell lines with differing sensitivities to cisplatin, Anticancer Res., 18, 2945 Raymon, 1990, Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells, Mol. Cell. Biol., 10, 1642, 10.1128/MCB.10.4.1642 Reed, 1995, Bcl-2: prevention of apoptosis as a mechanism of drug resistance, Hematol. Oncol. Clin. N. Am., 9, 451, 10.1016/S0889-8588(18)30104-7 Reed, 1993, Platinum analogs in cancer, 390 Reifenberger, 1989, Wechsler W: Immunohistochemical determination of protein kinase C expression and proliferative activity in human brain tumors, Acta Neuropathol., 78, 166, 10.1007/BF00688205 Riordan, 1985, Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines, Nature, 316, 817, 10.1038/316817a0 Riodran, 1979, Purification of P-glycoprotein form plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability, J. Biol. Chem., 254, 12701, 10.1016/S0021-9258(19)86370-6 Robinson, 1983, Cross-linking of DNA induced by chloronitrosourea is prevented by O6-methylguanine-DNA methyltransferase, Nucleic Acids Res., 11, 7743, 10.1093/nar/11.22.7743 Roca, 1994, The mechanism of DNA topoisomerases, Trends Biochem. Sci., 20, 156, 10.1016/S0968-0004(00)88993-8 Roca, 1994, DNA transport by a type II DNA topoisomerases: evidence in favor of a two-gate mechanism, Cell, 77, 609, 10.1016/0092-8674(94)90222-4 Rome, 1991, Unlocking vaults: organelles in search of a function, Trends Cell Biol., 1, 47, 10.1016/0962-8924(91)90088-Q Rosenblum, 1983, Stem cell studies human malignant brain tumors. Part 1: Development of the stem assay and its potential, J. Neurosurg., 58, 170, 10.3171/jns.1983.58.2.0170 Rosenblum, 1977, Brain-tumor therapy: quantitative analysis using a model system, J. Neurosurg., 46, 145, 10.3171/jns.1977.46.2.0145 Rout, 1994, Pores for thought: nuclear pore complex proteins, Trends Cell Biol., 4, 357, 10.1016/0962-8924(94)90085-X Ruan, 1998, Overexpressed WAF1/Cip1 renders gioblastoma cells resistant to chemotherapy agents 1,3-bis(2-chloroethyl)-1-nitrosourea and cisplatin, Cancer Res., 58, 1538 Sahyoun, 1986, Protein kinase C phosphorylates topoisomerase II. Topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells, Proc. Natl. Acad. Sci. USA, 83, 1603, 10.1073/pnas.83.6.1603 Saito, 1991, Glutiathione and cellular response of ACNU-resistant rat glioma sublines to drugs and radiation, Int. J. Cancer, 48, 861, 10.1002/ijc.2910480612 Santi, 1984, Mechanisms of interaction of thymidylate synthase with 5-fluorodeoxyuridylate folates in pyrimidine nucleotide biosynthesis, 385 Santi, 1974, Mechanisms of interaction of thymidylate synthase with 5-fluorodeoxyuridylate, Biochemistry, 13, 471, 10.1021/bi00700a012 Sariban, 1987, DNA cross-linking response of human malignant glioma cell strains to chloroethylnitrosoureas, cisplatin and diaziquone, Cancer Res., 47, 3988 Sassone-Corsi, 1988, Fos-associated cellular p39 is related to nuclear transcription factor AP-1, Cell, 54, 553, 10.1016/0092-8674(88)90077-3 Sawada, 1994, Induction of metallothionein in astrocytes by cytokines and heavy metals, Biol. Signals, 3, 157, 10.1159/000109539 Sawada, 1993, Regulation of astrocyte proliferation by prostaglandin E2 and the alpha subtype of protein kinase C, Brain Res., 613, 67, 10.1016/0006-8993(93)90455-V Sawada, 1999, Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors, Brain Tumor Pathol., 16, 23, 10.1007/BF02478898 Scanlon, 1989, Molecular basis of cisplatin resistance in human carcinomas: model systems and patients, Anticancer Res., 9, 1301 Scheffer, 1995, The drug resistance-related protein LRP is the human major vault protein, Nat. Med., 1, 578, 10.1038/nm0695-578 Scheper, 1993, Overexpression of a 110 kD vesicular protein in non-P-glycoprotein mediated multidrug-resistance, Cancer Res., 53, 1475 Scheper, 1996, Transporter molecules in multdrug resistance, Cytotechnology, 19, 187, 10.1007/BF00744211 Schinkel, 1994, Distribution of the mouse md1a P-glycoprotein gene leads to deficiency in the blood–brain barrier and to increased sensitivity to drugs, Cells, 77, 491, 10.1016/0092-8674(94)90212-7 Schlosshauer, 1993, The blood–brain barrier: morphology, molecules, neurothelin, BioAssays, 15, 341, 10.1002/bies.950150508 Schluesener, 