Anticancer and apoptotic activities of parthenolide in combination with epirubicin in mda-mb-468 breast cancer cells

Harirchi I, Kolahdoozan S, Karbakhsh M, Chegini N, Mohseni S, Montazeri A et al (2010) Twenty years of breast cancer in Iran: downstaging without a formal screening program. Ann Oncol 22(1):93–97

Tang Y, Wang Y, Kiani MF, Wang B (2016) Classification, treatment strategy, and associated drug resistance in breast cancer. Clin Breast Cancer 16(5):335–343

Qin S-Y, Cheng Y-J, Lei Q, Zhang A-Q, Zhang X-Z (2018) Combinational strategy for high-performance cancer chemotherapy. Biomaterials 171:178–197

Arzi L, Riazi G, Sadeghizadeh M, Hoshyar R, Jafarzadeh N (2018) A comparative study on anti-invasion, antimigration, and antiadhesion effects of the bioactive carotenoids of saffron on 4T1 breast cancer cells through their effects on Wnt/β-catenin pathway genes. DNA Cell Biol 37(8):697–707

Ebrahimi S, Mollaei H, Hoshyar R (2017) Ziziphus Jujube: a review study of its anticancer effects in various tumor models invitro and invivo. (Noisy-le-Grand. France). Cell Mol Biol 63(10):122–127

Mollaei H, Safaralizadeh R, Babaei E, Abedini MR, Hoshyar R (2017) The anti-proliferative and apoptotic effects of crocin on chemosensitive and chemoresistant cervical cancer cells. Biomed Pharmacother 94:307–316

Sauter ER (2020) Cancer prevention and treatment using combination therapy with natural compounds. Exp Rev Clin Pharmacol 13(3):265–285

Hoshyar R, Mahboob Z, Zarban A (2016) The antioxidant and chemical properties of Berberis vulgaris and its cytotoxic effect on human breast carcinoma cells. Cytotechnology 68(4):1207–1213

Prasad S, Gupta SC, Tyagi AK (2017) Reactive oxygen species (ROS) and cancer: role of antioxidative nutraceuticals. Cancer Lett 387:95–105

Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495–516

Inoue-Yamauchi A, Jeng PS, Kim K, Chen H-C, Han S, Ganesan YT et al (2017) Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy. Nat Commun 8(1):1–14

Khanzadeh T, Hagh MF, Talebi M, Yousefi B, Azimi A, Baradaran B (2018) Investigation of BAX and BCL2 expression and apoptosis in a resveratrol-and prednisolone-treated human T-ALL cell line, CCRF-CEM. Blood Res 53(1):53–60

Yamaguchi N, Fujii T, Aoi S, Kozuch PS, Hortobagyi GN, Blum RH (2015) Comparison of cardiac events associated with liposomal doxorubicin, epirubicin and doxorubicin in breast cancer: a Bayesian network meta-analysis. Eur J Cancer 51(16):2314–2320

Hanafi-Bojd MY, Jaafari MR, Ramezanian N, Xue M, Amin M, Shahtahmassebi N et al (2015) Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells. Eur J Pharm Biopharm 89:248–258

Rabi T, Bishayee A (2009) d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: generation of reactive oxygen species and induction of apoptosis. J Carcinogen 8:9

Jafari N, Nazeri S, Enferadi ST (2018) Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor α–1 expression. Phytomedicine 41:67–73

Freund RR, Gobrecht P, Fischer D, Arndt H-D (2020) Advances in chemistry and bioactivity of parthenolide. Nat Prod Rep 37(4):541–565

Liu M, Xiao C, Sun M, Tan M, Hu L, Yu Q (2018) Parthenolide inhibits STAT3 signaling by covalently targeting janus kinases. Molecules 23(6):1478

Talib WH, Al Kury LT (2018) Parthenolide inhibits tumor-promoting effects of nicotine in lung cancer by inducing P53-dependent apoptosis and inhibiting VEGF expression. Biomed Pharmacother 107:1488–1495

Carlisi D, Buttitta G, Di Fiore R, Scerri C, Drago-Ferrante R, Vento R et al (2016) Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis. Cell Death Dis 7(4):e2194-e

Li H, Lu H, Lv M, Wang Q, Sun Y (2018) Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway. Oncol Lett 15(3):3572–3579

Kim S-L, Kim SH, Trang KTT, Kim IH, Lee S-O, Lee ST et al (2013) Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer. Cancer Lett 335(2):479–486

Valavi M, Saedabad AGA, Hoshyar R, Mollaei H (2018) Effects of combined crocin and epirubicin on apoptosis and cell cycle pathways in a human cervical cancer cell line. Int J Cancer Manag, 11(12): e82575.

Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. Cancer J Clin 61(2):69–90

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44–84

Dai J, Mumper RJ (2010) Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15(10):7313–7352

Wyrębska A, Szymański J, Gach K, Piekielna J, Koszuk J, Janecki T et al (2013) Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines. Mol Biol Rep 40(2):1655–1663

Moumou M, El Bouakher A, Allouchi H, El Hakmaoui A, Benharref A, Mathieu V et al (2014) Synthesis and biological evaluation of 9α-and 9β-hydroxyamino-parthenolides as novel anticancer agents. Bioorg Med Chem Lett 24(16):4014–4018

Parada-Turska J, Paduch R, Majdan M, Kandefer-Szerszeñ M, Rzeski W (2007) Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells. Pharmacol Rep 59(2):233

Sohma I, Fujiwara Y, Sugita Y, Yoshioka A, Shirakawa M, Moon J-H et al (2011) Parthenolide, an NF-κB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer. Cancer Genomics-Proteomics 8(1):39–47

Cheng G, Xie L (2011) Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro. Molecules 16(8):6758–6768

Lee CS, Kim YJ, Lee SA, Myung SC, Kim W (2012) Combined effect of H sp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells. Basic Clin Pharmacol Toxicol 111(3):173–81

Trang KTT, Kim S-L, Park S-B, Seo S-Y, Choi C-H, Park J-K et al (2014) Parthenolide sensitizes human colorectal cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through mitochondrial and caspase dependent pathway. Intest Res 12(1):34

Lan B, Wan Y-J, Pan S, Wang Y, Yang Y, Leng Q-L et al (2015) Parthenolide induces autophagy via the depletion of 4E-BP1. Biochem Biophys Res Commun 456(1):434–9

Kreuger MRO, Grootjans S, Biavatti MW, Vandenabeele P, D’Herde K (2012) Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anti-Cancer Drugs 23(9):883–896

Kim H-Y, Kim S-L, Park Y-R, Liu Y-C, Seo SY, Kim SH et al (2015) Balsalazide potentiates parthenolide-mediated inhibition of nuclear factor-κB signaling in HCT116 human colorectal cancer cells. Intest Res 13(3):233