Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis

Journal of Translational Autoimmunity - Tập 3 - Trang 100048 - 2020
Marco Bo1, Magdalena Niegowska1, Hayley L. Eames2, Hannah Almuttaqi2, Giannina Arru3, Gian Luca Erre4, Giuseppe Passiu4, Tariq E. Khoyratty2, Erinke van Grinsven2, Irina A. Udalova2, Leonardo A. Sechi1
1Department of Biomedical Sciences, Section of Microbiology and Virology, University of Sassari, Viale San Pietro 43b, 07100, Sassari, Italy
2Kennedy Institute of Rheumatology, Oxford University, Oxford, Roosevelt Drive, Headington, OX3 7FY, United Kingdom
3Department of Clinical, Surgical and Experimental Medicine, Neurological Clinic, University of Sassari, Viale San Pietro 8, 07100, Sassari, Italy
4Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria di Sassari, UOC of Rheumatology, Viale San Pietro 8, 07100, Sassari, Italy

Tài liệu tham khảo

Yamada, 2005, Citrullinated proteins in rheumatoid arthritis, Front. Biosci., 10, 54, 10.2741/1506 Kim, 2015, Development of synthetic anti-cyclic citrullinated peptide antibody and its arthritogenic role, Clinical & Translational Immunology, 4, e51, 10.1038/cti.2015.24 Jansen, 2003, The predictive value of anti-cyclic citrullinated peptide antibodies in early arthritis, J. Rheumatol., 30, 1691 Rantapää-Dahlqvist, 2003, Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis, Arthritis Rheum., 48, 2741, 10.1002/art.11223 Vojdani, 2014, A potential link between environmental triggers and autoimmunity, Autoimmune Dis., 1 Weiss, 2015, IRF5 controls both acute and chronic inflammation, Proc. Natl. Acad. Sci. Unit. States Am., 112, 11001, 10.1073/pnas.1506254112 Duffau, 2015, Promotion of inflammatory arthritis by interferon regulatory factor 5 in a mouse model, Arthritis & Rheumatology, 67, 3146, 10.1002/art.39321 Yang, 2012, Monocytes from irf5 −/− mice have an intrinsic defect in their response to pristane-induced lupus, J. Immunol., 189, 3741, 10.4049/jimmunol.1201162 Almuttaqi, 2019, Advances and challenges in targeting IRF5, a key regulator of inflammation, FEBS J., 286, 1624, 10.1111/febs.14654 Eames, 2016, Interferon regulatory factor 5 in human autoimmunity and murine models of autoimmune disease, Transl. Res., 167, 167, 10.1016/j.trsl.2015.06.018 Sharif, 2012, IRF5 polymorphism predicts prognosis in patients with systemic sclerosis, Ann. Rheum. Dis., 71, 1197, 10.1136/annrheumdis-2011-200901 Erre, 2015, Increased epstein-barr virus DNA load and antibodies against EBNA1 and EA in Sardinian patients with rheumatoid arthritis, Viral Immunol., 28, 385, 10.1089/vim.2015.0035 Sipka, 2017, Down-regulation of increased TRAF6 expression in the peripheral mononuclear cells of patients with primary Sjögren’s syndrome by an EBV-EBER1-specific synthetic single-stranded complementary DNA molecule, International Journal of Rheumatic Diseases, 20, 614, 10.1111/1756-185X.13087 Ascherio Farina, 2017, Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes, Arthritis Res. Ther., 19, 39, 10.1186/s13075-017-1237-9 Bo, 2018, Interferon regulatory factor 5 is a potential target of autoimmune response triggered by Epstein-barr virus and Mycobacterium avium subsp. paratuberculosis in rheumatoid arthritis: investigating a mechanism of molecular mimicry, Clin. Exp. Rheumatol., 36, 376 Cossu, 2017, Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system, Sci. Rep., 7, 3179, 10.1038/s41598-017-03370-z Slavin, 2018, High levels of antibodies against PtpA and PknG secreted by Mycobacterium avium ssp. paratuberculosis are present in neuromyelitis optica spectrum disorder