1991, Spontaneous multidrug transport in human glioma cells is regulated by transforming growth factor type beta, Acta Neuropathol., 81, 641, 10.1007/BF00296374 Schold, 1989, O6-alkylguanine-DNA alkyltransferase and sensivity to procarbazine in human brain-tumor xenografts, J. Neurosurg., 70, 573, 10.3171/jns.1989.70.4.0573 Schumacher, 1997, The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood–brain barrier development in the microvessels of the developing human brain, Histochem. Cell Biol., 108, 179, 10.1007/s004180050159 Scudiero, 1984, Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas, Cancer Res., 44, 2467 Seynaeve, 1993, Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells, Cancer Res., 53, 2081 Shen, 1998, Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3, Biochem. Pharmacol., 55, 1711, 10.1016/S0006-2952(98)00045-8 Shimosawa, 1990, Type-specific expression of protein kinase C isozymes in human brain tumours, Neurosci. Lett., 108, 11, 10.1016/0304-3940(90)90698-9 Schmid, 1993, Presence and possible significance of immunocytochemically demonstrable metallothionein overexpression in primary invasive ductal carcinoma of the breast, Virchows Arch., 422, 153, 10.1007/BF01607167 Silber, 1998, O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics, Cancer Res., 58, 1068 Silber, 1993, Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain, Cancer Res., 53, 3416 Siu, 1998, The prognostic role of p53, metallothionein, P-glycoprotein and MIB-1 in muscle invasive urothelial transitional cell carcinoma, Clin. Cancer Res., 4, 559 Skalski, 1990, Mechanisms of resistance to (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) in sensitive and resistant human glioma cells, Mol. Pharmacol., 38, 299 Smith, 2000, Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas, J. Clin. Oncol., 18, 636, 10.1200/JCO.2000.18.3.636 Smith, 1993, Topoisomerase IIa co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity, Oncogene, 8, 933 Smith, 1989, Denitrosation of 1,3-bis(2-chloroethyl) 1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells, Cancer Res., 49, 2621 Sonneveld, 1997, Drug resistance in multiple myeloma, Semin. Hematol., 34, 34 Spears, 1982, In vivo kinetics of thymidylate synthase inhibition in 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas, Cancer Res., 42, 450 Stan, 1999, Doxorubicin-induced cell death in highly invasive human gliomas, Anticancer Res., 19, 941 Strange, 1992, The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain, Biochim. Biophys. Acta, 1139, 222, 10.1016/0925-4439(92)90138-D Strasser, 1994, DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2, Cell, 79, 329, 10.1016/0092-8674(94)90201-1 Strik, 1999, BCL-2 family protein expression in initial and recurrent glioblastomas: modulation by radiochemotherapy, J. Neurol. Neurosurg. Psychiatry, 67, 763, 10.1136/jnnp.67.6.763 Sugawara, 1988, Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16, Cancer Res., 48, 1926 Sullivan, 1987, Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells, Cancer Res., 47, 3973 Sumantran, 1995, Overexpression of Bcl-xs sensitizes MCF-7 cells to chemotherapy-induced apoptosis, Cancer Res., 55, 2507 Susa, 1989, EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity, Cell, 57, 817, 10.1016/0092-8674(89)90796-4 Taagepera, 1993, DNA topoisomerase IIa is the major chromosome protein recognized by the mitotic phosphorprotein antibody MPM-2, Proc. Natl. Acad. Sci. USA, 90, 8407, 10.1073/pnas.90.18.8407 Tagliabue, 1992, Tumour levels of O6-alkylguanine-DNA-alkyltransferase and sensitivity to BCNU of human xenografts, Anticancer Res., 12, 2123 Taki, 1998, In vivo etoposide-resistant C6 glioma cell line: significance of altered DNA topoisomerase II activity in multi-drug resistance, J. Neurooncol., 36, 41, 10.1023/A:1005718912236 Tanaguchi, 1989, Glutathione S-transferase is an in vitro substrate of Ca++-phospholipid-dependent protein kinase (protein kinase C), Bochim. Biophys. Res. Commun., 162, 903, 10.1016/0006-291X(89)90757-2 Tanaka, 1994, Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas, Virchow Arch., 425, 133, 10.1007/BF00230349 Tandon, 1991, Significance of topoisomerase