Antibiotic resistance mechanisms in Acinetobacter spp. strains isolated from patients in a paediatric hospital in Mexico

Jones, 2004, Rates of antimicrobial resistance among common bacterial pathogens causing respiratory, blood, urine, and skin and soft tissue infections in pediatric patients, Eur J Clin Microbiol Infect Dis, 23, 445, 10.1007/s10096-004-1133-5 Traglia, 2014, Bacteremia caused by an Acinetobacter junii strain harboring class 1 integron and diverse DNA mobile elements, J Infect Dev Ctries, 8, 666, 10.3855/jidc.3747 Touchon, 2014, The genomic diversification of the whole Acinetobacter genus: origins, mechanisms, and consequences, Genome Biol Evol, 6, 2866, 10.1093/gbe/evu225 Perez, 2007, Global challenge of multidrug-resistant Acinetobacter baumannii, Antimicrob Agents Chemother, 51, 3471, 10.1128/AAC.01464-06 Périchon, 2014, Identification of 50 class D β-lactamases and 65 Acinetobacter-derived cephalosporinases in Acinetobacter spp, Antimicrob Agents Chemother, 58, 936, 10.1128/AAC.01261-13 Gundi, 2009, Validation of partial rpoB gene sequence analysis for the identification of clinically important and emerging Acinetobacter species, Microbiology, 155, 2333, 10.1099/mic.0.026054-0 Kumar, 2016, MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets, Mol Biol Evol, 33, 1870, 10.1093/molbev/msw054 Clinical and Laboratory Standards Institute (CLSI), 2018 Bello-López, 2019, Resistome and a novel blaNDM-1-harboring plasmid of an Acinetobacter haemolyticus strain from a children’s hospital in Puebla, Mexico, Microb Drug Resist, 25, 1023, 10.1089/mdr.2019.0034 Gholami, 2015, Efflux pump inhibitor phenylalanine-arginine β-naphthylamide effect on the minimum inhibitory concentration of imipenem in Acinetobacter baumannii strains isolated from hospitalized patients in Shahid Motahari Burn Hospital, Tehran, Iran, Jundishapur J Microbiol, 8, 10.5812/jjm.19048 Durmaz, 2009, The optimization of a rapid pulsed-field gel electrophoresis protocol for the typing of Acinetobacter baumannii, Escherichia coli and Klebsiella spp, Jpn J Infect Dis, 62, 372, 10.7883/yoken.JJID.2009.372 Tenover, 1995, Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing, J Clin Microbiol, 33, 2233, 10.1128/JCM.33.9.2233-2239.1995 Green, 2012 Wong, 2017, Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges, Clin Microbiol Rev, 30, 409, 10.1128/CMR.00058-16 Garza-González, 2010, Prevalence of multidrug-resistant bacteria at a tertiary-care teaching hospital in Mexico: special focus on Acinetobacter baumannii, Chemotherapy, 56, 275, 10.1159/000319903 Bocanegra-Ibarias, 2015, Genetic characterisation of drug resistance and clonal dynamics of Acinetobacter baumannii in a hospital setting in Mexico, Int J Antimicrob Agents, 45, 309, 10.1016/j.ijantimicag.2014.10.022 Schleicher, 2013, Molecular epidemiology of Acinetobacter baumannii and Acinetobacter nosocomialis in Germany over a 5-year period (2005–2009), Clin Microbiol Infect, 19, 737, 10.1111/1469-0691.12026 Tripathi, 2014, Clinical and antimicrobial profile of Acinetobacter spp.: an emerging nosocomial superbug, Adv Biomed Res, 3, 13, 10.4103/2277-9175.124642 Morfín-Otero, 2013, Acinetobacter baumannii infections in a tertiary care hospital in Mexico over the past 13 years, Chemotherapy, 59, 57, 10.1159/000351098 Al Atrouni, 2016, Reservoirs of non-baumannii Acinetobacter species, Front Microbiol, 7, 49, 10.3389/fmicb.2016.00049 Figueiredo, 2012, Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii, and Acinetobacter calcoaceticus, Clin