Antibodies against mouse nerve growth factor interfere in vivo with the development of avian sensory and sympathetic neurones

Development (Cambridge) - Tập 103 Số 3 - Trang 545-552 - 1988
Hermann Rohrer1, Magdalena Hofer1, Rainer Hellweg1, Sigrun I. Korsching1, August D. Stehle1, Siawusch Saadat1, H. Thoenen1
1Max-Planck Institute for Psychiatry, Department of Neurochemistry, Am Klopferspttz 18A, D-8033 Marttnsried, FRG

Tóm tắt

Abstract The monoclonal antibody 27/21 directed against mouse nerve growth factor (NGF) interferes in vivo with the survival of sensory dorsal root ganglion (DRG) neurones during the development of the quail embryo: the number of DRG neurones at embryonic day 11 (Ell) was reduced by about 30 % in embryos treated with the antibody between E3 and Ell. Neurone numbers in the nodose ganglion were not affected. The effect of NGF antibodies on sympathetic neurones was assessed by determining the levels of the adrenergic marker enzyme tyrosine hydroxylase. Both total tyrosine hydroxylase activity and protein levels in sympathetic chains were reduced by about 30 % in embryos treated with 27/21 antibody but not in embryos treated with a control antibody. The 27/21 antibody cross-reacts with chick NGF-like activity as shown in vitro by the ability of the antibody to partially block the survival activity of chick-embryo-fibroblast-conditioned medium for E9 chick DRG neurones.

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Tài liệu tham khảo

Acheson, 1984, Nerve growth factor-mediated enzyme induction in primary cultures of bovine adrenal chromaffin cells: specificity and level of regulation, J. Neurosci, 41, 1771, 10.1523/JNEUROSCI.04-07-01771.1984

Barde, 1980, Sensory neurons in culture: Changing requirements for survival factors during embryonic development, Proc, natn. Acad. Sci. U.S.A, 77, 1199, 10.1073/pnas.77.2.1199

Barde, 1978, New factor released by cultured glioma cells supporting survival and growth of sensory neurons, Nature, Lond, 274, 818, 10.1038/274818a0

Belew, 1986, Chick embryo nerve growth factor. Fractionation and biological activity, Expl Cell Res, 167, 550, 10.1016/0014-4827(86)90194-1

Bocchini, 1969, The nerve growth factor: Purification as a 30.000-molecular weight protein, Proc. natn. Acad. Sci. U.S.A, 64, 787, 10.1073/pnas.64.2.787

Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analyt. Biochem, 72, 248, 10.1016/0003-2697(76)90527-3

Brambell, 1970, The transfer of passive immunity from mother to young, In Frontiers in Biology

Cohen, 1960, Purification of a nerve-growth promoting protein from the mouse salivary gland and its neurocytotoxic antiserum, Proc. natn. Acad. Sci. U.S.A, 46, 302, 10.1073/pnas.46.3.302

Collins, 1978, Induction of neurite outgrowth by a conditioned-medium factor bound to the culture substratum, Proc. natn. Acad. Sci. U.S.A, 75, 5210, 10.1073/pnas.75.10.5210

Davies, 1986, Different factors from the central nervous system and periphery regulate the survival of sensory neurones, Nature, Lond, 319, 497, 10.1038/319497a0

Dimberg, 1987, Effects of nerve growth factor on sensory neurons in the chick embryo: a stereological study, Int. J. devl Neuroscience, 5, 207, 10.1016/0736-5748(87)90031-1

Ebendal, 1986, Structure and expression of the chicken /3-nerve growth factor gene, EMBO J, 5, 1483, 10.1002/j.1460-2075.1986.tb04386.x

Ebendal, 1984, Nerve growth factors in chick and rat tissues, In Cellular and Molecular Biology of Neuronal Development, 231, 10.1007/978-1-4613-2717-2_15

Edgar, 1982, Modulation of NGF-induced survival of chick sympathetic neurons by contact with a conditioned medium factor bound to the culture substrate, Dev. Brain Res, 5, 89, 10.1016/0165-3806(82)90115-8

Edgar, 1988, Structural requirements for the stimulation of neurite outgrowth by two variants of laminin and their inhibition by antibodies, J. Cell Biol, (in press), 10.1083/jcb.106.4.1299

Goedert, 1978, Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia, Brain Res, 148, 264, 10.1016/0006-8993(78)90401-8

Gorin, 1979, Experimental autoimmune model of nerve growth factor deprivation: effects on developing peripheral sympathetic and sensory neurons, Proc. natn. Acad. Sci. U.S.A, 76, 5382, 10.1073/pnas.76.10.5382

Gorin, 1980, Effects of exposure to nerve growth factor antibodies on the developing nervous system of the rat: an experimental autoimmune approach, Devi Biol, 80, 313, 10.1016/0012-1606(80)90407-8

Greene, 1980, The nerve growth factor: biochemistry, synthesis, and mechanism of action, A. Rev. Neurosci, 3, 353, 10.1146/annurev.ne.03.030180.002033

Hamburger, 1981, Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor, J. Neurosci, 1, 60, 10.1523/JNEUROSCI.01-01-00060.1981

Harper, 1983, Biological and immunological properties of the nerve growth factor from bovine seminal plasma. Comparison with the properties of mouse nerve growth factor, Neuroscience, 8, 375, 10.1016/0306-4522(83)90073-8