II in clinical breast cancer, Proc. Am. Assoc. Cancer Res., 32, 350 Taniguchi, 1999, Immunohistochemical staining of DNA topoisomerase II α in human gliomas, J. Neurosurg., 91, 477, 10.3171/jns.1999.91.3.0477 Teeter, 1991, Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activity, Cell Growth Diff., 2, 429 Tew, 1994, Glutathione-associated enzymes in anticancer drug resistance, Cancer Res., 54, 4313 Thiebaut, 1987, Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues, Proc. Natl. Acad. Sci. USA, 84, 7735, 10.1073/pnas.84.21.7735 Thompson, 1995, Apoptosis in the pathogenesis and treatment of disease, Science, 267, 1456, 10.1126/science.7878464 Tidefelt, 1992, Expression of glutathione transferase π as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia, Cancer Res., 52, 3281 Tishler, 1992, Development of multidrug resistance in a primitive neuroectodermal tumor cell line, J. Neurosurg., 76, 502, 10.3171/jns.1992.76.3.0502 Tishler, 1992, Multidrug resistance gene expression in pediatric primitve neuroectodermal tumors of the central nervous system, J. Neurosurg., 76, 507, 10.3171/jns.1992.76.3.0507 Todo, 1991, Immunohistochemical demonstration of protein kinase C isozymes in human brain tumors, Neurosurgery, 29, 399, 10.1227/00006123-199109000-00010 Tomlinson, 1991, Comparison of in vitro activity of epipodophyllotoxins with other chemotherapeutic agents in human medulloblastomas, Br. J. Cancer, 64, 1051, 10.1038/bjc.1991.464 Toth, 1996, MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors, Am. J. Pathol., 149, 853 Trepel, 1998, Chemosensitivity of human malignant glioma: modulation by p53 gene transfer, J. Neurooncol., 39, 19, 10.1023/A:1005910323338 Tuccari, 1993, Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: correlation with clinicopathological features, Virchows Arch., 423, 51, 10.1007/BF01606432 Tzortzatou-Stathopoulou, 1993, Dihydrofolate reductase activity in primary brain tumors in children, Am. J. Pediatr. Hematol. Oncol., 15, 316 Ueda, 1986, The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein, Biochem. Biophys. Res. Commun., 141, 956, 10.1016/S0006-291X(86)80136-X Ueda, 1992, Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone, J. Biol. Chem., 267, 24248, 10.1016/S0021-9258(18)35757-0 Van der Bliek, 1989, Multidrug resistance, Adv. Cancer Res., 52, 165, 10.1016/S0065-230X(08)60213-4 Van Kalken, 1993, Cortisol is transported by the multidrug resistance gene product P-glycoprotein, Br. J. Cancer, 67, 284, 10.1038/bjc.1993.54 Vasu, 1993, cDNA cloning and distribution of the major vault protein a gene (mvpA) in Dictyostelium discoideum, J. Cell Biol., 268, 15356 Vogelbaum, 1999, Overexpression of bax in human glioma cell lines, J. Neurosurg., 91, 483, 10.3171/jns.1999.91.3.0483 Volm, 1998, Multridrug resistance and its reversal, Anticancer Res., 18, 2905 Volm, 1997, Expression of lung resistance protein (LRP) in non-small cell lung carcinomas of smokers and non-smokers and its predictive value for doxorubicin resistance, Anti-Cancer Drugs, 8, 931, 10.1097/00001813-199711000-00003 Volm, 1995, Associated expression of protein kinase C with resistance to doxorubicin in human lung cancer, Anticancer Res., 15, 463 Walther, 1995, Gene transfer of human TNF alpha into glioblastoma cells permits modulation of Mdr1 expression and potentiation of chemosensitivity, Int. J. Cancer, 9, 832, 10.1002/ijc.2910610615 Wang, 1985, DNA topoisomerases, Annu. Rev. Biochem., 54, 665, 10.1146/annurev.bi.54.070185.003313 Ward, 1991, Distinct patterns of phorbol ester-induced down-regulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells, Cancer Lett., 58, 189, 10.1016/0304-3835(91)90099-4 Warhom, 1980, Indentification of a new glutathione S-transferase in human liver, Acta Chem. Scand., B34, 607, 10.3891/acta.chem.scand.34b-0607 Washtein, 1984, Increased levels of thymidylate synthase in cells exposed to 5-fluorouracil, Mol. Pharmacol., 25, 171 Watt, 1994, Structure and function of type II DNA topoisomerases, Biochem J., 303, 681, 10.1042/bj3030681 Wattel, 1994, p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies, Blood, 84, 3148, 10.1182/blood.V84.9.3148.3148 Waxman, 