and multiple sclerosis patients, J. Neuroimmunol., 323, 49, 10.1016/j.jneuroim.2018.07.007 Niegowska, 2017, Increased seroreactivity to proinsulin and homologous mycobacterial peptides in latent autoimmune diabetes in adults, PloS One, 12, 10.1371/journal.pone.0176584 Niegowska, 2016, Type 1 Diabetes at-risk children highly recognize Mycobacterium avium subspecies paratuberculosis epitopes homologous to human Znt8 and Proinsulin, Sci. Rep., 6, 22266, 10.1038/srep22266 Bo, 2018, Rheumatoid arthritis patient antibodies highly recognize IL-2 in the immune response pathway involving IRF5 and EBV antigens, Sci. Rep., 8, 1789, 10.1038/s41598-018-19957-z von Herrath, 2003, Microorganisms and autoimmunity: making the barren field fertile?, Nat. Rev. Microbiol., 1, 151, 10.1038/nrmicro754 Gómez-Bañuelos, 2019, Rheumatoid arthritis-associated mechanisms of Porphyromonas gingivalis and aggregatibacter actinomycetemcomitans, J. Clin. Med., 8, 1309, 10.3390/jcm8091309 Pratesi, 2006, Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti–citrullinated protein antibodies in rheumatoid arthritis, Arthritis Rheum., 54, 733, 10.1002/art.21629 Harley, 2018, Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity, Nat. Genet., 50, 699, 10.1038/s41588-018-0102-3 Aletaha, 2010, Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against Rheumatism collaborative initiative, Ann. Rheum. Dis., 69, 1580, 10.1136/ard.2010.138461 Petri, 2012, Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus, Arthritis Rheum., 64, 2677, 10.1002/art.34473 van den Hoogen, 2013, 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative, Ann. Rheum. Dis., 72, 1747, 10.1136/annrheumdis-2013-204424 Shiboski, 2016, American college of rheumatology/European league against rheumatism classification criteria for primary sjögren’s syndrome: a consensus and data-driven methodology involving three international patient cohorts, Arthritis & Rheumatology, 69, 35, 10.1002/art.39859 Gladman Dd, 2002, Systemic lupus erythematosus disease activity index 2000, J. Rheumatol., 29, 288 Valentini, 2001, European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes, Ann. Rheum. Dis., 60, 592, 10.1136/ard.60.6.592 Seror, 2010, EULAR Sjögren’s syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjögren’s syndrome, Ann. Rheum. Dis., 69, 1103, 10.1136/ard.2009.110619 Bevaart, 2010, Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis?, Arthritis Rheum., 62, 2192, 10.1002/art.27503 McInnes, 2011, The pathogenesis of rheumatoid arthritis, N. Engl. J. Med., 365, 2205, 10.1056/NEJMra1004965 Kollias, 2011, Animal models for arthritis: innovative tools for prevention and treatment, Ann. Rheum. Dis., 70, 1357, 10.1136/ard.2010.148551 Egan, 2008, Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis, Arthritis Rheum., 58, 3720, 10.1002/art.24075 Midwood, 2009, Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease, Nat. Med., 15, 774, 10.1038/nm.1987 Asquith, 2009, Animal models of rheumatoid arthritis, Eur. J. Immunol., 39, 2040, 10.1002/eji.200939578 Khoyratty, 2018, Diverse mechanisms of IRF5 action in inflammatory responses, Int. J. Biochem. Cell Biol., 99, 38, 10.1016/j.biocel.2018.03.012 Farina, 2014, Epstein–Barr virus infection induces aberrant TLR activation pathway and fibroblast–myofibroblast conversion in Scleroderma, J. Invest. Dermatol., 134, 954, 10.1038/jid.2013.423 Efthymiou, 2018, AB0751The epstein-barr virus infection in systemic sclerosis Severa, 2019, A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis, J. Autoimmun., 101, 1, 10.1016/j.jaut.2019.04.006