Helfand, 1978, Non-equivalence of conditioned medium and nerve growth factor for sympathetic, parasympathetic and sensory neurons, Expl Cell Res, 113, 39, 10.1016/0014-4827(78)90085-X

Heumann, 1984, Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues, EMBO. J, 3, 3183, 10.1002/j.1460-2075.1984.tb02277.x

Hill, 1981, Inability of antisera to mouse nerve growth factor to cause an immunosympathectomy in chick embryos, Proc. Austral. Physiol. Pharm. Soc, 12, 51

Hofer, 1988, Brain-derived neurotrophic factor prevents death in vivo, Nature, Lond, 331, 261, 10.1038/331261a0

Johnson, 1980, Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor, Science, 210, 916, 10.1126/science.7192014

Kaaden, 1982, Establishment and characterization of chicken embryo fibroblast clone LSCC-H32, In Vitro, 18, 827, 10.1007/BF02796323

Korsching, 1983, Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation, Proc. natn. Acad. Sci. U.S.A, 80, 3513, 10.1073/pnas.80.11.3513

Korsching, 1987, Two-site enzyme immunoassay for nerve growth factor, In Methods in Enzymology: Peptide Growth Factors, 167, 10.1016/0076-6879(87)47108-5

Levi-Montalcini, 1966, The nerve growth factor: its mode of action on sensory and sympathetic nerve cells, Harvey Leet, 60, 127

Levi-Montalcini, 1963, Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro, Devi Biol, 7, 653, 10.1016/0012-1606(63)90149-0

Levi-Montalcini, 1960, Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein, Proc. natn. Acad. Sci. U.S.A, 46, 384, 10.1073/pnas.46.3.384

Lindsay, 1985, Placodal sensory neurons in culture. Nodose ganglion neurons are unresponsive to NGF, lack NGF receptors but are supported by a liver-derived neurotrophic factor, Devi Biol, 112, 30, 10.1016/0012-1606(85)90116-2

Mccarthy, 1976, Preparation of pure neuronal and non-neuronal cultures of embryonic chick sympathetic ganglia: a new method based on both differential cell adhesiveness and the formation of homotypic neuronal aggregates, Brain Res, 114, 391, 10.1016/0006-8993(76)90962-8

Meier, 1986, Molecular cloning of bovine and chick nerve growth factor (NGF): delineation of conserved and unconserved domains and their relationship to the biological activity and antigenicity of NGF, EMBO J, 5, 1489, 10.1002/j.1460-2075.1986.tb04387.x

Norrgren, 1986, Nerve growth factor in medium conditioned by embryonic chicken heart cells, Int. J. devl Neurosci, 4, 41, 10.1016/0736-5748(86)90015-8

Palladini, 1961, Neurodegenerazione nella ontogenesi di quaglia (Cotumix cotumix japónica T.e.S, Riv. Neurobiol, 7, 383

Raivich, 1985, The spatial and temporal pattern of /3-NGF receptor expression in the developing chick embryo, EMBO J, 4, 637, 10.1002/j.1460-2075.1985.tb03677.x

Richardson, 1986, Distribution of neuronal receptors for nerve growth factor in the rat, J. Neurosci, 6, 2312, 10.1523/JNEUROSCI.06-08-02312.1986

Rohrer, 1986, Developmental potential of quail dorsal root ganglion cells analyzed in vitro and in vivo, J. Neurosci, 6, 2612, 10.1523/JNEUROSCI.06-09-02616.1986

Rohrer, 1982, Presence and disappearance of nerve growth factor receptors on sensory neurons in culture, Devi Biol, 89, 309, 10.1016/0012-1606(82)90320-7

Rohrer, 1988, The synthesis of nerve growth factor (NGF) in developing skin is independent of innervation, Devi Biol. (in press), 10.1016/0012-1606(88)90286-2

Shelton, 1984, Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs, Proc. natn. Acad. Sci. U.S.A, 81, 7951, 10.1073/pnas.81.24.7951

Suda, 1978, Nerve growth factor in mouse and rat serum: correlation between bioassay and radioimmunoassay determinations, Proc. natn. Acad. Sci. U.S.A, 75, 4042, 10.1073/pnas.75.8.4042

Sutter, 1979, Nerve growth factor receptor. Characterization of two distinct classes of binding sites on chick embryo sensory ganglion cells, J. biol. Chem, 254, 5972, 10.1016/S0021-9258(18)50507-X

Thoenen, 1987, The physiological function of nerve growth factor in the central nervous system: Comparison with the periphery, Rev. Physiol. Biochem. Pharmacol, 109, 145, 10.1007/BFb0031026

Thoenen, 1980, The physiology of nerve growth factor, Physiol. Rev, 60, 1284, 10.1152/physrev.1980.60.4.1284

Varón, 1981, Trophic and specifying factors directed to neural cells, In Advances in Cellular Neurobiology, 115

Vogel, 1972, Acetylcholine receptors of muscle grown in vitro, Proc. natn. Acad. Sci. U.S.A, 69, 3180, 10.1073/pnas.69.11.3180

Young, 1975, Secretion of a nerve growth factor by primary chick fibroblast cultures, Science, 187, 361, 10.1126/science.1167427

Zacchei, 1961, Lo sviluppo embrionale della quaglia giapponese (Coturnix cotumix japónica T.e.S, Arch. Ital. Anal. Embryol, 66, 36