1990, Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy: a review, Cancer Res., 50, 6449 Wedge, 1996, O6-Benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU, Br. J. Cancer, 73, 1049, 10.1038/bjc.1996.203 Wei, 1994, Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene, Hum. Gene Ther., 5, 969, 10.1089/hum.1994.5.8-969 Weller, 1995, Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation, J. Clin. Invest., 95, 2633, 10.1172/JCI117965 Weller, 1998, Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses, Int. J. Cancer, 79, 640, 10.1002/(SICI)1097-0215(19981218)79:6<640::AID-IJC15>3.0.CO;2-Z Weller, 1997, Hyericin-induced apoptosis of human malignant glioma cells is ligh-dependent, independent of bcl-2 expression, and does not require wild-type p53, Neurol. Res., 19, 459, 10.1080/01616412.1997.11740843 Wijnholds, 2000, Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood–cerebrospinal fluid barrier, J. Clin. Invest., 105, 279, 10.1172/JCI8267 Wilson C.B., Norrell H.A.Jr. Brain tumor chemotherapy with intrathecal methotrexate. Cancer 23 (1969) 1038-1045. Woessner, 1991, Proliferation and cell-cycle dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells, Cell Growth Differ., 2, 209 Woessner, 1990, Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170 kDA and 180 kDA froms of topoisomerase II, Cancer Res., 50, 2901 Xia, 1991, Glutathione S-transferase-π: its minimal promoter and downstream cis-acting element, Biochim. Biophys. Res. Commun., 176, 233, 10.1016/0006-291X(91)90914-S Yabuno, 1998, Drug resistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs, J. Neurooncol., 36, 105, 10.1023/A:1005878402133 Yarosh, 1985, The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis, Mutat. Res., 145, 1 Yokogami, 1998, Application of SPET using technetium-99m sestamibi in brain tumors and comparison with expression of the MDR-1 gene: is it possible to predict the response to chemotherapy in patients with gliomas by means of 99m Tc-sestamibi SPET?, Eur. J. Nucl. Med., 25, 401, 10.1007/s002590050238 Yong, 1992, Proliferation of human and mouse astrocytes in vitro: signaling through the protein kinase C pathway, J. Neurol. Sci., 111, 92, 10.1016/0022-510X(92)90117-4 Yoshida, 1987, Overcoming of ACNU resistance in an ACNU-resistant subline of rat C6 glioma in vivo through enhanced effect of ACNU by calmodulin inhibitor, No Shinkei Geka, 15, 261 Yoshida, 1992, Isolation and preliminary characterization of ACNU-resistant sublines of rat brain tumors in vivo, J. Neurosurg., 77, 451, 10.3171/jns.1992.77.3.0451 Yoshida, 1987, Possibility of overcoming ACNU resistance in ACNU-resistant sublines of rat brain tumors in vitro by a calmodulin inhibitor, No Shinkei Geka, 15, 143 Yoshida, 1986, Mechanism and overcoming of resistance in ACNU-resistant sublines of rat brain tumors, Gan To Kagaku Ryoho, 13, 2751 Yoshida, 1986, Studies on the mechanism of ACNU resistance in sublines of rat C6 glioma and 9L gliosarcoma in vitro, No Shinkei Geka, 14, 1299 Young, 1999, Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response, Clin. Cancer Res., 5, 673 Yu, 1991, Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein, Cancer Commun., 3, 181, 10.3727/095535491820873263 Zaman, 1994, The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump, Proc. Natl. Acad. Sci. USA, 91, 8822, 10.1073/pnas.91.19.8822 Zaman, 1993, Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug-resistant lung cancer cell lines, Cancer Res., 53, 1747 Zhang, 1995, High levels of constitutive WAF1/Cip 1 protein are associated with chemoresistance in acute myelogenous leukemia, Clin. Cancer Res., 1, 1051 Zhang, 1995, Growth inhibition and apoptosis in human neuroblastoma SK-N-SH cells induced by hypericin, a potent inhibitor of protein kinase C, Cancer Lett., 96, 31, 10.1016/0304-3835(95)03914-I Zhao, 1995, Modulation of O6-methylguanine-DNA methyltransferase-mediated nimustine resistance in recurrent malignant gliomas by streptozotocin — a preliminary report, Anticancer Res., 15, 645 Zhu, 1996, Differential effects of phorbol ester on apoptosis in HL-60 promyelocytic leukemia cells, Biochem. Pharmacol., 51, 1229, 10.1016/0006-2952(96)00096-2