Microbiol Infect, 18, 907, 10.1111/j.1469-0691.2011.03708.x Marquez-Ortiz, 2017, Genomic epidemiology of NDM-1-encoding plasmids in Latin American clinical isolates reveals insights into the evolution of multidrug resistance, Genome Biol Evol, 9, 1725, 10.1093/gbe/evx115 Fu, 2012, Epidemiological characteristics and genetic structure of blaNDM-1 in non-baumannii Acinetobacter spp. In China, J Antimicrob Chemother, 67, 2114, 10.1093/jac/dks192 Maravić, 2016, Urban riverine environment is a source of multidrug-resistant and ESBL-producing clinically important Acinetobacter spp, Environ Sci Pollut Res, 23, 3525, 10.1007/s11356-015-5586-0 Forcella, 2010, QnrB9 in association with TEM-116 extended-spectrum β-lactamase in Citrobacter freundii isolated from sewage effluent: first report from Italy, J Chemother, 22, 243, 10.1179/joc.2010.22.4.243 Hu, 2008, Phenotypic and molecular characterization of TEM-116 extended-spectrum®-lactamase produced by a Shigella flexneri clinical isolate from chickens, FEMS Microbiol Lett, 279, 162, 10.1111/j.1574-6968.2007.01017.x Lahlaoui, 2011, First detection of TEM-116 extended-spectrum β-lactamase in a Providencia stuartii isolate from a Tunisian hospital, Indian J Med Microbiol, 29, 258, 10.4103/0255-0857.83909 Lambert, 1993, Characterization of Acinetobacter haemolyticus aac(6ʹ)-Ig gene encoding an aminoglycoside 6ʹ-N-acetyltransferase which modifies amikacin, Antimicrob Agents Chemother, 37, 2093, 10.1128/AAC.37.10.2093 Doi, 2004, Spread of novel aminoglycoside resistance gene aac(6ʹ)-Iad among Acinetobacter clinical isolates in Japan, Antimicrob Agents Chemother, 48, 2075, 10.1128/AAC.48.6.2075-2080.2004 Wibberg, 2018, Complete genome sequencing of Acinetobacter baumannii strain K50 discloses the large conjugative plasmid pK50a encoding carbapenemase OXA-23 and extended-spectrum β-lactamase GES-11, Antimicrob Agents Chemother, 62, e00212, 10.1128/AAC.00212-18 Chagas, 2014, Characterization of carbapenem-resistant Acinetobacter baumannii in Brazil (2008–2011): countrywide spread of OXA-23-producing clones (CC15 and CC79), Diagn Microbiol Infect Dis, 79, 468, 10.1016/j.diagmicrobio.2014.03.006 Alcántar-Curiel, 2014, Molecular mechanisms associated with nosocomial carbapenem-resistant Acinetobacter baumannii in Mexico, Arch Med Res, 45, 553, 10.1016/j.arcmed.2014.10.006 Kaur, 2018, Prevalence of extended spectrum betalactamase (ESBL) and metallobetalactamase (MBL) producing Pseudomonas aeruginosa and Acinetobacter baumannii isolated from various clinical samples, J Pathog, 2018, 6845985, 10.1155/2018/6845985 Lin, 2017, Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance, J Microbiol Immunol Infect, 50, 224, 10.1016/j.jmii.2015.04.004 Coyne, 2011, Efflux-mediated antibiotic resistance in Acinetobacter spp, Antimicrob Agents Chemother, 55, 947, 10.1128/AAC.01388-10 Ostadi, 2019, The involvement of drug efflux system in amikacin resistance of multiple drug resistant Acinetobacter baumannii isolates in Isfahan, Iran, J Med Bacteriol, 8, 13 Rumbo, 2013, Contribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii, Antimicrob Agents Chemother, 57, 5247, 10.1128/AAC.00730-13 Sun, 2015, Mutant prevention concentrations of levofloxacin, pazufloxacin and ciprofloxacin for A. Baumannii and mutations in gyrA and parC genes, J Antibiot (Tokyo), 68, 313, 10.1038/ja.2014.150 Gu, 2015, Substitutions of Ser83Leu in GyrA and Ser80Leu in ParC associated with quinolone resistance in Acinetobacter pittii, Microb Drug Resist, 21, 345, 10.1089/mdr.2014.0057